Details of the Target

General Information of Target

Target ID LDTP12645
Target Name Inactive ubiquitin thioesterase OTULINL (OTULINL)
Gene Name OTULINL
Gene ID 54491
Synonyms
FAM105A; Inactive ubiquitin thioesterase OTULINL
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLVHLFRVGIRGGPFPGRLLPPLRFQTFSAVRNTWRNGKTGQLHKAEGEYSDGYRSSSLL
RAVAHLRSQLWAHLPRAPLAPRWSPSAWCWVGGALLGPMVLSKHPHLCLVALCEAEEAPP
ASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYT
RDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDI
TFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMV
ATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAE
LEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQT
VQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFS
YPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRT
LDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEG
YNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAG
RTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALDAPRTAAP
PPKKPEGPRSHQHKS
Target Bioclass
Enzyme
Family
Peptidase C65 family, Otulin subfamily
Subcellular location
Cytoplasm
Function Lacks deubiquitinase activity.
Uniprot ID
Q9NUU6
Ensemble ID
ENST00000274217.4
HGNC ID
HGNC:25629

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0221  [1]
DBIA
 Probe Info  		C177(1.09)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
Methacrolein
 Probe Info  		N.A.  LDD0218  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C177(0.68)  LDD1093  [2]
 LDCM0215  AC10 HCT 116 C177(0.93)  LDD0532  [2]
 LDCM0216  AC100 PaTu 8988t C177(1.03)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C177(1.17)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C177(1.36)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C177(1.13)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C177(0.99)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C177(1.20)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C177(1.07)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C177(1.23)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C177(1.17)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C177(1.16)  LDD1104  [2]
 LDCM0226  AC11 HCT 116 C177(1.00)  LDD0543  [2]
 LDCM0227  AC110 PaTu 8988t C177(1.66)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C177(1.16)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C177(1.21)  LDD1108  [2]
 LDCM0230  AC113 HCT 116 C177(1.17)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C177(0.90)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C177(1.19)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C177(1.29)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C177(0.88)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C177(0.84)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C177(0.85)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C177(0.88)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C177(1.02)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C177(0.83)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C177(1.05)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C177(0.91)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C177(1.08)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C177(0.98)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C177(1.06)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C177(0.88)  LDD0562  [2]
 LDCM0246  AC128 PaTu 8988t C177(1.33)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C177(1.52)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C177(1.59)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C177(1.68)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C177(1.07)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C177(1.31)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C177(1.42)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C177(1.52)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C177(1.24)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C177(1.50)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C177(1.72)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C177(1.31)  LDD1137  [2]
 LDCM0259  AC14 HCT 116 C177(0.81)  LDD0576  [2]
 LDCM0260  AC140 PaTu 8988t C177(1.23)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C177(1.41)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C177(1.46)  LDD1141  [2]
 LDCM0270  AC15 HCT 116 C177(0.83)  LDD0587  [2]
 LDCM0276  AC17 PaTu 8988t C177(1.13)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C177(0.98)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C177(1.04)  LDD1157  [2]
 LDCM0279  AC2 PaTu 8988t C177(0.55)  LDD1158  [2]
 LDCM0280  AC20 PaTu 8988t C177(1.06)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C177(0.96)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C177(1.04)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C177(1.06)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C177(1.16)  LDD1163  [2]
 LDCM0285  AC25 HCT 116 C177(0.78)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C177(1.04)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C177(1.04)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C177(0.98)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C177(1.22)  LDD0606  [2]
 LDCM0290  AC3 PaTu 8988t C177(0.69)  LDD1169  [2]
 LDCM0291  AC30 HCT 116 C177(1.10)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C177(1.40)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C177(1.00)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C177(1.21)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C177(1.02)  LDD0612  [2]
 LDCM0296  AC35 PaTu 8988t C177(1.11)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C177(1.38)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C177(1.38)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C177(1.37)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C177(1.49)  LDD1179  [2]
 LDCM0301  AC4 PaTu 8988t C177(0.54)  LDD1180  [2]
 LDCM0302  AC40 PaTu 8988t C177(1.67)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C177(1.35)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C177(1.16)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C177(1.33)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C177(1.42)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C177(1.14)  LDD1186  [2]
