Details of the Target

General Information of Target

Target ID LDTP12985
Target Name SH3 domain-binding protein 4 (SH3BP4)
Gene Name SH3BP4
Gene ID 23677
Synonyms
BOG25; EHB10; TTP; SH3 domain-binding protein 4; EH-binding protein 10; Transferrin receptor-trafficking protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGDGSDPEPPDAGEDSKSENGENAPIYCICRKPDINCFMIGCDNCNEWFHGDCIRITEK
MAKAIREWYCRECREKDPKLEIRYRHKKSRERDGNERDSSEPRDEGGGRKRPVPDPDLQR
RAGSGTGVGAMLARGSASPHKSSPQPLVATPSQHHQQQQQQIKRSARMCGECEACRRTED
CGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARESYKYFPSSLSPVTPSESLPRPRRPLP
TQQQPQPSQKLGRIREDEGAVASSTVKEPPEATATPEPLSDEDLPLDPDLYQDFCAGAFD
DHGLPWMSDTEESPFLDPALRKRAVKVKHVKRREKKSEKKKEERYKRHRQKQKHKDKWKH
PERADAKDPASLPQCLGPGCVRPAQPSSKYCSDDCGMKLAANRIYEILPQRIQQWQQSPC
IAEEHGKKLLERIRREQQSARTRLQEMERRFHELEAIILRAKQQAVREDEESNEGDSDDT
DLQIFCVSCGHPINPRVALRHMERCYAKYESQTSFGSMYPTRIEGATRLFCDVYNPQSKT
YCKRLQVLCPEHSRDPKVPADEVCGCPLVRDVFELTGDFCRLPKRQCNRHYCWEKLRRAE
VDLERVRVWYKLDELFEQERNVRTAMTNRAGLLALMLHQTIQHDPLTTDLRSSADR
Target Bioclass
Other
Subcellular location
Membrane, clathrin-coated pit
Function
May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.
Uniprot ID
Q9P0V3
Ensemble ID
ENST00000344528.8
HGNC ID
HGNC:10826

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A799V DBIA    Probe Info 
BICR22 Deletion: p.L745_S757del DBIA    Probe Info 
COLO829 SNV: p.A890V DBIA    Probe Info 
DU145 SNV: p.Q311H .
HCT15 SNV: p.P15T DBIA    Probe Info 
HT SNV: p.T203P; p.R770C .
Ishikawa (Heraklio) 02 ER SNV: p.Y645C DBIA    Probe Info 
JURKAT SNV: p.N174D .
JVM3 SNV: p.A854D .
KASUMI2 SNV: p.E100K .
L428 SNV: p.A228T .
MFE319 SNV: p.P333L; p.P348S; p.S373T DBIA    Probe Info 
NCIH2291 SNV: p.G777C DBIA    Probe Info 
NCIH358 SNV: p.G480C DBIA    Probe Info 
PF382 SNV: p.D908G .
