Details of the Target

General Information of Target

Target ID LDTP15524
Target Name Tubulin--tyrosine ligase (TTL)
Gene Name TTL
Gene ID 150465
Synonyms
Tubulin--tyrosine ligase; TTL; EC 6.3.2.25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKVFCEVLEELYKKVLLGATLENDSHDYIFYLNPAVSDQDCSTATSLEWANTCGIQGRHQ
PISVGVAPIAVAPVCLKTNSQMSGSREVMLLQLTVIKVMTTRILSVKTEFHAKEQYRDVI
KILLESAKVDSKLICMFQNSDKLLSHMAAQCLALLLYFQLREKITLSNSWIAFCQKNLSE
YSESNKAIYCLWTLTAIIKEIFKDSCSQKTEILKQFLTHFDTIFEVFYNSLFSQHFENCR
DTSKIVNILMCFLDLLELLIASRIHLKLHFTCQRILFLKPSCMLEVITWPIQAFVKRKVI
IFLKKCLLCKVGEDLCRGSVPALMPPDHHVAVDMLALANAVLQAVNSGLLKTLSVYEKHS
FFGGDEVQPECELITSPDHVILRAASLVIMKSLEIKFQNYSSASEVKVDLQRFMSELLTF
LKPHLQPSLQLHNPCKWLSRVFIEQDDDMLEAAKASLGIYLTLTRGCEATESLTQGKEMW
DHHTHENGYNPHCIFLFFLKNIGFDSTVLLDFLISSETCFLEYFVRYLKLLQKDWDNFFT
ICNNFDATESKYDISICGCVPSLVQDQSSNQTIPHRLTAPHSHRDVCARHSWASDAPSEP
LKAVMSKGAHTMCASSLSSPRASQSLVDYDSSDDSDVESTEQCLANSKQTSLHQQATKEI
QDAAGTSRDKKEFSLEPPSRPLVLKEFDTAFSFDCEVAPNDVVSEVGIFYRIVKCFQELQ
DAICRLQKKNLFPYNPTALLKLLKYIEVISNKTMNTL
Target Bioclass
Enzyme
Family
Tubulin--tyrosine ligase family
Function Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
Uniprot ID
Q8NG68
Ensemble ID
ENST00000233336.7
HGNC ID
HGNC:21586
ChEMBL ID
CHEMBL5549

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C72(1.33)  LDD1700  [1]
NAIA_5
 Probe Info  		C91(0.89)  LDD2227  [2]
DBIA
 Probe Info  		C238(1.13); C244(1.13)  LDD0078  [3]
ATP probe
 Probe Info  		K255(0.00); K247(0.00)  LDD0199  [4]
IA-alkyne
 Probe Info  		C294(0.00); C91(0.00)  LDD2241  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
IPM
 Probe Info  		N.A.  LDD0005  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C91(1.00)  LDD1093  [3]
 LDCM0215  AC10 PaTu 8988t C91(1.13)  LDD1094  [3]
 LDCM0216  AC100 HCT 116 C238(0.93); C244(0.93)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C238(1.17); C244(1.17)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C238(1.16); C244(1.16)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C238(1.44); C244(1.44)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C238(1.35); C244(1.35)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C238(1.26); C244(1.26)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C238(1.16); C244(1.16)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C238(0.64); C244(0.76)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C238(0.88); C244(0.85)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C238(0.86); C244(0.83)  LDD0542  [3]
 LDCM0226  AC11 PaTu 8988t C91(1.10)  LDD1105  [3]
 LDCM0227  AC110 HCT 116 C238(1.07); C244(1.04)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C238(0.81); C244(0.84)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C238(1.00); C244(1.03)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C238(0.96); C244(0.96)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C238(1.15); C244(1.15)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C238(1.42); C244(1.42)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C238(1.39); C244(1.39)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C238(1.09); C244(1.09)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C238(1.13); C244(1.13)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C238(1.16); C244(1.16)  LDD0553  [3]
 LDCM0237  AC12 PaTu 8988t C91(1.22)  LDD1116  [3]
 LDCM0238  AC120 HCT 116 C238(1.46); C244(1.46)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C238(1.06); C244(1.06)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C238(0.94); C244(0.94)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C238(1.09); C244(1.09)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C238(1.01); C244(1.01)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C238(0.92); C244(0.92)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C238(1.06); C244(1.06)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C238(1.28); C244(1.28)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C238(0.88); C244(0.88)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C238(0.79); C244(0.79)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C238(0.85); C244(0.85)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C238(0.78); C244(0.78)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C238(0.75); C244(0.75)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C238(0.81); C244(0.81)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C238(0.78); C244(0.78)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C238(0.83); C244(0.83)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C238(0.94); C244(0.94)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C238(0.91); C244(0.91)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C238(0.76); C244(0.76)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C238(0.74); C244(0.74)  LDD0575  [3]
 LDCM0259  AC14 PaTu 8988t C91(1.05)  LDD1138  [3]
 LDCM0260  AC140 HCT 116 C238(0.77); C244(0.77)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C238(0.74); C244(0.74)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C238(0.70); C244(0.70)  LDD0579  [3]
 LDCM0263  AC143 PaTu 8988t C238(1.46); C244(1.46)  LDD1142  [3]
 LDCM0264  AC144 PaTu 8988t C238(1.53); C244(1.53)  LDD1143  [3]
 LDCM0265  AC145 PaTu 8988t C238(1.76); C244(1.76)  LDD1144  [3]
 LDCM0266  AC146 PaTu 8988t C238(1.47); C244(1.47)  LDD1145  [3]
 LDCM0267  AC147 PaTu 8988t C238(1.41); C244(1.41)  LDD1146  [3]
 LDCM0268  AC148 PaTu 8988t C238(1.76); C244(1.76)  LDD1147  [3]
 LDCM0269  AC149 PaTu 8988t C238(1.74); C244(1.74)  LDD1148  [3]
 LDCM0270  AC15 PaTu 8988t C91(1.12)  LDD1149  [3]
 LDCM0271  AC150 PaTu 8988t C238(2.03); C244(2.03)  LDD1150  [3]
