Details of the Target

General Information of Target

Target ID LDTP16123
Target Name COMM domain-containing protein 8 (COMMD8)
Gene Name COMMD8
Gene ID 54951
Synonyms
COMM domain-containing protein 8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MILQQPLQRGPQGGAQRLPRAALGVTWGLDASSPLRGAVPMSTKRRLEEEQEPLRKQFLS
EENMATHFSQLSLHNDHPYCSPPMTFSPALPPLRSPCSELLLWRYPGSLIPEALRLLRLG
DTPSPPYPATPAGDIMEL
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B.
Uniprot ID
Q9NX08
Ensemble ID
ENST00000381571.6
HGNC ID
HGNC:26036

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C32(0.81)  LDD2101  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
DBIA
 Probe Info  		C32(0.97)  LDD0533  [3]
5E-2FA
 Probe Info  		H25(0.00); H86(0.00)  LDD2235  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
W1
 Probe Info  		N.A.  LDD0236  [7]
AOyne
 Probe Info  		13.00  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C32(0.79)  LDD1094  [3]
 LDCM0216  AC100 HCT 116 C32(0.97)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C32(0.81)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C32(0.99)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C32(1.06)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C32(1.04)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C32(0.99)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C32(0.92)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C32(0.87)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C32(1.02)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C32(1.13)  LDD0542  [3]
 LDCM0226  AC11 PaTu 8988t C32(0.77)  LDD1105  [3]
 LDCM0227  AC110 HCT 116 C32(0.90)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C32(1.01)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C32(0.98)  LDD0546  [3]
 LDCM0237  AC12 PaTu 8988t C32(0.60)  LDD1116  [3]
 LDCM0246  AC128 HCT 116 C32(0.84)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C32(0.83)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C32(0.77)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C32(0.84)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C32(1.04)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C32(0.86)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C32(0.73)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C32(0.86)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C32(0.91)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C32(0.95)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C32(0.81)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C32(0.95)  LDD0575  [3]
 LDCM0259  AC14 PaTu 8988t C32(1.19)  LDD1138  [3]
 LDCM0260  AC140 HCT 116 C32(0.88)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C32(0.88)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C32(0.96)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C32(1.03)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C32(0.63)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C32(0.78)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C32(0.66)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C32(0.62)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C32(0.48)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C32(0.65)  LDD0586  [3]
 LDCM0270  AC15 PaTu 8988t C32(1.02)  LDD1149  [3]
 LDCM0271  AC150 HCT 116 C32(1.00)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C32(1.04)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C32(0.67)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C32(0.51)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C32(0.70)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C32(0.68)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C32(0.83)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C32(0.96)  LDD2161  [3]
 LDCM0276  AC17 PaTu 8988t C32(0.69)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C32(0.52)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C32(0.55)  LDD1157  [3]
 LDCM0280  AC20 PaTu 8988t C32(0.61)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C32(0.51)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C32(0.48)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C32(0.52)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C32(0.51)  LDD1163  [3]
 LDCM0285  AC25 HEK-293T C32(1.37)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C32(1.43)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C32(1.44)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C32(1.32)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C32(1.46)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C32(0.97)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C32(1.35)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C32(1.15)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C32(1.39)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C32(1.26)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C32(1.26)  LDD0893  [3]
 LDCM0296  AC35 HCT 116 C32(0.82)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C32(0.95)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C32(1.02)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C32(1.15)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C32(1.04)  LDD0617  [3]
 LDCM0302  AC40 HCT 116 C32(1.02)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C32(0.99)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C32(0.90)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C32(1.11)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C32(1.01)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C32(0.98)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C32(0.82)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C32(1.01)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C32(1.05)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C32(0.72)  LDD0628  [3]
 LDCM0313  AC50 HCT 116 C32(0.75)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C32(1.27)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C32(0.86)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C32(0.66)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C32(0.83)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C32(0.67)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C32(0.54)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C32(0.69)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C32(0.64)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C32(0.73)  LDD0639  [3]
 LDCM0323  AC6 PaTu 8988t C32(0.86)  LDD1202  [3]
 LDCM0324  AC60 HCT 116 C32(0.69)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C32(0.71)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C32(0.61)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C32(0.68)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C32(0.67)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C32(0.74)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C32(0.74)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C32(0.49)  LDD0648  [3]
 LDCM0332  AC68 HEK-293T C32(1.12)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C32(1.07)  LDD0931  [3]
 LDCM0334  AC7 PaTu 8988t C32(0.92)  LDD1213  [3]
 LDCM0335  AC70 HEK-293T C32(1.33)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C32(1.23)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C32(1.28)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C32(1.01)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C32(1.83)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C32(1.78)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C32(1.65)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C32(1.34)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C32(1.28)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C32(1.21)  LDD0942  [3]
 LDCM0345  AC8 PaTu 8988t C32(1.07)  LDD1224  [3]