 LDCM0308  AC46 PaTu 8988t C177(1.02)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C177(1.23)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C177(1.30)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C177(1.39)  LDD1190  [2]
 LDCM0312  AC5 PaTu 8988t C177(0.77)  LDD1191  [2]
 LDCM0313  AC50 PaTu 8988t C177(1.35)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C177(2.22)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C177(1.48)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C177(1.46)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C177(1.39)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C177(1.17)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C177(1.63)  LDD1198  [2]
 LDCM0320  AC57 PaTu 8988t C177(0.95)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C177(1.17)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C177(1.03)  LDD1201  [2]
 LDCM0323  AC6 HCT 116 C177(1.00)  LDD0640  [2]
 LDCM0324  AC60 PaTu 8988t C177(0.82)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C177(0.92)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C177(0.99)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C177(0.87)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C177(0.87)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C177(1.09)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C177(1.16)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C177(0.79)  LDD1210  [2]
 LDCM0332  AC68 HCT 116 C177(1.39)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C177(1.31)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C177(0.88)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C177(1.22)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C177(1.33)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C177(1.46)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C177(1.74)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C177(1.67)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C177(1.88)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C177(1.48)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C177(1.44)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C177(1.40)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C177(1.20)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C177(1.06)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C177(1.86)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C177(1.25)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C177(2.04)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C177(1.20)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C177(1.13)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C177(1.03)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C177(1.00)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C177(0.82)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C177(0.84)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C177(0.97)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C177(0.89)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C177(0.83)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C177(0.80)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C177(0.86)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C177(0.98)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C177(0.94)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C177(1.01)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C177(0.96)  LDD0681  [2]
 LDCM0365  AC98 PaTu 8988t C177(1.22)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C177(0.99)  LDD1245  [2]
 LDCM0248  AKOS034007472 HCT 116 C177(0.80)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C177(0.82)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C177(1.23)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C177(1.09)  LDD0078  [2]
 LDCM0630  CCW28-3 231MFP C177(0.82)  LDD2214  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]
 LDCM0367  CL1 HEK-293T C100(1.11); C329(1.06); C177(0.97); C226(1.05)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C100(0.94); C329(1.36); C177(1.12); C226(1.66)  LDD1572  [5]
 LDCM0369  CL100 PaTu 8988t C177(0.58)  LDD1248  [2]
 LDCM0370  CL101 HCT 116 C177(0.96)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C177(0.82)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C177(0.93)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C177(0.72)  LDD0690  [2]
 LDCM0374  CL105 PaTu 8988t C177(0.95)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C177(1.08)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C177(0.90)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C177(0.86)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C177(1.14)  LDD1257  [2]
 LDCM0379  CL11 HEK-293T C100(1.14); C329(1.38); C177(0.94); C226(1.15)  LDD1583  [5]
 LDCM0380  CL110 PaTu 8988t C177(0.91)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C177(1.20)  LDD1260  [2]
 LDCM0382  CL112 HCT 116 C177(1.12)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C177(0.96)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C177(1.00)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C177(1.13)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C177(1.23)  LDD0703  [2]
 LDCM0387  CL117 PaTu 8988t C177(1.30)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C177(1.25)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C177(1.11)  LDD1268  [2]
 LDCM0390  CL12 HEK-293T C100(1.11); C329(1.34); C177(0.89); C226(1.24)  LDD1594  [5]
 LDCM0391  CL120 PaTu 8988t C177(1.20)  LDD1270  [2]
 LDCM0392  CL121 PaTu 8988t C177(1.26)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C177(1.55)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C177(1.34)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C177(1.32)  LDD1274  [2]
 LDCM0396  CL125 PaTu 8988t C177(1.00)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C177(1.04)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C177(1.15)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C177(1.07)  LDD1278  [2]
 LDCM0400  CL13 HEK-293T C100(1.20); C329(0.93); C177(0.92); C226(1.09)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C100(1.05); C329(1.07); C177(1.07); C226(0.91)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C100(0.97); C329(1.02); C177(0.90); C226(1.24)  LDD1606  [5]
