Details of the Target

General Information of Target

Target ID LDTP01147
Target Name Nephrocystin-4 (NPHP4)
Gene Name NPHP4
Gene ID 261734
Synonyms
KIAA0673; Nephrocystin-4; Nephroretinin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNDWHRIFTQNVLVPPHPQRARQPWKESTAFQCVLKWLDGPVIRQGVLEVLSEVECHLRV
SFFDVTYRHFFGRTWKTTVKPTKRPPSRIVFNEPLYFHTSLNHPHIVAVVEVVAEGKKRD
GSLQTLSCGFGILRIFSNQPDSPISASQDKRLRLYHGTPRALLHPLLQDPAEQNRHMTLI
ENCSLQYTLKPHPALEPAFHLLPENLLVSGLQQIPGLLPAHGESGDALRKPRLQKPITGH
LDDLFFTLYPSLEKFEEELLELHVQDHFQEGCGPLDGGALEILERRLRVGVHNGLGFVQR
PQVVVLVPEMDVALTRSASFSRKVVSSSKTSSGSQALVLRSRLRLPEMVGHPAFAVIFQL
EYVFSSPAGVDGNAASVTSLSNLACMHMVRWAVWNPLLEADSGRVTLPLQGGIQPNPSHC
LVYKVPSASMSSEEVKQVESGTLRFQFSLGSEEHLDAPTEPVSGPKVERRPSRKPPTSPS
SPPAPVPRVLAAPQNSPVGPGLSISQLAASPRSPTQHCLARPTSQLPHGSQASPAQAQEF
PLEAGISHLEADLSQTSLVLETSIAEQLQELPFTPLHAPIVVGTQTRSSAGQPSRASMVL
LQSSGFPEILDANKQPAEAVSATEPVTFNPQKEESDCLQSNEMVLQFLAFSRVAQDCRGT
SWPKTVYFTFQFYRFPPATTPRLQLVQLDEAGQPSSGALTHILVPVSRDGTFDAGSPGFQ
LRYMVGPGFLKPGERRCFARYLAVQTLQIDVWDGDSLLLIGSAAVQMKHLLRQGRPAVQA
SHELEVVATEYEQDNMVVSGDMLGFGRVKPIGVHSVVKGRLHLTLANVGHPCEQKVRGCS
TLPPSRSRVISNDGASRFSGGSLLTTGSSRRKHVVQAQKLADVDSELAAMLLTHARQGKG
PQDVSRESDATRRRKLERMRSVRLQEAGGDLGRRGTSVLAQQSVRTQHLRDLQVIAAYRE
RTKAESIASLLSLAITTEHTLHATLGVAEFFEFVLKNPHNTQHTVTVEIDNPELSVIVDS
QEWRDFKGAAGLHTPVEEDMFHLRGSLAPQLYLRPHETAHVPFKFQSFSAGQLAMVQASP
GLSNEKGMDAVSPWKSSAVPTKHAKVLFRASGGKPIAVLCLTVELQPHVVDQVFRFYHPE
LSFLKKAIRLPPWHTFPGAPVGMLGEDPPVHVRCSDPNVICETQNVGPGEPRDIFLKVAS
GPSPEIKDFFVIIYSDRWLATPTQTWQVYLHSLQRVDVSCVAGQLTRLSLVLRGTQTVRK
VRAFTSHPQELKTDPKGVFVLPPRGVQDLHVGVRPLRAGSRFVHLNLVDVDCHQLVASWL
VCLCCRQPLISKAFEIMLAAGEGKGVNKRITYTNPYPSRRTFHLHSDHPELLRFREDSFQ
VGGGETYTIGLQFAPSQRVGEEEILIYINDHEDKNEEAFCVKVIYQ
Target Bioclass
Other
Family
NPHP4 family
Subcellular location
Cytoplasm, cytoskeleton, cilium basal body
Function
Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1. In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling. Acts as a negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ.
Uniprot ID
O75161
Ensemble ID
ENST00000378156.9
HGNC ID
HGNC:19104

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW Substitution: p.T1004K .
AU565 SNV: p.E1376K .
CAL51 SNV: p.C1120Y .
CHL1 SNV: p.P579L .
COLO679 SNV: p.H1231Y .
ICC8 SNV: p.Q1314H .
JHH7 SNV: p.S1142P .
LS180 SNV: p.P579H .
MELJUSO SNV: p.L1043R .
MFE319 SNV: p.C657Y; p.C1174R .
MOLT4 SNV: p.G157D; p.D311N .
NCIH1048 SNV: p.Q1077Ter .
