Details of the Target

General Information of Target

Target ID LDTP13864
Target Name Protein strawberry notch homolog 2 (SBNO2)
Gene Name SBNO2
Gene ID 22904
Synonyms
KIAA0963; Protein strawberry notch homolog 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVRKLSISWQFLIVLVLILQILSALDFDPYRVLGVSRTASQADIKKAYKKLAREWHPDK
NKDPGAEDKFIQISKAYEILSNEEKRSNYDQYGDAGENQGYQKQQQQREYRFRHFHENFY
FDESFFHFPFNSERRDSIDEKYLLHFSHYVNEVVPDSFKKPYLIKITSDWCFSCIHIEPV
WKEVIQELEELGVGIGVVHAGYERRLAHHLGAHSTPSILGIINGKISFFHNAVVRENLRQ
FVESLLPGNLVEKVTNKNYVRFLSGWQQENKPHVLLFDQTPIVPLLYKLTAFAYKDYLSF
GYVYVGLRGTEEMTRRYNINIYAPTLLVFKEHINRPADVIQARGMKKQIIDDFITRNKYL
LAARLTSQKLFHELCPVKRSHRQRKYCVVLLTAETTKLSKPFEAFLSFALANTQDTVRFV
HVYSNRQQEFADTLLPDSEAFQGKSAVSILERRNTAGRVVYKTLEDPWIGSESDKFILLG
YLDQLRKDPALLSSEAVLPDLTDELAPVFLLRWFYSASDYISDCWDSIFHNNWREMMPLL
SLIFSALFILFGTVIVQAFSDSNDERESSPPEKEEAQEKTGKTEPSFTKENSSKIPKKGF
VEVTELTDVTYTSNLVRLRPGHMNVVLILSNSTKTSLLQKFALEVYTFTGSSCLHFSFLS
LDKHREWLEYLLEFAQDAAPIPNQYDKHFMERDYTGYVLALNGHKKYFCLFKPQKTVEEE
EAIGSCSDVDSSLYLGESRGKPSCGLGSRPIKGKLSKLSLWMERLLEGSLQRFYIPSWPE
LD
Target Bioclass
Other
Family
SBNO family
Function
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation. Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the pro-inflammatory cascade.
Uniprot ID
Q9Y2G9
Ensemble ID
ENST00000361757.8
HGNC ID
HGNC:29158

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P Deletion: p.G1334RfsTer16 DBIA    Probe Info 
CHL1 SNV: p.V553M .
CORL23 SNV: p.G1340E .
HCT15 SNV: p.R1000W; p.R1162W .
JURKAT SNV: p.A62P; p.P217S; p.H703Y .
KMCH1 SNV: p.S988Ter DBIA    Probe Info 
KO52 SNV: p.R843W .
KYM1 SNV: p.G791S .
LNCaP clone FGC SNV: p.D469Y .
LU65 SNV: p.W533Ter .
MCC13 SNV: p.M59L .
MDAMB231 SNV: p.E558Q .
MFE319 SNV: p.T73I .
NCIH23 SNV: p.G299C .
SNGM SNV: p.G1075S .
TE10 SNV: p.L35M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C501(20.00)  LDD2227  [1]
IA-alkyne
 Probe Info  		C501(8.94)  LDD1704  [2]
DBIA
 Probe Info  		C501(1.51)  LDD0531  [3]
CY4
 Probe Info  		N.A.  LDD0247  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C501(1.51)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C501(1.20)  LDD0532  [3]
 LDCM0216  AC100 PaTu 8988t C501(1.21)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C501(1.05)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C501(0.96)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C501(1.16)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C501(0.92)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C501(0.91)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C501(0.85)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C501(0.89)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C501(1.32)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C501(1.09)  LDD1104  [3]
 LDCM0226  AC11 HCT 116 C501(1.27)  LDD0543  [3]
 LDCM0227  AC110 PaTu 8988t C501(1.22)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C501(1.41)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C501(1.38)  LDD1108  [3]
 LDCM0230  AC113 PaTu 8988t C501(1.04)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C501(0.94)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C501(1.09)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C501(1.11)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C501(1.22)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C501(1.08)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C501(1.05)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C501(0.88)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C501(0.89)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C501(1.04)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C501(0.97)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C501(1.01)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C501(1.06)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C501(1.15)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C501(0.99)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C501(1.02)  LDD1124  [3]
 LDCM0246  AC128 PaTu 8988t C501(1.45)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C501(1.43)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C501(1.26)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C501(1.25)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C501(1.19)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C501(1.05)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C501(1.34)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C501(1.38)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C501(1.50)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C501(1.32)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C501(1.64)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C501(1.33)  LDD1137  [3]
 LDCM0259  AC14 HCT 116 C501(0.91)  LDD0576  [3]
 LDCM0260  AC140 PaTu 8988t C501(1.20)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C501(1.35)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C501(1.57)  LDD1141  [3]
 LDCM0263  AC143 PaTu 8988t C501(1.07)  LDD1142  [3]
 LDCM0264  AC144 PaTu 8988t C501(1.04)  LDD1143  [3]
 LDCM0265  AC145 PaTu 8988t C501(1.21)  LDD1144  [3]
 LDCM0266  AC146 PaTu 8988t C501(1.10)  LDD1145  [3]
 LDCM0267  AC147 PaTu 8988t C501(1.03)  LDD1146  [3]
 LDCM0268  AC148 PaTu 8988t C501(1.19)  LDD1147  [3]
 LDCM0269  AC149 PaTu 8988t C501(0.95)  LDD1148  [3]
 LDCM0270  AC15 HCT 116 C501(1.28)  LDD0587  [3]
 LDCM0271  AC150 PaTu 8988t C501(1.14)  LDD1150  [3]
 LDCM0272  AC151 PaTu 8988t C501(1.09)  LDD1151  [3]
 LDCM0273  AC152 PaTu 8988t C501(1.03)  LDD1152  [3]
 LDCM0274  AC153 PaTu 8988t C501(1.16)  LDD1153  [3]
 LDCM0621  AC154 PaTu 8988t C501(1.01)  LDD2166  [3]
 LDCM0622  AC155 PaTu 8988t C501(1.12)  LDD2167  [3]
 LDCM0623  AC156 PaTu 8988t C501(1.09)  LDD2168  [3]
 LDCM0624  AC157 PaTu 8988t C501(0.90)  LDD2169  [3]
 LDCM0276  AC17 PaTu 8988t C501(1.04)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C501(1.15)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C501(1.01)  LDD1157  [3]
 LDCM0279  AC2 HCT 116 C501(1.44)  LDD0596  [3]
 LDCM0280  AC20 PaTu 8988t C501(1.15)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C501(1.03)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C501(1.18)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C501(1.41)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C501(1.13)  LDD1163  [3]
 LDCM0285  AC25 PaTu 8988t C501(0.92)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C501(1.01)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C501(0.90)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C501(0.67)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C501(0.84)  LDD1168  [3]
