Details of the Target

General Information of Target

Target ID LDTP17395
Target Name F-box only protein 46 (FBXO46)
Gene Name FBXO46
Gene ID 23403
Synonyms
FBX46; FBXO34L; F-box only protein 46; F-box only protein 34-like
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSRSPLNPSQLRSVGSQDALAPLPPPAPQNPSTHSWDPLCGSLPWGLSCLLALQHVLVMA
SLLCVSHLLLLCSLSPGGLSYSPSQLLASSFFSCGMSTILQTWMGSRLPLVQAPSLEFLI
PALVLTSQKLPRAIQTPGNSSLMLHLCRGPSCHGLGHWNTSLQEVSGAVVVSGLLQGMMG
LLGSPGHVFPHCGPLVLAPSLVVAGLSAHREVAQFCFTHWGLALLVILLMVVCSQHLGSC
QFHVCPWRRASTSSTHTPLPVFRLLSVLIPVACVWIVSAFVGFSVIPQELSAPTKAPWIW
LPHPGEWNWPLLTPRALAAGISMALAASTSSLGCYALCGRLLHLPPPPPHACSRGLSLEG
LGSVLAGLLGSPMGTASSFPNVGKVGLIQAGSQQVAHLVGLLCVGLGLSPRLAQLLTTIP
LPVVGGVLGVTQAVVLSAGFSSFYLADIDSGRNIFIVGFSIFMALLLPRWFREAPVLFST
GWSPLDVLLHSLLTQPIFLAGLSGFLLENTIPGTQLERGLGQGLPSPFTAQEARMPQKPR
EKAAQVYRLPFPIQNLCPCIPQPLHCLCPLPEDPGDEEGGSSEPEEMADLLPGSGEPCPE
SSREGFRSQK
Target Bioclass
Other
Function Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Uniprot ID
Q6PJ61
Ensemble ID
ENST00000317683.4
HGNC ID
HGNC:25069

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C545(8.46)  LDD0209  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
Phosphinate-6
 Probe Info  		C288(0.00); C109(0.00)  LDD0018  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C306(0.81); C589(0.66)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C589(1.03)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C589(0.88)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C589(0.97)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C589(0.80)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C589(0.86)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C589(1.09)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C589(1.04)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C589(0.99)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C589(1.01)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C589(0.89)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C589(0.83)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C589(0.65)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C589(0.87)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C589(0.92)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C589(1.18)  LDD0546  [5]
 LDCM0237  AC12 HCT 116 C589(0.83)  LDD0554  [5]
 LDCM0246  AC128 HCT 116 C589(1.26)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C589(0.63)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C589(1.21)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C589(0.80)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C589(0.76)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C589(1.26)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C589(0.97)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C589(0.82)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C589(1.26)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C589(1.02)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C589(0.87)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C589(0.78)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C589(0.66)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C589(0.99)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C589(1.05)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C589(1.22)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C589(1.25)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C589(0.87)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C589(1.22)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C589(0.83)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C589(0.95)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C589(1.18)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C589(1.08)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C589(0.97)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C589(1.07)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C589(0.87)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C589(0.87)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C589(1.10)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C589(1.14)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C589(1.33)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C589(1.01)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C589(0.94)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C589(1.02)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C589(1.01)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C589(1.19)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C589(0.88); C306(0.95)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C589(1.10)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C589(0.99)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C589(0.99)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C589(1.05)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C589(1.06)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C500(1.13)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C500(1.31)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C500(1.25)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C500(1.43)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C500(1.46)  LDD0887  [5]
 LDCM0290  AC3 HCT 116 C589(1.03); C306(1.11)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C500(1.40)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C500(1.46)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C500(1.57)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C500(1.64)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C500(1.74)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C288(1.22); C589(1.03); C394(1.16)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C288(1.22); C589(1.02); C109(0.94); C306(1.05)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C288(0.98); C589(0.94); C306(0.97); C498(1.08)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C589(0.95); C224(1.10); C306(1.29); C394(1.09)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C589(1.19); C306(0.94)  LDD1539  [6]
 LDCM0301  AC4 HCT 116 C589(0.81); C306(0.89)  LDD0618  [5]
 LDCM0302  AC40 HEK-293T C589(1.00); C500(1.25)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C589(1.18); C109(0.92); C306(1.13)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C589(0.99); C224(1.13); C306(1.15); C394(1.30)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C288(0.93); C589(1.02); C394(1.26)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C288(0.83); C589(1.00); C109(1.14); C306(1.53)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C288(0.90); C589(0.96); C306(0.98); C498(1.06)  LDD1546  [6]
