Details of the Target

General Information of Target

Target ID LDTP12436
Target Name Serine/threonine-protein kinase PAK 6 (PAK6)
Gene Name PAK6
Gene ID 106821730
Synonyms
PAK5; Serine/threonine-protein kinase PAK 6; EC 2.7.11.1; PAK-5; p21-activated kinase 6; PAK-6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDSKVKVAVRIRPMNRRETDLHTKCVVDVDANKVILNPVNTNLSKGDARGQPKVFAYDH
CFWSMDESVKEKYAGQDIVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQP
GLIPRLCSGLFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLG
PYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSG
TSGEKVGKLSLVDLAGSERATKTGAAGDRLKEGSNINKSLTTLGLVISALADQSAGKNKN
KFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVN
EDPNARIIRDLREEVEKLREQLTKAEAMKSPELKDRLEESEKLIQEMTVTWEEKLRKTEE
IAQERQKQLESLGISLQSSGIKVGDDKCFLVNLNADPALNELLVYYLKEHTLIGSANSQD
IQLCGMGILPEHCIIDITSEGQVMLTPQKNTRTFVNGSSVSSPIQLHHGDRILWGNNHFF
RLNLPKKKKKAEREDEDQDPSMKNENSSEQLDVDGDSSSEVSSEVNFNYEYAQMEVTMKA
LGSNDPMQSILNSLEQQHEEEKRSALERQRLMYEHELEQLRRRLSPEKQNCRSMDRFSFH
SPSAQQRLRQWAEEREATLNNSLMRLREQIVKANLLVREANYIAEELDKRTEYKVTLQIP
ASSLDANRKRGSLLSEPAIQVRRKGKGKQIWSLEKLDNRLLDMRDLYQEWKECEEDNPVI
RSYFKRADPFYDEQENHSLIGVANVFLESLFYDVKLQYAVPIINQKGEVAGRLHVEVMRL
SGDVGERIAGGDEVAEVSFEKETQENKLVCMVKILQATGLPQHLSHFVFCKYSFWDQQEP
VIVAPEVDTSSSSVSKEPHCMVVFDHCNEFSVNITEDFIEHLSEGALAIEVYGHKINDPR
KNPALWDLGIIQAKTRSLRDRWSEVTRKLEFWVQILEQNENGEYCPVEVISAKDVPTGGI
FQLRQGQSRRVQVEVKSVQESGTLPLMEECILSVGIGCVKVRPLRAPRTHETFHEEEEDM
DSYQDRDLERLRRKWLNALTKRQEYLDQQLQKLVSKRDKTEDDADREAQLLEMRLTLTEE
RNAVMVPSAGSGIPGAPAEWTPVPGMETHIPVIFLDLNADDFSSQDNLDDPEAGGWDATL
TGEEEEEFFELQIVKQHDGEVKAEASWDSAVHGCPQLSRGTPVDERLFLIVRVTVQLSHP
ADMQLVLRKRICVNVHGRQGFAQSLLKKMSHRSSIPGCGVTFEIVSNIPEDAQGVEEREA
LARMAANVENPASADSEAYIEKYLRSVLAVENLLTLDRLRQEVAVKEQLTGKGKLSRRSI
SSPNVNRLSGSRQDLIPSYSLGSNKGRWESQQDVSQTTVSRGIAPAPALSVSPQNNHSPD
PGLSNLAASYLNPVKSFVPQMPKLLKSLFPVRDEKRGKRPSPLAHQPVPRIMVQSASPDI
RVTRMEEAQPEMGPDVLVQTMGAPALKICDKPAKVPSPPPVIAVTAVTPAPEAQDGPPSP
LSEASSGYFSHSVSTATLSDALGPGLDAAAPPGSMPTAPEAEPEAPISHPPPPTAVPAEE
PPGPQQLVSPGRERPDLEAPAPGSPFRVRRVRASELRSFSRMLAGDPGCSPGAEGNAPAP
GAGGQALASDSEEADEVPEWLREGEFVTVGAHKTGVVRYVGPADFQEGTWVGVELDLPSG
KNDGSIGGKQYFRCNPGYGLLVRPSRVRRATGPVRRRSTGLRLGAPEARRSATLSGSATN
LASLTAALAKADRSHKNPENRKSWAS
Target Bioclass
Enzyme
Family
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Subcellular location
Cytoplasm
Function
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
Uniprot ID
Q9NQU5
Ensemble ID
ENST00000260404.8
HGNC ID
HGNC:16061
ChEMBL ID
CHEMBL4311

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.S135F .
EFO27 SNV: p.S277N DBIA    Probe Info 
HEC1 SNV: p.R404W .
HT1197 SNV: p.A237S .
JURKAT Deletion: p.R353AfsTer33 .
MCC26 SNV: p.P274A .
MFE296 Deletion: p.P300QfsTer22 .
MFE319 Insertion: p.R353PfsTer28 .
MOLT4 SNV: p.A304V .
NCIH1155 SNV: p.G216E .
RL952 SNV: p.L342F .
