Details of the Target

General Information of Target

Target ID LDTP15291
Target Name Acetoacetyl-CoA synthetase (AACS)
Gene Name AACS
Gene ID 65985
Synonyms
ACSF1; Acetoacetyl-CoA synthetase; EC 6.2.1.16; Acyl-CoA synthetase family member 1; Protein sur-5 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTMAAAAVVARGAGARAATAAALRGGCGTAARGRPCAGPARPLCTAPGTAPDMKRYLWER
YREAKRSTEELVPSIMSNLLNPDAIFSNNEMSLSDIEIYGFDYDYTLVFYSKHLHTLIFN
AARDLLINEHRYPAEIRKYEYDPNFAIRGLHYDVQRAVLMKIDAFHYIQLGTVYRGLSVV
PDEEVIEMYEGSHVPLEQMSDFYGKSSHGNTMKQFMDIFSLPEMTLLSCVNEYFLKNNID
YEPVHLYKDVKDSIRDVHIKGIMYRAIEADIEKYICYAEQTRAVLAKLADHGKKMFLITN
SPSSFVDKGMSYIVGKDWRDLFDVVIVQAEKPNFFNDKRRPFRKMNEKGVLLWDKIHKLQ
KGQIYKQGNLYEFLKLTGWRGSRVLYFGDHIYSDLADLTLKHGWRTGAIIPELRSELKIM
NTEQYIQTMTWLQTLTGLLEQMQVHRDAESQLVLQEWKKERKEMREMTKSFFNAQFGSLF
RTDQNPTYFLRRLSRFADIYMASLSCLLNYDVSHTFYPRRTPLQHELPAWSERPPTFGTP
LLQEAQAK
Target Bioclass
Enzyme
Family
ATP-dependent AMP-binding enzyme family
Subcellular location
Cytoplasm, cytosol
Function Converts acetoacetate to acetoacetyl-CoA in the cytosol. Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids.
Uniprot ID
Q86V21
Ensemble ID
ENST00000316519.11
HGNC ID
HGNC:21298

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.F196C .
COLO679 SNV: p.P453S DBIA    Probe Info 
HCT116 Deletion: p.E64VfsTer14
SNV: p.R614Ter		 DBIA    Probe Info 
LUDLU1 SNV: p.G465D DBIA    Probe Info 
RKO Deletion: p.L359WfsTer15 .
TOV21G SNV: p.E564Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.87  LDD0402  [1]
STPyne
 Probe Info  		K222(5.26); K235(9.20); K509(8.10); K640(6.28)  LDD0277  [2]
Probe 1
 Probe Info  		Y77(46.81); Y419(20.99); Y663(16.78)  LDD3495  [3]
HHS-475
 Probe Info  		Y628(0.83)  LDD0264  [4]
DBIA
 Probe Info  		C487(1.17); C493(1.17)  LDD0078  [5]
IA-alkyne
 Probe Info  		C525(0.00); C444(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]
NAIA_5
 Probe Info  		C525(0.00); C299(0.00); C571(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C493(0.73)  LDD0812  [5]
 LDCM0215  AC10 HEK-293T C299(0.96); C487(1.37); C493(1.33)  LDD0813  [5]
 LDCM0216  AC100 HEK-293T C299(1.12); C487(1.05)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C299(0.91); C487(0.97)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C299(0.83); C487(1.07)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C299(0.76); C487(1.12)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C299(0.87); C487(1.04)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C299(1.62); C487(0.98)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C299(0.83); C487(0.96)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C299(0.84); C487(0.95)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C299(1.29); C487(1.04)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C299(0.88); C487(1.03)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C299(0.90); C487(1.27); C493(1.06)  LDD0824  [5]
 LDCM0227  AC110 HEK-293T C299(1.05); C487(1.36)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C299(1.07); C487(1.76)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C299(0.92); C487(1.41)  LDD0827  [5]
 LDCM0230  AC113 HCT 116 C487(1.40); C493(1.40)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C487(1.17); C493(1.17)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C487(0.54); C493(0.54)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C487(0.49); C493(0.49)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C487(0.94); C493(0.94)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C487(0.97); C493(0.97)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C487(1.02); C493(1.02)  LDD0553  [5]
 LDCM0237  AC12 HEK-293T C299(1.25); C487(1.37); C493(1.07)  LDD0835  [5]
 LDCM0238  AC120 HCT 116 C487(0.72); C493(0.72)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C487(1.02); C493(1.02)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C487(1.25); C493(1.25)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C487(1.04); C493(1.04)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C487(1.40); C493(1.40)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C487(1.33); C493(1.33)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C487(0.52); C493(0.52)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C487(0.52); C493(0.52)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C487(0.72); C493(0.72)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C487(2.15); C493(2.15)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C487(0.99); C493(0.99)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C487(1.78); C493(1.78)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C487(1.41); C493(1.41)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C487(0.97); C493(0.97)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C487(1.10); C493(1.10)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C487(0.83); C493(0.83)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C487(1.08); C493(1.08)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C487(1.21); C493(1.21)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C487(1.23); C493(1.23)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C487(0.82); C493(0.82)  LDD0575  [5]
 LDCM0259  AC14 HEK-293T C299(1.02); C487(1.33); C493(1.14)  LDD0857  [5]
 LDCM0260  AC140 HCT 116 C487(0.75); C493(0.75)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C487(1.23); C493(1.23)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C487(1.92); C493(1.92)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C487(0.81); C493(0.81)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C487(0.39); C493(0.39)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C487(1.30); C493(1.30)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C487(0.78); C493(0.78)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C487(0.40); C493(0.40)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C487(0.45); C493(0.45)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C487(0.46); C493(0.46)  LDD0586  [5]
