Details of the Target

General Information of Target

Target ID LDTP16178
Target Name Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2)
Gene Name SIPA1L2
Gene ID 57568
Synonyms
KIAA1389; Signal-induced proliferation-associated 1-like protein 2; SIPA1-like protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIVLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSR
TPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLDINDNPP
SFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRF
AELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRV
LDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRAREL
FGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISF
STVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAP
LDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGA
YIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFS
FQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLL
TRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEV
RDHGQPPLSSTATLVVQLVDGAVEPQGGGGSGGGGSGEHQRPSRSGGGETSLDLTLILII
ALGSVSFIFLLAMIVLAVRCQKEKKLNIYTCLASDCCLCCCCCGGGGSTCCGRQARARKK
KLSKSDIMLVQSSNVPSNPAQVPIEESGGFGSHHHNQNYCYQVCLTPESAKTDLMFLKPC
SPSRSTDTEHNPCGAIVTGYTDQQPDIISNGSILSNETKHQRAELSYLVDRPRRVNSSAF
QEADIVSSKDSGHGDSEQGDSDHDATNRAQSAGMDLFSNCTEECKALGHSDRCWMPSFVP
SDGRQAADYRSNLHVPGMDSVPDTEVFETPEAQPGAERSFSTFGKEKALHSTLERKELDG
LLTNTRAPYKPPYLTRKRIC
Target Bioclass
Other
Uniprot ID
Q9P2F8
Ensemble ID
ENST00000308942.4
HGNC ID
HGNC:23800

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.T1646I .
A2780 SNV: p.S1204G .
BXPC3 SNV: p.I552V .
COLO792 SNV: p.F830L .
DANG SNV: p.V1414E DBIA    Probe Info 
HCT15 SNV: p.R428Ter; p.P714H .
HT115 SNV: p.S1176N; p.S1472L .
Ishikawa (Heraklio) 02 ER SNV: p.S101N; p.D396N .
JEKO1 SNV: p.R1584G .
JURKAT SNV: p.P763L .
KMCH1 SNV: p.G1165A .
KMRC1 SNV: p.D1569H .
KYSE150 SNV: p.A787S; p.P1636Q .
MCAS SNV: p.D1171N .
NCIH23 Substitution: p.W99F .
NCIH661 Deletion: p.T1263del .
OCILY3 SNV: p.A224V .
OVCAR8 SNV: p.Q121Ter .
OVK18 Insertion: p.D1171RfsTer25 .
PANC0403 Substitution: p.G253R .
RL SNV: p.F1714V .
SHP77 Deletion: p.R805SfsTer5
SNV: p.Q1622H		 .
SUPT1 SNV: p.R514W .
SW403 SNV: p.S196Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1034(1.20); C1038(1.20); C741(1.13); C746(1.13)  LDD0078  [1]
IA-alkyne
 Probe Info  		C995(0.00); C328(0.00)  LDD0162  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
TFBX
 Probe Info  		C236(0.00); C995(0.00); C1092(0.00)  LDD0148  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1034(1.03); C1038(1.33)  LDD0812  [1]
 LDCM0215  AC10 HCT 116 C1034(0.88); C1038(0.88)  LDD0532  [1]
 LDCM0216  AC100 HEK-293T C1034(1.07); C1038(1.14); C409(1.17)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C1034(1.03); C1038(1.10); C409(1.03)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C1034(1.07); C1038(1.21); C409(1.05)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C1034(1.04); C1038(1.08); C409(1.17)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C1034(0.87); C1038(0.88); C409(1.02)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C1034(1.08); C1038(1.17); C409(1.03)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C1034(1.10); C1038(1.11); C409(0.95)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C1034(1.06); C1038(1.25); C409(1.06)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C1034(1.00); C1038(0.99); C409(0.95)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C1034(0.95); C1038(0.93); C409(1.05)  LDD0823  [1]
 LDCM0226  AC11 HCT 116 C1034(0.93); C1038(0.93)  LDD0543  [1]
 LDCM0227  AC110 HEK-293T C1034(1.12); C1038(1.26); C409(0.86)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C1034(1.13); C1038(1.18); C409(1.10)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C1034(1.04); C1038(1.03); C409(1.13)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C1038(0.87)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C1038(1.05)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C1038(1.03)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C1038(0.91)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C1038(1.15)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C1038(1.11)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C1038(1.32)  LDD0834  [1]
 LDCM0237  AC12 HCT 116 C1034(0.87); C1038(0.87)  LDD0554  [1]
 LDCM0238  AC120 HEK-293T C1038(1.35)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C1038(1.12)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C1038(1.14)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C1038(1.22)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C1038(1.19)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C1038(1.29)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C1038(1.84)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C1038(2.11)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C1038(0.80)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C1038(1.47)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C1038(1.07)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C1038(1.08)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C1038(1.00)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C1038(1.25)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C1038(1.43)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C1038(1.16)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C1038(1.18)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C1038(1.35)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C1038(1.27)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C1038(1.41)  LDD0856  [1]
 LDCM0259  AC14 HCT 116 C1034(0.75); C1038(0.75)  LDD0576  [1]
 LDCM0260  AC140 HEK-293T C1038(1.01)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C1038(1.54)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C1038(1.35)  LDD0860  [1]
