Details of the Target

General Information of Target

Target ID LDTP00528
Target Name Guanine nucleotide exchange factor DBS (MCF2L)
Gene Name MCF2L
Gene ID 23263
Synonyms
KIAA0362; OST; Guanine nucleotide exchange factor DBS; DBL's big sister; MCF2-transforming sequence-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFDCWRFILCKRPGSNSYSSPQRPNEAKKEETDHQIDVSDVIRLVQDTPEATAMATDEIM
HQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTS
IPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIA
FKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALM
VKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLR
ELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGF
REVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIG
NKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLAS
QPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQ
ASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALR
RGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAE
MDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMED
FQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKE
MLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWT
DHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVG
ITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRAL
EQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTS
HSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGD
VVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCLSSSGKAHVPRAHP
Target Bioclass
Other
Family
MCF2 family
Subcellular location
Cytoplasm
Function
Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus. Isoform 5 activates CDC42.; [Isoform 3]: Does not catalyze guanine nucleotide exchange on CDC42.
Uniprot ID
O15068
Ensemble ID
ENST00000375597.8
HGNC ID
HGNC:14576
ChEMBL ID
CHEMBL4524032

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C951(5.53)  LDD1706  [1]
DBIA
 Probe Info  		C951(1.33)  LDD0531  [2]
IPM
 Probe Info  		C951(0.00); C223(0.00); C580(0.00)  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C951(1.33)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C741(0.98); C744(0.98); C750(1.13)  LDD0813  [2]
 LDCM0216  AC100 HEK-293T C741(1.23); C744(1.23); C750(1.23)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C741(1.28); C744(1.28); C750(1.28)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C741(1.22); C744(1.22); C750(1.22)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C741(1.05); C744(1.05); C750(1.05)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C741(1.06); C744(1.06); C750(1.06)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C741(1.15); C744(1.15); C750(1.15)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C741(1.38); C744(1.38); C750(1.38)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C741(1.07); C744(1.07); C750(1.07)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C741(1.23); C744(1.23); C750(1.23)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C741(1.03); C744(1.03); C750(1.03)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C741(0.88); C744(0.88); C750(0.94)  LDD0824  [2]
 LDCM0227  AC110 HEK-293T C741(1.37); C744(1.37); C750(1.37)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C741(1.36); C744(1.36); C750(1.36)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C741(1.15); C744(1.15); C750(1.15)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C741(1.07)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C741(1.01)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C741(1.07)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C741(1.06)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C741(1.08)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C741(1.25)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C741(1.16)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C741(1.24); C744(1.24); C750(1.13)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C741(1.06)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C741(1.02)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C741(1.21)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C741(1.31)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C741(1.19)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C741(1.04)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C741(1.06)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C741(1.29)  LDD0843  [2]
 LDCM0259  AC14 HEK-293T C741(1.35); C744(1.35); C750(1.17)  LDD0857  [2]
 LDCM0263  AC143 HEK-293T C750(1.28)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C750(1.58)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C750(1.84)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C750(1.33)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C750(1.88)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C750(0.73)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C750(0.98)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C741(0.87); C744(0.87); C750(0.98)  LDD0868  [2]
 LDCM0271  AC150 HEK-293T C750(1.37)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C750(1.33)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C750(1.26)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C750(1.54)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C750(0.96)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C750(1.00)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C750(1.76)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C750(2.17)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C951(1.47)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C951(1.43)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C951(1.15)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C951(1.53)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C951(1.20)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C951(1.47)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C951(1.07)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C951(1.06)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C951(1.37)  LDD0601  [2]
 LDCM0286  AC26 HEK-293T C223(1.63); C580(1.08)  LDD1525  [4]
 LDCM0290  AC3 HCT 116 C951(1.15)  LDD0607  [2]
 LDCM0293  AC32 HEK-293T C223(1.04)  LDD1532  [4]
 LDCM0295  AC34 HEK-293T C223(1.02); C580(1.24)  LDD1534  [4]
 LDCM0301  AC4 HCT 116 C951(1.00)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C223(1.58)  LDD1541  [4]