 LDCM0270  AC15 HEK-293T C299(0.83); C487(1.20); C493(1.98)  LDD0868  [5]
 LDCM0271  AC150 HCT 116 C487(0.93); C493(0.93)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C487(1.27); C493(1.27)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C487(0.49); C493(0.49)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C487(0.41); C493(0.41)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C487(0.52); C493(0.52)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C487(0.55); C493(0.55)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C487(1.16); C493(1.16)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C487(1.25); C493(1.25)  LDD2161  [5]
 LDCM0276  AC17 HEK-293T C487(0.95); C493(1.77)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C487(1.00); C493(1.42)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C487(1.01); C493(1.34)  LDD0876  [5]
 LDCM0279  AC2 HEK-293T C493(0.80)  LDD0877  [5]
 LDCM0280  AC20 HEK-293T C487(0.97); C493(1.82)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C487(0.94); C493(1.47)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C487(1.01); C493(1.52)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C487(0.87); C493(1.69)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C487(1.14); C493(1.20)  LDD0882  [5]
 LDCM0285  AC25 HEK-293T C299(1.20); C493(1.60)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C299(1.17); C493(1.73)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C299(1.09); C493(1.28)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C299(0.98); C493(2.76)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C299(1.15); C493(1.77)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C493(0.79)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C299(1.20); C493(1.51)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C299(1.28); C493(1.19)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C299(1.19); C493(1.55)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C299(1.06); C493(1.31)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C299(1.16); C493(1.53)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C299(0.97); C487(1.04)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C299(1.18); C487(0.82)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C299(1.14); C487(0.74)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C299(1.00); C487(0.92)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C299(0.96); C487(0.89)  LDD0898  [5]
 LDCM0301  AC4 HEK-293T C493(1.29)  LDD0899  [5]
 LDCM0302  AC40 HEK-293T C299(0.96); C487(0.92)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C299(0.99); C487(0.93)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C299(0.97); C487(0.94)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C299(1.10); C487(1.00)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C299(1.06); C487(0.89)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C299(1.02); C487(0.77)  LDD0905  [5]
 LDCM0308  AC46 HCT 116 C487(0.88); C493(0.88)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C487(0.47); C493(0.47)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C487(1.47); C493(1.47)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C487(0.36); C493(0.36)  LDD0628  [5]
 LDCM0312  AC5 HEK-293T C493(0.84)  LDD0910  [5]
 LDCM0313  AC50 HCT 116 C487(0.36); C493(0.36)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C487(0.90); C493(0.90)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C487(0.66); C493(0.66)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C487(0.43); C493(0.43)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C487(0.38); C493(0.38)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C487(0.41); C493(0.41)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C487(0.48); C493(0.48)  LDD0636  [5]
 LDCM0320  AC57 HEK-293T C299(1.08); C487(1.16)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C299(1.14); C487(1.00)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C299(1.40); C487(0.97)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C299(1.24); C487(1.18); C493(1.03)  LDD0921  [5]
 LDCM0324  AC60 HEK-293T C299(0.88); C487(0.88)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C299(1.01); C487(0.87)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C299(0.93); C487(0.80)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C299(0.90); C487(0.86)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C299(1.29); C487(0.78)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C299(0.89); C487(0.81)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C299(1.09); C487(0.86)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C299(1.11); C487(0.86)  LDD0929  [5]
 LDCM0332  AC68 HEK-293T C299(0.96); C487(1.14); C493(0.92)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C299(0.98); C487(1.12); C493(0.92)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C299(0.94); C487(1.15); C493(0.90)  LDD0932  [5]
 LDCM0335  AC70 HEK-293T C299(1.13); C487(1.03); C493(0.99)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C299(1.16); C487(1.12); C493(1.06)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C299(0.88); C487(1.12); C493(1.15)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C299(0.93); C487(1.05); C493(1.07)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C299(1.09); C487(1.30); C493(1.19)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C299(1.14); C487(1.24); C493(1.09)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C299(1.24); C487(1.41); C493(1.15)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C299(1.17); C487(1.06); C493(1.11)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C299(1.09); C487(1.08); C493(1.05)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C299(1.18); C487(1.09); C493(1.07)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C299(0.69); C487(1.23); C493(2.05)  LDD0943  [5]
 LDCM0346  AC80 HEK-293T C299(1.20); C487(1.30); C493(1.36)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C299(0.89); C487(1.09); C493(1.26)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C299(1.19); C487(1.19); C493(1.57)  LDD0946  [5]