 LDCM0272  AC151 PaTu 8988t C238(2.31); C244(2.31)  LDD1151  [3]
 LDCM0273  AC152 PaTu 8988t C238(1.68); C244(1.68)  LDD1152  [3]
 LDCM0274  AC153 PaTu 8988t C238(2.28); C244(2.28)  LDD1153  [3]
 LDCM0621  AC154 PaTu 8988t C238(1.97); C244(1.97)  LDD2166  [3]
 LDCM0622  AC155 PaTu 8988t C238(1.77); C244(1.77)  LDD2167  [3]
 LDCM0623  AC156 PaTu 8988t C238(1.96); C244(1.96)  LDD2168  [3]
 LDCM0624  AC157 PaTu 8988t C238(1.99); C244(1.99)  LDD2169  [3]
 LDCM0276  AC17 HEK-293T C238(1.19); C244(1.19)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C238(0.99); C244(0.99)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C238(1.10); C244(1.10)  LDD0876  [3]
 LDCM0279  AC2 PaTu 8988t C91(0.88)  LDD1158  [3]
 LDCM0280  AC20 HEK-293T C238(1.16); C244(1.16)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C238(1.12); C244(1.12)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C238(1.13); C244(1.13)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C238(0.85); C244(0.85)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C238(1.19); C244(1.19)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C238(0.71); C244(0.71)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C238(0.81); C244(0.81)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C238(0.81); C244(0.81)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C238(0.63); C244(0.63)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C238(3.11); C244(3.11)  LDD0887  [3]
 LDCM0290  AC3 PaTu 8988t C91(0.78)  LDD1169  [3]
 LDCM0291  AC30 HEK-293T C238(0.91); C244(0.91)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C238(0.76); C244(0.76)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C238(0.74); C244(0.74)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C238(0.75); C244(0.75)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C238(0.81); C244(0.81)  LDD0893  [3]
 LDCM0296  AC35 HCT 116 C238(1.11); C244(1.11)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C238(1.08); C244(1.08)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C238(0.87); C244(0.87)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C238(1.24); C244(1.24)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C238(1.41); C244(1.41)  LDD0617  [3]
 LDCM0301  AC4 PaTu 8988t C91(0.71)  LDD1180  [3]
 LDCM0302  AC40 HCT 116 C238(1.23); C244(1.23)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C238(0.93); C244(0.93)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C238(1.10); C244(1.10)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C238(0.75); C244(0.75)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C238(0.89); C244(0.89)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C238(0.92); C244(0.92)  LDD0624  [3]
 LDCM0308  AC46 PaTu 8988t C91(1.19)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C91(1.10)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C91(1.24)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C91(1.42)  LDD1190  [3]
 LDCM0312  AC5 PaTu 8988t C91(0.91)  LDD1191  [3]
 LDCM0313  AC50 PaTu 8988t C91(1.24)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C91(0.76)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C91(1.22)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C91(1.29)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C91(1.28)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C91(1.26)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C91(1.34)  LDD1198  [3]
 LDCM0320  AC57 HEK-293T C238(1.18); C244(1.18)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C238(1.00); C244(1.00)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C238(0.93); C244(0.93)  LDD0920  [3]
 LDCM0323  AC6 PaTu 8988t C91(1.13)  LDD1202  [3]
 LDCM0324  AC60 HEK-293T C238(1.14); C244(1.14)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C238(1.04); C244(1.04)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C238(0.78); C244(0.78)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C238(0.81); C244(0.81)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C238(0.99); C244(0.99)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C238(1.06); C244(1.06)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C238(0.81); C244(0.81)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C238(0.94); C244(0.94)  LDD0929  [3]
 LDCM0332  AC68 HCT 116 C238(0.89); C244(0.89)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C238(0.86); C244(0.86)  LDD0650  [3]
 LDCM0334  AC7 PaTu 8988t C91(0.96)  LDD1213  [3]
 LDCM0335  AC70 HCT 116 C238(3.24); C244(3.24)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C238(0.92); C244(0.92)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C238(0.95); C244(0.95)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C238(0.94); C244(0.94)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C238(1.07); C244(1.07)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C238(1.05); C244(1.05)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C238(0.91); C244(0.91)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C238(0.73); C244(0.73)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C238(0.76); C244(0.76)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C238(0.86); C244(0.86)  LDD0661  [3]
 LDCM0345  AC8 PaTu 8988t C91(0.93)  LDD1224  [3]
