Details of the Target

General Information of Target

Target ID LDTP12560
Target Name E3 ubiquitin-protein ligase Topors (TOPORS)
Gene Name TOPORS
Gene ID 10210
Synonyms
LUN; TP53BPL; E3 ubiquitin-protein ligase Topors; EC 2.3.2.27; RING-type E3 ubiquitin transferase Topors; SUMO1-protein E3 ligase Topors; Topoisomerase I-binding RING finger protein; Topoisomerase I-binding arginine/serine-rich protein; Tumor suppressor p53-binding protein 3; p53-binding protein 3; p53BP3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM
QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG
VAMMFIINFEYVTDNENAATPERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSLPQEDP
DVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKCSPLVNISGPLDHSSP
KRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASEDNG
RNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIA
PKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIY
TAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEE
VVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARK
LDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYN
DSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFG
NVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVL
KGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLT
ALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQRED
LLEVLDMYPEFSDHFLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESE
GEKENSTNDPEDSADTIRHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSGIVDSSPGIG
KASGLDFEETVPTSGRMHIDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGIS
ETESDLTYGEVEQRLDLLQEQLNRLESQMTTDIQTILQLLQKQTTVVPPAYSMVTAGSEY
QRPIIQLMRTSQPEASIKTDRSFSPSSQCPEFLDLEKSKLKSKESLSSGVHLNTASEDNL
TSLLKQDSDLSLELHLRQRKTYVHPIRHPSLPDSSLSTVGIVGLHRHVSDPGLPGK
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
Uniprot ID
Q9NS56
Ensemble ID
ENST00000360538.7
HGNC ID
HGNC:21653

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.L184V .
CCK81 SNV: p.F110S; p.Y761H .
HEC1 SNV: p.E1001Ter DBIA    Probe Info 
HEC1B SNV: p.E1001Ter .
LS180 Deletion: p.N754IfsTer34
SNV: p.H855R;p.T862S		 .
MFE319 SNV: p.D1043V DBIA    Probe Info 
NCIH446 Substitution: p.R673L .
SNGM SNV: p.R594S .
SW1271 SNV: p.G482V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C292(2.44)  LDD2153  [1]
DBIA
 Probe Info  		C103(1.08); C106(1.08)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_5
 Probe Info  		N.A.  LDD2225  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
TFBX
 Probe Info  		C550(0.00); C49(0.00)  LDD0148  [6]
AOyne
 Probe Info  		14.90  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C138(0.96); C141(0.96); C292(0.99); C49(1.07)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C138(1.32); C141(1.32)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C138(2.38); C141(2.38); C49(0.79)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C138(1.56); C141(1.56); C49(0.95)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C138(1.05); C141(1.05); C49(0.86)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C138(1.42); C141(1.42); C49(1.39)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C138(1.27); C141(1.27); C49(1.07)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C138(1.31); C141(1.31); C49(1.12)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C138(1.91); C141(1.91); C49(1.04)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C138(1.57); C141(1.57); C49(1.13)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C138(2.42); C141(2.42); C49(0.70)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C138(1.21); C141(1.21); C49(0.87)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C138(1.20); C141(1.20)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C138(1.51); C141(1.51); C49(0.79)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C138(1.29); C141(1.29); C49(1.07)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C138(1.44); C141(1.44); C49(1.05)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C138(0.99); C141(0.99)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C138(1.18); C141(1.18)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C138(1.10); C141(1.10)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C138(1.34); C141(1.34)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C138(1.15); C141(1.15)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C138(1.04); C141(1.04)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C138(1.14); C141(1.14)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C138(1.10); C141(1.10)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C138(1.26); C141(1.26)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C138(1.11); C141(1.11)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C138(1.19); C141(1.19)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C138(1.08); C141(1.08)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C138(1.12); C141(1.12)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C138(1.22); C141(1.22)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C138(1.50); C141(1.50)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C138(1.48); C141(1.48)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C550(0.88)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C550(0.90)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C550(0.98)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C550(0.91)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C550(0.86)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C550(1.21)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C550(1.04)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C550(1.21)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C550(1.19)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C550(1.00)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C550(0.88)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C550(0.93)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C138(0.91); C141(0.91)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C550(1.20)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C550(1.34)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C550(1.03)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C49(0.99); C138(1.18); C141(1.18)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C49(0.94); C141(1.11); C138(1.20)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C49(1.00); C141(1.10); C138(1.25)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C49(0.98); C141(1.35); C138(1.51