 LDCM0349  AC83 HEK-293T C299(0.86); C487(0.96)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C299(0.91); C487(0.94)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C299(0.99); C487(0.99)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C299(0.96); C487(0.90)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C299(0.94); C487(0.98)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C299(0.77); C487(1.02)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C299(0.81); C487(1.03)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C299(0.92); C487(0.98)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C299(0.78); C487(1.00)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C299(0.88); C487(1.02)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C299(0.97); C487(0.99)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C299(0.80); C487(1.00)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C299(0.96); C487(1.12)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C299(1.40); C487(1.14)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C299(1.03); C487(1.44)  LDD0962  [5]
 LDCM0365  AC98 HEK-293T C299(0.72); C487(1.09)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C299(0.99); C487(1.00)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C299(1.02); C487(1.46); C493(0.98)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C299(0.87); C487(1.29); C493(1.22)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C299(1.19); C487(1.38); C493(1.34)  LDD0873  [5]
 LDCM0020  ARS-1620 HCC44 C487(1.17); C493(1.17)  LDD0078  [5]
 LDCM0632  CL-Sc Hep-G2 C15(1.22)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C487(0.73)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C487(1.12)  LDD0966  [5]
 LDCM0369  CL100 HEK-293T C493(0.80)  LDD0967  [5]
 LDCM0370  CL101 HEK-293T C299(1.28); C487(1.08); C493(1.09)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C299(0.78); C487(1.26); C493(1.05)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C299(0.92); C487(1.13); C493(1.30)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C299(0.98); C487(1.44); C493(1.41)  LDD0971  [5]
 LDCM0374  CL105 HEK-293T C487(1.06); C493(1.39)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C487(1.11); C493(1.10)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C487(1.00); C493(1.53)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C487(1.14); C493(1.67)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C487(1.01); C493(1.22)  LDD0976  [5]
 LDCM0379  CL11 HEK-293T C487(1.04)  LDD0977  [5]
 LDCM0380  CL110 HEK-293T C487(1.01); C493(1.54)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C487(0.93); C493(1.57)  LDD0979  [5]
 LDCM0382  CL112 HEK-293T C299(1.06); C493(1.30)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C299(1.29); C493(1.20)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C299(1.06); C493(1.57)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C299(0.99); C493(1.73)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C299(1.07); C493(1.56)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C299(1.04); C487(0.88)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C299(1.03); C487(1.04)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C299(1.06); C487(0.77)  LDD0987  [5]
 LDCM0390  CL12 HEK-293T C487(0.97)  LDD0988  [5]
 LDCM0391  CL120 HEK-293T C299(0.99); C487(1.04)  LDD0989  [5]
 LDCM0392  CL121 HCT 116 C487(0.94); C493(0.94)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C487(0.85); C493(0.85)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C487(0.41); C493(0.41)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C487(0.43); C493(0.43)  LDD0712  [5]
 LDCM0396  CL125 HEK-293T C299(1.02); C487(1.06)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C299(0.90); C487(0.86)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C299(0.93); C487(0.95)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C299(1.19); C487(0.99)  LDD0997  [5]
 LDCM0400  CL13 HEK-293T C487(0.99)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C487(0.86)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C487(0.86)  LDD1000  [5]
 LDCM0403  CL16 HCT 116 C487(0.60); C493(0.60)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C487(0.67); C493(0.67)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C487(0.72); C493(0.72)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C487(1.50); C493(1.50)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C487(1.03)  LDD1005  [5]
 LDCM0408  CL20 HCT 116 C487(0.48); C493(0.48)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C487(0.31); C493(0.31)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C487(0.23); C493(0.23)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C487(0.35); C493(0.35)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C487(0.26); C493(0.26)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C487(0.27); C493(0.27)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C487(0.48); C493(0.48)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C487(0.52); C493(0.52)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C487(0.50); C493(0.50)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C487(0.48); C493(0.48)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C487(1.00)  LDD1016  [5]
 LDCM0419  CL30 HCT 116 C487(0.71); C493(0.71)  LDD0736  [5]
 LDCM0420  CL31 HEK-293T C487(1.12)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C487(0.97)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C487(0.89)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C487(1.00)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C487(0.94)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C487(1.01)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C487(0.88)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C487(0.95)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C487(0.82)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C487(0.95)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C487(1.00)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C487(0.98)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C487(1.00)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C487(1.00)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C487(0.89)  LDD1033  [5]