NCIH2286 SNV: p.A988S .
OCUG1 SNV: p.P527L .
PF382 SNV: p.R1398K .
RKO SNV: p.E261K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1174(1.37); C1181(1.37)  LDD0532  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1174(1.16)  LDD0812  [1]
 LDCM0215  AC10 HCT 116 C1174(1.37); C1181(1.37)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C1174(1.05); C1181(1.05)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C1174(0.98); C1181(0.98)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C1174(1.06); C1181(1.06)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C1174(1.06); C1181(1.06)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C1174(0.95); C1181(0.95)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C1174(1.04); C1181(1.04)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C1174(1.04); C1181(1.04)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C1174(1.07); C1181(1.07)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C1174(0.94); C1181(0.94)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C1174(1.00); C1181(1.00)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C1174(1.16); C1181(1.16)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C1174(1.08); C1181(1.08)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C1174(1.08); C1181(1.08)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C1174(0.93); C1181(0.93)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C1174(0.86); C1181(0.86)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C1174(0.82); C1181(0.87)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C1174(1.03); C1181(0.80)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C1174(0.79); C1181(1.04)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C1174(0.95); C1181(0.76)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C1174(0.79); C1181(0.85)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C1174(0.84); C1181(0.81)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C1174(1.07); C1181(1.07)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C1174(0.67); C1181(0.78)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C1174(0.92); C1181(0.91)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C1174(0.73); C1181(0.68)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C1174(1.25); C1181(0.88)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C1174(0.84); C1181(0.92)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C1174(0.75); C1181(0.76)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C1174(0.71); C1181(0.69)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C1174(0.80); C1181(0.80)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C1174(0.80); C1181(0.80)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C1174(0.86); C1181(0.86)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C1174(0.90); C1181(0.90)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C1174(0.91); C1181(0.91)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C1174(0.95); C1181(0.95)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C1174(0.91); C1181(0.91)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C1174(0.73); C1181(0.73)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C1174(0.83); C1181(0.83)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C1174(0.88); C1181(0.88)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C1174(0.89); C1181(0.89)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C1174(0.88); C1181(0.88)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C1174(1.00); C1181(1.00)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C1174(1.29); C1181(1.29)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C1174(0.77); C1181(0.77)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C1174(0.82); C1181(0.82)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C1174(0.90); C1181(0.90)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C1174(1.07); C1181(1.07)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C1174(1.17); C1181(1.17)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C1174(1.17); C1181(1.17)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C1174(1.33); C1181(1.33)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C1174(1.07); C1181(1.07)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C1174(2.36); C1181(2.36)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C1174(1.70); C1181(1.70)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C1174(1.18); C1181(1.18)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C1174(1.07); C1181(1.07)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C1174(1.32); C1181(1.32)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C1174(1.10); C1181(1.10)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C1174(1.73); C1181(1.73)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C1174(1.15); C1181(1.15)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C1174(1.27); C1181(1.27)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C1174(1.24); C1181(1.24)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C1174(1.28); C1181(1.28)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C1174(0.81); C1181(0.81)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C1174(0.80); C1181(0.80)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C1174(1.01); C1181(1.01)  LDD0595  [1]
 LDCM0279  AC2 HEK-293T C1174(1.05)  LDD0877  [1]
 LDCM0280  AC20 HCT 116 C1174(1.08); C1181(1.08)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C1174(0.86); C1181(0.86)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C1174(1.16); C1181(1.16)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C1174(0.96); C1181(0.96)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C1174(1.10); C1181(1.10)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C1174(1.04); C1181(1.04)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C1174(0.99); C1181(0.99)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C1174(1.25); C1181(1.25)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C1174(1.13); C1181(1.13)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C1174(0.97); C1181(0.97)  LDD0606  [1]
 LDCM0290  AC3 HEK-293T C1174(0.88)  LDD0888  [1]
 LDCM0291  AC30 HCT 116 C1174(1.03); C1181(1.03)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C1174(0.90); C1181(0.90)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C1174(0.87); C1181(0.87)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C1174(1.23); C1181(1.23)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C1174(1.12); C1181(1.12)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C1174(1.03); C1181(1.03)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C1174(1.05); C1181(1.05)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C1174(1.29); C1181(1.29)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C1174(1.08); C1181(1.08)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C1174(1.09); C1181(1.09)  LDD0617  [1]
 LDCM0301  AC4 HEK-293T C1174(1.08)  LDD0899  [1]
