Details of the Target

General Information of Target

Target ID LDTP12360
Target Name Ubinuclein-1 (UBN1)
Gene Name UBN1
Gene ID 29855
Synonyms
Ubinuclein-1; HIRA-binding protein; Protein VT4; Ubiquitously expressed nuclear protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSSPEDCLSSPE
FLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHRAVGVKLSSFSTVGESLLYMLEKC
LGPAFTPATRAAWSQLYGAVVQAMSRGWDGE
Target Bioclass
Other
Family
Ubinuclein family
Subcellular location
Nucleus, nucleoplasm
Function
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.
Uniprot ID
Q9NPG3
Ensemble ID
ENST00000262376.11
HGNC ID
HGNC:12506

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.A276V DBIA    Probe Info 
EFO27 SNV: p.Q926H .
HEC1 SNV: p.P509H DBIA    Probe Info 
HGC27 Insertion: p.R716KfsTer7 DBIA    Probe Info 
KYSE30 SNV: p.E752D .
MFE319 SNV: p.L683S; p.G971S .
NCIH2172 SNV: p.G241V DBIA    Probe Info 
PC14 SNV: p.D207H .
REH SNV: p.A1129V .
RKO Deletion: p.S1081PfsTer94 .
SKMEL28 SNV: p.D498H DBIA    Probe Info 
SKMEL30 SNV: p.P1110R .
SUPT1 SNV: p.A227T DBIA    Probe Info 
TE8 SNV: p.K83E DBIA    Probe Info 
TKKK SNV: p.F817C DBIA    Probe Info 
TOV21G SNV: p.A369D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y463(11.99)  LDD0257  [2]
ONAyne
 Probe Info  		N.A.  LDD0273  [3]
BTD
 Probe Info  		C837(0.49)  LDD2089  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
DBIA
 Probe Info  		C420(1.38); C467(1.08)  LDD0078  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
Lodoacetamide azide
 Probe Info  		C548(0.00); C467(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
IPM
 Probe Info  		N.A.  LDD0005  [10]
TFBX
 Probe Info  		C59(0.00); C837(0.00)  LDD0148  [11]
Phosphinate-6
 Probe Info  		C711(0.00); C38(0.00); C837(0.00); C420(0.00)  LDD0018  [12]
Methacrolein
 Probe Info  		C38(0.00); C467(0.00)  LDD0218  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C59(1.28)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C59(1.41)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C59(0.69)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C59(0.83)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C59(0.86)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C59(1.00)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C59(0.94)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C59(0.86)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C59(0.91)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C59(0.93)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C59(0.88)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C59(0.88)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C59(1.49)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C59(0.80)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C59(0.90)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C59(0.83)  LDD0546  [6]
 LDCM0230  AC113 HEK-293T C59(1.15)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C59(1.33)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C59(1.18)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C59(1.22)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C59(1.11)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C59(1.07)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C59(1.17)  LDD0834  [6]
 LDCM0237  AC12 HCT 116 C59(1.32)  LDD0554  [6]
 LDCM0238  AC120 HEK-293T C59(1.07)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C59(1.31)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C59(1.26)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C59(1.23)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C59(1.44)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C59(1.30)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C59(1.32)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C59(1.19)  LDD0843  [6]
 LDCM0246  AC128 HCT 116 C59(1.11)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C59(0.74)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C59(1.03)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C59(0.85)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C59(1.01)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C59(0.90)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C59(1.05)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C59(1.07)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C59(0.96)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C59(0.89)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C59(1.04)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C59(1.04)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C59(1.22)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C59(1.05)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C59(0.93)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C59(0.92)  LDD0579  [6]
