Details of the Target

General Information of Target

Target ID LDTP13722
Target Name Protein Smaug homolog 1 (SAMD4A)
Gene Name SAMD4A
Gene ID 23034
Synonyms
KIAA1053; SAMD4; SMAUG1; Protein Smaug homolog 1; Smaug 1; hSmaug1; Sterile alpha motif domain-containing protein 4A; SAM domain-containing protein 4A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGAGARAEEGGGGGEGAAQGAAAEPGAGPAREPARLCGYLQKLSGKGPLRGYRSRWFVF
DARRCYLYYFKSPQDALPLGHLDIADACFSYQGPDEAAEPGTEPPAHFQVHSAGAVTVLK
APNRQLMTYWLQELQQKRWEYCNSLDMVKWDSRTSPTPGDFPKGLVARDNTDLIYPHPNA
SAEKARNVLAVETVPGELVGEQAANQPAPGHPNSINFYSLKQWGNELKNSMSSFRPGRGH
NDSRRTVFYTNEEWELLDPTPKDLEESIVQEEKKKLTPEGNKGVTGSGFPFDFGRNPYKG
KRPLKDIIGSYKNRHSSGDPSSEGTSGSGSVSIRKPASEMQLQVQSQQEELEQLKKDLSS
QKELVRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQILGLTSQLERFSLEKE
SLQQEVRTLKSKVGELNEQLGMLMETIQAKDEVIIKLSEGEGNGPPPTVAPSSPSVVPVA
RDQLELDRLKDNLQGYKTQNKFLNKEILELSALRRNAERRERDLMAKYSSLEAKLCQIES
KYLILLQEMKTPVCSEDQGPTREVIAQLLEDALQVESQEQPEQAFVKPHLVSEYDIYGFR
TVPEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLIR
AGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTLPN
NKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVE
VFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSV
VSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTRTILDARK
LISISFGDLNPFPLRQIRNRRAYHLEKVRLELTELEAIREDFLRERDTSPDKGELVSDEE
EDT
Target Bioclass
Other
Family
SMAUG family
Subcellular location
Cytoplasm
Function Acts as a translational repressor of SRE-containing messengers.
Uniprot ID
Q9UPU9
Ensemble ID
ENST00000251091.9
HGNC ID
HGNC:23023

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.E361Ter .
CCK81 Deletion: p.L488CfsTer31 .
COLO792 SNV: p.D452N .
HCT15 SNV: p.G709Ter .
HEC1 SNV: p.G709Ter .
HKGZCC SNV: p.E516G .
KELLY SNV: p.I131T .
LS180 Deletion: p.L488CfsTer31 .
MFE296 Deletion: p.L488CfsTer31 .
NCIH1944 SNV: p.G397A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K559(2.22)  LDD0277  [1]
AHL-Pu-1
 Probe Info  		C20(2.38)  LDD0171  [2]
DBIA
 Probe Info  		C20(56.05)  LDD0209  [3]
IA-alkyne
 Probe Info  		C20(0.97); C20(0.44)  LDD2207  [4]
NAIA_4
 Probe Info  		C199(0.00); C283(0.00)  LDD2226  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C20(2.38)  LDD0171  [2]
 LDCM0214  AC1 PaTu 8988t C44(1.29); C52(1.29)  LDD1093  [8]
 LDCM0215  AC10 HCT 116 C199(0.92)  LDD0532  [8]
 LDCM0216  AC100 PaTu 8988t C44(1.22); C52(1.22)  LDD1095  [8]
 LDCM0217  AC101 PaTu 8988t C44(1.52); C52(1.52)  LDD1096  [8]
 LDCM0218  AC102 PaTu 8988t C44(1.49); C52(1.49)  LDD1097  [8]
 LDCM0219  AC103 PaTu 8988t C44(1.10); C52(1.10)  LDD1098  [8]
 LDCM0220  AC104 PaTu 8988t C44(1.12); C52(1.12)  LDD1099  [8]
 LDCM0221  AC105 PaTu 8988t C44(1.31); C52(1.31)  LDD1100  [8]
 LDCM0222  AC106 PaTu 8988t C44(1.21); C52(1.21)  LDD1101  [8]
 LDCM0223  AC107 PaTu 8988t C44(1.43); C52(1.43)  LDD1102  [8]
 LDCM0224  AC108 PaTu 8988t C44(1.14); C52(1.14)  LDD1103  [8]
 LDCM0225  AC109 PaTu 8988t C44(1.40); C52(1.40)  LDD1104  [8]