TE1 SNV: p.R21C DBIA    Probe Info 
TFK1 SNV: p.G196D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C192(1.85); C198(1.85)  LDD0532  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C192(1.85); C198(1.85)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C192(1.02); C198(1.02)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C192(1.06); C198(1.06)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C192(0.82); C198(0.82)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C192(1.29); C198(1.29)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C192(1.09); C198(1.09)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C192(1.25); C198(1.25)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C192(1.86); C198(1.86)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C192(1.24); C198(1.24)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C192(1.02); C198(1.02)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C192(0.73); C198(0.73)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C192(1.35); C198(1.35)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C192(1.52); C198(1.52)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C192(1.48); C198(1.48)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C192(1.32); C198(1.32)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C192(1.32); C198(1.32); C548(1.00)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C192(1.23); C198(1.23); C548(0.72)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C192(1.08); C198(1.08); C548(0.65)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C192(1.39); C198(1.39); C548(0.76)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C192(1.26); C198(1.26); C548(0.82)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C192(1.21); C198(1.21); C548(0.81)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C192(1.25); C198(1.25); C548(0.73)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C192(1.13); C198(1.13)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C192(1.48); C198(1.48); C548(0.83)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C192(1.03); C198(1.03); C548(0.86)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C192(1.07); C198(1.07); C548(0.76)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C192(1.30); C198(1.30); C548(0.80)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C192(1.23); C198(1.23); C548(0.90)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C192(1.40); C198(1.40); C548(0.79)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C192(1.39); C198(1.39); C548(0.70)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C192(1.76); C198(1.76); C548(0.70)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C192(0.87); C198(0.87)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C192(0.74); C198(0.74)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C192(0.82); C198(0.82)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C192(0.98); C198(0.98)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C192(1.18); C198(1.18)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C192(1.13); C198(1.13)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C192(1.16); C198(1.16)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C192(1.31); C198(1.31)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C192(1.02); C198(1.02)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C192(1.16); C198(1.16)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C192(0.92); C198(0.92)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C192(1.35); C198(1.35)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C192(1.64); C198(1.64)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C192(1.19); C198(1.19)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C192(1.21); C198(1.21)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C192(1.13); C198(1.13)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C548(0.89); C192(1.19); C198(1.19)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C548(0.55); C192(1.35); C198(1.48)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C548(0.65); C192(1.03); C198(1.20)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C548(0.65); C192(1.24); C198(1.28)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C548(0.57); C192(1.27); C198(1.31)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C548(0.50); C192(1.64); C198(1.90)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C548(0.58); C192(1.38); C198(1.51)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C192(1.94); C198(1.94)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C548(0.79); C192(0.97); C198(0.99)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C548(0.68); C192(0.83); C198(0.96)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C548(0.51); C192(1.03); C198(1.10)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C548(0.53); C192(1.31); C198(1.57)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C192(1.05); C198(1.14); C548(0.62)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C192(1.15); C198(1.39); C548(0.64)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C192(1.20); C198(1.32); C548(0.81)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C192(1.07); C198(1.32); C548(0.79)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C548(0.89); C192(0.89); C198(0.89)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C548(0.73); C192(0.93); C198(0.93)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C192(0.83); C198(0.83); C548(0.87)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C192(0.76); C198(0.76); C548(0.93)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C192(0.77); C198(0.77); C548(0.79)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C192(0.85); C198(0.85); C548(0.97)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C192(0.87); C198(0.87); C548(0.95)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C548(0.88); C192(1.06); C198(1.06)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C548(0.84)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C548(0.79)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C548(0.77)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C548(0.68)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C548(0.73)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C548(0.74)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C548(0.68)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C548(0.63)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C548(0.72)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C548(0.59)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C192(1.09); C198(1.09); C548(1.18)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C548(1.15); C192(1.40); C198(1.40)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C548(1.15); C192(1.21); C198(1.21)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C192(1.06); C198(1.06); C548(1.31)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C192(0.88); C198(0.88); C548(1.12)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C548(1.01); C192(1.09); C198(1.09)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C548(1.06); C192(1.19); C198(1.19)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C192(0.88); C198(0.88); C548(1.04)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C548(1.06); C192(1.17); C198(1.17)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C548(1.02); C192(1.43); C198(1.43)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C548(0.88); C192(1.27); C198(1.27)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C192(1.27); C198(1.27)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C192(1.02); C198(1.02)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C192(1.07); C198(1.07)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C192(1.30); C198(1.30)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C192(1.44); C198(1.44)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C192(0.97); C198(0.97)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C192(1.12); C198(1.12)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C192(0.91); C198(0.91)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C192(1.16); C198(1.16)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C192(1.10); C198(1.10)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C192(0.74); C198(0.74)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C192(0.85); C198(0.85)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C192(0.92); C198(0.92)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C192(0.87); C198(0.87)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C192(2.36); C198(2.36)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C192(1.03); C198(1.03)