 LDCM0403  CL16 PaTu 8988t C177(0.88)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C177(0.98)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C177(1.16)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C177(1.21)  LDD1285  [2]
 LDCM0407  CL2 HEK-293T C100(0.98); C329(1.09); C177(0.90); C226(0.91)  LDD1611  [5]
 LDCM0408  CL20 PaTu 8988t C177(1.00)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C177(1.39)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C177(1.11)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C177(0.97)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C177(0.81)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C177(0.83)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C177(1.11)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C177(0.93)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C177(0.97)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C177(1.19)  LDD1296  [2]
 LDCM0418  CL3 HEK-293T C100(1.28); C329(1.11); C177(0.86); C226(0.95)  LDD1622  [5]
 LDCM0419  CL30 PaTu 8988t C177(1.22)  LDD1298  [2]
 LDCM0420  CL31 PaTu 8988t C177(0.92)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C177(1.01)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C177(1.21)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C177(0.98)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C177(1.00)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C177(0.81)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C177(1.23)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C177(1.22)  LDD1307  [2]
 LDCM0429  CL4 HEK-293T C100(0.86); C329(1.14); C177(0.84); C226(1.19)  LDD1633  [5]
 LDCM0430  CL40 PaTu 8988t C177(1.28)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C177(1.12)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C177(1.08)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C177(1.37)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C177(1.26)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C177(1.42)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C177(1.17)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C177(1.21)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C177(1.09)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C177(1.12)  LDD1318  [2]
 LDCM0440  CL5 HEK-293T C100(1.16); C329(1.22); C177(0.95); C226(1.05)  LDD1644  [5]
 LDCM0441  CL50 PaTu 8988t C177(1.26)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C177(0.85)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C177(1.07)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C177(1.06)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C177(1.13)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C177(1.17)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C177(0.94)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C177(1.22)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C177(1.38)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C177(1.25)  LDD1329  [2]
 LDCM0451  CL6 HEK-293T C100(1.02); C329(1.01); C177(1.14); C226(1.20)  LDD1654  [5]
 LDCM0452  CL60 PaTu 8988t C177(1.18)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C177(1.06)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C177(1.41)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C177(1.33)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C177(1.07)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C177(1.07)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C177(1.36)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C177(1.18)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C177(0.66)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C177(1.22)  LDD1340  [2]
 LDCM0462  CL7 HEK-293T C100(1.02); C329(1.15); C177(1.05); C226(1.00)  LDD1665  [5]
 LDCM0463  CL70 PaTu 8988t C177(0.56)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C177(1.15)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C177(0.95)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C177(1.41)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C177(1.22)  LDD1346  [2]
 LDCM0469  CL76 HCT 116 C177(1.29)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C177(2.13)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C177(1.23)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C177(1.21)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C329(1.12); C177(1.68); C226(1.56)  LDD1676  [5]
 LDCM0474  CL80 HCT 116 C177(1.70)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C177(1.35)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C177(1.79)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C177(1.51)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C177(1.87)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C177(1.25)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C177(1.29)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C177(1.34)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C177(1.29)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C177(2.00)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C100(0.92); C329(1.22); C177(0.87); C226(1.05)  LDD1687  [5]
 LDCM0485  CL90 HCT 116 C177(1.11)  LDD0802  [2]
 LDCM0486  CL91 PaTu 8988t C177(0.63)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C177(0.59)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C177(0.57)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C177(0.66)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C177(0.81)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C177(0.63)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C177(0.59)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C177(0.72)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C177(0.62)  LDD1373  [2]
 LDCM0495  E2913 HEK-293T C100(0.95); C329(0.98); C177(0.83); C226(0.88)  LDD1698  [5]
 LDCM0468  Fragment33 PaTu 8988t C177(1.51)  LDD1347  [2]
 LDCM0427  Fragment51 PaTu 8988t C177(1.21)  LDD1306  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [1]
 LDCM0022  KB02 HCT 116 C177(2.14)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C177(1.28)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C177(4.26)  LDD0082  [2]
 LDCM0109  NEM HeLa H350(0.00); H352(0.00)  LDD0223  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vesicle transport protein GOT1A (GOLT1A) GOT1 family Q6ZVE7
Serine protease HTRA2, mitochondrial (HTRA2) Peptidase S1C family O43464
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402