Details of the Target

General Information of Target

Target ID LDTP15756
Target Name Transmembrane protein 87B (TMEM87B)
Gene Name TMEM87B
Gene ID 84910
Synonyms
Transmembrane protein 87B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVQRLWVSRLLRHRKAQLLLVNLLTFGLEVCLAAGITYVPPLLLEVGVEEKFMTMVLGIG
PVLGLVCVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLIPRAGWLAGLLCPDPRPL
ELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYSVYAFMISLGGCLGYLLPA
IDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVAEEAALGPTEPAEGLSAPSLSPH
CCPCRARLAFRNLGALLPRLHQLCCRMPRTLRRLFVAELCSWMALMTFTLFYTDFVGEGL
YQGVPRAEPGTEARRHYDEGVRMGSLGLFLQCAISLVFSLVMDRLVQRFGTRAVYLASVA
AFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLASLYHREKQVFLPKYRGDTGG
ASSEDSLMTSFLPGPKPGAPFPNGHVGAGGSGLLPPPPALCGASACDVSVRVVVGEPTEA
RVVPGRGICLDLAILDSAFLLSQVAPSLFMGSIVQLSQSVTAYMVSAAGLGLVAIYFATQ
VVFDKSDLAKYSA
Target Bioclass
Transporter and channel
Family
LU7TM family, TMEM87 subfamily
Subcellular location
Golgi apparatus membrane
Function May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).
Uniprot ID
Q96K49
Ensemble ID
ENST00000283206.9
HGNC ID
HGNC:25913

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU6 SNV: p.N140S DBIA    Probe Info 
CAMA1 SNV: p.E510K .
HCT15 SNV: p.W214Ter; p.K388R .
IM95 SNV: p.E45A .
LS180 SNV: p.R418I .
MOLT4 Deletion: p.S521LfsTer6 .
NCIH196 SNV: p.A455V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		16.17  LDD0318  [1]
BTD
 Probe Info  		C81(1.01)  LDD2093  [2]
IA-alkyne
 Probe Info  		C81(4.48)  LDD2182  [3]
IPM
 Probe Info  		C121(2.24)  LDD1702  [2]
DBIA
 Probe Info  		C422(0.72)  LDD0602  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
NAIA_5
 Probe Info  		C121(0.00); C81(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C129(0.38); C422(0.24)  LDD1093  [4]
 LDCM0215  AC10 PaTu 8988t C129(0.65); C422(1.04)  LDD1094  [4]
 LDCM0216  AC100 PaTu 8988t C129(0.52); C422(1.54)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C129(0.45); C422(1.04)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C129(0.54); C422(0.94)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C129(0.54); C422(0.96)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C129(0.72); C422(1.25)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C129(0.70); C422(1.16)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C129(0.47); C422(0.91)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C129(0.82); C422(0.99)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C129(0.88); C422(1.00)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C129(0.43); C422(0.93)  LDD1104  [4]
 LDCM0226  AC11 PaTu 8988t C129(0.67); C422(0.93)  LDD1105  [4]
 LDCM0227  AC110 PaTu 8988t C129(0.47); C422(1.08)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C129(0.51); C422(1.19)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C129(0.36); C422(1.00)  LDD1108  [4]
 LDCM0230  AC113 PaTu 8988t C422(1.30)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C422(1.24)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C422(1.35)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C422(1.48)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C422(1.17)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C422(1.24)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C422(1.03)  LDD1115  [4]
 LDCM0237  AC12 PaTu 8988t C129(0.56); C422(0.89)  LDD1116  [4]
 LDCM0238  AC120 PaTu 8988t C422(1.31)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C422(1.16)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C422(1.15)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C422(1.02)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C422(1.19)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C422(1.04)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C422(1.28)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C422(1.17)  LDD1124  [4]
 LDCM0246  AC128 PaTu 8988t C422(0.97)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C422(0.85)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C422(0.90)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C422(0.97)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C422(1.15)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C422(1.00)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C422(0.96)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C422(1.01)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C422(1.26)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C422(0.94)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C422(0.70)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C422(0.97)  LDD1137  [4]
 LDCM0259  AC14 PaTu 8988t C129(0.66); C422(0.96)  LDD1138  [4]
 LDCM0260  AC140 PaTu 8988t C422(1.08)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C422(0.99)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C422(0.98)  LDD1141  [4]
 LDCM0263  AC143 PaTu 8988t C422(0.94)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C422(0.89)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C422(0.85)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C422(0.85)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C422(0.87)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C422(0.65)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C422(0.90)  LDD1148  [4]
 LDCM0270  AC15 PaTu 8988t C129(0.73); C422(0.98)  LDD1149  [4]
