Details of the Target

General Information of Target

Target ID LDTP00094
Target Name TRPM8 channel-associated factor 2 (TCAF2)
Gene Name TCAF2
Gene ID 285966
Synonyms
FAM115C; FAM139A; TRPM8 channel-associated factor 2; TRP channel-associated factor 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATIAAAAFEALMDGVTCWDVPRGPIPSELLLIGEAAFPVMVNDKGQVLIAASSYGRGRL
VVVSHEGYLSHTGLAPFLLNAVSWLCPCPGAPVGVHPSLAPLVNILQDAGLEAQVKPEPG
EPLGVYCINAYNDTLTATLIQFVKHGGGLLIGGQAWYWASQHGPDKVLSRFPGNKVTSVA
GVYFTDTYGDRDRFKVSKKVPKIPLHVRYGEDVRQDQQQLLEGISELDIRTGGVPSQLLV
HGALAFPLGLDASLNCFLAAAHYGRGRVVLAAHECLLCAPKMGPFLLNAVRWLARGQTGK
VGVNTNLKDLCPLLSEHGLQCSLEPHLNSDLCVYCCKAYSDKEAKQLQEFVAEGGGLLIG
GQAWWWASQNPGHCPLAGFPGNIILNCFGLSILPQTLKAGCFPVPTPEMRSYHFRKALSQ
FQAILNHENGNLEKSCLAKLRVDGAAFLQIPAEGVPAYISLHRLLRKMLRGSGLPAVSRE
NPVASDSYEAAVLSLATGLAHSGTDCSQLAQGLGTWTCSSSLYPSKHPITVEINGINPGN
NDCWVSTGLYLLEGQNAEVSLSEAAASAGLRVQIGCHTDDLTKARKLSRAPVVTHQCWMD
RTERSVSCLWGGLLYVIVPKGSQLGPVPVTIRGAVPAPYYKLGKTSLEEWKRQMQENLAP
WGELATDNIILTVPTTNLQALKDPEPVLRLWDEMMQAVARLAAEPFPFRRPERIVADVQI
SAGWMHSGYPIMCHLESVKEIINEMDMRSRGVWGPIHELGHNQQRHGWEFPPHTTEATCN
LWSVYVHETVLGIPRAQAHEALSPPERERRIKAHLGKGAPLCDWNVWTALETYLQLQEAF
GWEPFTQLFAEYQTLSHLPKDNTGRMNLWVKKFSEKVKKNLVPFFEAWGWPIQKEVADSL
ASLPEWQENPMQVYLRARK
Target Bioclass
Other
Family
TCAF family
Subcellular location
Cell membrane
Function
[Isoform 2]: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner.
Uniprot ID
A6NFQ2
Ensemble ID
ENST00000357344.9
HGNC ID
HGNC:26878

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C597(1.01)  LDD0531  [1]
YN-1
 Probe Info  		N.A.  LDD0447  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C597(1.01)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C597(1.36)  LDD0813  [1]
 LDCM0216  AC100 HEK-293T C597(0.94)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C597(0.72)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C597(0.89)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C597(1.08)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C597(1.08)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C597(0.87)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C597(0.65)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C597(1.03)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C597(1.02)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C597(0.94)  LDD0823  [1]
 LDCM0226  AC11 HEK-293T C597(1.02)  LDD0824  [1]
 LDCM0227  AC110 HEK-293T C597(1.54)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C597(1.48)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C597(1.29)  LDD0827  [1]
 LDCM0230  AC113 PaTu 8988t C275(0.99); C278(0.99); C597(0.99)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C275(1.03); C278(1.03); C597(1.09)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C275(1.29); C278(1.29); C597(0.91)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C275(1.06); C278(1.06); C597(1.07)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C275(1.14); C278(1.14); C597(0.90)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C275(1.23); C278(1.23); C597(1.14)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C275(1.11); C278(1.11); C597(0.98)  LDD1115  [1]
 LDCM0237  AC12 HEK-293T C597(1.24)  LDD0835  [1]
 LDCM0238  AC120 PaTu 8988t C275(0.94); C278(0.94); C597(1.05)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C275(1.05); C278(1.05); C597(1.14)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C275(1.07); C278(1.07); C597(1.11)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C275(1.06); C278(1.06); C597(1.10)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C275(1.11); C278(1.11); C597(1.17)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C275(1.16); C278(1.16); C597(1.08)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C275(1.09); C278(1.09); C597(1.11)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C275(1.12); C278(1.12); C597(1.26)  LDD1124  [1]
 LDCM0246  AC128 HEK-293T C597(1.21)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C597(1.11)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C597(1.19)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C597(1.13)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C597(1.16)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C597(1.30)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C597(1.25)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C597(1.31)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C597(1.27)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C597(1.42)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C597(1.63)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C597(1.45)  LDD0856  [1]
 LDCM0259  AC14 HEK-293T C597(1.35)  LDD0857  [1]
 LDCM0260  AC140 HEK-293T C597(1.50)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C597(1.50)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C597(1.50)  LDD0860  [1]
 LDCM0263  AC143 HEK-293T C597(1.04)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C597(0.90)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C597(0.95)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C597(1.09)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C597(0.68)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C597(0.85)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C597(0.92)  LDD0867  [1]
 LDCM0270  AC15 HEK-293T C597(1.87)  LDD0868  [1]
 LDCM0271  AC150 HEK-293T C597(0.80)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C597(0.81)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C597(0.90)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C597(0.79)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C597(0.75)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C597(0.81)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C597(0.82)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C597(0.83)  LDD2165  [1]
