Details of the Target

General Information of Target

Target ID LDTP20038
Target Name Zinc finger protein 706 (ZNF706)
Gene Name ZNF706
Gene ID 51123
Synonyms
Zinc finger protein 706
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVSLWVEGTFPPPGFGLAHVACSGHGMKQKRKPASSEPTPEDALGGSAVPVRFHLHPEGL
LWCSRCFFSHGPKGSEPPGRSAGLQGATERSGRPSVQAQAQACENLVPATVWDG
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4.
Uniprot ID
Q9Y5V0
Ensemble ID
ENST00000311212.9
HGNC ID
HGNC:24992

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K13(4.44); K61(4.38)  LDD0277  [1]
BTD
 Probe Info  		C41(4.99)  LDD2120  [2]
DBIA
 Probe Info  		C44(0.99)  LDD0533  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C44(0.99)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C44(1.08)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C44(1.06)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C44(0.99)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C44(0.84)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C44(1.06)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C44(0.99)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C44(0.82)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C44(0.82)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C44(0.81)  LDD0542  [3]
 LDCM0227  AC110 HCT 116 C44(0.83)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C44(0.84)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C44(0.71)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C44(1.04)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C44(0.92)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C44(0.85)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C44(0.98)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C44(1.11)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C44(1.05)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C44(0.97)  LDD0553  [3]
 LDCM0238  AC120 HCT 116 C44(0.87)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C44(1.03)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C44(0.88)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C44(1.09)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C44(1.07)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C44(0.92)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C44(0.98)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C44(1.03)  LDD0562  [3]
 LDCM0263  AC143 HCT 116 C44(0.65)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C44(1.04)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C44(1.08)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C44(0.69)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C44(1.23)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C44(0.61)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C44(0.70)  LDD0586  [3]
 LDCM0271  AC150 HCT 116 C44(0.90)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C44(0.90)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C44(0.85)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C44(0.42)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C44(0.88)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C44(0.60)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C44(0.78)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C44(0.66)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C44(1.13)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C44(1.01)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C44(1.02)  LDD0595  [3]
 LDCM0280  AC20 HCT 116 C44(1.00)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C44(1.09)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C44(1.12)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C44(0.94)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C44(1.06)  LDD0601  [3]
 LDCM0296  AC35 HCT 116 C44(0.94)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C44(0.96)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C44(0.93)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C44(0.75)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C44(0.90)  LDD0617  [3]
 LDCM0302  AC40 HCT 116 C44(0.86)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C44(0.77)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C44(0.84)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C44(0.94)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C44(1.09)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C44(0.82)  LDD0624  [3]
 LDCM0332  AC68 HCT 116 C44(1.13)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C44(0.87)  LDD0650  [3]
 LDCM0335  AC70 HCT 116 C44(0.88)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C44(0.94)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C44(0.90)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C44(0.94)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C44(1.22)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C44(0.96)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C44(1.08)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C44(1.22)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C44(0.80)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C44(0.92)  LDD0661  [3]
 LDCM0346  AC80 HCT 116 C44(0.88)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C44(0.79)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C44(1.06)  LDD0665  [3]
 LDCM0365  AC98 HCT 116 C44(1.16)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C44(0.81)  LDD0683  [3]
 LDCM0020  ARS-1620 HCC44 C41(1.45); C44(1.45)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C44(0.93)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C44(0.82)  LDD0685  [3]
 LDCM0374  CL105 HCT 116 C44(0.87)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C44(0.72)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C44(0.90)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C44(1.03)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C44(1.03)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C44(0.87)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C44(0.92)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C44(0.96)  LDD0698  [3]
 LDCM0387  CL117 HCT 116 C44(0.76)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C44(1.04)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C44(1.08)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C44(0.86)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C44(0.89)  LDD0708  [3]
 LDCM0400  CL13 HCT 116 C44(0.95)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C44(1.06)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C44(0.97)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C44(0.95)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C44(0.87)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C44(1.02)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C44(1.03)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C44(0.83)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C44(0.97)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C44(1.15)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C44(1.30)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C44(1.28)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C44(1.29)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C44(1.07)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C44(0.94)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C44(0.91)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C44(1.02)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C44(1.16)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C44(0.87)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C44(1.18)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C44(0.77)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C44(0.78)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C44(0.77)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C44(0.81)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C44(0.84)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C44(0.67)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C44(0.66)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C44(0.91)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C44(0.69)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C44(0.63)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C44(0.66)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C44(0.71)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C44(0.81)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C44(0.61)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C44(0.62)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C44(1.10)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C44(1.04)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C44(1.01)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C44(1.23)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C44(0.93)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C44(0.91)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C44(1.15)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C44(0.86)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C44(1.22)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C44(0.96)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C44(1.03)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C44(1.07)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C44(1.41)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C44(1.16)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C44(1.26)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C44(1.01)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C44(0.95)  LDD0769  [3]
 LDCM0462  CL7 HCT 116 C44(0.99)  LDD0779  [3]
 LDCM0469  CL76 HCT 116 C44(0.93)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C44(0.98)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C44(0.93)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C44(1.07)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C44(0.86)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C44(1.08)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C44(1.19)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C44(1.07)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C44(1.06)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C44(1.05)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C44(1.02)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C44(1.17)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C44(1.12)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C44(1.01)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C44(1.29)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C44(0.96)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C44(1.26)  LDD0802  [3]
 LDCM0427  Fragment51 HCT 116 C44(0.53)  LDD0744  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C41(4.99)  LDD2120  [2]
 LDCM0021  THZ1 HCT 116 C41(1.45); C44(1.45)  LDD2173  [3]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004