 LDCM0271  AC150 PaTu 8988t C422(1.06)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C422(0.77)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C422(0.76)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C422(0.69)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C422(0.84)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C422(0.80)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C422(0.93)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C422(0.80)  LDD2169  [4]
 LDCM0276  AC17 PaTu 8988t C129(0.87); C422(1.17)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C129(0.80); C422(1.18)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C129(0.65); C422(1.23)  LDD1157  [4]
 LDCM0279  AC2 PaTu 8988t C129(0.54); C422(0.26)  LDD1158  [4]
 LDCM0280  AC20 PaTu 8988t C129(0.85); C422(1.15)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C129(0.79); C422(1.24)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C129(0.79); C422(1.22)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C129(0.87); C422(1.26)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C129(0.80); C422(1.29)  LDD1163  [4]
 LDCM0285  AC25 HCT 116 C422(0.72)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C422(0.81)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C422(0.70)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C422(0.64)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C422(0.86)  LDD0606  [4]
 LDCM0290  AC3 PaTu 8988t C129(0.37); C422(0.28)  LDD1169  [4]
 LDCM0291  AC30 HCT 116 C422(0.65)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C422(0.80)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C422(0.65)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C422(0.66)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C422(0.69)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C422(0.85)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C422(1.03)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C422(1.20)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C422(1.06)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C422(0.99)  LDD0617  [4]
 LDCM0301  AC4 PaTu 8988t C129(0.48); C422(0.26)  LDD1180  [4]
 LDCM0302  AC40 HCT 116 C422(1.05)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C422(1.16)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C422(1.14)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C422(1.17)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C422(1.30)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C422(1.06)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C422(1.22)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C422(1.40)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C422(1.07)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C422(1.19)  LDD0628  [4]
 LDCM0312  AC5 PaTu 8988t C129(0.42); C422(0.25)  LDD1191  [4]
 LDCM0313  AC50 HCT 116 C422(1.24)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C422(1.42)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C422(1.50)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C422(1.29)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C422(1.05)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C422(1.14)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C422(1.40)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C422(1.16)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C422(1.09)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C422(0.98)  LDD0639  [4]
 LDCM0323  AC6 PaTu 8988t C129(0.81); C422(0.81)  LDD1202  [4]
 LDCM0324  AC60 HCT 116 C422(0.89)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C422(1.12)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C422(1.21)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C422(1.14)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C422(1.23)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C422(2.14)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C422(1.65)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C422(1.87)  LDD0648  [4]
 LDCM0332  AC68 PaTu 8988t C129(1.36); C422(0.93)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C129(1.10); C422(1.21)  LDD1212  [4]
 LDCM0334  AC7 PaTu 8988t C129(1.11); C422(1.13)  LDD1213  [4]
 LDCM0335  AC70 PaTu 8988t C129(1.27); C422(1.03)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C129(1.16); C422(1.11)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C129(1.06); C422(1.18)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C129(1.03); C422(1.38)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C129(1.03); C422(1.25)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C129(0.99); C422(1.23)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C129(0.98); C422(1.06)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C129(1.21); C422(1.04)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C129(1.16); C422(1.09)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C129(1.23); C422(0.96)  LDD1223  [4]
 LDCM0345  AC8 PaTu 8988t C129(0.84); C422(1.04)  LDD1224  [4]
 LDCM0346  AC80 PaTu 8988t C129(1.18); C422(1.09)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C129(1.25); C422(1.35)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C129(1.18); C422(1.00)  LDD1227  [4]
