Details of the Target

General Information of Target

Target ID LDTP13543
Target Name Zinc transporter ZIP10 (SLC39A10)
Gene Name SLC39A10
Gene ID 57181
Synonyms
KIAA1265; ZIP10; Zinc transporter ZIP10; Solute carrier family 39 member 10; Zrt- and Irt-like protein 10; ZIP-10
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPWLSGGRRRRRGQPREAPREPPPSAQPQREPPPAPPAAVPTPPAPSAPPPRARESAELP
LPAGWEEARDYDGRVFYIDHNTRQTSWIDPRDRITKPLTFADCVGDELPLGWETVYDKQI
GVYYMDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEE
YQQLHKMCEDDSRSYASSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQY
KEKGVETLQEIDRKMSSTHTSYKLDEAQAIMSELRTIKKAICTGEKERRDLMHSLAKLTD
SFKNSCSVTDSLVDFPHHVGVPGDAGVPQQFCDAGSQTDIIGEFVFDDKTRLVDRVRLNW
QYEEARKRVANIQQQLARLDNESWPSTAEADRDRLQLIKEKEALLQELQLIIAQRRSAGD
VARLEEERERLEEELRRARATSAQGATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSL
CASTLTVSSGSSRGSLASSRGSLASSRGSLSSVSFTDIYGLPQYEKPDAEGSQLLRFDLI
PFDSLGRDAPFSEPPGPSGFHKQRRSLDTPQSLASLSSRSSLSSLSPPSSPLDTPFLPAS
RDSPLAQLADSCEGPGLGALDRLRAHASAMGDEDLPGMAALQPHGVPGDGEGPHERGPPP
ASAPVGGTVTLREDSAKRLERRARRISACLSDYSLASDSGVFEPLTKRNEDAEEPAYGDT
ASNGDPQIHVGLLRDSGSECLLVHVLQLKNPAGLAVKEDCKVHIRVYLPPLDSGTPNTYC
SKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIAQINLADYDSLS
EMQLRWHSVQVFTSSEPSRTREAGCAGESSARDPAHTISISGKTDAVTVLLARTTAQLQA
VERELAEERAKLEYTEEEVLEMERKEEQAEAISERSWQADSVDSGCSNCTQTSPPYPEPC
CMGIDSILGHPFAAQAGPYSPEKFQPSPLKVDKETNTEDLFLEEAASLVKERPSRRARGS
PFVRSGTIVRSQTFSPGARSQYVCRLYRSDSDSSTLPRKSPFVRNTLERRTLRYKQSCRS
SLAELMARTSLDLELDLQASRTRQRQLNEELCALRELRQRLEDAQLRGQTDLPPWVLRDE
RLRGLLREAERQTRQTKLDYRHEQAAEKMLKKASKEIYQLRGQSHKEPIQVQTFREKIAF
FTRPRINIPPLPADDV
Target Bioclass
Transporter and channel
Family
ZIP transporter (TC 2.A.5) family
Subcellular location
Membrane
Function
Zinc-influx transporter. When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Plays an important for both mature B-cell maintenance and humoral immune responses. When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT.
Uniprot ID
Q9ULF5
Ensemble ID
ENST00000359634.10
HGNC ID
HGNC:20861

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.Y63H .
CALU6 SNV: p.V425L DBIA    Probe Info 
HEC1B SNV: p.T702I .
ICC3 SNV: p.L77V .
LNCaP clone FGC SNV: p.G699R DBIA    Probe Info 
MFE319 Deletion: p.K61NfsTer26
SNV: p.S144G;p.V635M		 .
