Details of the Target

General Information of Target

Target ID LDTP13892
Target Name Kelch-like protein 20 (KLHL20)
Gene Name KLHL20
Gene ID 27252
Synonyms
KLEIP; KLHLX; Kelch-like protein 20; Kelch-like ECT2-interacting protein; Kelch-like protein X
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDRDLNEDDSVVDLSFEAESPLAPPTELLERLPSYDWLLQGGRGQIFFPPLEAPGRPQEQ
RSWPSFLEHRVPAMTEEVAREALLSFVDSKCCYSSTVAGDLVIQELKRQTLCRYRLETFS
ESRISEWTFQPFTNHSVDGPQRGASPRLWDIKVQGPPMFQEDTRKFQVPHSSLVKECHKC
HGRGRYKCSGCHGAGTVRCPSCCGAKRKAKQSRRCQLCAGSGRRRCSTCSGRGNKTCATC
KGEKKLLHFIQLVIMWKNSLFEFVSEHRLNCPRELLAKAKGENLFKDENSVVYPIVDFPL
RDISLASQRGIAEHSAALASRARVLQQRQTIELIPLTEVHYWYQGKTYVYYIYGTDHQVY
AVDYPERYCCGCTIV
Target Bioclass
Other
Subcellular location
Cytoplasm, perinuclear region
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11. In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression.
Uniprot ID
Q9Y2M5
Ensemble ID
ENST00000209884.5
HGNC ID
HGNC:25056

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.S47A .
HCT15 SNV: p.V109A; p.V465I .
HS936T SNV: p.E431Ter .
JHH4 SNV: p.W345S DBIA    Probe Info 
JURKAT SNV: p.G269S .
LUDLU1 SNV: p.R300L .
MEWO SNV: p.P167S .
NCIH446 SNV: p.N196I .
SNU1 SNV: p.C283Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C182(1.09)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
VSF
 Probe Info  		N.A.  LDD0007  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C182(1.09)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C402(1.09); C25(0.97)  LDD1508  [6]
 LDCM0216  AC100 HCT 116 C182(0.66)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C182(0.61)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C182(0.52)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C182(0.57)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C182(0.57)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C182(0.51)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C182(0.46)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C182(0.60)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C182(0.64)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C182(0.54)  LDD0542  [1]
 LDCM0226  AC11 HEK-293T C182(1.01); C25(1.21)  LDD1509  [6]
 LDCM0227  AC110 HCT 116 C182(0.47)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C182(0.49)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C182(0.64)  LDD0546  [1]
 LDCM0230  AC113 HEK-293T C604(1.07)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C604(1.02)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C604(1.09)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C604(1.35)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C604(1.20)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C604(1.29)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C604(1.72)  LDD0834  [1]
 LDCM0237  AC12 HEK-293T C25(1.05)  LDD1510  [6]
 LDCM0238  AC120 HEK-293T C604(1.44)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C604(1.65)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C604(2.34)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C604(1.83)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C604(1.58)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C604(1.84)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C604(3.07)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C604(4.06)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C604(0.84)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C604(1.87)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C604(1.60)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C604(0.78)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C604(1.17)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C604(1.61)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C604(1.19)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C604(1.43)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C604(1.18)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C604(2.34)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C604(1.91)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C604(2.46)  LDD0856  [1]
 LDCM0259  AC14 HEK-293T C182(1.18); C25(1.03)  LDD1512  [6]
 LDCM0260  AC140 HEK-293T C604(1.70)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C604(1.79)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C604(1.43)  LDD0860  [1]
 LDCM0263  AC143 HCT 116 C182(1.09)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C182(0.90)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C182(0.94)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C182(0.94)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C182(0.88)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C182(0.98)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C182(0.93)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C182(1.07); C25(1.30)  LDD1513  [6]
 LDCM0271  AC150 HCT 116 C182(0.98)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C182(1.03)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C182(0.94)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C182(1.12)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C182(0.91)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C182(1.10)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C182(0.99)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C182(1.03)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C402(1.08)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C402(0.92); C25(1.03)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C182(1.10); C25(1.22)  LDD1517  [6]
 LDCM0279  AC2 HCT 116 C182(1.15)  LDD0596  [1]
 LDCM0280  AC20 HEK-293T C25(1.09)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C402(0.89); C25(0.98)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C182(1.14); C25(0.90)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C182(0.90); C25(1.48)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C25(1.02)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C604(1.33)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C604(1.25)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C604(1.32)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C604(1.40)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C604(1.46)  LDD0887  [1]
 LDCM0290  AC3 HCT 116 C182(1.02)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C604(1.30)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C604(1.37)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C604(1.48)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C604(1.56)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C604(1.47)  LDD0893  [1]