)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C49(1.00); C141(1.19); C138(1.26)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C49(1.08); C141(1.68); C138(1.79)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C49(1.14); C141(1.45); C138(1.68)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C138(1.17); C141(1.17)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C49(0.71); C141(1.08); C138(1.16)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C141(0.91); C49(1.09); C138(1.23)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C49(0.91); C141(1.29); C138(1.31)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C49(0.76); C141(1.68); C138(1.84)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C138(1.24); C141(1.11); C49(0.73)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C138(1.46); C141(1.24); C49(0.88)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C138(1.19); C141(1.04); C49(1.00)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C138(1.13); C141(0.90); C49(0.91)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C292(1.11); C138(1.18); C141(1.18)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C292(0.93); C138(1.18); C141(1.18)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C292(0.86); C138(1.23); C141(1.23)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C49(0.91); C292(0.95); C138(1.03); C141(1.03)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C292(0.88); C138(0.93); C141(0.93)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C292(0.87); C138(0.95); C141(0.95)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C138(0.89); C141(0.89); C292(0.93)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C292(0.84); C138(1.00); C141(1.00)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C292(0.96); C138(1.11); C141(1.11)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C550(0.80)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C550(0.78)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C550(0.86)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C550(2.90)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C550(0.83)  LDD0887  [2]
 LDCM0290  AC3 HCT 116 C292(0.96); C49(0.96); C138(1.07); C141(1.07)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C550(0.90)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C550(0.77)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C550(0.71)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C550(0.99)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C550(0.85)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C550(1.05)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C550(1.14); C292(1.04); C966(1.13)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C550(1.00); C292(1.05); C966(1.08); C138(1.11)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C550(0.93); C292(1.08); C138(0.99); C141(0.99)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C550(1.08); C292(1.19); C138(1.02); C141(1.02)  LDD1539  [8]
 LDCM0301  AC4 HCT 116 C292(0.90); C138(0.92); C141(0.92); C49(0.97)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C550(1.01); C292(1.09); C127(1.07); C138(1.00)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C550(1.08); C966(0.92)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C550(1.03); C292(1.01); C49(1.14); C127(0.94)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C550(0.98)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C550(1.07); C292(1.04); C966(1.15)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C550(1.02); C292(1.17); C966(1.09); C138(1.13)  LDD1546  [8]
 LDCM0308  AC46 HCT 116 C138(1.27); C141(1.27)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C138(1.28); C141(1.28)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C138(1.19); C141(1.19)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C138(1.61); C141(1.61)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C49(0.94); C138(0.95); C141(0.95); C292(0.97)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C138(1.74); C141(1.74)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C138(1.44); C141(1.44)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C138(1.34); C141(1.34)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C138(1.38); C141(1.38)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C138(1.32); C141(1.32)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C138(1.24); C141(1.24)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C138(1.40); C141(1.40)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C550(0.91); C966(0.97)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C550(0.99); C292(1.09); C49(1.01); C127(1.08)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C550(0.91)  LDD1561  [8]
 LDCM0323  AC6 HCT 116 C138(1.15); C141(1.15)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C550(1.03); C292(0.95); C966(1.12)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C550(0.94); C292(1.10); C966(1.05); C138(1.12)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C550(0.95); C292(1.04); C138(1.07); C141(1.07)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C550(1.08); C292(1.17); C138(0.96); C141(0.96)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C550(0.96); C292(1.06); C127(0.96); C138(0.91)  LDD1567  [8]
 LDCM0332  AC68 HCT 116 C292(0.87); C49(1.01); C138(1.21); C141(1.21)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C292(0.93); C49(1.08); C138(1.37); C141(1.37)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C138(1.03); C141(1.03)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C49(1.03); C292(1.22); C138(1.29); C141(1.29)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C292(0.99); C49(1.03); C138(1.32); C141(1.32)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C49(1.15); C292(1.17); C138(1.33); C141(1.33)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C292(1.08); C49(1.52); C138(1.90); C141(1.90)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C292(0.81); C49(1.36); C138(1.77); C141(1.77)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C292(1.20); C49(1.80); C138(1.87); C141(1.87)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C49(1.09); C292(1.13); C138(1.47); C141(1.47)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C292(0.83); C49(1.22); C138(1.37); C141(1.37)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C49(1.04); C292(1.05); C138(1.18); C141(1.18)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C292