RKO SNV: p.S413C DBIA    Probe Info 
SNU1 Deletion: p.K61NfsTer26 DBIA    Probe Info 
SW1116 SNV: p.E156G DBIA    Probe Info 
TGBC1TKB SNV: p.N389H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.60  LDD0318  [1]
ONAyne
 Probe Info  		K61(0.39)  LDD0274  [2]
OPA-S-S-alkyne
 Probe Info  		K66(0.90); K317(6.58)  LDD3494  [3]
BTD
 Probe Info  		C376(0.88)  LDD2091  [4]
Acrolein
 Probe Info  		N.A.  LDD0221  [5]
DBIA
 Probe Info  		C598(0.57)  LDD0531  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [7]
IPM
 Probe Info  		N.A.  LDD0025  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [5]
Methacrolein
 Probe Info  		C598(0.00); C376(0.00)  LDD0218  [5]
AOyne
 Probe Info  		12.10  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C376(1.12)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C376(1.38)  LDD2152  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C376(0.47)  LDD2131  [4]
 LDCM0214  AC1 HCT 116 C598(0.57)  LDD0531  [6]
 LDCM0215  AC10 HEK-293T C598(1.29)  LDD0813  [6]
 LDCM0226  AC11 HEK-293T C598(1.04)  LDD0824  [6]
 LDCM0237  AC12 HEK-293T C598(1.23)  LDD0835  [6]
 LDCM0259  AC14 HEK-293T C598(1.24)  LDD0857  [6]
 LDCM0270  AC15 HEK-293T C598(1.50)  LDD0868  [6]
 LDCM0276  AC17 PaTu 8988t C598(0.87)  LDD1155  [6]
 LDCM0277  AC18 PaTu 8988t C598(1.10)  LDD1156  [6]
 LDCM0278  AC19 PaTu 8988t C598(0.90)  LDD1157  [6]
 LDCM0279  AC2 HCT 116 C598(0.92)  LDD0596  [6]
 LDCM0280  AC20 PaTu 8988t C598(1.03)  LDD1159  [6]
 LDCM0281  AC21 PaTu 8988t C598(0.99)  LDD1160  [6]
 LDCM0282  AC22 PaTu 8988t C598(1.04)  LDD1161  [6]
 LDCM0283  AC23 PaTu 8988t C598(1.28)  LDD1162  [6]
 LDCM0284  AC24 PaTu 8988t C598(1.23)  LDD1163  [6]
 LDCM0285  AC25 PaTu 8988t C598(0.92)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C598(1.12)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C598(1.42)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C598(1.51)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C598(1.03)  LDD1168  [6]
 LDCM0290  AC3 HCT 116 C598(1.08)  LDD0607  [6]
 LDCM0291  AC30 PaTu 8988t C598(1.49)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C598(1.13)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C598(1.45)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C598(1.67)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C598(1.18)  LDD1174  [6]
 LDCM0296  AC35 HEK-293T C598(0.87); C364(0.88)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C598(0.91); C364(1.01); C376(0.98)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C364(1.13); C376(1.01)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C364(0.87)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C364(1.15); C376(1.04)  LDD1539  [11]
 LDCM0301  AC4 HCT 116 C598(0.89)  LDD0618  [6]
 LDCM0302  AC40 HEK-293T C598(0.97); C364(1.28); C376(1.04)  LDD1541  [11]
 LDCM0304  AC42 HEK-293T C598(1.06); C364(1.25); C376(1.07)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C598(0.95); C364(0.86)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C598(0.95); C364(1.08); C376(0.97)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C364(0.97); C376(1.01)  LDD1546  [11]
 LDCM0308  AC46 HCT 116 C598(1.36)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C598(1.06)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C598(1.05)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C598(1.17)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C598(1.06)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C598(1.03)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C598(0.94)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C598(1.05)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C598(0.98)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C598(0.93)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C598(1.29)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C598(1.00)  LDD0636  [6]
 LDCM0321  AC58 HEK-293T C598(0.97); C364(1.15); C376(1.01)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C598(0.98); C364(1.25)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C598(1.05)  LDD0921  [6]
 LDCM0324  AC60 HEK-293T C598(0.89); C364(1.00); C376(0.99)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C364(1.08); C376(0.99)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C364(1.26)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C364(1.10); C376(1.00)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C598(1.03); C364(0.90); C376(1.09)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C598(1.18)  LDD0932  [6]
 LDCM0345  AC8 HEK-293T C598(1.72)  LDD0943  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C376(0.83)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C598(1.41)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C598(1.51)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C598(1.29)  LDD0873  [6]
 LDCM0498  BS-3668 MDA-MB-231 C376(0.88)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0367  CL1 HEK-293T C598(1.12); C364(1.30)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C364(1.60)  LDD1572  [11]
 LDCM0369  CL100 HCT 116 C598(0.99)  LDD0686  [6]
 LDCM0370  CL101 HEK-293T C598(1.25)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C598(1.29)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C598(1.33)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C598(1.43)  LDD0971  [6]
 LDCM0374  CL105 PaTu 8988t C598(1.15)  LDD1253  [6]
 LDCM0375  CL106 PaTu 8988t C598(1.00)  LDD1254  [6]
 LDCM0376  CL107 PaTu 8988t C598(0.99)  LDD1255  [6]
 LDCM0377  CL108 PaTu 8988t C598(1.01)  LDD1256  [6]
 LDCM0378  CL109 PaTu 8988t C598(1.01)  LDD1257  [6]
 LDCM0379  CL11 HEK-293T C364(1.06); C376(1.02)  LDD1583  [11]
 LDCM0380  CL110 PaTu 8988t C598(1.22)  LDD1259  [6]
 LDCM0381  CL111 PaTu 8988t C598(1.28)  LDD1260  [6]
 LDCM0382  CL112 PaTu 8988t C598(1.21)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C598(1.11)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C598(1.09)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C598(1.05)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C598(1.15)  LDD1265  [6]
 LDCM0387  CL117 HEK-293T C598(1.04); C364(1.03)  LDD1591  [11]
 LDCM0389  CL119 HEK-293T C598(0.99); C364(1.07)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C598(1.08); C364(1.11); C376(1.29)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C364(0.99)  LDD1595  [11]
 LDCM0392  CL121 HCT 116 C598(1.08)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C598(0.80)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C598(0.78)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C598(1.06)  LDD0712  [6]
 LDCM0396  CL125 HEK-293T C598(1.01); C364(0.87)  LDD1600  [11]
 LDCM0398  CL127 HEK-293T C598(0.96); C364(1.09)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C364(1.08)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C598(1.07); C364(0.89)  LDD1604  [11]