 LDCM0226  AC11 HCT 116 C199(1.17)  LDD0543  [8]
 LDCM0227  AC110 PaTu 8988t C44(1.13); C52(1.13)  LDD1106  [8]
 LDCM0228  AC111 PaTu 8988t C44(0.96); C52(0.96)  LDD1107  [8]
 LDCM0229  AC112 PaTu 8988t C44(1.19); C52(1.19)  LDD1108  [8]
 LDCM0230  AC113 PaTu 8988t C44(0.85); C450(1.05); C52(0.85)  LDD1109  [8]
 LDCM0231  AC114 PaTu 8988t C44(1.08); C450(1.15); C52(1.08)  LDD1110  [8]
 LDCM0232  AC115 PaTu 8988t C44(1.29); C450(1.42); C52(1.29)  LDD1111  [8]
 LDCM0233  AC116 PaTu 8988t C44(1.10); C450(1.06); C52(1.10)  LDD1112  [8]
 LDCM0234  AC117 PaTu 8988t C44(1.09); C450(1.10); C52(1.09)  LDD1113  [8]
 LDCM0235  AC118 PaTu 8988t C44(1.03); C450(0.99); C52(1.03)  LDD1114  [8]
 LDCM0236  AC119 PaTu 8988t C44(0.86); C450(1.20); C52(0.86)  LDD1115  [8]
 LDCM0237  AC12 HCT 116 C199(0.97)  LDD0554  [8]
 LDCM0238  AC120 PaTu 8988t C44(1.19); C450(0.98); C52(1.19)  LDD1117  [8]
 LDCM0239  AC121 PaTu 8988t C44(1.10); C450(0.93); C52(1.10)  LDD1118  [8]
 LDCM0240  AC122 PaTu 8988t C44(1.13); C450(0.86); C52(1.13)  LDD1119  [8]
 LDCM0241  AC123 PaTu 8988t C44(1.03); C450(0.84); C52(1.03)  LDD1120  [8]
 LDCM0242  AC124 PaTu 8988t C44(1.38); C450(0.87); C52(1.38)  LDD1121  [8]
 LDCM0243  AC125 PaTu 8988t C44(0.82); C450(1.06); C52(0.82)  LDD1122  [8]
 LDCM0244  AC126 PaTu 8988t C44(0.91); C450(1.07); C52(0.91)  LDD1123  [8]
 LDCM0245  AC127 PaTu 8988t C44(0.96); C450(1.02); C52(0.96)  LDD1124  [8]
 LDCM0259  AC14 HCT 116 C199(1.06)  LDD0576  [8]
 LDCM0263  AC143 PaTu 8988t C20(1.03); C450(0.98)  LDD1142  [8]
 LDCM0264  AC144 PaTu 8988t C20(1.18); C450(1.45)  LDD1143  [8]
 LDCM0265  AC145 PaTu 8988t C20(0.90); C450(1.38)  LDD1144  [8]
 LDCM0266  AC146 PaTu 8988t C20(3.00); C450(1.18)  LDD1145  [8]
 LDCM0267  AC147 PaTu 8988t C20(1.49); C450(1.38)  LDD1146  [8]
 LDCM0268  AC148 PaTu 8988t C20(1.37); C450(1.42)  LDD1147  [8]
 LDCM0269  AC149 PaTu 8988t C20(1.02); C450(1.47)  LDD1148  [8]
 LDCM0270  AC15 HCT 116 C199(0.90)  LDD0587  [8]
 LDCM0271  AC150 PaTu 8988t C20(0.96); C450(1.22)  LDD1150  [8]
 LDCM0272  AC151 PaTu 8988t C20(1.22); C450(1.73)  LDD1151  [8]
 LDCM0273  AC152 PaTu 8988t C20(1.51); C450(1.47)  LDD1152  [8]
 LDCM0274  AC153 PaTu 8988t C20(1.05); C450(1.43)  LDD1153  [8]
 LDCM0621  AC154 PaTu 8988t C20(1.49); C450(1.69)  LDD2166  [8]
 LDCM0622  AC155 PaTu 8988t C20(1.24); C450(1.67)  LDD2167  [8]
 LDCM0623  AC156 PaTu 8988t C20(0.95); C450(1.92)  LDD2168  [8]
 LDCM0624  AC157 PaTu 8988t C20(1.15); C450(1.70)  LDD2169  [8]
 LDCM0276  AC17 HEK-293T C20(0.86)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C20(0.86)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C20(0.72); C700(0.89)  LDD1517  [9]
 LDCM0279  AC2 PaTu 8988t C44(1.24); C52(1.24)  LDD1158  [8]
 LDCM0280  AC20 HEK-293T C20(0.94)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C20(1.03)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C20(1.03)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C20(0.89)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C20(1.16)  LDD1523  [9]
