Details of the Target

General Information of Target

Target ID LDTP12666
Target Name Ubiquinol-cytochrome c reductase complex assembly factor 1 (UQCC1)
Gene Name UQCC1
Gene ID 55245
Synonyms
BZFB; C20orf44; UQCC; Ubiquinol-cytochrome c reductase complex assembly factor 1; Basic FGF-repressed Zic-binding protein; bFGF-repressed Zic-binding protein; bFZb; Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMNYNAKDEVDGGPPCAPGGTAKTRRPDNTAFKQQRLPAWQPILTAGTVLPIFFIIGLI
FIPIGIGIFVTSNNIREIEIDYTGTEPSSPCNKCLSPDVTPCFCTINFTLEKSFEGNVFM
YYGLSNFYQNHRRYVKSRDDSQLNGDSSALLNPSKECEPYRRNEDKPIAPCGAIANSMFN
DTLELFLIGNDSYPIPIALKKKGIAWWTDKNVKFRNPPGGDNLEERFKGTTKPVNWLKPV
YMLDSDPDNNGFINEDFIVWMRTAALPTFRKLYRLIERKSDLHPTLPAGRYSLNVTYNYP
VHYFDGRKRMILSTISWMGGKNPFLGIAYIAVGSISFLLGVVLLVINHKYRNSSNTADIT
I
Target Bioclass
Other
Family
CBP3 family
Subcellular location
Mitochondrion inner membrane
Function
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability.
Uniprot ID
Q9NVA1
Ensemble ID
ENST00000349714.9
HGNC ID
HGNC:15891