 LDCM0308  AC46 HCT 116 C589(1.23)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C589(0.96)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C589(1.05)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C589(1.30)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C589(0.73); C306(0.99)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C589(1.32)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C589(1.17)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C589(1.10)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C589(1.15)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C589(1.27)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C589(1.04)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C589(1.08)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C306(1.27)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C306(1.13)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C306(1.26)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C589(1.19)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C306(1.14)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C306(1.17)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C306(1.02)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C306(1.52)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C306(1.35)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C306(1.15)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C306(1.39)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C306(1.05)  LDD0648  [5]
 LDCM0334  AC7 HCT 116 C589(0.90)  LDD0651  [5]
 LDCM0345  AC8 HCT 116 C589(0.78)  LDD0662  [5]
 LDCM0349  AC83 HCT 116 C306(0.25); C589(1.21)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C306(0.40); C589(1.28)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C306(0.26); C589(1.38)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C306(0.24); C589(1.08)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C306(0.22); C589(1.00)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C306(0.25); C589(1.10)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C306(0.26); C589(1.16)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C306(0.25); C589(1.12)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C306(0.22); C589(1.14)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C306(0.24); C589(1.10)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C306(0.28); C589(1.13)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C306(0.23); C589(1.30)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C306(0.27); C589(1.20)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C306(0.30); C589(1.26)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C306(0.26); C589(1.33)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C589(1.09)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C589(0.94)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C589(0.89)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C589(0.82)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C589(0.89)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C565(1.52); C566(1.52)  LDD2171  [5]
 LDCM0367  CL1 HEK-293T C589(0.93)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C589(1.07); C224(1.09); C306(1.07); C394(0.48)  LDD1572  [6]
 LDCM0369  CL100 HCT 116 C589(0.72); C306(0.96)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C589(0.99)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C589(0.86)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C589(0.72)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C589(1.00)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C589(1.00)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C589(0.85)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C589(1.00)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C589(0.88)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C589(1.09)  LDD0695  [5]
 LDCM0379  CL11 HEK-293T C589(1.02); C306(1.01)  LDD1583  [6]
 LDCM0380  CL110 HCT 116 C589(0.93)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C589(1.14)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C500(1.45)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C500(1.55)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C500(2.07)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C500(1.82)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C500(1.82)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C589(1.03)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C589(0.91); C109(1.17); C498(1.06)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C589(1.06); C306(0.89)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C589(0.83); C500(1.38)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C589(1.03); C109(1.10)  LDD1595  [6]
 LDCM0392  CL121 HCT 116 C589(1.13)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C589(1.15)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C589(1.27)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C589(1.35)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C306(1.19)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C306(1.32)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C306(0.96)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C306(1.19)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C589(1.24)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C589(1.02); C109(0.90); C498(1.27)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C589(1.01); C306(1.19)  LDD1606  [6]
 LDCM0403  CL16 HCT 116 C306(0.64)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C306(0.94); C589(1.16)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C306(0.73); C589(1.05)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C306(0.91); C589(1.00)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C589(1.01); C109(0.97); C498(0.98)  LDD1611  [6]
 LDCM0408  CL20 HCT 116 C306(1.05); C589(1.20)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C306(1.08); C589(1.24)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C306(0.59); C589(0.97)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C589(1.06); C306(1.44)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C589(1.03); C306(1.13)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C306(0.74); C589(0.96)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C306(1.18); C589(1.03)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C306(0.68); C589(1.13)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C306(0.72); C589(1.07)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C306(0.58); C589(1.07)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C589(1.04); C306(1.13)  LDD1622  [6]
 LDCM0419  CL30 HCT 116 C306(0.97); C589(0.92)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C589(0.94)  LDD0737  [5]