 LDCM0285  AC25 PaTu 8988t C20(0.80); C44(1.02); C52(1.02)  LDD1164  [8]
 LDCM0286  AC26 PaTu 8988t C20(0.81); C44(1.18); C52(1.18)  LDD1165  [8]
 LDCM0287  AC27 PaTu 8988t C20(0.95); C44(1.21); C52(1.21)  LDD1166  [8]
 LDCM0288  AC28 PaTu 8988t C20(1.18); C44(0.90); C52(0.90)  LDD1167  [8]
 LDCM0289  AC29 PaTu 8988t C20(0.68); C44(1.19); C52(1.19)  LDD1168  [8]
 LDCM0290  AC3 PaTu 8988t C44(1.11); C52(1.11)  LDD1169  [8]
 LDCM0291  AC30 PaTu 8988t C20(0.80); C44(1.11); C52(1.11)  LDD1170  [8]
 LDCM0292  AC31 PaTu 8988t C20(0.74); C44(1.18); C52(1.18)  LDD1171  [8]
 LDCM0293  AC32 PaTu 8988t C20(0.81); C44(1.00); C52(1.00)  LDD1172  [8]
 LDCM0294  AC33 PaTu 8988t C20(1.22); C44(1.06); C52(1.06)  LDD1173  [8]
 LDCM0295  AC34 PaTu 8988t C20(1.01); C44(1.14); C52(1.14)  LDD1174  [8]
 LDCM0296  AC35 HCT 116 C199(1.16)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C199(1.15)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C199(1.17)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C199(1.01)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C199(0.92)  LDD0617  [8]
 LDCM0301  AC4 PaTu 8988t C44(1.09); C52(1.09)  LDD1180  [8]
 LDCM0302  AC40 HCT 116 C199(1.30)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C199(1.13)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C199(1.23)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C199(0.98)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C199(1.10)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C199(1.30)  LDD0624  [8]
 LDCM0308  AC46 PaTu 8988t C20(1.30)  LDD1187  [8]
 LDCM0309  AC47 PaTu 8988t C20(1.21)  LDD1188  [8]
 LDCM0310  AC48 PaTu 8988t C20(1.69)  LDD1189  [8]
 LDCM0311  AC49 PaTu 8988t C20(2.06)  LDD1190  [8]
 LDCM0312  AC5 PaTu 8988t C44(1.33); C52(1.33)  LDD1191  [8]
 LDCM0313  AC50 PaTu 8988t C20(1.81)  LDD1192  [8]
 LDCM0314  AC51 PaTu 8988t C20(1.44)  LDD1193  [8]
 LDCM0315  AC52 PaTu 8988t C20(2.00)  LDD1194  [8]
 LDCM0316  AC53 PaTu 8988t C20(1.74)  LDD1195  [8]
 LDCM0317  AC54 PaTu 8988t C20(2.27)  LDD1196  [8]
 LDCM0318  AC55 PaTu 8988t C20(1.10)  LDD1197  [8]
 LDCM0319  AC56 PaTu 8988t C20(4.10)  LDD1198  [8]
 LDCM0320  AC57 PaTu 8988t C20(1.21)  LDD1199  [8]
 LDCM0321  AC58 PaTu 8988t C20(1.06)  LDD1200  [8]
 LDCM0322  AC59 PaTu 8988t C20(1.18)  LDD1201  [8]
 LDCM0323  AC6 HCT 116 C199(1.10)  LDD0640  [8]
 LDCM0324  AC60 PaTu 8988t C20(1.26)  LDD1203  [8]
 LDCM0325  AC61 PaTu 8988t C20(0.69)  LDD1204  [8]
 LDCM0326  AC62 PaTu 8988t C20(0.82)  LDD1205  [8]
 LDCM0327  AC63 PaTu 8988t C20(0.82)  LDD1206  [8]
 LDCM0328  AC64 PaTu 8988t C20(0.77)  LDD1207  [8]
 LDCM0329  AC65 PaTu 8988t C20(0.76)  LDD1208  [8]
 LDCM0330  AC66 PaTu 8988t C20(0.72)  LDD1209  [8]
 LDCM0331  AC67 PaTu 8988t C20(0.67)  LDD1210  [8]
 LDCM0334  AC7 HCT 116 C199(0.99)  LDD0651  [8]
 LDCM0345  AC8 HCT 116 C199(1.07)  LDD0662  [8]
 LDCM0365  AC98 PaTu 8988t C44(1.23); C52(1.23)  LDD1244  [8]