(1.07); C49(1.12); C138(1.41); C141(1.41)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C138(1.08); C141(1.08)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C292(1.07); C49(1.17); C138(1.31); C141(1.31)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C292(0.92); C49(1.00); C138(1.46); C141(1.46)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C292(1.08); C49(1.69); C138(1.87); C141(1.87)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C138(0.62); C141(0.62); C292(1.32); C49(1.69)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C138(0.48); C141(0.48); C292(1.19); C49(1.57)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C138(0.56); C141(0.56); C292(1.25); C49(1.34)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C138(0.68); C141(0.68); C49(1.17); C292(1.26)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C138(0.59); C141(0.59); C49(1.10); C292(1.22)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C138(0.66); C141(0.66); C292(0.99); C49(1.46)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C138(0.67); C141(0.67); C292(1.09); C49(1.60)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C138(0.69); C141(0.69); C49(0.78); C292(1.15)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C138(0.52); C141(0.52); C292(1.11); C49(1.95)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C138(0.63); C141(0.63); C292(1.15); C49(1.95)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C138(0.50); C141(0.50); C292(1.18); C49(1.49)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C138(0.43); C141(0.43); C292(1.06); C49(1.73)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C138(0.59); C141(0.59); C292(1.04); C49(1.44)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C138(0.32); C141(0.32); C292(1.17); C49(1.91)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C138(0.75); C141(0.75); C292(1.14); C49(2.38)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C49(1.86); C138(2.17); C141(2.17)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C49(0.86); C138(1.58); C141(1.58)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C138(1.00); C141(1.00)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C138(0.87); C141(0.87)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C138(1.11); C141(1.11)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C103(1.08); C106(1.08)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C292(0.94)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C292(0.89)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C292(0.89); C138(0.91); C141(0.91); C49(1.11)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C138(1.14); C141(1.14)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C138(1.20); C141(1.20)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C138(1.26); C141(1.26)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C138(1.06); C141(1.06)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C138(0.95); C141(0.95); C292(1.08)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C138(0.94); C141(0.94); C292(1.07)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C138(0.97); C141(0.97); C292(1.12)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C292(1.16); C138(1.24); C141(1.24)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C138(0.92); C141(0.92); C292(0.96)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C292(0.99)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C138(1.11); C141(1.11); C292(1.16)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C292(0.99); C138(1.15); C141(1.15)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C550(0.88)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C550(0.80)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C550(0.77)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C550(1.02)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C550(0.87)  LDD0984  [2]
 LDCM0387  CL117 HEK-293T C550(1.00); C292(0.75); C49(1.02); C138(0.93)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C550(1.11); C966(1.04)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C550(1.00); C292(1.19); C138(1.01); C141(1.01)  LDD1593  [8]
 LDCM0390  CL12 HCT 116 C292(0.97)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C550(1.03); C532(1.09); C127(1.00); C138(1.06)  LDD1595  [8]
 LDCM0392  CL121 HCT 116 C138(1.09); C141(1.09)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C138(1.13); C141(1.13)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C138(1.45); C141(1.45)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C138(1.36); C141(1.36)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C550(0.86); C292(1.07); C49(1.05); C138(0.91)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C550(0.82); C966(0.81)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C550(0.94); C292(1.20); C138(1.00); C141(1.00)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C550(0.94); C532(0.79); C127(1.05); C138(0.96)  LDD1603  [8]
 LDCM0400  CL13 HCT 116 C292(1.02)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C292(0.92)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C292(1.10)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C292(0.83); C138(0.99); C141(0.99)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C292(1.05); C138(1.16); C141(1.16)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C292(0.98); C138(1.18); C141(1.18)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C292(0.98); C138(1.08); C141(1.08)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C292(0.90)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C292(1.12); C138(1.26); C141(1.26)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C138(1.08); C141(1.08); C292(1.31)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C138(1.17); C141(1.17); C292(1.32)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C292(0.84); C138(0.99); C141(0.99)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C138(1.15); C141(1.15); C292(1.08)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C138(1.21); C141(1.21); C292(1.04)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C138(0.98); C141(0.98); C292(0.90)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C138(1.30); C141(1.30); C292(1.13)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C138(1.24); C141(1.24); C292(0.75)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C138(1.27); C141(1.27); C292(1.20)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C292(1.06)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C138(1.36); C141(1.36); C292(0.93)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C292(0.81)  LDD0737  [2]