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C192(0.81); C198(0.81)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C192(1.01); C198(1.01)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C192(1.17); C198(1.17)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C192(1.13); C198(1.13)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C192(1.01); C198(1.01)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C192(1.13); C198(1.13)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C192(1.10); C198(1.10)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C192(0.66); C198(0.66)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C192(0.52); C198(0.52)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C192(1.41); C198(1.41)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C192(0.49); C198(0.49)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C192(0.65); C198(0.65)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C192(0.73); C198(0.73)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C192(0.67); C198(0.67)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C192(0.54); C198(0.54)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C192(0.88); C198(0.88)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C192(0.87); C198(0.87)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C192(0.74); C198(0.74)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C192(0.82); C198(0.82)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C192(0.78); C198(0.78)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C192(1.16); C198(1.16)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C192(0.83); C198(0.83)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C192(0.87); C198(0.87)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C192(0.89); C198(0.89)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C548(0.64); C192(1.15); C198(1.15)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C548(0.69); C192(1.17); C198(1.17)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C548(0.75); C192(1.35); C198(1.35)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C548(0.86); C192(1.40); C198(1.40)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C548(0.92); C192(1.10); C198(1.10)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C548(0.82); C192(0.96); C198(0.96)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C548(0.66); C192(1.22); C198(1.22)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C548(1.40); C192(1.50); C198(1.50)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C548(0.58); C192(1.50); C198(1.50)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C548(0.60); C192(1.44); C198(1.44)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C548(0.76); C192(1.21); C198(1.21)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C548(0.79); C192(1.04); C198(1.04)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C548(0.65); C192(1.37); C198(1.37)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C548(0.71); C192(1.36); C198(1.36)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C548(0.66); C192(1.35); C198(1.35)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C192(1.32); C198(1.32)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C192(1.18); C198(1.18)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C192(1.09); C198(1.09)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C192(1.73); C198(1.73)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C192(3.57); C198(3.57)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C192(0.83); C198(0.83)  LDD2171  [1]
 LDCM0370  CL101 HCT 116 C192(2.37); C198(2.37)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C192(1.49); C198(1.49)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C192(2.98); C198(2.98)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C192(1.65); C198(1.65)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C192(0.57); C198(0.57); C548(0.74)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C548(0.64); C192(0.67); C198(0.67)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C548(0.72); C192(0.79); C198(0.79)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C548(0.64); C192(0.69); C198(0.69)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C548(0.76); C192(0.90); C198(0.90)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C548(0.65); C192(0.97); C198(0.97)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C548(0.77); C192(0.93); C198(0.93)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C548(0.83)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C548(0.62)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C548(0.72)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C548(0.78)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C548(0.75)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C548(0.97); C192(1.18); C198(1.18)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C548(1.00); C192(1.30); C198(1.30)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C548(0.88); C192(1.42); C198(1.42)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C548(0.96); C192(1.27); C198(1.27)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C192(0.88); C198(0.88)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C192(1.28); C198(1.28)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C192(1.17); C198(1.17)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C192(1.50); C198(1.50)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C192(1.10); C198(1.10)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C192(0.97); C198(0.97)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C192(0.95); C198(0.95)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C192(0.88); C198(0.88)  LDD0716  [1]
 LDCM0403  CL16 HCT 116 C192(1.13); C198(1.13)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C192(1.40); C198(1.40)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C192(1.22); C198(1.22)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C192(1.04); C198(1.04)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C192(1.59); C198(1.59)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C192(1.28); C198(1.28)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C192(1.04); C198(1.04)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C192(0.79); C198(0.79)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C192(1.32); C198(1.32)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C192(0.96); C198(0.96)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C192(1.00); C198(1.00)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C192(1.21); C198(1.21)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C192(1.53); C198(1.53)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C192(1.47); C198(1.47)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C192(1.21); C198(1.21)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C192(1.20); C198(1.20); C548(0.88)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C192(0.85); C198(0.85); C548(0.74)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C192(1.46); C198(1.46); C548(0.94)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C192(0.74); C198(0.74); C548(0.79)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C192(1.00); C198(1.00); C548(0.84)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C192(0.89); C198(0.89); C548(0.66)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C192(0.79); C198(0.79); C548(0.65)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C192(0.97); C198(0.97); C548(0.94)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C192(0.99); C198(0.99); C548(0.77)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C192(1.04); C198(1.04); C548(0.87)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C192(0.67); C198(0.67); C548(0.80)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C192(1.06); C198(1.06); C548(0.86)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C192(0.84); C198(0.84); C548(0.79)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C192(0.93); C198(0.93); C548(0.91)  LDD0752  [1]
 LDCM0427  Fragment51 HCT 116 C192(1.11); C198(1.11); C548(0.87)  LDD0744  [1]
 LDCM0022  KB02 42-MG-BA C590(2.11)  LDD2244  [3]
 LDCM0023  KB03 42-MG-BA C590(2.37)  LDD2661  [3]
 LDCM0024  KB05 COLO792 C590(2.77)  LDD3310  [3]
 LDCM0021  THZ1 HCT 116 C192(0.83); C198(0.83)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Rho-related GTP-binding protein RhoJ (RHOJ) Rho family Q9H4E5
Rho-related GTP-binding protein RhoV (RHOV) Rho family Q96L33
Cell division control protein 42 homolog (CDC42) Rho family P60953
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock factor 2-binding protein (HSF2BP) . O75031

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840