Details of the Target

General Information of Target

Target ID LDTP12731
Target Name p21-activated protein kinase-interacting protein 1 (PAK1IP1)
Gene Name PAK1IP1
Gene ID 55003
Synonyms
PIP1; WDR84; p21-activated protein kinase-interacting protein 1; PAK/PLC-interacting protein 1; hPIP1; PAK1-interacting protein 1; WD repeat-containing protein 84
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSPLGPPCLPVMDPETTLEEPETARLRFRGFCYQEVAGPREALARLRELCCQWLQPEAH
SKEQMLEMLVLEQFLGTLPPEIQAWVRGQRPGSPEEAAALVEGLQHDPGQLLGWITAHVL
KQEVLPAAQKTEEPLGSPHPSGTVESPGEGPQDTRIEGSVQLSCSVKEEPNVDGQEVAPS
SPPLAAQSPEGNHGHQEPASTSFHPPRIQEEWGLLDRSQKELYWDAMLEKYGTVVSLGLP
PHQPEAQAQSELGMLLTGTGVCRSLRSGNESEGPPGCPEAQPPQGPGPAAWEGLSGAATP
APTVRPGTPPVPTQPTPAETRLEPAATPRKPYTCEQCGRGFDWKSVFVIHHRTHTSGPGV
QSPGLATGESTEKPPQGEVAFPHHPRRSLTGPRSYPCEECGCSFSWKSQLVIHRKSHTGQ
RRHFCSDCGRAFDWKSQLVIHRKGHRPEVP
Target Bioclass
Other
Subcellular location
Nucleus, nucleolus
Function
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
Uniprot ID
Q9NWT1
Ensemble ID
ENST00000379568.4
HGNC ID
HGNC:20882

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C115(0.97)  LDD2099  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
DBIA
 Probe Info  		C232(1.29); C239(1.29)  LDD0547  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C106(0.00); C298(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
Lodoacetamide azide
 Probe Info  		C298(0.00); C106(0.00)  LDD0037  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [3]
W1
 Probe Info  		N.A.  LDD0236  [8]
AOyne
 Probe Info  		8.20  LDD0443  [9]
NAIA_5
 Probe Info  		C87(0.00); C298(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C288(0.23)  LDD2142  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C115(1.08); C288(1.01)  LDD2117  [2]
 LDCM0214  AC1 PaTu 8988t C298(0.92); C239(0.53); C232(0.53)  LDD1093  [4]
 LDCM0215  AC10 PaTu 8988t C298(0.95); C239(0.89); C232(0.89)  LDD1094  [4]
 LDCM0216  AC100 PaTu 8988t C239(0.68); C232(0.68)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C239(0.81); C232(0.81)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C239(0.81); C232(0.81)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C239(0.67); C232(0.67)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C239(0.84); C232(0.84)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C239(0.95); C232(0.95)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C239(0.78); C232(0.78)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C239(0.96); C232(0.96)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C239(0.85); C232(0.85)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C239(0.79); C232(0.79)  LDD1104  [4]
 LDCM0226  AC11 PaTu 8988t C298(0.95); C239(0.93); C232(0.93)  LDD1105  [4]
 LDCM0227  AC110 PaTu 8988t C239(0.80); C232(0.80)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C239(0.67); C232(0.67)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C239(0.97); C232(0.97)  LDD1108  [4]
 LDCM0230  AC113 HCT 116 C232(1.29); C239(1.29)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C232(1.02); C239(1.02)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C232(1.31); C239(1.31)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C232(1.18); C239(1.18)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C232(1.10); C239(1.10)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C232(0.80); C239(0.80)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C232(0.90); C239(0.90)  LDD0553  [4]
 LDCM0237  AC12 PaTu 8988t C298(0.94); C239(0.87); C232(0.87)  LDD1116  [4]
 LDCM0238  AC120 HCT 116 C232(1.14); C239(1.14)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C232(1.06); C239(1.06)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C232(0.98); C239(0.98)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C232(1.23); C239(1.23)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C232(0.72); C239(0.72)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C232(1.17); C239(1.17)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C232(0.90); C239(0.90)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C232(1.12); C239(1.12)  LDD0562  [4]
 LDCM0259  AC14 PaTu 8988t C298(0.99); C239(0.99); C232(0.99)  LDD1138  [4]
 LDCM0263  AC143 HCT 116 C232(0.68); C239(0.68)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C232(0.68); C239(0.68)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C232(0.79); C239(0.79)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C232(1.00); C239(1.00)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C232(0.68); C239(0.68)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C232(0.77); C239(0.77)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C232(0.85); C239(0.85)  LDD0586  [4]