 LDCM0346  AC80 HCT 116 C238(1.00); C244(1.00)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C238(1.25); C244(1.25)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C238(1.22); C244(1.22)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C238(0.90); C244(0.90)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C238(1.03); C244(1.03)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C238(0.84); C244(0.84)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C238(0.87); C244(0.87)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C238(0.86); C244(0.86)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C238(1.14); C244(1.14)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C238(0.79); C244(0.79)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C238(0.90); C244(0.90)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C238(0.62); C244(0.62)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C238(0.68); C244(0.68)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C238(0.96); C244(0.96)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C238(0.62); C244(0.62)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C238(0.83); C244(0.83)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C238(0.65); C244(0.65)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C238(0.82); C244(0.82)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C238(1.21); C244(1.21)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C238(1.22); C244(1.22)  LDD0683  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C91(1.12)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C91(1.31)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C91(1.12)  LDD1154  [3]
 LDCM0020  ARS-1620 HCC44 C238(1.13); C244(1.13)  LDD0078  [3]
 LDCM0498  BS-3668 MDA-MB-231 C72(1.37)  LDD2091  [1]
 LDCM0632  CL-Sc Hep-G2 C91(0.89)  LDD2227  [2]
 LDCM0367  CL1 HCT 116 C238(1.09); C244(1.09)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C238(1.04); C244(1.04)  LDD0685  [3]
 LDCM0369  CL100 PaTu 8988t C91(0.71)  LDD1248  [3]
 LDCM0370  CL101 PaTu 8988t C91(1.08)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C91(1.19)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C91(1.16)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C91(1.15)  LDD1252  [3]
 LDCM0374  CL105 HEK-293T C238(1.07); C244(1.07)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C238(1.02); C244(1.02)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C238(1.08); C244(1.08)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C238(1.16); C244(1.16)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C238(1.09); C244(1.09)  LDD0976  [3]
 LDCM0379  CL11 HCT 116 C238(0.93); C244(0.93)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C238(1.10); C244(1.10)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C238(1.02); C244(1.02)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C238(0.71); C244(0.71)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C238(0.83); C244(0.83)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C238(0.66); C244(0.66)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C238(0.73); C244(0.73)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C238(0.76); C244(0.76)  LDD0984  [3]
 LDCM0387  CL117 HCT 116 C238(1.15); C244(1.15)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C238(1.10); C244(1.10)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C238(0.73); C244(0.73)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C238(1.00); C244(1.00)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C238(1.01); C244(1.01)  LDD0708  [3]
 LDCM0392  CL121 PaTu 8988t C91(1.16)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C91(1.18)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C91(1.16)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C91(1.27)  LDD1274  [3]
 LDCM0396  CL125 HEK-293T C238(1.04); C244(1.04)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C238(1.11); C244(1.11)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C238(1.10); C244(1.10)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C238(1.37); C244(1.37)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C238(0.80); C244(0.80)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C238(0.86); C244(0.86)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C238(0.51); C244(0.51)  LDD0719  [3]
 LDCM0403  CL16 PaTu 8988t C238(0.81); C244(0.81); C91(1.01)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C238(0.73); C244(0.73); C91(1.10)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C238(0.88); C244(0.88); C91(0.98)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C238(0.84); C244(0.84); C91(1.05)  LDD1285  [3]
 LDCM0407  CL2 HCT 116 C238(0.96); C244(0.96)  LDD0724  [3]
 LDCM0408  CL20 PaTu 8988t C238(0.90); C244(0.90); C91(1.17)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C238(1.39); C244(1.39); C91(1.22)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C238(0.92); C244(0.92); C91(1.18)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C238(0.83); C244(0.83); C91(1.25)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C238(0.85); C244(0.85); C91(1.04)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C238(0.73); C244(0.73); C91(1.00)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C238(0.94); C244(0.94); C91(1.05)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C238(0.78); C244(0.78); C91(1.24)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C238(0.97); C244(0.97); C91(1.11)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C238(0.67); C244(0.67); C91(1.22)  LDD1296  [3]
 LDCM0418  CL3 HCT 116 C238(1.05); C244(1.05)  LDD0735  [3]
 LDCM0419  CL30 PaTu 8988t C238(0.87); C244(0.87); C91(1.37)  LDD1298  [3]
 LDCM0420  CL31 PaTu 8988t C91(1.38)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C91(1.46)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C91(1.31)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C91(1.33)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C91(1.04)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C91(0.87)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C91(1.05)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C91(1.21)  LDD1307  [3]
