Details of the Target

General Information of Target

Target ID LDTP00219
Target Name Hyaluronan synthase 3 (HAS3)
Gene Name HAS3
Gene ID 3038
Synonyms
Hyaluronan synthase 3; EC 2.4.1.212; Hyaluronate synthase 3; Hyaluronic acid synthase 3; HA synthase 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS
LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM
VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA
STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG
VGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLE
DWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKS
YFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVG
IIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIG
LIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCG
KKPEQYSLAFAEV
Target Bioclass
Enzyme
Family
NodC/HAS family
Subcellular location
Cell membrane
Function
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis.
Uniprot ID
O00219
Ensemble ID
ENST00000219322.7
HGNC ID
HGNC:4820

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LS180 SNV: p.R194H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C312(0.86)  LDD0531  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C312(0.86)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C312(0.94)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C312(0.99)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C312(1.01)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C312(0.87)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C312(1.02)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C312(0.95)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C312(0.95)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C312(0.80)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C312(0.82)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C312(0.72)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C312(0.70)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C312(1.00)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C312(0.85)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C312(0.68)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C312(0.70)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C312(1.13)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C312(0.98)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C312(1.06)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C312(1.15)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C312(1.02)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C312(1.03)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C312(1.08)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C312(1.07)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C312(0.94)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C312(0.93)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C312(1.09)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C312(0.97)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C312(1.00)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C312(0.98)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C312(1.11)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C312(0.97)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C312(0.80)  LDD0576  [1]
 LDCM0263  AC143 HCT 116 C312(1.19)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C312(1.10)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C312(1.40)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C312(0.89)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C312(1.15)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C312(1.10)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C312(0.92)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C312(1.53)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C312(0.84)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C312(1.04)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C312(0.92)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C312(1.22)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C312(1.14)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C312(0.88)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C312(0.86)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C312(1.08)  LDD2161  [1]
 LDCM0279  AC2 HCT 116 C312(1.02)  LDD0596  [1]
 LDCM0285  AC25 HCT 116 C312(1.40)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C312(1.29)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C312(1.18)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C312(1.32)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C312(1.10)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C312(1.00)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C312(0.93)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C312(1.22)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C312(1.20)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C312(1.15)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C312(0.79)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C312(1.28)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C312(1.34)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C312(1.37)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C312(1.26)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C312(1.23)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C312(1.15)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C312(1.02)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C312(1.12)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C312(1.02)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C312(0.93)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C312(1.05)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C312(1.13)  LDD0624  [1]
 LDCM0312  AC5 HCT 116 C312(1.07)  LDD0629  [1]
 LDCM0320  AC57 HCT 116 C312(1.08)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C312(1.23)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C312(1.17)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C312(1.06)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C312(1.38)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C312(1.21)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C312(1.50)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C312(1.34)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C312(1.20)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C312(2.45)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C312(1.60)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C312(1.67)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C312(1.16)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C312(1.01)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C312(1.16)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C312(0.87)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C312(1.13)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C312(1.02)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C312(1.08)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C312(1.16)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C312(0.75)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C312(1.00)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C312(0.94)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C312(0.78)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C312(0.83)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C312(1.03)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C312(1.06)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C312(0.99)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C312(0.98)  LDD0665  [1]
 LDCM0365  AC98 HCT 116 C312(1.39)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C312(1.01)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C312(1.24)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C312(1.04)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C312(1.19)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C312(1.06)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C312(1.00)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C312(0.95)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C312(1.01)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C312(1.08)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C312(1.02)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C312(1.17)  LDD0690  [1]
 LDCM0379  CL11 HCT 116 C312(1.06)  LDD0696  [1]
 LDCM0382  CL112 HCT 116 C312(1.06)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C312(1.03)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C312(1.34)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C312(0.84)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C312(1.19)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C312(0.90)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C312(1.45)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C312(1.25)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C312(1.03)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C312(1.07)  LDD0708  [1]
 LDCM0396  CL125 HCT 116 C312(0.96)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C312(0.82)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C312(0.91)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C312(1.43)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C312(1.17)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C312(1.11)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C312(1.28)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C312(1.08)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C312(1.02)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C312(1.08)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C312(1.16)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C312(1.17)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C312(1.07)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C312(1.44)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C312(1.09)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C312(0.98)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C312(1.17)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C312(1.27)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C312(1.04)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C312(1.07)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C312(1.24)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C312(1.12)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C312(1.01)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C312(1.23)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C312(1.36)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C312(1.41)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C312(1.36)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C312(1.08)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C312(1.22)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C312(1.21)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C312(1.09)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C312(1.28)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C312(1.24)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C312(1.30)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C312(1.23)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C312(0.98)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C312(1.15)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C312(1.28)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C312(1.26)  LDD0752  [1]
 LDCM0440  CL5 HCT 116 C312(1.06)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C312(1.17)  LDD0768  [1]
 LDCM0453  CL61 HCT 116 C312(1.15)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C312(1.15)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C312(1.31)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C312(1.07)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C312(1.27)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C312(1.18)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C312(1.14)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C312(1.07)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C312(1.35)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C312(1.24)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C312(1.02)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C312(1.06)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C312(1.10)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C312(1.20)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C312(1.29)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C312(0.83)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C312(0.81)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C312(1.34)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C312(1.12)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C312(1.11)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C312(1.02)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C312(1.01)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C312(0.94)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C312(0.87)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C312(1.10)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C312(0.92)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C312(0.96)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C312(1.08)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C312(1.22)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C312(1.20)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C312(1.26)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C312(1.23)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C312(0.84)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C312(0.75)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C312(0.91)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C312(1.05)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C312(0.98)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C312(1.14)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C312(1.04)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C312(0.94)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C312(0.93)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C312(1.22)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C312(1.19)  LDD0744  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hyaluronan synthase 1 (HAS1) NodC/HAS family Q92839
Hyaluronan synthase 2 (HAS2) NodC/HAS family Q92819
Hyaluronan synthase 3 (HAS3) NodC/HAS family O00219
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) Chemokine-like factor family Q96FZ5
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC) . Q8N912

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.