 LDCM0296  AC35 HCT 116 C182(1.10)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C182(1.07)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C182(1.04)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C182(1.19)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C182(1.05)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C182(0.98)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C182(1.13)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C182(1.19)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C182(1.11)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C182(1.04)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C182(1.21)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C182(1.15)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C182(0.97); C327(1.14)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C182(0.92); C327(0.96)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C327(0.97); C182(1.21)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C182(1.04); C327(1.50)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C182(0.94)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C182(0.88); C327(1.28)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C327(0.97); C182(1.07)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C182(1.15); C327(1.22)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C327(0.95); C182(1.02)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C182(0.90); C327(1.16)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C182(1.22); C327(1.33)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C182(1.29); C327(1.40)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C604(1.00)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C604(0.88)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C604(1.03)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C182(1.22); C25(1.38)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C604(0.98)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C604(1.40)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C604(1.04)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C604(1.24)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C604(1.01)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C604(1.28)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C604(0.97)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C604(1.15)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C604(1.01)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C604(1.04)  LDD0931  [1]
 LDCM0334  AC7 HEK-293T C182(1.02); C25(1.61)  LDD1568  [6]
 LDCM0335  AC70 HEK-293T C604(1.25)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C604(1.11)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C604(1.13)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C604(1.34)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C604(1.14)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C604(1.19)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C604(0.95)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C604(1.15)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C604(1.43)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C604(1.14)  LDD0942  [1]
 LDCM0345  AC8 HEK-293T C25(1.12)  LDD1569  [6]
 LDCM0346  AC80 HEK-293T C604(1.30)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C604(1.27)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C604(1.87)  LDD0946  [1]
 LDCM0349  AC83 HCT 116 C327(2.60)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C327(1.37)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C327(1.18)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C327(1.38)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C327(1.52)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C327(1.82)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C327(1.80)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C327(1.20)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C327(3.38)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C327(2.35)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C327(0.92)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C327(0.98)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C327(1.90)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C327(1.66)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C327(1.40)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C182(0.50)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C182(0.63)  LDD0683  [1]
 LDCM0248  AKOS034007472 HEK-293T C402(1.11); C25(0.87)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C402(1.04)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C25(1.02)  LDD1514  [6]
 LDCM0020  ARS-1620 HCC44 C316(1.02); C327(1.02)  LDD2171  [1]
 LDCM0367  CL1 HEK-293T C182(0.90); C402(0.95)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C182(1.17); C25(0.74)  LDD1572  [6]
 LDCM0369  CL100 HCT 116 C182(1.17)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C182(0.96); C402(1.36)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C25(1.05)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C402(1.03); C25(1.23)  LDD1576  [6]
 LDCM0374  CL105 HEK-293T C182(0.94); C402(0.87)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C25(0.88)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C402(0.71); C25(1.11)  LDD1580  [6]
 LDCM0378  CL109 HEK-293T C182(0.94); C402(1.49)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C182(1.23); C25(0.99)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C25(1.03)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C402(0.96); C25(2.46)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C604(1.52)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C604(1.48)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C604(2.08)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C604(1.86)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C604(1.76)  LDD0984  [1]
 LDCM0387  CL117 HCT 116 C182(1.26)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C182(1.04)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C182(1.11)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C25(1.17)  LDD1594  [6]
 LDCM0391  CL120 HCT 116 C182(1.16)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C182(0.87); C327(1.11)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C182(1.01); C327(1.57)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C182(1.10); C327(1.29)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C327(1.04); C182(1.40)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C604(1.07)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C604(0.94)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C604(0.92)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C604(0.86)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C182(1.03); C402(1.42)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C25(0.87)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C402(0.93); C25(1.49)  LDD1606  [6]
 LDCM0403  CL16 HCT 116 C182(1.02); C327(1.05)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C182(0.79); C327(1.09)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C182(1.10); C327(1.29)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C182(0.94); C327(1.21)  LDD0723  [1]
 LDCM0407  CL2 HEK-293T C25(1.07)  LDD1611  [6]