 LDCM0349  AC83 PaTu 8988t C422(1.12)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C422(1.24)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C422(1.71)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C422(1.45)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C422(1.76)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C422(1.12)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C422(1.13)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C422(1.37)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C422(1.06)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C422(1.35)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C422(1.38)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C422(1.47)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C422(1.34)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C422(1.32)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C422(1.18)  LDD1243  [4]
 LDCM0365  AC98 PaTu 8988t C129(0.57); C422(1.03)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C129(0.48); C422(0.99)  LDD1245  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C129(0.68); C422(1.04)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C129(0.90); C422(1.15)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C129(0.79); C422(0.96)  LDD1154  [4]
 LDCM0367  CL1 PaTu 8988t C129(0.74); C422(1.06)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C129(0.64); C422(0.90)  LDD1247  [4]
 LDCM0369  CL100 PaTu 8988t C129(0.44); C422(0.25)  LDD1248  [4]
 LDCM0370  CL101 PaTu 8988t C129(0.84); C422(0.86)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C129(0.78); C422(1.00)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C129(0.68); C422(0.91)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C129(0.72); C422(0.94)  LDD1252  [4]
 LDCM0374  CL105 PaTu 8988t C129(0.94); C422(1.18)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C129(0.73); C422(1.12)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C129(1.02); C422(1.03)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C129(0.77); C422(1.35)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C129(0.81); C422(1.22)  LDD1257  [4]
 LDCM0379  CL11 PaTu 8988t C129(0.76); C422(0.83)  LDD1258  [4]
 LDCM0380  CL110 PaTu 8988t C129(0.92); C422(1.36)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C129(0.79); C422(1.21)  LDD1260  [4]
 LDCM0382  CL112 HCT 116 C422(0.87)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C422(0.76)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C422(0.84)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C422(0.76)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C422(0.75)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C422(1.27)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C422(1.08)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C422(1.01)  LDD0706  [4]
 LDCM0390  CL12 PaTu 8988t C129(0.69); C422(0.91)  LDD1269  [4]
 LDCM0391  CL120 HCT 116 C422(1.05)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C422(1.38)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C422(1.38)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C422(1.27)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C422(1.42)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C422(1.24)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C422(1.02)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C422(1.08)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C422(0.99)  LDD0716  [4]
 LDCM0400  CL13 PaTu 8988t C129(0.59); C422(1.14)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C129(0.55); C422(1.00)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C129(0.73); C422(0.97)  LDD1281  [4]
 LDCM0403  CL16 PaTu 8988t C422(0.88)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C422(0.94)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C422(0.94)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C422(0.82)  LDD1285  [4]
 LDCM0407  CL2 PaTu 8988t C129(0.86); C422(0.77)  LDD1286  [4]
 LDCM0408  CL20 PaTu 8988t C422(0.94)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C422(0.79)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C422(0.99)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C422(1.02)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C422(1.27)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C422(1.06)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C422(0.92)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C422(0.93)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C422(1.14)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C422(0.97)  LDD1296  [4]
 LDCM0418  CL3 PaTu 8988t C129(0.94); C422(0.92)  LDD1297  [4]
 LDCM0419  CL30 PaTu 8988t C422(0.77)  LDD1298  [4]
 LDCM0420  CL31 PaTu 8988t C129(0.68); C422(1.11)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C129(0.54); C422(1.16)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C129(0.57); C422(0.88)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C129(0.42); C422(0.88)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C129(0.61); C422(0.92)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C129(0.18); C422(0.59)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C129(0.47); C422(1.10)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C129(0.50); C422(1.03)  LDD1307  [4]
 LDCM0429  CL4 PaTu 8988t C129(1.00); C422(0.86)  LDD1308  [4]
 LDCM0430  CL40 PaTu 8988t C129(0.69); C422(1.00)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C129(0.57); C422(1.06)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C129(0.59); C422(1.11)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C129(0.56); C422(1.12)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C129(0.47); C422(1.16)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C129(0.47); C422(0.98)  LDD1314  [4]