 LDCM0290  AC3 HCT 116 C501(1.50)  LDD0607  [3]
 LDCM0291  AC30 PaTu 8988t C501(0.84)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C501(0.83)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C501(0.64)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C501(0.58)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C501(1.13)  LDD1174  [3]
 LDCM0296  AC35 PaTu 8988t C501(1.06)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C501(1.30)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C501(1.41)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C501(1.45)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C501(1.72)  LDD1179  [3]
 LDCM0301  AC4 HCT 116 C501(1.65)  LDD0618  [3]
 LDCM0302  AC40 PaTu 8988t C501(1.62)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C501(1.43)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C501(1.77)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C501(1.35)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C501(1.96)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C501(1.83)  LDD1186  [3]
 LDCM0308  AC46 PaTu 8988t C501(0.94)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C501(0.79)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C501(1.06)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C501(1.08)  LDD1190  [3]
 LDCM0312  AC5 HCT 116 C501(1.70)  LDD0629  [3]
 LDCM0313  AC50 PaTu 8988t C501(1.13)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C501(0.41)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C501(1.13)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C501(0.96)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C501(1.14)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C501(1.59)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C501(1.21)  LDD1198  [3]
 LDCM0320  AC57 HCT 116 C501(1.15)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C501(1.18)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C501(1.29)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C501(1.52)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C501(0.95)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C501(1.06)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C501(1.26)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C501(1.09)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C501(1.03)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C501(1.16)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C501(1.01)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C501(1.09)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C501(0.63)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C501(0.58)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C501(1.49)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C501(0.98)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C501(0.75)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C501(0.74)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C501(0.96)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C501(0.89)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C501(0.94)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C501(0.66)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C501(0.79)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C501(0.86)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C501(0.79)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C501(1.13)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C501(0.65)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C501(0.77)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C501(0.80)  LDD0665  [3]
 LDCM0349  AC83 PaTu 8988t C501(1.07)  LDD1228  [3]
 LDCM0350  AC84 PaTu 8988t C501(0.84)  LDD1229  [3]
 LDCM0351  AC85 PaTu 8988t C501(1.10)  LDD1230  [3]
 LDCM0352  AC86 PaTu 8988t C501(0.96)  LDD1231  [3]
 LDCM0353  AC87 PaTu 8988t C501(1.07)  LDD1232  [3]
 LDCM0354  AC88 PaTu 8988t C501(0.88)  LDD1233  [3]
 LDCM0355  AC89 PaTu 8988t C501(0.99)  LDD1234  [3]
 LDCM0357  AC90 PaTu 8988t C501(1.01)  LDD1236  [3]
 LDCM0358  AC91 PaTu 8988t C501(0.97)  LDD1237  [3]
 LDCM0359  AC92 PaTu 8988t C501(1.05)  LDD1238  [3]
 LDCM0360  AC93 PaTu 8988t C501(0.86)  LDD1239  [3]
 LDCM0361  AC94 PaTu 8988t C501(0.89)  LDD1240  [3]
 LDCM0362  AC95 PaTu 8988t C501(1.01)  LDD1241  [3]
 LDCM0363  AC96 PaTu 8988t C501(0.81)  LDD1242  [3]
 LDCM0364  AC97 PaTu 8988t C501(0.95)  LDD1243  [3]
 LDCM0365  AC98 PaTu 8988t C501(0.84)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C501(0.97)  LDD1245  [3]
 LDCM0248  AKOS034007472 HCT 116 C501(1.35)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C501(0.95)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C501(1.99)  LDD0592  [3]
 LDCM0632  CL-Sc Hep-G2 C501(20.00)  LDD2227  [1]
 LDCM0367  CL1 HCT 116 C501(1.44)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C501(2.73)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C501(1.83)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C501(1.23)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C501(0.83)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C501(1.71)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C501(1.14)  LDD0690  [3]
 LDCM0374  CL105 PaTu 8988t C501(1.14)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C501(1.00)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C501(0.89)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C501(1.19)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C501(1.26)  LDD1257  [3]
 LDCM0379  CL11 HCT 116 C501(1.60)  LDD0696  [3]
 LDCM0380  CL110 PaTu 8988t C501(1.15)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C501(1.26)  LDD1260  [3]
 LDCM0382  CL112 PaTu 8988t C501(1.11)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C501(0.80)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C501(1.06)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C501(0.94)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C501(0.77)  LDD1265  [3]
 LDCM0387  CL117 PaTu 8988t C501(1.76)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C501(1.68)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C501(1.52)  LDD1268  [3]
 LDCM0390  CL12 HCT 116 C501(1.52)  LDD0707  [3]
 LDCM0391  CL120 PaTu 8988t C501(1.29)  LDD1270  [3]
 LDCM0392  CL121 PaTu 8988t C501(1.15)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C501(1.10)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C501(0.99)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C501(1.24)  LDD1274  [3]