 LDCM0436  CL46 HEK-293T C487(0.89)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C487(0.78)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C487(0.88)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C487(0.78)  LDD1037  [5]
 LDCM0440  CL5 HEK-293T C487(0.97)  LDD1038  [5]
 LDCM0441  CL50 HEK-293T C487(0.88)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C487(0.91)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C487(0.85)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C487(0.80)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C487(0.87)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C487(0.95)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C487(0.83)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C487(0.91)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C487(0.85)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C487(0.76)  LDD1048  [5]
 LDCM0451  CL6 HEK-293T C487(0.92)  LDD1049  [5]
 LDCM0452  CL60 HEK-293T C487(0.86)  LDD1050  [5]
 LDCM0453  CL61 HEK-293T C299(1.06); C15(1.12); C444(0.99)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C299(1.07); C15(1.04)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C15(1.02); C444(1.10)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C299(1.16); C15(1.04)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C299(0.95); C15(1.05)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C299(1.01); C15(1.18); C444(0.93); C493(1.16)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C299(1.03); C15(1.17); C444(1.00)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C299(1.22); C15(1.18)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C299(1.40); C15(1.08); C444(0.86)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C487(0.84)  LDD1060  [5]
 LDCM0463  CL70 HEK-293T C299(1.53); C15(1.25)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C299(1.80); C15(1.24); C444(0.96); C487(1.87)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C299(1.43); C15(1.28)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C299(1.17); C15(1.02); C444(1.11)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C299(1.00); C15(1.03)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C493(1.17)  LDD1067  [5]
 LDCM0470  CL77 HEK-293T C493(1.08)  LDD1068  [5]
 LDCM0471  CL78 HEK-293T C493(1.87)  LDD1069  [5]
 LDCM0472  CL79 HEK-293T C493(1.40)  LDD1070  [5]
 LDCM0473  CL8 HEK-293T C487(1.87)  LDD1071  [5]
 LDCM0474  CL80 HEK-293T C493(1.37)  LDD1072  [5]
 LDCM0475  CL81 HEK-293T C493(1.26)  LDD1073  [5]
 LDCM0476  CL82 HEK-293T C493(0.99)  LDD1074  [5]
 LDCM0477  CL83 HEK-293T C493(1.12)  LDD1075  [5]
 LDCM0478  CL84 HEK-293T C493(1.70)  LDD1076  [5]
 LDCM0479  CL85 HEK-293T C493(1.31)  LDD1077  [5]
 LDCM0480  CL86 HEK-293T C493(1.93)  LDD1078  [5]
 LDCM0481  CL87 HEK-293T C493(1.24)  LDD1079  [5]
 LDCM0482  CL88 HEK-293T C493(1.36)  LDD1080  [5]
 LDCM0483  CL89 HEK-293T C493(1.60)  LDD1081  [5]
 LDCM0484  CL9 HEK-293T C487(1.35)  LDD1082  [5]
 LDCM0485  CL90 HEK-293T C493(1.07)  LDD1083  [5]
 LDCM0486  CL91 HEK-293T C493(0.78)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C493(0.97)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C493(0.81)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C493(1.03)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C493(1.28)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C493(1.20)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C493(0.83)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C493(0.79)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C493(0.91)  LDD1092  [5]
 LDCM0495  E2913 HEK-293T C15(1.01); C444(1.23)  LDD1698  [10]
 LDCM0625  F8 Ramos C525(0.78)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C525(0.46)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C525(0.48)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C525(0.59)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C525(0.91)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C525(0.75)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C525(0.67)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C525(0.54)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C525(0.93)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C525(0.71)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C525(1.05)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C525(0.57)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C525(0.62)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C525(0.45)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C15(1.02); C444(0.87)  LDD1671  [10]
 LDCM0596  Fragment38 Ramos C525(0.69)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C525(1.22)  LDD2184  [11]
 LDCM0427  Fragment51 HEK-293T C487(1.01)  LDD1025  [5]
 LDCM0610  Fragment52 Ramos C525(0.85)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C525(0.62)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C525(1.01)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C525(0.70)  LDD2188  [11]
 LDCM0116  HHS-0101 DM93 Y628(0.83)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y628(0.84)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y628(0.85)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y628(0.77)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y628(1.31)  LDD0268  [4]
 LDCM0022  KB02 HEK-293T C15(0.98)  LDD1492  [10]
 LDCM0023  KB03 Jurkat C15(13.45)  LDD0209  [12]
 LDCM0024  KB05 COLO792 C525(1.15)  LDD3310  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) Chemokine-like factor family Q96DZ9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840