 LDCM0304  AC42 HEK-293T C223(0.89); C580(1.08)  LDD1543  [4]
 LDCM0308  AC46 HEK-293T C951(0.96)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C951(0.91)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C951(0.86)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C951(1.00)  LDD0909  [2]
 LDCM0312  AC5 HCT 116 C951(0.97)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C951(0.95)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C951(0.98)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C951(0.94)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C951(1.07)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C951(1.03)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C951(0.90)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C951(1.00)  LDD0917  [2]
 LDCM0320  AC57 HCT 116 C741(1.37); C750(1.39); C744(1.42)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C741(1.15); C750(1.17); C744(1.18)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C744(1.23); C750(1.24); C741(1.26)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C741(1.06); C744(1.06); C750(1.20)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C741(1.19); C750(1.24); C744(1.29)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C741(1.21); C750(1.42); C744(1.63)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C744(0.93); C750(1.02); C741(1.12)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C741(1.36); C750(1.38); C744(1.39)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C741(1.23); C750(1.29); C744(1.35)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C741(1.44); C750(1.50); C744(1.56)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C741(1.37); C750(1.50); C744(1.63)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C741(1.38); C750(1.47); C744(1.56)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C951(0.79)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C951(0.85)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C741(0.87); C744(0.87); C750(1.00)  LDD0932  [2]
 LDCM0335  AC70 HCT 116 C951(1.06)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C951(0.82)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C951(1.01)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C951(1.14)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C951(1.09)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C951(1.04)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C951(1.09)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C951(0.82)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C951(1.09)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C951(1.05)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C741(1.10); C744(1.10); C750(1.87)  LDD0943  [2]
 LDCM0346  AC80 HCT 116 C951(1.05)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C951(1.11)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C951(0.96)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C744(0.91); C750(0.91)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C744(0.89); C750(0.89)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C744(0.87); C750(0.87)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C744(0.96); C750(0.96)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C744(1.30); C750(1.30)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C744(0.86); C750(0.86)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C744(0.77); C750(0.77)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C744(1.51); C750(1.51)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C744(0.82); C750(0.82)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C744(0.75); C750(0.75)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C744(1.10); C750(1.10)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C744(1.26); C750(1.26)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C744(1.24); C750(1.24)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C744(0.83); C750(0.83)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C744(0.92); C750(0.92)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C741(1.26); C744(1.26); C750(1.26)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C741(1.32); C744(1.32); C750(1.32)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C741(1.26); C744(1.26); C750(1.20)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C741(1.13); C744(1.13); C750(1.51)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C741(1.08); C744(1.08); C750(1.48)  LDD0873  [2]
 LDCM0367  CL1 HCT 116 C741(0.93); C744(0.93); C750(0.93)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C741(1.22); C744(1.22); C750(1.22)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C951(1.04)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C741(0.91); C744(0.91); C750(1.29)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C741(1.04); C744(1.04); C750(1.20)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C741(0.90); C744(0.90); C750(1.18)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C741(1.23); C744(1.23); C750(1.34)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C951(1.20)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C951(1.83)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C951(1.78)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C951(1.81)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C951(1.39)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C741(0.96); C744(0.96); C750(0.96)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C951(1.40)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C951(1.57)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C223(1.13)  LDD1586  [4]
 LDCM0386  CL116 HEK-293T C223(1.02)  LDD1590  [4]
 LDCM0390  CL12 HCT 116 C741(1.46); C744(1.46); C750(1.46)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C223(0.99)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C951(0.97)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C951(1.01)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C951(0.89)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C951(0.91)  LDD0993  [2]