 LDCM0408  CL20 HCT 116 C182(0.96); C327(1.42)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C182(0.91); C327(1.70)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C182(0.97); C327(1.80)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C182(0.85); C327(1.28)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C182(1.00); C327(1.76)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C182(0.99); C327(2.25)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C182(0.94); C327(1.07)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C182(0.98); C327(1.56)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C182(1.01); C327(1.30)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C182(1.00); C327(1.50)  LDD0734  [1]
 LDCM0418  CL3 HEK-293T C402(0.95); C25(1.15)  LDD1622  [6]
 LDCM0419  CL30 HCT 116 C182(0.91); C327(1.27)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C182(0.92)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C182(0.74)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C182(0.80)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C182(0.70)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C182(0.73)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C182(0.79)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C182(0.79)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C182(1.06)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C182(0.96)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C182(0.79)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C182(0.75)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C182(0.95)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C182(0.88)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C182(0.75)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C182(1.28); C25(0.74)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C182(1.20); C25(0.92)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C25(1.13)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C182(1.06); C402(0.95)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C402(1.04)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C25(1.01)  LDD1645  [6]
 LDCM0444  CL53 HEK-293T C402(0.79)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C402(0.97); C25(0.70)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C182(1.04); C25(0.91)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C25(1.11)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C402(0.88); C25(0.74)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C182(1.18); C25(0.80)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C182(1.14); C25(1.25)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C402(0.96); C25(0.76)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C25(1.10)  LDD1655  [6]
 LDCM0453  CL61 HCT 116 C327(1.17)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C327(1.04)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C327(1.44)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C327(1.81)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C327(0.93)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C327(2.02)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C327(1.03)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C327(1.56)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C327(1.29)  LDD0778  [1]
 LDCM0462  CL7 HEK-293T C182(1.01); C25(0.91)  LDD1665  [6]
 LDCM0463  CL70 HCT 116 C327(1.08)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C327(1.27)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C327(1.20)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C327(1.34)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C327(1.09)  LDD0784  [1]
 LDCM0470  CL77 HEK-293T C402(0.86)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C402(0.88); C25(1.14)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C182(0.95); C25(0.99)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C25(1.02)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C25(1.20)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C402(0.75); C25(0.85)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C182(1.28); C25(0.81)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C182(1.07); C25(0.99)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C25(1.08)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C182(0.96); C402(1.52)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C25(1.28)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C402(0.83); C25(1.12)  LDD1684  [6]
 LDCM0483  CL89 HEK-293T C402(1.23)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C402(0.81); C25(0.74)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C402(1.20); C25(0.79)  LDD1688  [6]
 LDCM0486  CL91 HCT 116 C182(1.18)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C182(1.02)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C182(1.01)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C182(1.02)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C182(0.98)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C182(1.09)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C182(1.12)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C182(1.06)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C182(1.11)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C402(0.71); C25(1.74)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C327(1.13)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C182(0.90)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C402(1.05); C182(1.09)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C402(0.99); C182(0.97)  LDD1497  [6]
 LDCM0024  KB05 SNU-1196 C402(1.36)  LDD3439  [7]
 LDCM0021  THZ1 HCT 116 C316(1.02); C327(1.02)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 6 (PRMT6) Protein arginine N-methyltransferase family Q96LA8
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Dopamine beta-hydroxylase (DBH) Copper type II ascorbate-dependent monooxygenase family P09172
Cullin-3 (CUL3) Cullin family Q13618
Nitric oxide synthase 3 (NOS3) NOS family P29474
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Serine protease HTRA2, mitochondrial (HTRA2) Peptidase S1C family O43464
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH) PhyH family O14832
Death-associated protein kinase 1 (DAPK1) CAMK Ser/Thr protein kinase family P53355
Serine/threonine-protein kinase PAK 1 (PAK1) STE Ser/Thr protein kinase family Q13153
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Coagulation factor XIII A chain (F13A1) Transglutaminase family P00488
Transthyretin (TTR) Transthyretin family P02766
Ataxin-3 (ATXN3) . P54252
Protein PML (PML) . P29590
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
Huntingtin (HTT) Huntingtin family P42858
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Alpha-synuclein (SNCA) Synuclein family P37840
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Progranulin (GRN) Granulin family P28799
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Gelsolin (GSN) Villin/gelsolin family P06396
Methyl-CpG-binding protein 2 (MECP2) . P51608
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840