 LDCM0436  CL46 PaTu 8988t C422(0.81)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C422(0.86)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C422(0.77)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C422(0.95)  LDD1318  [4]
 LDCM0440  CL5 PaTu 8988t C129(0.59); C422(1.06)  LDD1319  [4]
 LDCM0441  CL50 PaTu 8988t C422(1.00)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C422(0.96)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C422(0.90)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C422(0.79)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C422(0.87)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C422(0.89)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C422(0.51)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C422(0.82)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C422(0.99)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C422(0.98)  LDD1329  [4]
 LDCM0451  CL6 PaTu 8988t C129(0.62); C422(0.78)  LDD1330  [4]
 LDCM0452  CL60 PaTu 8988t C422(0.90)  LDD1331  [4]
 LDCM0453  CL61 PaTu 8988t C422(0.94)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C422(0.84)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C422(0.87)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C422(0.95)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C422(0.84)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C422(0.93)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C422(1.10)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C422(1.04)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C422(1.04)  LDD1340  [4]
 LDCM0462  CL7 PaTu 8988t C129(0.64); C422(0.84)  LDD1341  [4]
 LDCM0463  CL70 PaTu 8988t C422(1.07)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C422(0.81)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C422(1.04)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C422(0.97)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C422(1.07)  LDD1346  [4]
 LDCM0469  CL76 PaTu 8988t C129(1.06); C422(0.94)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C129(1.19); C422(0.90)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C129(1.46); C422(1.16)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C129(1.75); C422(1.21)  LDD1351  [4]
 LDCM0473  CL8 PaTu 8988t C129(0.86); C422(1.09)  LDD1352  [4]
 LDCM0474  CL80 PaTu 8988t C129(1.24); C422(1.07)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C129(0.91); C422(1.01)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C129(1.03); C422(1.04)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C129(0.92); C422(1.05)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C129(1.10); C422(1.10)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C129(1.12); C422(1.05)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C129(1.04); C422(1.00)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C129(0.98); C422(0.99)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C129(0.89); C422(0.92)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C129(1.07); C422(1.00)  LDD1362  [4]
 LDCM0484  CL9 PaTu 8988t C129(0.60); C422(0.90)  LDD1363  [4]
 LDCM0485  CL90 PaTu 8988t C129(1.28); C422(1.13)  LDD1364  [4]
 LDCM0486  CL91 PaTu 8988t C129(0.56); C422(0.36)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C129(0.58); C422(0.29)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C129(0.39); C422(0.28)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C129(0.48); C422(0.33)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C129(0.43); C422(0.29)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C129(0.44); C422(0.32)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C129(0.61); C422(0.28)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C129(0.42); C422(0.24)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C129(0.47); C422(0.27)  LDD1373  [4]
 LDCM0495  E2913 HEK-293T C129(1.20)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C121(2.24)  LDD1702  [2]
 LDCM0625  F8 Ramos C81(2.43)  LDD2187  [3]
 LDCM0573  Fragment11 Ramos C81(3.90)  LDD2190  [3]
 LDCM0574  Fragment12 Ramos C81(4.21)  LDD2191  [3]
 LDCM0575  Fragment13 Ramos C81(1.08)  LDD2192  [3]
 LDCM0576  Fragment14 Ramos C81(0.67)  LDD2193  [3]
 LDCM0580  Fragment21 Ramos C81(0.99)  LDD2195  [3]
 LDCM0582  Fragment23 Ramos C81(0.93)  LDD2196  [3]
 LDCM0578  Fragment27 Ramos C81(0.85)  LDD2197  [3]
 LDCM0586  Fragment28 Ramos C81(0.60)  LDD2198  [3]
 LDCM0588  Fragment30 Ramos C81(1.29)  LDD2199  [3]
 LDCM0589  Fragment31 Ramos C81(1.35)  LDD2200  [3]
 LDCM0468  Fragment33 PaTu 8988t C422(0.97)  LDD1347  [4]
 LDCM0596  Fragment38 Ramos C81(1.93)  LDD2203  [3]
 LDCM0566  Fragment4 Ramos C81(2.33)  LDD2184  [3]
 LDCM0427  Fragment51 PaTu 8988t C129(0.47); C422(0.93)  LDD1306  [4]
 LDCM0610  Fragment52 Ramos C81(1.18)  LDD2204  [3]
 LDCM0614  Fragment56 Ramos C81(1.67)  LDD2205  [3]
 LDCM0569  Fragment7 Ramos C81(3.16)  LDD2186  [3]
 LDCM0022  KB02 Ramos C81(4.48)  LDD2182  [3]
 LDCM0023  KB03 Ramos C81(2.64)  LDD2183  [3]
 LDCM0024  KB05 HMCB C121(2.31); C129(2.70)  LDD3312  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C81(1.01)  LDD2093  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C81(1.09)  LDD2129  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C81(0.89)  LDD2137  [2]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840