 LDCM0270  AC15 PaTu 8988t C298(0.91); C239(0.89); C232(0.89)  LDD1149  [4]
 LDCM0271  AC150 HCT 116 C232(0.72); C239(0.72)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C232(0.69); C239(0.69)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C232(0.70); C239(0.70)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C232(0.72); C239(0.72)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C232(0.64); C239(0.64)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C232(0.76); C239(0.76)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C232(0.80); C239(0.80)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C232(0.77); C239(0.77)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C232(0.93); C239(0.93)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C232(0.79); C239(0.79)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C232(1.30); C239(1.30)  LDD0595  [4]
 LDCM0279  AC2 PaTu 8988t C298(0.87); C239(0.56); C232(0.56)  LDD1158  [4]
 LDCM0280  AC20 HCT 116 C232(1.00); C239(1.00)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C232(0.93); C239(0.93)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C232(0.84); C239(0.84)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C232(0.98); C239(0.98)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C232(1.17); C239(1.17)  LDD0601  [4]
 LDCM0285  AC25 PaTu 8988t C239(1.09); C232(1.09)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C239(1.07); C232(1.07)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C239(0.95); C232(0.95)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C239(1.03); C232(1.03)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C239(0.93); C232(0.93)  LDD1168  [4]
 LDCM0290  AC3 PaTu 8988t C298(0.86); C239(0.52); C232(0.52)  LDD1169  [4]
 LDCM0291  AC30 PaTu 8988t C239(0.89); C232(0.89)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C239(1.10); C232(1.10)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C239(1.10); C232(1.10)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C239(0.82); C232(0.82)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C239(0.83); C232(0.83)  LDD1174  [4]
 LDCM0296  AC35 PaTu 8988t C237(0.85); C298(1.03); C239(0.97); C232(0.97)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C237(0.70); C298(0.96); C239(0.74); C232(0.74)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C237(0.78); C298(1.13); C239(0.78); C232(0.78)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C237(0.74); C298(1.06); C239(0.71); C232(0.71)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C237(0.70); C298(1.00); C239(0.74); C232(0.74)  LDD1179  [4]
 LDCM0301  AC4 PaTu 8988t C298(0.95); C239(0.55); C232(0.55)  LDD1180  [4]
 LDCM0302  AC40 PaTu 8988t C237(0.67); C298(0.92); C239(0.67); C232(0.67)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C237(0.77); C298(0.97); C239(0.80); C232(0.80)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C237(0.95); C298(1.06); C239(0.93); C232(0.93)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C237(0.71); C298(0.92); C239(0.69); C232(0.69)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C237(0.75); C298(1.01); C239(0.75); C232(0.75)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C237(0.77); C298(0.92); C239(0.81); C232(0.81)  LDD1186  [4]
 LDCM0308  AC46 HCT 116 C232(0.95); C239(0.95)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C232(1.00); C239(1.00)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C232(1.31); C239(1.31)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C232(0.91); C239(0.91)  LDD0628  [4]
 LDCM0312  AC5 PaTu 8988t C298(0.84); C239(0.49); C232(0.49)  LDD1191  [4]
 LDCM0313  AC50 HCT 116 C232(0.87); C239(0.87)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C232(1.66); C239(1.66)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C232(1.27); C239(1.27)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C232(0.82); C239(0.82)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C232(0.87); C239(0.87)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C232(1.09); C239(1.09)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C232(0.93); C239(0.93)  LDD0636  [4]
 LDCM0320  AC57 PaTu 8988t C237(0.96); C239(0.96); C232(0.96)  LDD1199  [4]
 LDCM0321  AC58 PaTu 8988t C237(0.90); C239(0.90); C232(0.90)  LDD1200  [4]
 LDCM0322  AC59 PaTu 8988t C237(0.99); C239(0.99); C232(0.99)  LDD1201  [4]
 LDCM0323  AC6 PaTu 8988t C298(0.97); C239(0.83); C232(0.83)  LDD1202  [4]
 LDCM0324  AC60 PaTu 8988t C237(1.18); C239(1.18); C232(1.18)  LDD1203  [4]
 LDCM0325  AC61 PaTu 8988t C237(1.19); C239(1.19); C232(1.19)  LDD1204  [4]
 LDCM0326  AC62 PaTu 8988t C237(1.00); C239(1.00); C232(1.00)  LDD1205  [4]