 LDCM0366  AC99 PaTu 8988t C44(1.13); C52(1.13)  LDD1245  [8]
 LDCM0248  AKOS034007472 HCT 116 C199(1.06)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C199(1.13)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C199(0.99)  LDD0592  [8]
 LDCM0367  CL1 PaTu 8988t C450(1.04)  LDD1246  [8]
 LDCM0368  CL10 PaTu 8988t C450(1.36)  LDD1247  [8]
 LDCM0369  CL100 PaTu 8988t C44(1.21); C52(1.21)  LDD1248  [8]
 LDCM0370  CL101 HCT 116 C199(1.15)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C199(1.08)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C199(1.08)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C199(1.14)  LDD0690  [8]
 LDCM0374  CL105 HEK-293T C20(1.16)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C20(1.23)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C20(0.96)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C20(1.23)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C20(1.38)  LDD1582  [9]
 LDCM0379  CL11 PaTu 8988t C450(1.13)  LDD1258  [8]
 LDCM0380  CL110 HEK-293T C20(1.67)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C20(1.87)  LDD1585  [9]
 LDCM0382  CL112 PaTu 8988t C20(0.84); C44(0.89); C52(0.89)  LDD1261  [8]
 LDCM0383  CL113 PaTu 8988t C20(0.80); C44(1.07); C52(1.07)  LDD1262  [8]
 LDCM0384  CL114 PaTu 8988t C20(1.29); C44(0.97); C52(0.97)  LDD1263  [8]
 LDCM0385  CL115 PaTu 8988t C20(1.29); C44(0.87); C52(0.87)  LDD1264  [8]
 LDCM0386  CL116 PaTu 8988t C20(1.11); C44(1.00); C52(1.00)  LDD1265  [8]
 LDCM0387  CL117 HCT 116 C199(1.00)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C199(1.00)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C199(1.10)  LDD0706  [8]
 LDCM0390  CL12 PaTu 8988t C450(1.10)  LDD1269  [8]
 LDCM0391  CL120 HCT 116 C199(1.07)  LDD0708  [8]
 LDCM0392  CL121 PaTu 8988t C20(1.28)  LDD1271  [8]
 LDCM0393  CL122 PaTu 8988t C20(10.20)  LDD1272  [8]
 LDCM0394  CL123 PaTu 8988t C20(1.84)  LDD1273  [8]
 LDCM0395  CL124 PaTu 8988t C20(1.35)  LDD1274  [8]
 LDCM0396  CL125 PaTu 8988t C20(1.16)  LDD1275  [8]
 LDCM0397  CL126 PaTu 8988t C20(1.21)  LDD1276  [8]
 LDCM0398  CL127 PaTu 8988t C20(1.40)  LDD1277  [8]
 LDCM0399  CL128 PaTu 8988t C20(1.99)  LDD1278  [8]
 LDCM0400  CL13 PaTu 8988t C450(1.59)  LDD1279  [8]
 LDCM0401  CL14 PaTu 8988t C450(1.63)  LDD1280  [8]
 LDCM0402  CL15 PaTu 8988t C450(1.29)  LDD1281  [8]
 LDCM0403  CL16 HCT 116 C199(1.04)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C199(0.72)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C199(1.04)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C199(0.98)  LDD0723  [8]
 LDCM0407  CL2 PaTu 8988t C450(1.11)  LDD1286  [8]
 LDCM0408  CL20 HCT 116 C199(0.94)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C199(1.07)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C199(1.15)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C199(1.05)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C199(0.99)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C199(1.16)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C199(0.96)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C199(1.10)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C199(1.09)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C199(1.08)  LDD0734  [8]
