Details of the Target

General Information of Target

Target ID LDTP12545
Target Name Protein kish-B (TMEM167B)
Gene Name TMEM167B
Gene ID 56900
Synonyms
C1orf119; Protein kish-B; Transmembrane protein 167B
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGSVLGLCSMASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYALFLLVGVCVACVMLIPG
MEEQLNKIPGFCENEKGVVPCNILVGYKAVYRLCFGLAMFYLLLSLLMIKVKSSSDPRAA
VHNGFWFFKFAAAIAIIIGAFFIPEGTFTTVWFYVGMAGAFCFILIQLVLLIDFAHSWNE
SWVEKMEEGNSRCWYAALLSATALNYLLSLVAIVLFFVYYTHPASCSENKAFISVNMLLC
VGASVMSILPKIQESQPRSGLLQSSVITVYTMYLTWSAMTNEPETNCNPSLLSIIGYNTT
STVPKEGQSVQWWHAQGIIGLILFLLCVFYSSIRTSNNSQVNKLTLTSDESTLIEDGGAR
SDGSLEDGDDVHRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWYRYEPSREMKSQW
TAVWVKISSSWIGIVLYVWTLVAPLVLTNRDFD
Target Bioclass
Other
Family
KISH family
Subcellular location
Golgi apparatus membrane
Function Involved in the early part of the secretory pathway.
Uniprot ID
Q9NRX6
Ensemble ID
ENST00000338272.9
HGNC ID
HGNC:30187

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C107
 Probe Info  		5.86  LDD1794  [1]
C159
 Probe Info  		8.06  LDD1839  [1]
C160
 Probe Info  		9.51  LDD1840  [1]
C161
 Probe Info  		11.16  LDD1841  [1]
C210
 Probe Info  		50.56  LDD1884  [1]
C264
 Probe Info  		17.39  LDD1935  [1]
C388
 Probe Info  		39.95  LDD2047  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q9NRZ7
Palmitoyltransferase ZDHHC21 (ZDHHC21) DHHC palmitoyltransferase family Q8IVQ6
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Microsomal glutathione S-transferase 2 (MGST2) MAPEG family Q99735
Sphingomyelin phosphodiesterase 2 (SMPD2) Neutral sphingomyelinase family O60906
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
Lanosterol synthase (LSS) Terpene cyclase/mutase family P48449
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) . Q9NTJ5
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane 4 L6 family member 19 (TM4SF19) L6 tetraspanin family Q96DZ7
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Aquaporin-10 (AQP10) MIP/aquaporin (TC 1.A.8) family Q96PS8
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Sodium-dependent phosphate transport protein 2C (SLC34A3) SLC34A transporter family Q8N130
LETM1 domain-containing protein 1 (LETMD1) . Q6P1Q0
Transmembrane protein 100 (TMEM100) . Q9NV29
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Taste receptor type 2 member 19 (TAS2R19) G-protein coupled receptor T2R family P59542
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CMRF35-like molecule 6 (CD300C) CD300 family Q08708
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atypical chemokine receptor 2 (ACKR2) G-protein coupled receptor 1 family O00590
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cortexin-3 (CTXN3) Cortexin family Q4LDR2
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Plasmolipin (PLLP) MAL family Q9Y342
Vesicle-trafficking protein SEC22b (SEC22B) Synaptobrevin family O75396
Syntaxin-12 (STX12) Syntaxin family Q86Y82
Syntaxin-1B (STX1B) Syntaxin family P61266
Protein unc-50 homolog (UNC50) Unc-50 family Q53HI1
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC) . Q8N912
Transmembrane protein 107 (TMEM107) . Q6UX40

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587