 LDCM0327  AC63 PaTu 8988t C237(1.13); C239(1.13); C232(1.13)  LDD1206  [4]
 LDCM0328  AC64 PaTu 8988t C237(1.15); C239(1.15); C232(1.15)  LDD1207  [4]
 LDCM0329  AC65 PaTu 8988t C237(1.15); C239(1.15); C232(1.15)  LDD1208  [4]
 LDCM0330  AC66 PaTu 8988t C237(1.22); C239(1.22); C232(1.22)  LDD1209  [4]
 LDCM0331  AC67 PaTu 8988t C237(1.16); C239(1.16); C232(1.16)  LDD1210  [4]
 LDCM0332  AC68 HCT 116 C232(1.24); C239(1.24)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C232(1.20); C239(1.20)  LDD0650  [4]
 LDCM0334  AC7 PaTu 8988t C298(0.99); C239(1.26); C232(1.26)  LDD1213  [4]
 LDCM0335  AC70 HCT 116 C232(0.97); C239(0.97)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C232(1.02); C239(1.02)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C232(1.63); C239(1.63)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C232(1.09); C239(1.09)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C232(1.03); C239(1.03)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C232(1.06); C239(1.06)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C232(1.09); C239(1.09)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C232(0.94); C239(0.94)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C232(1.00); C239(1.00)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C232(1.26); C239(1.26)  LDD0661  [4]
 LDCM0345  AC8 PaTu 8988t C298(1.08); C239(1.22); C232(1.22)  LDD1224  [4]
 LDCM0346  AC80 HCT 116 C232(1.14); C239(1.14)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C232(0.59); C239(0.59)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C232(0.54); C239(0.54)  LDD0665  [4]
 LDCM0349  AC83 PaTu 8988t C237(1.11); C239(1.11); C232(1.11)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C237(1.12); C239(1.12); C232(1.12)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C237(1.20); C239(1.20); C232(1.20)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C237(1.09); C239(1.09); C232(1.09)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C237(1.22); C239(1.22); C232(1.22)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C237(1.08); C239(1.08); C232(1.08)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C237(1.16); C239(1.16); C232(1.16)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C237(1.27); C239(1.27); C232(1.27)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C237(1.26); C239(1.26); C232(1.26)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C237(1.27); C239(1.27); C232(1.27)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C237(1.25); C239(1.25); C232(1.25)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C237(1.20); C239(1.20); C232(1.20)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C237(1.19); C239(1.19); C232(1.19)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C237(1.24); C239(1.24); C232(1.24)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C237(1.18); C239(1.18); C232(1.18)  LDD1243  [4]
 LDCM0365  AC98 PaTu 8988t C239(1.31); C232(1.31)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C239(0.79); C232(0.79)  LDD1245  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C298(1.10); C239(0.89); C232(0.89)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C298(1.04); C239(1.13); C232(1.13)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C298(0.98); C239(1.01); C232(1.01)  LDD1154  [4]
 LDCM0156  Aniline NCI-H1299 12.53  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C298(0.00); C239(0.00)  LDD0222  [3]
 LDCM0367  CL1 PaTu 8988t C298(0.85)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C298(0.86)  LDD1247  [4]
 LDCM0369  CL100 PaTu 8988t C298(0.82); C239(0.60); C232(0.60)  LDD1248  [4]
 LDCM0370  CL101 PaTu 8988t C298(0.87); C239(0.82); C232(0.82)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C298(0.81); C239(1.08); C232(1.08)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C298(0.99); C239(0.87); C232(0.87)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C298(0.97); C239(0.94); C232(0.94)  LDD1252  [4]
 LDCM0374  CL105 HCT 116 C232(0.96); C239(0.96)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C232(1.19); C239(1.19)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C232(1.07); C239(1.07)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C232(1.06); C239(1.06)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C232(0.91); C239(0.91)  LDD0695  [4]
 LDCM0379  CL11 PaTu 8988t C298(0.94)  LDD1258  [4]
 LDCM0380  CL110 HCT 116 C232(1.02); C239(1.02)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C232(0.99); C239(0.99)  LDD0698  [4]