 LDCM0402  CL15 HEK-293T C598(1.01); C364(0.85)  LDD1606  [11]
 LDCM0403  CL16 HCT 116 C598(1.06)  LDD0720  [6]
 LDCM0404  CL17 HEK-293T C598(1.20)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C598(1.32)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C598(1.00)  LDD1004  [6]
 LDCM0408  CL20 HEK-293T C598(1.02)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C598(1.50)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C598(1.14)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C598(0.89)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C598(1.33)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C598(1.70)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C598(0.92)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C598(1.47)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C598(0.86)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C598(1.05)  LDD1015  [6]
 LDCM0418  CL3 HEK-293T C598(0.95); C364(0.97)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C598(1.10)  LDD1017  [6]
 LDCM0420  CL31 HCT 116 C598(0.89)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C598(1.11)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C598(1.09)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C598(1.15)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C598(1.13)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C598(0.99)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C598(1.00)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C598(1.00)  LDD0745  [6]
 LDCM0429  CL4 HEK-293T C364(1.16)  LDD1633  [11]
 LDCM0430  CL40 HCT 116 C598(0.98)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C598(0.98)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C598(0.94)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C598(1.02)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C598(1.05)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C598(1.04)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C598(0.88)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C598(1.05)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C598(0.76)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C598(0.80)  LDD0756  [6]
 LDCM0441  CL50 HCT 116 C598(1.04)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C598(1.46)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C598(0.74)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C598(1.09)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C598(1.14)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C598(1.14)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C598(0.79)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C598(1.03)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C598(0.92)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C598(0.96)  LDD0767  [6]
 LDCM0451  CL6 HEK-293T C598(0.83); C364(1.30); C376(1.03)  LDD1654  [11]
 LDCM0452  CL60 HCT 116 C598(0.80)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C598(0.88)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C598(0.92)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C598(1.26)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C598(1.27)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C598(1.05)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C598(1.44)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C598(1.58)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C598(1.33)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C598(1.45)  LDD0778  [6]
 LDCM0462  CL7 HEK-293T C598(0.96); C364(0.98)  LDD1665  [11]
 LDCM0463  CL70 HCT 116 C598(1.04)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C598(0.99)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C598(0.94)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C598(1.29)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C598(1.56)  LDD0784  [6]
 LDCM0469  CL76 HEK-293T C598(0.98)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C598(0.99)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C598(0.98)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C598(1.07)  LDD1070  [6]
 LDCM0473  CL8 HEK-293T C598(0.78); C364(1.32); C376(1.36)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C598(0.98)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C598(0.93)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C598(1.16)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C598(1.01)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C598(0.93)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C598(0.97)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C598(0.96)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C598(1.12)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C598(1.03)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C598(1.02)  LDD1081  [6]
 LDCM0484  CL9 HEK-293T C364(1.23); C376(1.21)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C598(1.08)  LDD1083  [6]
 LDCM0486  CL91 HCT 116 C598(0.27)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C598(0.76)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C598(1.12)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C598(0.86)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C598(0.88)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C598(1.04)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C598(1.07)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C598(1.07)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C598(1.03)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C598(1.08); C364(0.88)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C376(5.69)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C598(1.54)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C598(0.96)  LDD0744  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 HEK-293T C598(0.92); C376(0.97); C364(0.84)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C598(1.13); C376(1.08); C364(0.97)  LDD1497  [11]
 LDCM0024  KB05 HMCB C598(1.54)  LDD3312  [12]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C376(1.11)  LDD2093  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C376(1.07)  LDD2097  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C376(1.46)  LDD2101  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C376(1.14)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C376(1.91)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C376(1.31)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C376(0.93)  LDD2115  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C376(0.76)  LDD2133  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C376(1.71)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C376(1.25)  LDD2136  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C376(1.39)  LDD2144  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C376(0.83)  LDD2148  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840