 LDCM0263  AC143 HEK-293T C59(0.74)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C59(0.79)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C59(0.84)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C59(0.76)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C59(0.66)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C59(0.74)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C59(0.75)  LDD0867  [6]
 LDCM0270  AC15 HCT 116 C59(1.42)  LDD0587  [6]
 LDCM0271  AC150 HEK-293T C59(0.85)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C59(0.75)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C59(0.87)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C59(0.68)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C59(0.83)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C59(0.85)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C59(0.88)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C59(0.64)  LDD2165  [6]
 LDCM0276  AC17 HEK-293T C38(0.98); C765(0.83); C711(1.19); C524(0.96)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C38(1.11); C765(1.08); C467(1.22); C420(1.03)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C38(0.97); C765(1.25); C467(1.23); C420(0.94)  LDD1517  [13]
 LDCM0279  AC2 HCT 116 C59(1.14)  LDD0596  [6]
 LDCM0280  AC20 HEK-293T C38(0.99); C765(0.96); C711(1.01); C467(1.11)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C38(1.23); C765(0.97); C711(1.13); C837(0.92)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C38(1.02); C765(0.83); C711(1.01); C467(0.82)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C38(1.00); C765(1.08); C711(0.98); C420(0.97)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C38(0.95); C765(1.02); C837(1.18); C467(1.04)  LDD1523  [13]
 LDCM0285  AC25 PaTu 8988t C59(1.03)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C59(1.26)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C59(1.50)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C59(1.63)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C59(1.26)  LDD1168  [6]
 LDCM0290  AC3 HCT 116 C59(1.08)  LDD0607  [6]
 LDCM0291  AC30 PaTu 8988t C59(1.09)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C59(1.15)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C59(1.29)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C59(1.39)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C59(0.92)  LDD1174  [6]
 LDCM0296  AC35 PaTu 8988t C59(1.23)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C59(1.63)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C59(1.21)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C59(1.43)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C59(1.53)  LDD1179  [6]
 LDCM0301  AC4 HCT 116 C59(1.23)  LDD0618  [6]
 LDCM0302  AC40 PaTu 8988t C59(1.59)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C59(1.07)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C59(1.17)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C59(1.25)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C59(1.35)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C59(1.20)  LDD1186  [6]
 LDCM0308  AC46 HEK-293T C38(0.97); C765(0.81); C711(1.02); C467(0.93)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C38(0.79); C765(1.01); C711(0.98); C420(0.92)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C38(1.10); C765(1.14); C837(1.11); C467(1.07)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C38(1.12); C765(1.00); C711(1.16); C524(1.02)  LDD1550  [13]
 LDCM0312  AC5 HCT 116 C59(1.32)  LDD0629  [6]
 LDCM0313  AC50 HEK-293T C38(1.13); C765(1.05); C467(1.05); C420(0.99)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C38(0.97); C765(0.99); C467(1.02); C420(0.95)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C38(0.98); C765(1.15); C711(1.06); C467(1.16)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C38(1.05); C765(0.93); C711(0.89); C837(0.90)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C38(0.90); C765(0.93); C711(0.95); C467(0.86)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C38(1.08); C765(0.87); C711(0.95); C420(1.01)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C38(1.05); C765(1.08); C837(0.99); C467(1.01)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C38(1.03); C765(1.07); C711(0.99); C524(1.04)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C38(1.24); C765(1.06); C467(1.06); C420(1.12)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C38(0.95); C765(0.97); C467(1.05); C420(0.96)  LDD1561  [13]
 LDCM0323  AC6 HCT 116 C59(1.10)  LDD0640  [6]