 LDCM0382  CL112 PaTu 8988t C239(1.15); C232(1.15)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C239(1.09); C232(1.09)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C239(0.89); C232(0.89)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C239(1.12); C232(1.12)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C239(1.75); C232(1.75)  LDD1265  [4]
 LDCM0387  CL117 PaTu 8988t C237(0.79); C298(0.99); C239(0.83); C232(0.83)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C237(1.10); C298(1.36); C239(1.18); C232(1.18)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C237(0.84); C298(1.07); C239(0.90); C232(0.90)  LDD1268  [4]
 LDCM0390  CL12 PaTu 8988t C298(1.00)  LDD1269  [4]
 LDCM0391  CL120 PaTu 8988t C237(0.72); C298(0.99); C239(0.71); C232(0.71)  LDD1270  [4]
 LDCM0392  CL121 HCT 116 C232(0.78); C239(0.78)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C232(1.32); C239(1.32)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C232(0.88); C239(0.88)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C232(0.97); C239(0.97)  LDD0712  [4]
 LDCM0396  CL125 PaTu 8988t C237(0.96); C239(0.96); C232(0.96)  LDD1275  [4]
 LDCM0397  CL126 PaTu 8988t C237(0.93); C239(0.93); C232(0.93)  LDD1276  [4]
 LDCM0398  CL127 PaTu 8988t C237(1.03); C239(1.03); C232(1.03)  LDD1277  [4]
 LDCM0399  CL128 PaTu 8988t C237(1.00); C239(1.00); C232(1.00)  LDD1278  [4]
 LDCM0400  CL13 PaTu 8988t C298(1.08)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C298(0.92)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C298(0.97)  LDD1281  [4]
 LDCM0403  CL16 HCT 116 C232(0.96); C239(0.96)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C232(1.20); C239(1.20)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C232(1.75); C239(1.75)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C232(1.36); C239(1.36)  LDD0723  [4]
 LDCM0407  CL2 PaTu 8988t C298(0.75)  LDD1286  [4]
 LDCM0408  CL20 HCT 116 C232(1.16); C239(1.16)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C232(0.88); C239(0.88)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C232(1.18); C239(1.18)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C232(1.00); C239(1.00)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C232(1.01); C239(1.01)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C232(1.09); C239(1.09)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C232(0.85); C239(0.85)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C232(0.94); C239(0.94)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C232(1.05); C239(1.05)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C232(1.00); C239(1.00)  LDD0734  [4]
 LDCM0418  CL3 PaTu 8988t C298(1.02)  LDD1297  [4]
 LDCM0419  CL30 HCT 116 C232(1.20); C239(1.20)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C232(0.88); C239(0.88)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C232(1.35); C239(1.35)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C232(0.98); C239(0.98)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C232(0.88); C239(0.88)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C232(0.83); C239(0.83)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C232(0.95); C239(0.95)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C232(0.90); C239(0.90)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C232(0.79); C239(0.79)  LDD0745  [4]
 LDCM0429  CL4 PaTu 8988t C298(1.33)  LDD1308  [4]
 LDCM0430  CL40 HCT 116 C232(0.94); C239(0.94)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C232(1.08); C239(1.08)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C232(0.83); C239(0.83)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C232(1.06); C239(1.06)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C232(0.98); C239(0.98)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C232(0.88); C239(0.88)  LDD0752  [4]
 LDCM0436  CL46 PaTu 8988t C237(0.80); C232(0.80)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C237(0.83); C232(0.83)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C237(0.73); C232(0.73)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C237(0.79); C232(0.79)  LDD1318  [4]
 LDCM0440  CL5 PaTu 8988t C298(1.15)  LDD1319  [4]
 LDCM0441  CL50 PaTu 8988t C237(0.69); C232(0.69)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C237(0.63); C232(0.63)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C237(0.79); C232(0.79)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C237(0.78); C232(0.78)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C237(0.71); C232(0.71)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C237(0.65); C232(0.65)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C237(0.66); C232(0.66)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C237(0.66); C232(0.66)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C237(0.81); C232(0.81)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C237(0.72); C232(0.72)  LDD1329  [4]