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL78 SNV: p.K107Ter .
HCC1395 SNV: p.W44S .
NUGC3 SNV: p.G225R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.74  LDD0402  [1]
STPyne
 Probe Info  		K198(10.00)  LDD0277  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
BTD
 Probe Info  		C124(0.56)  LDD2109  [4]
DBIA
 Probe Info  		C124(0.91)  LDD0547  [5]
IA-alkyne
 Probe Info  		C239(0.00); C124(0.00)  LDD0162  [6]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [7]
FFF probe14
 Probe Info  		20.00  LDD0477  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C124(1.07)  LDD2117  [4]
 LDCM0214  AC1 HEK-293T C124(0.87)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C124(0.96)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C124(0.94)  LDD1509  [8]
 LDCM0230  AC113 HCT 116 C124(0.91)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C124(0.95)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C124(0.98)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C124(0.95)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C124(0.92)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C124(0.94)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C124(0.95)  LDD0553  [5]
 LDCM0238  AC120 HCT 116 C124(1.00)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C124(0.80)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C124(0.88)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C124(0.89)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C124(0.93)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C124(0.83)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C124(1.03)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C124(0.87)  LDD0562  [5]
 LDCM0259  AC14 HEK-293T C124(0.99)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C124(0.96)  LDD1513  [8]
 LDCM0276  AC17 HCT 116 C124(1.09)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C124(0.67)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C124(0.81)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C124(1.00)  LDD1518  [8]
 LDCM0280  AC20 HCT 116 C124(1.22)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C124(0.76)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C124(0.80)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C124(0.97)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C124(0.85)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C124(1.40)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C124(1.29)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C124(1.19)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C124(1.31)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C124(1.11)  LDD0606  [5]
 LDCM0290  AC3 HEK-293T C124(0.97)  LDD1529  [8]
 LDCM0291  AC30 HCT 116 C124(1.12)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C124(1.19)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C124(1.18)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C124(1.05)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C124(1.00)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C124(0.93)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C124(1.04)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C124(1.12)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C124(0.91)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C124(1.05)  LDD0617  [5]
 LDCM0302  AC40 HCT 116 C124(0.87)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C124(0.95)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C124(1.03)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C124(1.15)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C124(0.95)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C124(1.05)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C124(0.73)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C124(0.62)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C124(0.52)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C124(0.43)  LDD0628  [5]
 LDCM0313  AC50 HCT 116 C124(0.81)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C124(0.63)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C124(0.73)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C124(1.08)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C124(0.93)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C124(0.67)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C124(0.72)  LDD0636  [5]
 LDCM0320  AC57 HEK-293T C124(0.94)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C124(1.00)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C124(0.98)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C124(1.11)  LDD1562  [8]
 LDCM0326  AC62 HEK-293T C124(1.02)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C124(1.00)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C124(0.97)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C124(0.97)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C124(0.99)  LDD1569  [8]
 LDCM0356  AKOS034007680 HEK-293T C124(0.92)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C124(0.96)  LDD1514  [8]
 LDCM0367  CL1 HCT 116 C124(1.05)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C124(1.17)  LDD0685  [5]
 LDCM0369  CL100 HEK-293T C124(0.99)  LDD1573  [8]
 LDCM0373  CL104 HEK-293T C124(1.00)  LDD1577  [8]
 LDCM0374  CL105 HCT 116 C124(0.67)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C124(0.46)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C124(0.75)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C124(0.98)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C124(0.89)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C124(1.07)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C124(0.84)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C124(0.89)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C124(1.23)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C124(1.07)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C124(0.98)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C124(1.14)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C124(0.95)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C124(1.10)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C124(1.06)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C124(1.08)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C124(1.08)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C124(1.16)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C124(0.66)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C124(0.44)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C124(0.73)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C124(0.99)  LDD0712  [5]
 LDCM0399  CL128 HEK-293T C124(1.00)  LDD1603  [8]
 LDCM0400  CL13 HCT 116 C124(0.99)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C124(1.08)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C124(1.23)  LDD0719  [5]
 LDCM0403  CL16 HEK-293T C124(0.97)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C124(0.97)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C124(0.99)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C124(1.06)  LDD1610  [8]
 LDCM0407  CL2 HCT 116 C124(0.98)  LDD0724  [5]
 LDCM0410  CL22 HEK-293T C124(1.20)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C124(1.26)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C124(1.22)  LDD1616  [8]
 LDCM0416  CL28 HEK-293T C124(0.99)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C124(0.91)  LDD1621  [8]
 LDCM0418  CL3 HCT 116 C124(1.16)  LDD0735  [5]
 LDCM0419  CL30 HEK-293T C124(0.96)  LDD1623  [8]
 LDCM0420  CL31 HCT 116 C124(1.79)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C124(1.18)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C124(0.97)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C124(1.57)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C124(1.06)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C124(1.22)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C124(1.08)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C124(1.59)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C124(1.06)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C124(1.79)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C124(1.43)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C124(1.06)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C124(1.68)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C124(1.26)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C124(1.50)  LDD0752  [5]
 LDCM0436  CL46 HEK-293T C124(1.27)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C124(1.30)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C124(1.25)  LDD1642  [8]
 LDCM0440  CL5 HCT 116 C124(1.42)  LDD0757  [5]
 LDCM0443  CL52 HEK-293T C124(0.98)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C124(1.08)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C124(1.16)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C124(1.07)  LDD1649  [8]
 LDCM0449  CL58 HEK-293T C124(1.34)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C124(1.38)  LDD1653  [8]
 LDCM0451  CL6 HCT 116 C124(1.37)  LDD0768  [5]
 LDCM0452  CL60 HEK-293T C124(1.26)  LDD1655  [8]
 LDCM0456  CL64 HEK-293T C124(1.08)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C124(0.77)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C124(0.97)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C124(1.06)  LDD1662  [8]
 LDCM0462  CL7 HCT 116 C124(1.28)  LDD0779  [5]
 LDCM0463  CL70 HEK-293T C124(1.31)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C124(1.19)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C124(1.11)  LDD1668  [8]
 LDCM0469  CL76 HEK-293T C124(1.01)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C124(0.92)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C124(1.02)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C124(1.00)  LDD1675  [8]
 LDCM0473  CL8 HCT 116 C124(1.09)  LDD0790  [5]
 LDCM0476  CL82 HEK-293T C124(1.13)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C124(1.28)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C124(1.22)  LDD1681  [8]
 LDCM0482  CL88 HEK-293T C124(1.07)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C124(0.99)  LDD1686  [8]
 LDCM0484  CL9 HCT 116 C124(1.14)  LDD0801  [5]
 LDCM0485  CL90 HEK-293T C124(1.64)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C124(1.08)  LDD1689  [8]
 LDCM0489  CL94 HEK-293T C124(1.22)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C124(1.63)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C124(1.27)  LDD1694  [8]
 LDCM0625  F8 Ramos C124(0.54)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C124(0.52)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C124(18.69)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C124(0.44)  LDD2191  [9]
 LDCM0576  Fragment14 Ramos C124(0.65)  LDD2193  [9]
 LDCM0579  Fragment20 Ramos C124(0.35)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C124(0.95)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C124(0.27)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C124(1.41)  LDD2197  [9]
 LDCM0588  Fragment30 Ramos C124(2.62)  LDD2199  [9]
 LDCM0590  Fragment32 Ramos C124(0.37)  LDD2201  [9]
 LDCM0468  Fragment33 Ramos C124(1.28)  LDD2202  [9]
 LDCM0596  Fragment38 Ramos C124(1.06)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C124(0.41)  LDD2184  [9]
 LDCM0427  Fragment51 HCT 116 C124(1.48)  LDD0744  [5]
 LDCM0569  Fragment7 Ramos C124(0.31)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C124(0.36)  LDD2188  [9]
 LDCM0022  KB02 Ramos C124(0.16)  LDD2182  [9]
 LDCM0023  KB03 Ramos C124(0.27)  LDD2183  [9]
 LDCM0024  KB05 IGR37 C56(3.51)  LDD3314  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C124(0.56)  LDD2109  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C124(0.98)  LDD2123  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C124(1.14)  LDD2136  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840