 LDCM0324  AC60 HEK-293T C38(0.98); C765(1.06); C711(0.99); C467(0.93)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C38(0.91); C765(0.84); C711(1.03); C837(0.92)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C38(0.95); C765(0.96); C711(0.97); C467(1.01)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C38(1.09); C765(1.03); C711(1.02); C420(0.87)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C38(1.18); C765(0.98); C837(0.98); C467(1.01)  LDD1567  [13]
 LDCM0332  AC68 PaTu 8988t C59(0.95)  LDD1211  [6]
 LDCM0333  AC69 PaTu 8988t C59(0.92)  LDD1212  [6]
 LDCM0334  AC7 HCT 116 C59(1.29)  LDD0651  [6]
 LDCM0335  AC70 PaTu 8988t C59(0.85)  LDD1214  [6]
 LDCM0336  AC71 PaTu 8988t C59(0.85)  LDD1215  [6]
 LDCM0337  AC72 PaTu 8988t C59(0.93)  LDD1216  [6]
 LDCM0338  AC73 PaTu 8988t C59(0.87)  LDD1217  [6]
 LDCM0339  AC74 PaTu 8988t C59(1.29)  LDD1218  [6]
 LDCM0340  AC75 PaTu 8988t C59(0.97)  LDD1219  [6]
 LDCM0341  AC76 PaTu 8988t C59(0.99)  LDD1220  [6]
 LDCM0342  AC77 PaTu 8988t C59(1.00)  LDD1221  [6]
 LDCM0343  AC78 PaTu 8988t C59(0.89)  LDD1222  [6]
 LDCM0344  AC79 PaTu 8988t C59(1.03)  LDD1223  [6]
 LDCM0345  AC8 HCT 116 C59(1.15)  LDD0662  [6]
 LDCM0346  AC80 PaTu 8988t C59(1.18)  LDD1225  [6]
 LDCM0347  AC81 PaTu 8988t C59(0.90)  LDD1226  [6]
 LDCM0348  AC82 PaTu 8988t C59(0.96)  LDD1227  [6]
 LDCM0349  AC83 PaTu 8988t C59(1.09)  LDD1228  [6]
 LDCM0350  AC84 PaTu 8988t C59(1.14)  LDD1229  [6]
 LDCM0351  AC85 PaTu 8988t C59(1.14)  LDD1230  [6]
 LDCM0352  AC86 PaTu 8988t C59(1.13)  LDD1231  [6]
 LDCM0353  AC87 PaTu 8988t C59(1.03)  LDD1232  [6]
 LDCM0354  AC88 PaTu 8988t C59(1.02)  LDD1233  [6]
 LDCM0355  AC89 PaTu 8988t C59(1.13)  LDD1234  [6]
 LDCM0357  AC90 PaTu 8988t C59(1.00)  LDD1236  [6]
 LDCM0358  AC91 PaTu 8988t C59(1.04)  LDD1237  [6]
 LDCM0359  AC92 PaTu 8988t C59(1.15)  LDD1238  [6]
 LDCM0360  AC93 PaTu 8988t C59(1.01)  LDD1239  [6]
 LDCM0361  AC94 PaTu 8988t C59(0.99)  LDD1240  [6]
 LDCM0362  AC95 PaTu 8988t C59(1.07)  LDD1241  [6]
 LDCM0363  AC96 PaTu 8988t C59(0.94)  LDD1242  [6]
 LDCM0364  AC97 PaTu 8988t C59(1.05)  LDD1243  [6]
 LDCM0365  AC98 HCT 116 C59(0.93)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C59(0.95)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C59(1.16)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C59(1.09)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C59(1.55)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C420(1.38); C467(1.08)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0632  CL-Sc Hep-G2 C467(20.00)  LDD2227  [9]
 LDCM0367  CL1 PaTu 8988t C59(0.96)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C59(1.01)  LDD1247  [6]
 LDCM0369  CL100 HCT 116 C59(1.07)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C59(1.68)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C59(1.25)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C59(0.87)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C59(1.37)  LDD0690  [6]
 LDCM0374  CL105 HEK-293T C38(0.79); C765(0.92); C711(1.10)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C38(0.79); C765(0.96); C711(1.09); C467(0.91)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C38(0.82); C765(0.94); C711(0.97); C467(1.03)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C38(1.04); C765(0.94); C711(0.96); C548(1.08)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C38(0.68); C765(1.11); C711(1.17)  LDD1582  [13]
 LDCM0379  CL11 PaTu 8988t C59(0.80)  LDD1258  [6]
 LDCM0380  CL110 HEK-293T C38(0.96); C765(1.07); C711(1.18); C467(0.87)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C38(0.73); C765(0.92); C711(1.01); C467(1.05)  LDD1585  [13]
 LDCM0382  CL112 PaTu 8988t C59(1.06)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C59(1.18)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C59(1.05)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C59(0.91)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C59(1.39)  LDD1265  [6]
 LDCM0387  CL117 PaTu 8988t C59(1.00)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C59(1.06)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C59(1.34)  LDD1268  [6]
 LDCM0390  CL12 PaTu 8988t C59(1.04)  LDD1269  [6]
 LDCM0391  CL120 PaTu 8988t C59(1.46)  LDD1270  [6]
 LDCM0392  CL121 HEK-293T C38(0.82); C765(1.17); C711(1.04)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C38(1.02); C765(1.06); C711(0.99); C467(0.95)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C38(0.92); C765(0.91); C711(0.90); C467(0.96)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C38(1.05); C765(0.98); C711(0.98); C548(1.19)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C38(0.67); C765(0.99); C711(1.03)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C38(0.88); C765(1.02); C711(1.07); C467(0.91)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C38(0.79); C765(0.90); C711(0.98); C467(1.11)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C38(1.21); C765(1.01); C711(0.91); C548(1.01)  LDD1603  [13]