 LDCM0418  CL3 PaTu 8988t C450(1.27)  LDD1297  [8]
 LDCM0419  CL30 HCT 116 C199(0.99)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C199(1.25)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C199(1.31)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C199(1.38)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C199(1.14)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C199(1.34)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C199(1.45)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C199(1.37)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C199(1.16)  LDD0745  [8]
 LDCM0429  CL4 PaTu 8988t C450(1.17)  LDD1308  [8]
 LDCM0430  CL40 HCT 116 C199(1.38)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C199(1.08)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C199(1.26)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C199(1.18)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C199(1.36)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C199(1.32)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C199(0.92)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C199(0.93)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C199(1.18)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C199(1.02)  LDD0756  [8]
 LDCM0440  CL5 PaTu 8988t C450(1.70)  LDD1319  [8]
 LDCM0441  CL50 HCT 116 C199(1.14)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C199(0.94)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C199(1.19)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C199(1.19)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C199(0.97)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C199(1.05)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C199(1.04)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C199(0.98)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C199(1.04)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C199(1.02)  LDD0767  [8]
 LDCM0451  CL6 PaTu 8988t C450(1.27)  LDD1330  [8]
 LDCM0452  CL60 HCT 116 C199(1.08)  LDD0769  [8]
 LDCM0453  CL61 PaTu 8988t C20(0.81); C44(1.14); C450(0.98); C52(1.14)  LDD1332  [8]
 LDCM0454  CL62 PaTu 8988t C20(1.21); C44(0.88); C450(0.65); C52(0.88)  LDD1333  [8]
 LDCM0455  CL63 PaTu 8988t C20(0.86); C44(1.29); C450(0.78); C52(1.29)  LDD1334  [8]
 LDCM0456  CL64 PaTu 8988t C20(1.14); C44(1.08); C450(0.81); C52(1.08)  LDD1335  [8]
 LDCM0457  CL65 PaTu 8988t C20(0.97); C44(0.93); C450(0.80); C52(0.93)  LDD1336  [8]
 LDCM0458  CL66 PaTu 8988t C20(1.09); C44(1.42); C450(0.87); C52(1.42)  LDD1337  [8]
 LDCM0459  CL67 PaTu 8988t C20(1.04); C44(1.17); C450(1.21); C52(1.17)  LDD1338  [8]