 LDCM0276  AC17 HCT 116 C597(1.02)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C597(0.87)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C597(0.90)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C597(1.23)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C597(0.93)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C597(1.03)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C597(0.89)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C597(0.88)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C597(0.99)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C597(0.95)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C597(1.10)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C597(1.18)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C597(1.13)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C597(1.01)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C597(1.14)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C597(1.16)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C597(1.39)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C597(1.23)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C597(1.14)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C597(1.08)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C597(0.87)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C597(0.78)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C597(0.81)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C597(1.01)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C597(1.02)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C597(1.28)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C597(0.88)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C597(1.06)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C597(1.09)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C597(1.15)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C597(0.94)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C597(1.04)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C597(1.32)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C597(1.69)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C597(1.56)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C597(1.50)  LDD0909  [1]
 LDCM0312  AC5 HCT 116 C597(1.15)  LDD0629  [1]
 LDCM0313  AC50 HEK-293T C597(1.41)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C597(1.64)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C597(1.40)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C597(1.34)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C597(1.40)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C597(1.72)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C597(1.53)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C597(0.98)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C597(1.20)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C597(1.11)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C597(0.97)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C597(1.15)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C597(1.05)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C597(1.26)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C597(1.37)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C597(1.65)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C597(1.44)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C597(1.06)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C597(1.21)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C597(0.84)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C597(0.81)  LDD0931  [1]
 LDCM0334  AC7 HEK-293T C597(1.00)  LDD0932  [1]
 LDCM0335  AC70 HEK-293T C597(0.71)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C597(0.77)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C597(1.02)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C597(0.74)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C597(0.88)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C597(0.65)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C597(0.81)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C597(0.71)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C597(0.68)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C597(0.75)  LDD0942  [1]
 LDCM0345  AC8 HEK-293T C597(1.24)  LDD0943  [1]
 LDCM0346  AC80 HEK-293T C597(0.75)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C597(0.75)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C597(0.70)  LDD0946  [1]
 LDCM0349  AC83 HEK-293T C597(0.95)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C597(1.07)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C597(0.74)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C597(1.00)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C597(1.03)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C597(0.97)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C597(1.05)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C597(1.02)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C597(0.70)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C597(0.71)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C597(0.91)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C597(0.94)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C597(0.92)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C597(0.87)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C597(1.08)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C597(0.96)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C597(0.82)  LDD0964  [1]
 LDCM0248  AKOS034007472 HEK-293T C597(1.34)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C597(1.34)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C597(1.44)  LDD0873  [1]
 LDCM0367  CL1 HCT 116 C597(0.80)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C597(1.06)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C597(1.01)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C597(1.38)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C597(1.18)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C597(1.35)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C597(1.34)  LDD0971  [1]
 LDCM0374  CL105 HCT 116 C597(1.11)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C597(1.28)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C597(1.08)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C597(1.22)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C597(1.00)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C597(1.05)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C597(1.06)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C597(0.95)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C597(0.95)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C597(1.01)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C597(0.96)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C597(1.12)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C597(1.23)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C597(1.28)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C597(1.15)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C597(0.87)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C597(1.10)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C597(1.12)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C597(1.67)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C597(1.63)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C597(1.14)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C597(2.32)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C597(1.20)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C597(1.03)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C597(1.19)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C597(1.18)  LDD0997  [1]