 LDCM0263  AC143 HEK-293T C1034(0.92); C1038(0.87); C409(1.70)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C1034(0.99); C1038(1.19); C409(1.14)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C1034(0.99); C1038(0.99); C409(1.29)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C1034(0.97); C1038(1.05); C409(1.60)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C1034(0.93); C1038(1.01); C409(1.69)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C1034(0.97); C1038(0.86); C409(1.40)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C1034(1.04); C1038(0.91); C409(1.35)  LDD0867  [1]
 LDCM0270  AC15 HCT 116 C1034(0.86); C1038(0.86)  LDD0587  [1]
 LDCM0271  AC150 HEK-293T C1034(0.91); C1038(0.96); C409(1.22)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C1034(0.92); C1038(0.99); C409(1.29)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C1034(0.98); C1038(1.02); C409(1.21)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C1034(1.06); C1038(1.07); C409(1.25)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C1034(0.91); C1038(1.21); C409(1.20)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C1034(1.00); C1038(0.99); C409(1.09)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C1034(0.97); C1038(1.14); C409(1.26)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C1034(1.06); C1038(1.22); C409(1.12)  LDD2165  [1]
 LDCM0276  AC17 HEK-293T C409(1.59)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C409(1.39)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C409(0.98)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C1034(0.94); C1038(1.02)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C409(1.49)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C409(1.14)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C409(1.15)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C409(2.07)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C409(1.03)  LDD0882  [1]
 LDCM0285  AC25 HCT 116 C1034(1.00); C1038(1.00)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C1034(1.13); C1038(1.13)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C1034(1.05); C1038(1.05)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C1034(1.10); C1038(1.10)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C1034(1.19); C1038(1.19)  LDD0606  [1]
 LDCM0290  AC3 HEK-293T C1034(0.99); C1038(0.93)  LDD0888  [1]
 LDCM0291  AC30 HCT 116 C1034(1.16); C1038(1.16)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C1034(1.04); C1038(1.04)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C1034(1.21); C1038(1.21)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C1034(1.08); C1038(1.08)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C1034(1.01); C1038(1.01)  LDD0612  [1]
 LDCM0296  AC35 HEK-293T C1034(1.05); C1038(1.07)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C1034(0.98); C1038(1.22)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C1034(0.92); C1038(1.02)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C1034(1.01); C1038(1.19)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C1034(1.07); C1038(1.21)  LDD0898  [1]
 LDCM0301  AC4 HEK-293T C1034(0.87); C1038(0.78)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C1034(1.05); C1038(1.25)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C1034(0.99); C1038(1.06)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C1034(0.93); C1038(1.03)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C1034(0.97); C1038(1.19)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C1034(0.98); C1038(1.12)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C1034(0.97); C1038(1.07)  LDD0905  [1]
 LDCM0308  AC46 HEK-293T C1034(1.04); C1038(0.81)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C1034(1.08); C1038(0.84)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C1034(1.08); C1038(0.83)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C1034(1.09); C1038(1.13)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C1034(0.89); C1038(0.81)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C1034(1.09); C1038(1.06)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C1034(1.08); C1038(0.97)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C1034(1.11); C1038(1.03)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C1034(1.19); C1038(1.12)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C1034(1.16); C1038(1.00)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C1034(1.25); C1038(1.10)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C1034(1.07); C1038(0.90)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C1038(1.14)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C1038(1.26)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C1038(1.55)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C1034(1.14); C1038(1.14)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C1038(0.55)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C1038(0.89)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C1038(1.05)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C1038(1.13)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C1038(1.73)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C1038(1.23)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C1038(1.30)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C1038(1.43)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C1034(0.65); C1038(0.65)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C1034(0.73); C1038(0.73)  LDD0931  [1]
 LDCM0334  AC7 HCT 116 C1034(1.01); C1038(1.01)  LDD0651  [1]
 LDCM0335  AC70 HEK-293T C1034(1.12); C1038(1.12)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C1034(0.79); C1038(0.79)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C1034(1.35); C1038(1.35)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C1034(1.10); C1038(1.10)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C1034(0.94); C1038(0.94)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C1034(1.20); C1038(1.20)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C1034(0.87); C1038(0.87)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C1034(0.64); C1038(0.64)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C1034(1.02); C1038(1.02)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C1034(0.82); C1038(0.82)  LDD0942  [1]