 LDCM0429  CL4 HCT 116 C238(0.92); C244(0.92)  LDD0746  [3]
 LDCM0430  CL40 PaTu 8988t C91(1.22)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C91(1.08)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C91(1.15)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C91(1.14)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C91(1.23)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C91(1.45)  LDD1314  [3]
 LDCM0436  CL46 HCT 116 C238(0.56); C244(0.56)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C238(0.69); C244(0.69)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C238(0.60); C244(0.60)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C238(0.51); C244(0.51)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C238(0.79); C244(0.79)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C238(0.69); C244(0.69)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C238(0.56); C244(0.56)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C238(0.72); C244(0.72)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C238(1.72); C244(1.72)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C238(0.65); C244(0.65)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C238(0.78); C244(0.78)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C238(0.71); C244(0.71)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C238(0.65); C244(0.65)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C238(0.52); C244(0.52)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C238(0.69); C244(0.69)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C238(0.59); C244(0.59)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C238(0.44); C244(0.44)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C238(0.93); C244(0.93)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C238(0.87); C244(0.87)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C238(1.07); C244(1.07)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C238(0.92); C244(0.92)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C238(1.01); C244(1.01)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C238(1.22); C244(1.22)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C238(1.30); C244(1.30)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C238(1.54); C244(1.54)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C238(0.88); C244(0.88)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C238(0.61); C244(0.61)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C238(1.15); C244(1.15)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C238(1.22); C244(1.22)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C238(1.20); C244(1.20)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C238(1.10); C244(1.10)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C238(1.12); C244(1.12)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C238(1.62); C244(1.62)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C238(2.20); C244(2.20)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C238(1.14); C244(1.14)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C238(1.26); C244(1.26)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C238(1.03); C244(1.03)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C238(1.00); C244(1.00)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C238(0.96); C244(0.96)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C238(1.04); C244(1.04)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C238(1.05); C244(1.05)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C238(1.48); C244(1.48)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C238(1.62); C244(1.62)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C238(1.54); C244(1.54)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C238(1.53); C244(1.53)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C238(1.70); C244(1.70)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C238(1.18); C244(1.18)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C238(0.66); C244(0.66)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C238(1.24); C244(1.24)  LDD0802  [3]
 LDCM0486  CL91 PaTu 8988t C91(0.64)  LDD1365  [3]
 LDCM0487  CL92 PaTu 8988t C91(1.07)  LDD1366  [3]
 LDCM0488  CL93 PaTu 8988t C91(0.79)  LDD1367  [3]
 LDCM0489  CL94 PaTu 8988t C91(0.69)  LDD1368  [3]
 LDCM0490  CL95 PaTu 8988t C91(0.70)  LDD1369  [3]
 LDCM0491  CL96 PaTu 8988t C91(0.85)  LDD1370  [3]
 LDCM0492  CL97 PaTu 8988t C91(1.24)  LDD1371  [3]
 LDCM0493  CL98 PaTu 8988t C91(1.13)  LDD1372  [3]
 LDCM0494  CL99 PaTu 8988t C91(0.84)  LDD1373  [3]
 LDCM0495  E2913 HEK-293T C91(0.98); C338(0.88)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C238(1.11); C244(1.11)  LDD0785  [3]
 LDCM0427  Fragment51 PaTu 8988t C91(1.14)  LDD1306  [3]
 LDCM0022  KB02 HCT 116 C238(2.23); C244(2.23)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C238(1.58); C244(1.58)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C238(2.08); C244(2.08)  LDD0082  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C72(0.76)  LDD2093  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C72(0.77)  LDD2107  [1]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C72(2.25)  LDD2111  [1]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C72(1.07)  LDD2135  [1]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C72(1.33)  LDD1700  [1]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C72(1.17)  LDD2143  [1]
 LDCM0021  THZ1 HCT 116 C238(1.00); C244(1.00)  LDD2173  [3]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402