 LDCM0396  CL125 HCT 116 C741(0.91); C750(1.17); C744(1.43)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C741(1.26); C750(1.27); C744(1.28)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C741(1.01); C750(1.05); C744(1.10)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C744(1.15); C750(1.21); C741(1.28)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C741(0.86); C744(0.86); C750(0.86)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C741(0.98); C744(0.98); C750(0.98)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C741(1.09); C744(1.09); C750(1.09)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C741(0.88); C744(0.88); C750(0.88)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C741(0.93); C744(0.93); C750(0.93)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C741(0.83); C744(0.83); C750(0.83)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C741(0.92); C744(0.92); C750(0.92)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C741(1.25); C744(1.25); C750(1.25)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C741(1.10); C744(1.10); C750(1.10)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C741(1.19); C744(1.19); C750(1.19)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C741(1.15); C744(1.15); C750(1.15)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C741(0.79); C744(0.79); C750(0.79)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C741(0.94); C744(0.94); C750(0.94)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C741(0.95); C744(0.95); C750(0.95)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C741(1.01); C744(1.01); C750(1.01)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C741(1.16); C744(1.16); C750(1.16)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C741(1.05); C744(1.05); C750(1.05)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C741(1.08); C744(1.08); C750(1.08)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C741(0.72); C744(0.72); C750(0.72)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C741(0.94); C744(0.94); C750(0.94)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C951(1.02)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C951(0.92)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C951(1.07)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C951(1.11)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C951(1.06)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C951(0.98)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C951(1.04)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C951(0.95)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C741(1.04); C744(1.04); C750(1.04)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C951(0.82)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C951(1.19)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C951(0.97)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C951(1.19)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C951(1.07)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C951(1.05)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C750(1.67)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C750(1.12)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C750(1.34)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C750(1.08)  LDD1037  [2]
 LDCM0440  CL5 HCT 116 C741(0.87); C744(0.87); C750(0.87)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C750(1.22)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C750(1.00)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C750(0.73)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C750(0.91)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C750(1.31)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C750(1.08)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C750(0.83)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C750(0.85)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C750(0.71)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C750(1.21)  LDD1048  [2]
 LDCM0451  CL6 HCT 116 C741(0.75); C744(0.75); C750(0.75)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C750(1.35)  LDD1050  [2]
 LDCM0456  CL64 HEK-293T C223(1.06)  LDD1659  [4]
 LDCM0458  CL66 HEK-293T C223(1.06); C580(1.23)  LDD1661  [4]
 LDCM0462  CL7 HCT 116 C741(1.00); C744(1.00); C750(1.00)  LDD0779  [2]
 LDCM0465  CL72 HEK-293T C223(1.19)  LDD1668  [4]
 LDCM0469  CL76 HCT 116 C741(0.98); C744(0.98); C750(0.98)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C741(1.28); C744(1.28); C750(1.28)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C741(0.96); C744(0.96); C750(0.96)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C741(0.95); C744(0.95); C750(0.95)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C741(1.71); C744(1.71); C750(1.71)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C741(0.71); C744(0.71); C750(0.71)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C741(0.80); C744(0.80); C750(0.80)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C741(1.10); C744(1.10); C750(1.10)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C741(0.94); C744(0.94); C750(0.94)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C741(1.11); C744(1.11); C750(1.11)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C741(0.91); C744(0.91); C750(0.91)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C741(0.87); C744(0.87); C750(0.87)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C741(0.87); C744(0.87); C750(0.87)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C741(0.91); C744(0.91); C750(0.91)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C741(1.05); C744(1.05); C750(1.05)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C741(0.89); C744(0.89); C750(0.89)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C741(0.98); C744(0.98); C750(0.98)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C951(1.66)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C951(1.07)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C951(0.86)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C951(1.17)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C951(1.18)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C951(1.35)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C951(1.30)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C951(1.24)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C951(1.01)  LDD0811  [2]
 LDCM0427  Fragment51 HCT 116 C951(0.95)  LDD0744  [2]
 LDCM0022  KB02 A2780 C583(2.11)  LDD2254  [5]
 LDCM0023  KB03 A2780 C583(2.37)  LDD2671  [5]
 LDCM0024  KB05 SKMEL24 C583(2.18)  LDD3323  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840