 LDCM0346  AC80 HEK-293T C32(2.06)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C32(1.36)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C32(2.21)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C32(0.92)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C32(0.95)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C32(1.01)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C32(0.84)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C32(0.90)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C32(1.09)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C32(0.90)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C32(0.73)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C32(1.26)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C32(1.08)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C32(0.83)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C32(1.31)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C32(0.83)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C32(1.54)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C32(0.86)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C32(1.02)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C32(1.03)  LDD0683  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C32(0.96)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C32(0.69)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C32(0.72)  LDD1154  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 PaTu 8988t C32(0.98)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C32(0.62)  LDD1247  [3]
 LDCM0370  CL101 PaTu 8988t C32(0.84)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C32(0.87)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C32(0.70)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C32(0.78)  LDD1252  [3]
 LDCM0374  CL105 PaTu 8988t C32(0.68)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C32(0.58)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C32(0.61)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C32(0.65)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C32(0.58)  LDD1257  [3]
 LDCM0379  CL11 PaTu 8988t C32(0.81)  LDD1258  [3]
 LDCM0380  CL110 PaTu 8988t C32(0.56)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C32(0.40)  LDD1260  [3]
 LDCM0382  CL112 HEK-293T C32(1.90)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C32(1.29)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C32(1.87)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C32(1.78)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C32(1.52)  LDD0984  [3]
 LDCM0387  CL117 HCT 116 C32(0.86)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C32(0.92)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C32(0.92)  LDD0706  [3]
 LDCM0390  CL12 PaTu 8988t C32(0.87)  LDD1269  [3]
 LDCM0391  CL120 HCT 116 C32(1.06)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C32(1.49)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C32(0.88)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C32(0.83)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C32(0.69)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C32(0.98)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C32(0.79)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C32(0.92)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C32(0.82)  LDD0716  [3]
 LDCM0400  CL13 PaTu 8988t C32(0.52)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C32(0.46)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C32(0.75)  LDD1281  [3]
 LDCM0403  CL16 HEK-293T C32(0.93)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C32(1.02)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C32(1.21)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C32(1.44)  LDD1004  [3]
 LDCM0407  CL2 PaTu 8988t C32(0.74)  LDD1286  [3]
 LDCM0408  CL20 HEK-293T C32(1.31)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C32(1.44)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C32(1.45)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C32(1.20)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C32(1.26)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C32(1.10)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C32(1.22)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C32(1.22)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C32(1.35)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C32(1.26)  LDD1015  [3]
 LDCM0418  CL3 PaTu 8988t C32(0.63)  LDD1297  [3]
 LDCM0419  CL30 HEK-293T C32(1.60)  LDD1017  [3]
 LDCM0420  CL31 PaTu 8988t C32(0.81)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C32(0.78)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C32(0.58)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C32(0.60)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C32(0.67)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C32(0.57)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C32(0.52)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C32(0.71)  LDD1307  [3]
 LDCM0429  CL4 PaTu 8988t C32(0.70)  LDD1308  [3]
 LDCM0430  CL40 PaTu 8988t C32(0.68)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C32(0.56)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C32(0.53)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C32(0.42)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C32(0.51)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C32(0.65)  LDD1314  [3]
 LDCM0436  CL46 HCT 116 C32(1.23)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C32(1.07)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C32(1.70)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C32(1.28)  LDD0756  [3]
 LDCM0440  CL5 PaTu 8988t C32(0.55)  LDD1319  [3]
 LDCM0441  CL50 HCT 116 C32(1.03)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C32(1.80)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C32(1.26)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C32(1.18)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C32(1.15)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C32(1.32)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C32(1.47)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C32(1.21)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C32(0.88)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C32(2.13)  LDD0767  [3]
 LDCM0451  CL6 PaTu 8988t C32(0.68)  LDD1330  [3]
 LDCM0452  CL60 HCT 116 C32(1.40)  LDD0769  [3]
 LDCM0459  CL67 HEK-293T C32(0.93)  LDD1662  [11]
 LDCM0462  CL7 PaTu 8988t C32(0.66)  LDD1341  [3]
 LDCM0469  CL76 HCT 116 C32(0.90)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C32(0.87)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C32(1.06)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C32(0.77)  LDD0789  [3]
 LDCM0473  CL8 PaTu 8988t C32(0.60)  LDD1352  [3]
 LDCM0474  CL80 HCT 116 C32(0.95)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C32(0.92)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C32(0.79)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C32(0.83)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C32(0.61)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C32(0.90)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C32(0.94)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C32(0.80)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C32(0.81)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C32(1.02)  LDD0800  [3]
 LDCM0484  CL9 PaTu 8988t C32(0.62)  LDD1363  [3]
 LDCM0485  CL90 HCT 116 C32(1.00)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C32(1.06)  LDD1689  [11]
 LDCM0427  Fragment51 PaTu 8988t C32(0.38)  LDD1306  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 769-P C32(1.33)  LDD2246  [12]
 LDCM0023  KB03 769-P C32(2.53)  LDD2663  [12]
 LDCM0024  KB05 COLO792 C32(3.32)  LDD3310  [12]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C32(0.81)  LDD2101  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C32(0.47)  LDD2107  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C32(0.81)  LDD2136  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C32(0.35)  LDD2148  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 22 (CCDC22) CCDC22 family O60826
Coiled-coil domain-containing protein 93 (CCDC93) CCDC93 family Q567U6
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 474 (ZNF474) . Q6S9Z5
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COMM domain-containing protein 1 (COMMD1) . Q8N668
COMM domain-containing protein 3 (COMMD3) . Q9UBI1
COMM domain-containing protein 4 (COMMD4) . Q9H0A8

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840