 LDCM0451  CL6 PaTu 8988t C298(0.97)  LDD1330  [4]
 LDCM0452  CL60 PaTu 8988t C237(0.75); C232(0.75)  LDD1331  [4]
 LDCM0453  CL61 HCT 116 C232(1.02); C239(1.02)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C232(0.63); C239(0.63)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C232(0.68); C239(0.68)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C232(0.81); C239(0.81)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C232(0.77); C239(0.77)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C232(0.61); C239(0.61)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C232(0.83); C239(0.83)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C232(0.87); C239(0.87)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C232(0.89); C239(0.89)  LDD0778  [4]
 LDCM0462  CL7 PaTu 8988t C298(1.25)  LDD1341  [4]
 LDCM0463  CL70 HCT 116 C232(0.87); C239(0.87)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C232(0.72); C239(0.72)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C232(0.69); C239(0.69)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C232(0.74); C239(0.74)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C232(0.72); C239(0.72)  LDD0784  [4]
 LDCM0469  CL76 PaTu 8988t C237(0.98); C298(0.94); C239(0.98); C232(0.98)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C237(0.87); C298(0.82); C239(0.87); C232(0.87)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C237(0.93); C298(0.80); C239(0.93); C232(0.93)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C237(0.81); C298(0.92); C239(0.81); C232(0.81)  LDD1351  [4]
 LDCM0473  CL8 PaTu 8988t C298(0.97)  LDD1352  [4]
 LDCM0474  CL80 PaTu 8988t C237(1.11); C298(0.83); C239(1.11); C232(1.11)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C237(0.89); C298(0.67); C239(0.89); C232(0.89)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C237(1.01); C298(0.82); C239(1.01); C232(1.01)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C237(0.96); C298(0.99); C239(0.96); C232(0.96)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C237(0.83); C298(0.86); C239(0.83); C232(0.83)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C237(0.89); C298(0.91); C239(0.89); C232(0.89)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C237(0.80); C298(0.84); C239(0.80); C232(0.80)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C237(0.97); C298(0.95); C239(0.97); C232(0.97)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C237(0.85); C298(0.82); C239(0.85); C232(0.85)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C237(0.94); C298(0.96); C239(0.94); C232(0.94)  LDD1362  [4]
 LDCM0484  CL9 PaTu 8988t C298(1.09)  LDD1363  [4]
 LDCM0485  CL90 PaTu 8988t C237(0.70); C298(0.68); C239(0.70); C232(0.70)  LDD1364  [4]
 LDCM0486  CL91 PaTu 8988t C298(0.92); C239(0.61); C232(0.61)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C298(0.75); C239(0.50); C232(0.50)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C298(0.77); C239(0.54); C232(0.54)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C298(0.79); C239(0.54); C232(0.54)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C298(0.60); C239(0.50); C232(0.50)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C298(0.77); C239(0.54); C232(0.54)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C298(0.79); C239(0.53); C232(0.53)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C298(0.84); C239(0.59); C232(0.59)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C298(0.87); C239(0.53); C232(0.53)  LDD1373  [4]
 LDCM0495  E2913 HEK-293T C239(0.96)  LDD1698  [11]
 LDCM0468  Fragment33 HCT 116 C232(0.64); C239(0.64)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C232(0.81); C239(0.81)  LDD0744  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 HEK-293T C298(0.92)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C298(0.88)  LDD1497  [11]
 LDCM0024  KB05 HMCB C298(2.60)  LDD3312  [12]
 LDCM0109  NEM HeLa N.A.  LDD0224  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C115(0.97)  LDD2099  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C288(0.28)  LDD2106  [2]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C288(0.33)  LDD2110  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C115(0.99); C288(1.36)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C288(0.80)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C115(0.86); C288(1.03)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C115(1.38); C288(0.76)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C115(0.86); C288(2.06)  LDD2137  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840