 LDCM0345  AC8 HCT 116 C1034(1.22); C1038(1.22)  LDD0662  [1]
 LDCM0346  AC80 HEK-293T C1034(1.04); C1038(1.04)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C1034(0.59); C1038(0.59)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C1034(1.13); C1038(1.13)  LDD0946  [1]
 LDCM0349  AC83 HEK-293T C1034(0.99); C1038(0.86)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C1034(0.99); C1038(1.02)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C1034(1.00); C1038(1.11)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C1034(1.00); C1038(1.03)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C1034(1.20); C1038(1.43)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C1034(1.31); C1038(1.71)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C1034(1.13); C1038(1.37)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C1034(1.29); C1038(1.68)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C1034(0.97); C1038(1.05)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C1034(0.86); C1038(0.80)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C1034(1.10); C1038(1.35)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C1034(0.90); C1038(0.95)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C1034(1.05); C1038(1.18)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C1034(0.73); C1038(0.72)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C1034(0.95); C1038(0.95)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C1034(1.03); C1038(0.97); C409(0.92)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C1034(1.02); C1038(1.14); C409(1.04)  LDD0964  [1]
 LDCM0248  AKOS034007472 HCT 116 C1034(0.94); C1038(0.94)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C1034(1.17); C1038(1.17)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C1034(0.81); C1038(0.81)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C1034(1.20); C1038(1.20); C741(1.13); C746(1.13)  LDD0078  [1]
 LDCM0367  CL1 HEK-293T C1034(1.51); C1038(1.50)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C1034(1.20); C1038(1.30)  LDD0966  [1]
 LDCM0369  CL100 HEK-293T C1034(0.83); C1038(0.88)  LDD0967  [1]
 LDCM0370  CL101 HCT 116 C1034(0.82); C1038(0.82)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C1034(0.75); C1038(0.75)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C1034(0.87); C1038(0.87)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C1034(0.85); C1038(0.85)  LDD0690  [1]
 LDCM0374  CL105 HEK-293T C409(1.06)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C409(1.06)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C409(0.99)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C409(1.20)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C409(1.05)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C1034(1.14); C1038(1.03)  LDD0977  [1]
 LDCM0380  CL110 HEK-293T C409(1.28)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C409(1.23)  LDD0979  [1]
 LDCM0382  CL112 HCT 116 C1034(1.06); C1038(1.06)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C1034(1.14); C1038(1.14)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C1034(1.10); C1038(1.10)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C1034(1.20); C1038(1.20)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C1034(1.01); C1038(1.01)  LDD0703  [1]
 LDCM0387  CL117 HEK-293T C1034(1.32); C1038(1.48)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C1034(1.02); C1038(1.11)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C1034(0.86); C1038(0.91)  LDD0987  [1]
 LDCM0390  CL12 HEK-293T C1034(1.14); C1038(1.15)  LDD0988  [1]
 LDCM0391  CL120 HEK-293T C1034(0.99); C1038(1.06)  LDD0989  [1]
 LDCM0392  CL121 HEK-293T C1034(1.12); C1038(1.01)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C1034(1.19); C1038(1.09)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C1034(1.52); C1038(1.13)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C1034(1.08); C1038(1.09)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C1038(1.35)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C1038(1.32)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C1038(0.91)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C1038(1.26)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C1034(1.01); C1038(1.01)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C1034(1.31); C1038(1.32)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C1034(1.29); C1038(1.57)  LDD1000  [1]
 LDCM0403  CL16 HEK-293T C1034(0.94)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C1034(1.43)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C1034(0.83)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C1034(1.50)  LDD1004  [1]
 LDCM0407  CL2 HEK-293T C1034(1.22); C1038(1.27)  LDD1005  [1]
 LDCM0408  CL20 HEK-293T C1034(0.86)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C1034(1.27)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C1034(1.24)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C1034(0.88)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C1034(0.82)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C1034(1.31)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C1034(1.25)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C1034(0.91)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C1034(1.47)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C1034(0.88)  LDD1015  [1]
 LDCM0418  CL3 HEK-293T C1034(1.08); C1038(1.04)  LDD1016  [1]