SHP77 SNV: p.D147E DBIA    Probe Info 
SNGM Deletion: p.S188VfsTer82 DBIA    Probe Info 
SNU869 SNV: p.V714M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K565(10.00); K663(10.00)  LDD0277  [1]
IPM
 Probe Info  		C67(0.00); C809(0.00)  LDD0241  [2]
OPA-S-S-alkyne
 Probe Info  		K679(3.02)  LDD3494  [3]
BTD
 Probe Info  		C809(0.45)  LDD2091  [4]
AHL-Pu-1
 Probe Info  		C605(2.16)  LDD0169  [5]
DBIA
 Probe Info  		C730(1.40); C748(1.40)  LDD0532  [6]
IA-alkyne
 Probe Info  		C809(0.00); C787(0.00)  LDD0162  [7]
NAIA_4
 Probe Info  		C605(0.00); C787(0.00)  LDD2226  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C809(1.08); C833(0.98)  LDD2117  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C605(2.16)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C787(1.11)  LDD1507  [12]
 LDCM0215  AC10 HCT 116 C730(1.40); C748(1.40)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C415(0.87)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C415(0.69)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C415(0.57)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C415(0.65)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C415(0.68)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C415(0.74)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C415(0.74)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C415(0.77)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C415(0.64)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C415(0.63)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C730(0.97); C748(0.97)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C415(0.69)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C415(0.63)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C415(0.76)  LDD0546  [6]
 LDCM0230  AC113 HEK-293T C415(0.70)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C415(0.83)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C415(1.04)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C415(0.90)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C415(0.64)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C415(0.86)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C415(0.94)  LDD0834  [6]
 LDCM0237  AC12 HCT 116 C730(1.00); C748(1.00)  LDD0554  [6]
 LDCM0238  AC120 HEK-293T C415(0.98)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C415(0.75)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C415(0.68)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C415(0.71)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C415(0.77)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C415(0.79)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C415(0.85)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C415(0.78)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C415(0.96); C748(0.66)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C415(1.36); C748(0.69)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C415(1.02); C748(0.69)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C415(0.91); C748(0.62)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C415(1.23); C748(0.91)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C415(1.04); C748(0.80)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C415(0.99); C748(1.14)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C415(0.93); C748(1.41)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C415(0.94); C748(0.69)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C415(1.19); C748(1.20)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C415(0.95); C748(0.71)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C415(1.17); C748(0.68)  LDD0856  [6]
 LDCM0259  AC14 HCT 116 C730(1.28); C748(1.28)  LDD0576  [6]
 LDCM0260  AC140 HEK-293T C415(1.10); C748(0.67)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C415(1.05); C748(1.05)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C415(0.89); C748(0.94)  LDD0860  [6]
 LDCM0270  AC15 HCT 116 C730(1.23); C748(1.23)  LDD0587  [6]
 LDCM0276  AC17 HEK-293T C730(0.51); C748(0.57); C787(1.30)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C730(0.55); C748(0.72); C787(1.04)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C730(0.61); C748(0.66); C787(1.32)  LDD0876  [6]
 LDCM0279  AC2 HEK-293T C787(0.98); C809(0.93)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C730(0.50); C748(0.55); C787(1.43)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C730(0.57); C748(0.72); C787(1.02)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C730(0.58); C748(0.60); C787(1.07)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C730(0.56); C748(0.67); C787(1.20)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C730(0.61); C748(0.60); C787(1.17)  LDD0882  [6]
 LDCM0285  AC25 HCT 116 C415(0.93)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C415(0.74)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C415(0.94)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C415(0.91)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C415(0.87)  LDD0606  [6]
 LDCM0290  AC3 HEK-293T C787(1.08); C748(1.03)  LDD1529  [12]
 LDCM0291  AC30 HCT 116 C415(0.91)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C415(0.99)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C415(0.75)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C415(0.71)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C415(0.71)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C730(0.76); C748(0.76); C415(1.51)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C730(1.24); C748(1.24); C415(1.62)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C730(0.95); C748(0.95); C415(1.23)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C415(1.33); C730(1.50); C748(1.50)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C730(0.93); C748(0.93); C415(1.36)  LDD0617  [6]
 LDCM0301  AC4 HEK-293T C787(1.05); C809(1.22); C499(0.92); C372(1.09)  LDD1540  [12]
 LDCM0302  AC40 HCT 116 C730(0.85); C748(0.85); C415(1.18)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C730(0.93); C748(0.93); C415(1.28)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C730(0.94); C748(0.94); C415(1.20)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C415(1.16); C730(1.26); C748(1.26)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C730(0.80); C748(0.80); C415(1.25)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C730(1.01); C748(1.01); C415(1.20)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C415(0.92)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C415(0.89)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C415(1.07)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C415(0.92)  LDD0628  [6]