 LDCM0302  AC40 HCT 116 C1174(1.03); C1181(1.03)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C1174(1.10); C1181(1.10)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C1174(1.05); C1181(1.05)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C1174(1.04); C1181(1.04)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C1174(1.06); C1181(1.06)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C1174(1.10); C1181(1.10)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C1174(0.91); C1181(0.91)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C1174(0.85); C1181(0.85)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C1174(0.98); C1181(0.98)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C1174(0.74); C1181(0.74)  LDD0628  [1]
 LDCM0312  AC5 HEK-293T C1174(1.54)  LDD0910  [1]
 LDCM0313  AC50 HCT 116 C1174(0.85); C1181(0.85)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C1174(0.95); C1181(0.95)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C1174(0.86); C1181(0.86)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C1174(1.09); C1181(1.09)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C1174(0.81); C1181(0.81)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C1174(1.03); C1181(1.03)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C1174(0.91); C1181(0.91)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C1174(0.96); C1181(0.96)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C1174(1.06); C1181(1.06)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C1174(1.19); C1181(1.19)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C1174(1.18); C1181(1.18)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C1174(1.03); C1181(1.03)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C1174(1.03); C1181(1.03)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C1174(1.24); C1181(1.24)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C1174(0.98); C1181(0.98)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C1174(1.19); C1181(1.19)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C1174(1.19); C1181(1.19)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C1174(1.05); C1181(1.05)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C1174(0.82); C1181(0.82)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C1174(0.97); C1181(0.97)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C1174(0.88); C1181(0.88)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C1174(1.21); C1181(1.21)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C1174(0.82); C1181(0.82)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C1174(1.36); C1181(1.36)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C1174(0.89); C1181(0.89)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C1174(1.01); C1181(1.01)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C1174(0.90); C1181(0.90)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C1174(1.09); C1181(1.09)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C1174(1.29); C1181(1.29)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C1174(1.08); C1181(1.08)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C1174(0.94); C1181(0.94)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C1174(1.12); C1181(1.12)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C1174(0.95); C1181(0.95)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C1174(1.12); C1181(1.12)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C1174(0.98); C1181(0.98)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C1174(0.96); C1181(0.96)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C1174(0.68); C1181(0.68)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C1174(0.61); C1181(0.61)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C1174(0.67); C1181(0.67)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C1174(0.94); C1181(0.94)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C1174(0.78); C1181(0.78)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C1174(0.91); C1181(0.91)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C1174(0.80); C1181(0.80)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C1174(0.79); C1181(0.79)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C1174(0.92); C1181(0.92)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C1174(0.84); C1181(0.84)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C1174(0.67); C1181(0.67)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C1174(0.85); C1181(0.85)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C1174(0.92); C1181(0.92)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C1174(1.05); C1181(1.05)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C1174(0.68); C1181(0.68)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C1174(0.93); C1181(0.93)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C1174(0.95); C1181(0.95)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C1174(1.19); C1181(1.19)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C1174(1.02); C1181(1.02)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C1174(1.17); C1181(1.17)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C1174(0.94); C1181(0.94)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C1174(0.89); C1181(0.89)  LDD0685  [1]
 LDCM0369  CL100 HEK-293T C1174(1.01)  LDD0967  [1]
 LDCM0370  CL101 HCT 116 C1174(1.11); C1181(1.11)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C1174(1.20); C1181(1.20)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C1174(1.15); C1181(1.15)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C1174(1.10); C1181(1.10)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C1174(1.05); C1181(1.05)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C1174(0.88); C1181(0.88)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C1174(0.80); C1181(0.80)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C1174(0.72); C1181(0.72)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C1174(1.12); C1181(1.12)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C1174(1.00); C1181(1.00)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C1174(1.35); C1181(1.35)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C1174(0.79); C1181(0.79)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C1174(0.98); C1181(0.98)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C1174(0.98); C1181(0.98)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C1174(0.90); C1181(0.90)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C1174(0.88); C1181(0.88)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C1174(0.97); C1181(0.97)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C1174(1.00); C1181(1.00)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C1174(1.12); C1181(1.12)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C1174(1.02); C1181(1.02)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C1174(0.91); C1181(0.91)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C1174(1.09); C1181(1.09)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C1174(1.46); C1181(1.46)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C1174(0.82); C1181(0.82)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C1174(1.12); C1181(1.12)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C1174(0.90); C1181(0.90)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C1174(1.26); C1181(1.26)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C1174(0.93); C1181(0.93)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C1174(0.95); C1181(0.95)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C1174(1.22); C1181(1.22)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C1174(0.87); C1181(0.87)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C1174(1.34); C1181(1.34)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C1174(1.07); C1181(1.07)  LDD0719  [1]