 LDCM0400  CL13 HCT 116 C597(1.01)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C597(1.17)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C597(1.22)  LDD0719  [1]
 LDCM0403  CL16 HEK-293T C597(1.01)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C597(1.49)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C597(1.39)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C597(1.18)  LDD1004  [1]
 LDCM0407  CL2 HCT 116 C597(1.01)  LDD0724  [1]
 LDCM0408  CL20 HEK-293T C597(1.02)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C597(1.20)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C597(1.06)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C597(1.36)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C597(0.99)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C597(1.44)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C597(1.34)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C597(1.50)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C597(1.25)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C597(1.37)  LDD1015  [1]
 LDCM0418  CL3 HCT 116 C597(0.89)  LDD0735  [1]
 LDCM0419  CL30 HEK-293T C597(1.55)  LDD1017  [1]
 LDCM0420  CL31 HCT 116 C597(1.17)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C597(1.42)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C597(1.05)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C597(1.35)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C597(0.76)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C597(1.02)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C597(1.07)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C597(1.16)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C597(1.14)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C597(1.24)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C597(1.28)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C597(1.89)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C597(1.08)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C597(1.72)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C597(1.39)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C597(0.94)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C597(0.63)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C597(0.74)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C597(0.80)  LDD1037  [1]
 LDCM0440  CL5 HCT 116 C597(1.09)  LDD0757  [1]
 LDCM0441  CL50 HEK-293T C597(0.67)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C597(0.78)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C597(0.77)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C597(0.69)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C597(0.67)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C597(0.72)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C597(0.70)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C597(0.83)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C597(0.72)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C597(0.79)  LDD1048  [1]
 LDCM0451  CL6 HCT 116 C597(0.94)  LDD0768  [1]
 LDCM0452  CL60 HEK-293T C597(0.81)  LDD1050  [1]
 LDCM0453  CL61 HCT 116 C597(0.89)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C597(0.97)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C597(0.90)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C597(0.91)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C597(1.04)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C597(1.20)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C597(1.02)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C597(1.04)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C597(0.98)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C597(1.12)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C597(0.98)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C597(0.95)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C597(0.87)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C597(1.07)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C597(1.04)  LDD0784  [1]
 LDCM0469  CL76 PaTu 8988t C275(1.15); C278(1.15); C597(0.99)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C275(1.22); C278(1.22); C597(1.13)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C275(1.19); C278(1.19); C597(1.24)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C275(1.11); C278(1.11); C597(1.18)  LDD1351  [1]
 LDCM0473  CL8 HCT 116 C597(1.24)  LDD0790  [1]
 LDCM0474  CL80 PaTu 8988t C275(1.16); C278(1.16); C597(1.35)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C275(1.27); C278(1.27); C597(1.20)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C275(1.24); C278(1.24); C597(1.39)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C275(1.54); C278(1.54); C597(1.17)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C275(1.08); C278(1.08); C597(1.18)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C275(1.03); C278(1.03); C597(1.22)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C275(1.07); C278(1.07); C597(1.16)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C275(1.27); C278(1.27); C597(1.31)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C275(1.06); C278(1.06); C597(1.24)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C275(1.06); C278(1.06); C597(1.23)  LDD1362  [1]
 LDCM0484  CL9 HCT 116 C597(1.18)  LDD0801  [1]
 LDCM0485  CL90 PaTu 8988t C275(1.35); C278(1.35); C597(1.15)  LDD1364  [1]
 LDCM0486  CL91 HCT 116 C597(1.04)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C597(0.95)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C597(0.84)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C597(1.07)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C597(1.23)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C597(1.22)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C597(1.05)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C597(1.13)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C597(1.13)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C597(1.09)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C597(1.08)  LDD0744  [1]
 LDCM0022  KB02 42-MG-BA C401(1.04); C597(2.08); C576(1.98)  LDD2244  [3]
 LDCM0023  KB03 42-MG-BA C597(1.80)  LDD2661  [3]
 LDCM0024  KB05 UACC257 C597(2.12)  LDD3325  [3]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840