 LDCM0460  CL68 PaTu 8988t C20(0.84); C44(1.09); C450(1.15); C52(1.09)  LDD1339  [8]
 LDCM0461  CL69 PaTu 8988t C20(1.08); C44(0.97); C450(1.16); C52(0.97)  LDD1340  [8]
 LDCM0462  CL7 PaTu 8988t C450(1.46)  LDD1341  [8]
 LDCM0463  CL70 PaTu 8988t C20(0.54); C44(1.49); C450(1.07); C52(1.49)  LDD1342  [8]
 LDCM0464  CL71 PaTu 8988t C20(0.98); C44(1.35); C450(0.80); C52(1.35)  LDD1343  [8]
 LDCM0465  CL72 PaTu 8988t C20(0.80); C44(0.96); C450(0.70); C52(0.96)  LDD1344  [8]
 LDCM0466  CL73 PaTu 8988t C20(0.99); C44(1.23); C450(1.20); C52(1.23)  LDD1345  [8]
 LDCM0467  CL74 PaTu 8988t C20(0.88); C44(1.00); C450(0.83); C52(1.00)  LDD1346  [8]
 LDCM0469  CL76 HEK-293T C20(1.07)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C20(1.73)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C20(0.98)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C20(0.99); C700(1.25)  LDD1675  [9]
 LDCM0473  CL8 PaTu 8988t C450(1.25)  LDD1352  [8]
 LDCM0474  CL80 HEK-293T C20(0.92)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C20(1.15)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C20(1.01)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C20(1.88)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C20(2.11)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C20(1.04)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C20(1.24)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C20(1.19)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C20(1.00)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C20(1.17)  LDD1686  [9]
 LDCM0484  CL9 PaTu 8988t C450(1.27)  LDD1363  [8]
 LDCM0485  CL90 HEK-293T C20(2.19)  LDD1688  [9]
 LDCM0486  CL91 PaTu 8988t C44(0.94); C52(0.94)  LDD1365  [8]
 LDCM0487  CL92 PaTu 8988t C44(1.25); C52(1.25)  LDD1366  [8]
 LDCM0488  CL93 PaTu 8988t C44(1.30); C52(1.30)  LDD1367  [8]
 LDCM0489  CL94 PaTu 8988t C44(1.11); C52(1.11)  LDD1368  [8]
 LDCM0490  CL95 PaTu 8988t C44(1.11); C52(1.11)  LDD1369  [8]
 LDCM0491  CL96 PaTu 8988t C44(0.95); C52(0.95)  LDD1370  [8]
 LDCM0492  CL97 PaTu 8988t C44(1.12); C52(1.12)  LDD1371  [8]
 LDCM0493  CL98 PaTu 8988t C44(1.21); C52(1.21)  LDD1372  [8]
 LDCM0494  CL99 PaTu 8988t C44(1.20); C52(1.20)  LDD1373  [8]
 LDCM0495  E2913 HEK-293T C20(0.95)  LDD1698  [9]
 LDCM0468  Fragment33 PaTu 8988t C20(1.30); C44(0.98); C450(0.84); C52(0.98)  LDD1347  [8]
 LDCM0427  Fragment51 HCT 116 C199(1.31)  LDD0744  [8]
 LDCM0022  KB02 HEK-293T C20(0.64)  LDD1492  [9]
 LDCM0023  KB03 Jurkat C20(56.05)  LDD0209  [3]
 LDCM0024  KB05 HEK-293T C20(0.91)  LDD1502  [9]
 LDCM0628  OTUB2-COV-1 HEK-293T C20(0.97); C20(0.44)  LDD2207  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
NUT family member 1 (NUTM1) NUT family Q86Y26
Ankyrin repeat family A protein 2 (ANKRA2) . Q9H9E1
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Heat shock factor 2-binding protein (HSF2BP) . O75031
TBC1 domain family member 21 (TBC1D21) . Q8IYX1

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402