 LDCM0419  CL30 HEK-293T C1034(0.81)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C1034(1.05)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C1034(1.14)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C1034(0.90)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C1034(1.42)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C1034(0.80)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C1034(1.15)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C1034(0.95)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C1034(0.96)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C1034(1.38); C1038(1.32)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C1034(0.75)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C1034(0.85)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C1034(0.80)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C1034(0.80)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C1034(1.24)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C1034(1.02)  LDD1033  [1]
 LDCM0436  CL46 HCT 116 C1034(0.83); C1038(0.83)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C1034(0.63); C1038(0.63)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C1034(0.72); C1038(0.72)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C1034(0.81); C1038(0.81)  LDD0756  [1]
 LDCM0440  CL5 HEK-293T C1034(1.15); C1038(1.24)  LDD1038  [1]
 LDCM0441  CL50 HCT 116 C1034(0.71); C1038(0.71)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C1034(0.67); C1038(0.67)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C1034(0.96); C1038(0.96)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C1034(0.46); C1038(0.46)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C1034(0.69); C1038(0.69)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C1034(1.00); C1038(1.00)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C1034(1.08); C1038(1.08)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C1034(0.71); C1038(0.71)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C1034(0.80); C1038(0.80)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C1034(0.93); C1038(0.93)  LDD0767  [1]
 LDCM0451  CL6 HEK-293T C1034(1.23); C1038(1.45)  LDD1049  [1]
 LDCM0452  CL60 HCT 116 C1034(1.01); C1038(1.01)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C1034(0.87); C1038(0.87)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C1034(0.86); C1038(0.86)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C1034(1.01); C1038(1.01)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C1034(1.21); C1038(1.21)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C1034(1.11); C1038(1.11)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C1034(1.09); C1038(1.09)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C1034(1.01); C1038(1.01)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C1034(0.84); C1038(0.84)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C1034(0.89); C1038(0.89)  LDD0778  [1]
 LDCM0462  CL7 HEK-293T C1034(1.10); C1038(1.20)  LDD1060  [1]
 LDCM0463  CL70 HCT 116 C1034(1.04); C1038(1.04)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C1034(1.03); C1038(1.03)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C1034(1.03); C1038(1.03)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C1034(1.21); C1038(1.21)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C1034(1.08); C1038(1.08)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C1034(0.93); C1038(0.93)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C1034(1.02); C1038(1.02)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C1034(0.98); C1038(0.98)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C1034(0.92); C1038(0.92)  LDD0789  [1]
 LDCM0473  CL8 HEK-293T C1034(1.36); C1038(0.92)  LDD1071  [1]
 LDCM0474  CL80 HCT 116 C1034(1.22); C1038(1.22)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C1034(0.98); C1038(0.98)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C1034(1.20); C1038(1.20)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C1034(0.76); C1038(0.76)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C1034(0.91); C1038(0.91)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C1034(0.88); C1038(0.88)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C1034(1.09); C1038(1.09)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C1034(0.98); C1038(0.98)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C1034(1.03); C1038(1.03)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C1034(1.11); C1038(1.11)  LDD0800  [1]
 LDCM0484  CL9 HEK-293T C1034(1.14); C1038(1.03)  LDD1082  [1]
 LDCM0485  CL90 HCT 116 C1034(1.03); C1038(1.03)  LDD0802  [1]
 LDCM0486  CL91 HEK-293T C1034(1.02); C1038(1.00)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C1034(1.27); C1038(1.55)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C1034(1.12); C1038(1.25)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C1034(1.07); C1038(1.09)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C1034(1.23); C1038(1.76)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C1034(1.02); C1038(0.95)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C1034(1.09); C1038(1.23)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C1034(0.93); C1038(1.14)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C1034(1.00); C1038(1.01)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C1559(0.84); C1054(1.10); C581(1.06); C1034(1.31)  LDD1698  [4]
 LDCM0468  Fragment33 HCT 116 C1034(0.97); C1038(0.97)  LDD0785  [1]
 LDCM0427  Fragment51 HEK-293T C1034(0.95)  LDD1025  [1]
 LDCM0022  KB02 HEK-293T C1054(0.97); C409(1.00); C928(1.11)  LDD1492  [4]
 LDCM0023  KB03 Jurkat C1054(39.97); C1493(12.42)  LDD0209  [5]
 LDCM0024  KB05 MKN45 C581(1.96); C614(2.52); C409(1.92)  LDD3332  [6]
 LDCM0021  THZ1 HCT 116 C1034(1.14); C1038(1.14)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-3 complex subunit mu-1 (AP3M1) Adaptor complexes medium subunit family Q9Y2T2

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840