 LDCM0421  CL32 HEK-293T C550(1.13); C292(1.02); C966(1.01)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C550(0.91); C292(1.09); C966(0.89); C138(3.61)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C550(0.94); C292(1.03); C138(4.57); C141(4.57)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C550(0.90); C292(0.97); C138(5.20); C141(5.20)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C550(1.02); C292(0.96); C127(1.02); C138(2.85)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C550(0.94); C292(0.78); C49(0.94); C138(0.89)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C550(0.91); C292(1.56); C138(1.31); C141(1.31)  LDD1632  [8]
 LDCM0429  CL4 HCT 116 C292(1.68)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C550(1.03); C532(1.02); C127(1.13); C138(1.06)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C550(1.08); C966(0.87)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C550(0.84); C292(0.98); C49(1.00); C127(0.99)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C550(0.93)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C550(1.03); C292(0.96); C966(1.34)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C550(0.93); C292(1.07); C966(0.95); C138(2.93)  LDD1639  [8]
 LDCM0436  CL46 HCT 116 C138(2.18); C141(2.18); C49(1.10)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C138(1.01); C141(1.01); C49(0.99)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C138(1.27); C141(1.27); C49(0.97)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C138(1.94); C141(1.94); C49(0.81)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C292(1.00)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C138(1.70); C141(1.70); C49(0.95)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C138(1.73); C141(1.73); C49(0.83)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C138(1.95); C141(1.95); C49(1.23)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C138(1.05); C141(1.05); C49(1.25)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C138(1.35); C141(1.35); C49(1.11)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C138(1.21); C141(1.21); C49(1.11)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C138(0.91); C141(0.91); C49(0.82)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C138(1.12); C141(1.12); C49(0.80)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C138(1.53); C141(1.53); C49(1.36)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C138(1.03); C141(1.03); C49(0.93)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C292(0.98)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C138(1.95); C141(1.95); C49(0.88)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C292(1.22)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C292(1.17)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C292(1.19)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C292(1.38)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C292(1.03)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C292(1.26)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C292(1.15)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C292(1.33)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C292(1.11)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C292(1.04)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C292(1.19)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C292(1.42)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C292(1.04)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C292(1.42)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C292(1.19)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C138(0.92); C141(0.92)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C138(0.73); C141(0.73)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C138(0.72); C141(0.72)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C138(0.80); C141(0.80)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C292(0.97)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C138(0.92); C141(0.92)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C138(0.74); C141(0.74)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C138(0.86); C141(0.86)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C138(0.80); C141(0.80)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C138(0.85); C141(0.85)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C138(0.86); C141(0.86)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C138(0.75); C141(0.75)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C138(0.76); C141(0.76)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C138(0.79); C141(0.79)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C138(0.77); C141(0.77)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C292(1.13)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C138(0.75); C141(0.75)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C138(0.96); C141(0.96); C292(1.22); C49(1.06)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C138(0.83); C141(0.83); C292(0.94); C49(1.14)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C138(0.96); C141(0.96); C292(0.83); C49(0.95)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C138(0.98); C141(0.98); C292(0.82); C49(1.09)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C138(0.98); C141(0.98); C292(1.48); C49(1.84)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C138(0.81); C141(0.81); C292(1.06); C49(1.14)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C138(1.02); C141(1.02); C292(1.24); C49(1.16)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C138(1.09); C141(1.09); C292(1.21); C49(1.06)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C138(0.99); C141(0.99); C292(1.16); C49(1.08)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C550(1.03); C292(1.17); C138(1.31); C141(1.31)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C292(1.01)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C550(1.09); C966(1.05)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C550(1.01)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C550(0.99)  LDD1497  [8]
 LDCM0024  KB05 HMCB C966(1.40)  LDD3312  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C292(2.44)  LDD2153  [1]
 LDCM0021  THZ1 HCT 116 C103(1.19); C106(1.19)  LDD2173  [2]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840