 LDCM0396  CL125 HCT 116 C501(1.31)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C501(1.61)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C501(1.27)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C501(1.00)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C501(1.31)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C501(1.48)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C501(1.81)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C501(0.99)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C501(1.42)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C501(1.25)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C501(1.12)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C501(0.91)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C501(1.04)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C501(1.76)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C501(2.03)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C501(1.22)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C501(1.68)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C501(1.49)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C501(1.03)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C501(1.06)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C501(1.52)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C501(1.20)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C501(0.97)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C501(1.01)  LDD0736  [3]
 LDCM0420  CL31 PaTu 8988t C501(1.28)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C501(1.37)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C501(3.04)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C501(1.41)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C501(1.34)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C501(2.09)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C501(1.17)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C501(1.57)  LDD1307  [3]
 LDCM0429  CL4 HCT 116 C501(1.02)  LDD0746  [3]
 LDCM0430  CL40 PaTu 8988t C501(1.28)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C501(1.60)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C501(1.48)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C501(1.30)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C501(1.51)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C501(2.18)  LDD1314  [3]
 LDCM0436  CL46 HCT 116 C501(0.99)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C501(0.97)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C501(0.92)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C501(1.06)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C501(0.98)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C501(0.83)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C501(0.99)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C501(1.00)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C501(1.04)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C501(0.98)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C501(0.94)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C501(1.12)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C501(1.06)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C501(0.97)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C501(1.23)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C501(1.72)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C501(1.26)  LDD0769  [3]
 LDCM0453  CL61 PaTu 8988t C501(1.11)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C501(0.79)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C501(1.12)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C501(1.22)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C501(0.90)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C501(1.03)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C501(0.92)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C501(0.97)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C501(1.01)  LDD1340  [3]
 LDCM0462  CL7 HCT 116 C501(1.14)  LDD0779  [3]
 LDCM0463  CL70 PaTu 8988t C501(1.20)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C501(0.94)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C501(0.65)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C501(1.23)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C501(1.05)  LDD1346  [3]
 LDCM0469  CL76 HCT 116 C501(1.06)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C501(1.86)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C501(1.31)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C501(1.54)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C501(2.33)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C501(1.22)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C501(1.31)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C501(1.90)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C501(1.91)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C501(2.32)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C501(1.42)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C501(1.33)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C501(1.79)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C501(1.66)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C501(1.87)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C501(1.24)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C501(1.98)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C501(1.67)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C501(1.67)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C501(1.43)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C501(2.11)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C501(1.87)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C501(1.46)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C501(1.97)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C501(1.63)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C501(1.69)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C908(1.17); C501(1.06)  LDD1698  [5]
 LDCM0468  Fragment33 PaTu 8988t C501(0.96)  LDD1347  [3]
 LDCM0427  Fragment51 PaTu 8988t C501(1.47)  LDD1306  [3]
 LDCM0022  KB02 T cell-activated C501(8.94)  LDD1704  [2]
 LDCM0023  KB03 769-P C908(2.56)  LDD2663  [6]
 LDCM0024  KB05 MKN-1 C908(2.62)  LDD3331  [6]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840