 LDCM0403  CL16 PaTu 8988t C1174(1.06); C1181(1.06)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C1174(1.19); C1181(1.19)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C1174(0.78); C1181(0.78)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C1174(0.87); C1181(0.87)  LDD1285  [1]
 LDCM0407  CL2 HCT 116 C1174(0.97); C1181(0.97)  LDD0724  [1]
 LDCM0408  CL20 PaTu 8988t C1174(0.92); C1181(0.92)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C1174(0.96); C1181(0.96)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C1174(1.03); C1181(1.03)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C1174(1.04); C1181(1.04)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C1174(1.12); C1181(1.12)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C1174(1.10); C1181(1.10)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C1174(0.85); C1181(0.85)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C1174(1.08); C1181(1.08)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C1174(0.94); C1181(0.94)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C1174(1.04); C1181(1.04)  LDD1296  [1]
 LDCM0418  CL3 HCT 116 C1174(1.02); C1181(1.02)  LDD0735  [1]
 LDCM0419  CL30 PaTu 8988t C1174(0.86); C1181(0.86)  LDD1298  [1]
 LDCM0420  CL31 HEK-293T C1120(0.69)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C1120(0.67)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C1120(0.73)  LDD1626  [2]
 LDCM0424  CL35 HEK-293T C1120(0.96)  LDD1628  [2]
 LDCM0429  CL4 HCT 116 C1174(0.98); C1181(0.98)  LDD0746  [1]
 LDCM0433  CL43 HEK-293T C1120(0.80)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C1120(0.82)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C1120(0.96)  LDD1639  [2]
 LDCM0436  CL46 HCT 116 C1174(1.07); C1181(1.07)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C1174(1.03); C1181(1.03)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C1174(1.23); C1181(1.23)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C1174(1.19); C1181(1.19)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C1174(0.88); C1181(0.88)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C1174(1.09); C1181(1.09)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C1174(1.19); C1181(1.19)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C1174(1.42); C1181(1.42)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C1174(1.45); C1181(1.45)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C1174(0.98); C1181(0.98)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C1174(1.08); C1181(1.08)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C1174(1.09); C1181(1.09)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C1174(1.15); C1181(1.15)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C1174(1.03); C1181(1.03)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C1174(0.96); C1181(0.96)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C1174(0.90); C1181(0.90)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C1174(1.00); C1181(1.00)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C1174(0.80); C1181(0.80)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C1174(0.93); C1181(0.93)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C1174(0.91); C1181(0.91)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C1174(0.88); C1181(0.88)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C1174(0.88); C1181(0.88)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C1174(0.92); C1181(0.92)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C1174(0.85); C1181(0.85)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C1174(0.87); C1181(0.87)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C1174(0.80); C1181(0.80)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C1174(0.89); C1181(0.89)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C1174(0.99); C1181(0.99)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C1174(0.74); C1181(0.74)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C1174(0.88); C1181(0.88)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C1174(0.85); C1181(0.85)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C1174(0.91); C1181(0.91)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C1174(0.75); C1181(0.75)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C1174(0.80); C1181(0.80)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C1174(0.96); C1181(0.96)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C1174(0.85); C1181(0.85)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C1174(0.97); C1181(0.97)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C1174(0.80); C1181(0.80)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C1174(0.83); C1181(0.83)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C1174(0.84); C1181(0.84)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C1174(0.82); C1181(0.82)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C1174(0.80); C1181(0.80)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C1174(0.88); C1181(0.88)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C1174(0.76); C1181(0.76)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C1174(0.98); C1181(0.98)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C1174(0.82); C1181(0.82)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C1174(0.86); C1181(0.86)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C1174(0.83); C1181(0.83)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C1174(0.73); C1181(0.73)  LDD0802  [1]
 LDCM0486  CL91 HEK-293T C1174(1.49)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C1174(1.12)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C1174(1.08)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C1174(1.52)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C1174(1.25)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C1174(1.29)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C1174(1.31)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C1174(0.98)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C1174(1.10)  LDD1092  [1]
 LDCM0468  Fragment33 HCT 116 C1174(0.73); C1181(0.73)  LDD0785  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein-tyrosine kinase 2-beta (PTK2B) Tyr protein kinase family Q14289
RuvB-like 1 (RUVBL1) RuvB family Q9Y265
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Jade-1 (JADE1) JADE family Q6IE81
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein inturned (INTU) Inturned family Q9ULD6
Nephrocystin-1 (NPHP1) Nephrocystin-1 family O15259
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1) RPGRIP1 family Q96KN7

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402