 LDCM0421  CL32 HEK-293T C288(0.95); C589(0.88); C109(0.93); C306(1.24)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C288(0.98); C589(0.92); C306(1.52); C498(1.22)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C589(0.94); C224(1.14); C306(1.25); C394(0.61)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C589(0.89); C306(1.34)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C589(0.94); C500(1.04)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C589(0.97)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C589(0.68); C306(0.96)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C589(0.93); C109(1.01)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C589(0.97); C109(0.96)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C589(0.99); C109(1.00); C306(0.83)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C589(1.01); C224(1.10); C306(1.20); C394(1.10)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C288(0.71); C589(1.01); C394(1.40)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C288(1.02); C589(0.94); C109(1.00); C306(1.02)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C288(1.05); C589(1.13); C306(1.04); C498(1.31)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C589(1.05); C224(1.06); C306(0.96); C394(0.77)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C589(0.90); C306(1.06)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C589(0.81); C500(1.30)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C589(1.00)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C589(1.07); C109(0.98); C306(0.99)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C589(0.96); C109(1.02); C498(1.08)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C589(1.00); C109(0.93)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C589(1.16); C109(1.05); C306(1.02)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C589(0.88); C224(1.22); C306(1.11); C394(1.06)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C288(1.08); C589(0.94); C394(1.13)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C288(0.97); C589(1.15); C109(0.83); C306(1.17)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C288(1.38); C589(1.02); C306(1.05); C498(1.19)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C589(1.08); C224(1.19); C306(1.36); C394(0.93)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C589(0.99); C306(1.33)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C589(0.96); C224(1.00); C306(1.17); C394(1.54)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C589(0.92); C500(1.43)  LDD1655  [6]
 LDCM0453  CL61 HCT 116 C589(0.90)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C589(0.93)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C589(1.03)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C589(0.85)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C589(0.83)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C589(0.91)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C589(0.79)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C589(0.92)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C589(1.05)  LDD0778  [5]
 LDCM0462  CL7 HEK-293T C288(1.04); C589(1.00); C394(1.12)  LDD1665  [6]
 LDCM0463  CL70 HCT 116 C589(0.85)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C589(1.11)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C589(1.16)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C589(1.05)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C589(0.88)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C589(0.59)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C589(0.73)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C589(0.76)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C589(0.65)  LDD0789  [5]
 LDCM0473  CL8 HEK-293T C288(1.16); C589(0.89); C109(0.86); C306(1.17)  LDD1676  [6]
 LDCM0474  CL80 HCT 116 C589(0.71)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C589(0.66)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C589(0.54)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C589(0.73)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C589(0.69)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C589(0.65)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C589(0.60)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C589(0.72)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C589(0.72)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C589(0.57)  LDD0800  [5]
 LDCM0484  CL9 HEK-293T C288(1.00); C589(1.01); C306(1.00); C498(1.10)  LDD1687  [6]
 LDCM0485  CL90 HCT 116 C589(0.70)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C306(1.04); C589(0.77)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C306(0.95); C589(1.32)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C306(1.05); C589(0.99)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C306(0.95); C589(0.70)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C306(0.90); C589(1.13)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C306(0.83); C589(1.17)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C306(0.99); C589(1.14)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C306(0.48); C589(1.09)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C306(0.92); C589(1.01)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C589(0.99); C306(0.94)  LDD1698  [6]
 LDCM0625  F8 Ramos C589(1.81); C288(1.31)  LDD2187  [7]
 LDCM0572  Fragment10 Ramos C288(1.86)  LDD2189  [7]
 LDCM0573  Fragment11 Ramos C589(1.00)  LDD2190  [7]
 LDCM0574  Fragment12 Ramos C589(1.04); C288(0.71)  LDD2191  [7]
 LDCM0575  Fragment13 Ramos C589(0.75); C288(1.25)  LDD2192  [7]
 LDCM0576  Fragment14 Ramos C589(0.67); C288(0.92)  LDD2193  [7]
 LDCM0579  Fragment20 Ramos C589(0.85); C288(0.70)  LDD2194  [7]
 LDCM0580  Fragment21 Ramos C589(1.04); C288(0.67)  LDD2195  [7]
 LDCM0582  Fragment23 Ramos C589(0.95); C288(0.83)  LDD2196  [7]
 LDCM0578  Fragment27 Ramos C589(1.04); C288(0.74)  LDD2197  [7]
 LDCM0586  Fragment28 Ramos C288(1.16)  LDD2198  [7]
 LDCM0588  Fragment30 Ramos C589(1.12); C288(0.94)  LDD2199  [7]
 LDCM0589  Fragment31 Ramos C589(0.75); C288(1.19)  LDD2200  [7]
 LDCM0590  Fragment32 Ramos C589(1.32); C288(1.14)  LDD2201  [7]
 LDCM0468  Fragment33 HCT 116 C589(0.97)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C589(1.15); C288(0.68)  LDD2203  [7]
 LDCM0566  Fragment4 Ramos C589(0.54); C288(1.31)  LDD2184  [7]
 LDCM0427  Fragment51 HEK-293T C589(0.95); C109(0.91); C498(1.05)  LDD1631  [6]
 LDCM0610  Fragment52 Ramos C589(1.97); C288(1.51)  LDD2204  [7]
 LDCM0614  Fragment56 Ramos C589(0.61); C288(1.12)  LDD2205  [7]
 LDCM0569  Fragment7 Ramos C589(0.62); C288(1.37)  LDD2186  [7]
 LDCM0571  Fragment9 Ramos C589(0.78); C288(1.16)  LDD2188  [7]
 LDCM0022  KB02 HEK-293T C224(0.88); C589(0.81)  LDD1492  [6]
 LDCM0023  KB03 Jurkat C545(8.46)  LDD0209  [1]
 LDCM0024  KB05 G361 C224(2.78)  LDD3311  [8]
 LDCM0021  THZ1 HCT 116 C565(1.52); C566(1.52)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-phase kinase-associated protein 1 (SKP1) SKP1 family P63208

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840