 LDCM0313  AC50 HCT 116 C415(0.85)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C415(1.22)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C415(1.07)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C415(0.96)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C415(0.83)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C415(0.87)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C415(0.82)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C415(1.07)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C415(1.22)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C415(1.37)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C730(1.09); C748(1.09)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C415(1.25)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C415(1.25)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C415(0.98)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C415(0.94)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C415(1.61)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C415(1.59)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C415(1.44)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C415(1.24)  LDD0648  [6]
 LDCM0334  AC7 HCT 116 C730(1.42); C748(1.42)  LDD0651  [6]
 LDCM0345  AC8 HCT 116 C730(0.98); C748(0.98)  LDD0662  [6]
 LDCM0349  AC83 HCT 116 C415(1.03)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C415(1.17)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C415(1.23)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C415(0.87)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C415(1.23)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C415(1.12)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C415(0.96)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C415(1.62)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C415(0.99)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C415(0.89)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C415(0.83)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C415(1.06)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C415(1.27)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C415(1.25)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C415(0.93)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C415(0.49)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C415(0.85)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C730(1.18); C748(1.18)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C730(1.05); C748(1.05)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C730(1.50); C748(1.50)  LDD0592  [6]
 LDCM0498  BS-3668 MDA-MB-231 C809(0.45)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HEK-293T C809(1.23)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C787(0.60)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C787(0.98)  LDD1573  [12]
 LDCM0370  CL101 HCT 116 C730(1.04); C748(1.04)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C730(0.89); C748(0.89)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C730(1.06); C748(1.06)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C730(1.22); C748(1.22)  LDD0690  [6]
 LDCM0374  CL105 HEK-293T C730(0.71); C748(0.69); C787(0.98)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C730(0.65); C748(0.64); C787(1.19)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C730(0.69); C748(0.68); C787(1.34)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C730(0.59); C748(0.66); C787(1.27)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C730(0.68); C748(0.66); C787(2.02)  LDD0976  [6]
 LDCM0379  CL11 HEK-293T C787(0.37); C809(0.71)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C730(0.55); C748(0.65); C787(1.22)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C730(0.67); C748(0.66); C787(1.57)  LDD0979  [6]
 LDCM0382  CL112 HCT 116 C415(0.85)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C415(0.89)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C415(0.83)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C415(0.80)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C415(0.95)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C730(0.88); C748(0.88); C415(1.03)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C415(1.05); C730(1.07); C748(1.07)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C730(0.79); C748(0.79); C415(0.99)  LDD0706  [6]
 LDCM0390  CL12 HEK-293T C809(0.76); C605(0.96)  LDD1594  [12]
 LDCM0391  CL120 HCT 116 C415(1.04); C730(1.04); C748(1.04)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C415(0.90)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C415(0.85)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C415(0.81)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C415(0.82)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C415(1.21)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C415(1.11)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C415(1.34)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C415(1.42)  LDD0716  [6]
 LDCM0400  CL13 HEK-293T C809(1.31)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C787(0.92); C809(0.81)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C787(0.94)  LDD1606  [12]
 LDCM0403  CL16 HCT 116 C730(0.82); C748(0.82)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C730(0.98); C748(0.98)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C730(1.15); C748(1.15)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C730(0.92); C748(0.92)  LDD0723  [6]
 LDCM0407  CL2 HEK-293T C787(1.05); C809(0.79)  LDD1611  [12]
 LDCM0408  CL20 HCT 116 C730(0.65); C748(0.65)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C730(0.77); C748(0.77)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C730(0.89); C748(0.89)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C730(0.97); C748(0.97)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C730(0.81); C748(0.81)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C730(0.59); C748(0.59)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C730(0.81); C748(0.81)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C730(0.93); C748(0.93)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C730(0.76); C748(0.76)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C730(0.87); C748(0.87)  LDD0734  [6]
 LDCM0418  CL3 HEK-293T C787(1.12)  LDD1622  [12]
 LDCM0419  CL30 HCT 116 C730(0.90); C748(0.90)  LDD0736  [6]
 LDCM0420  CL31 HEK-293T C730(0.83); C748(0.77); C787(1.30)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C730(0.79); C748(0.78); C787(1.18)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C730(0.64); C748(0.70); C787(1.23)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C730(0.75); C748(0.97); C787(1.21)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C730(0.89); C748(0.88); C787(1.25)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C730(0.73); C748(0.79); C787(1.35)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C730(0.72); C748(0.85); C787(1.63)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C730(0.71); C748(0.85); C787(1.49)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C787(0.94)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C730(0.90); C748(1.00); C787(1.79)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C730(0.62); C748(0.83); C787(1.65)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C730(0.81); C748(0.88); C787(1.53)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C730(0.68); C748(0.98); C787(1.52)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C730(0.64); C748(0.87); C787(1.24)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C730(0.68); C748(0.80); C787(1.82)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C730(0.95)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C730(0.68)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C730(1.00)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C730(0.83)  LDD1037  [6]
 LDCM0440  CL5 HEK-293T C787(1.14)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C730(0.82)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C730(0.67)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C730(1.16)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C730(0.98)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C730(0.76)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C730(0.82)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C730(0.84)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C730(0.67)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C730(0.76)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C730(1.14)  LDD1048  [6]
 LDCM0451  CL6 HEK-293T C787(0.92); C809(1.24)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C730(0.94)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C730(1.43)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C730(0.67)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C730(0.70)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C730(0.66)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C730(0.61)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C730(0.76)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C730(0.81)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C730(0.67)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C730(0.66)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C787(0.91); C748(0.99)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C730(0.59)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C730(0.55)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C730(0.71)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C730(0.77)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C730(0.59)  LDD1065  [6]
 LDCM0469  CL76 HCT 116 C415(1.05); C730(0.94); C748(0.94)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C415(0.82); C730(1.07); C748(1.07)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C415(0.88); C730(0.77); C748(0.77)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C415(1.09); C730(0.74); C748(0.74)  LDD0789  [6]
 LDCM0473  CL8 HEK-293T C787(1.09); C809(1.20); C499(0.80); C372(1.17)  LDD1676  [12]
 LDCM0474  CL80 HCT 116 C415(1.02); C730(1.13); C748(1.13)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C415(0.99); C730(0.83); C748(0.83)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C415(0.86); C730(0.71); C748(0.71)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C415(0.90); C730(0.79); C748(0.79)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C415(0.85); C730(0.79); C748(0.79)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C415(0.87); C730(1.00); C748(1.00)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C415(0.98); C730(1.19); C748(1.19)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C415(0.87); C730(1.06); C748(1.06)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C415(0.99); C730(0.71); C748(0.71)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C415(1.06); C730(0.80); C748(0.80)  LDD0800  [6]
 LDCM0485  CL90 HCT 116 C415(1.01); C730(1.22); C748(1.22)  LDD0802  [6]
 LDCM0486  CL91 HEK-293T C787(0.92); C748(0.93)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C787(1.06); C809(1.12); C499(0.95); C372(1.17)  LDD1690  [12]
 LDCM0489  CL94 HEK-293T C787(1.02)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C787(1.06); C809(0.92)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C809(0.86); C605(1.00)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C809(1.22)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C787(0.97); C809(0.88)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C787(0.82)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C787(1.03)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C415(1.67)  LDD1702  [4]
 LDCM0468  Fragment33 HEK-293T C730(0.58)  LDD1066  [6]
 LDCM0427  Fragment51 HEK-293T C730(0.58); C748(0.69); C787(1.24)  LDD1025  [6]
 LDCM0022  KB02 HEK-293T C809(0.64); C372(1.03)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C809(0.78); C372(0.99)  LDD1497  [12]
 LDCM0024  KB05 COLO792 C67(1.68); C372(4.17); C787(1.84); C415(2.97)  LDD3310  [13]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C809(0.72)  LDD2121  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C809(1.11)  LDD2104  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C833(1.04)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C809(0.72)  LDD2109  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C809(1.04)  LDD2114  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C833(1.04)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C809(0.87); C833(1.03)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C809(1.02); C415(0.78)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C809(0.81)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C415(0.89)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C809(1.73)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C809(1.13); C833(1.30)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C809(0.71); C833(1.09)  LDD2140  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C415(0.76)  LDD2146  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynamin-2 (DNM2) Dynamin/Fzo/YdjA family P50570
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transferrin receptor protein 1 (TFRC) Peptidase M28 family P02786
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cip1-interacting zinc finger protein (CIZ1) . Q9ULV3
Epidermal growth factor receptor substrate 15 (EPS15) . P42566
Pleckstrin homology domain-containing family A member 1 (PLEKHA1) . Q9HB21
SH3 domain-binding protein 4 (SH3BP4) . Q9P0V3

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840