 LDCM0400  CL13 PaTu 8988t C59(1.43)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C59(1.39)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C59(1.13)  LDD1281  [6]
 LDCM0403  CL16 HCT 116 C59(1.08)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C59(1.04)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C59(1.64)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C59(1.15)  LDD0723  [6]
 LDCM0407  CL2 PaTu 8988t C59(0.93)  LDD1286  [6]
 LDCM0408  CL20 HCT 116 C59(1.14)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C59(1.43)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C59(1.43)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C59(1.30)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C59(1.41)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C59(1.13)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C59(1.20)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C59(1.31)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C59(1.32)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C59(1.34)  LDD0734  [6]
 LDCM0418  CL3 PaTu 8988t C59(1.20)  LDD1297  [6]
 LDCM0419  CL30 HCT 116 C59(1.28)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C59(0.97)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C59(1.05)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C59(1.11)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C59(1.25)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C59(1.06)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C59(1.02)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C59(1.17)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C59(1.04)  LDD0745  [6]
 LDCM0429  CL4 PaTu 8988t C59(1.15)  LDD1308  [6]
 LDCM0430  CL40 HCT 116 C59(1.01)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C59(1.09)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C59(1.39)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C59(1.21)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C59(1.16)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C59(1.25)  LDD0752  [6]
 LDCM0436  CL46 HEK-293T C59(0.87)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C59(0.71)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C59(0.75)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C59(1.31)  LDD1037  [6]
 LDCM0440  CL5 PaTu 8988t C59(1.30)  LDD1319  [6]
 LDCM0441  CL50 HEK-293T C59(1.15)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C59(0.87)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C59(0.82)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C59(0.59)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C59(1.00)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C59(0.60)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C59(0.84)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C59(0.69)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C59(0.78)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C59(1.07)  LDD1048  [6]
 LDCM0451  CL6 PaTu 8988t C59(1.03)  LDD1330  [6]
 LDCM0452  CL60 HEK-293T C59(1.22)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C38(0.76); C765(1.06); C711(0.99)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C38(1.03); C765(0.99); C711(1.08); C467(0.98)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C38(0.74); C765(0.82); C711(1.02); C467(1.02)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C38(0.98); C765(0.98); C711(1.03); C548(0.98)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C38(1.16); C765(1.04); C711(1.27); C524(1.01)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C38(1.17); C765(1.02); C467(1.01); C420(1.18)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C38(1.04); C765(0.95); C467(1.04); C420(1.03)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C38(1.00); C765(1.18); C711(0.98); C467(1.11)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C38(1.34); C765(0.86); C711(0.96); C837(1.03)  LDD1664  [13]
 LDCM0462  CL7 PaTu 8988t C59(1.11)  LDD1341  [6]
 LDCM0463  CL70 HEK-293T C38(1.21); C765(0.93); C711(1.07); C467(0.79)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C38(0.91); C765(0.98); C711(1.01); C420(0.93)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C38(1.19); C765(1.05); C837(1.10); C467(0.97)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C38(0.77); C765(1.03); C711(1.12)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C38(0.76); C765(0.99); C711(1.05); C467(0.99)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C59(0.95)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C59(0.90)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C59(1.23)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C59(1.02)  LDD1070  [6]
 LDCM0473  CL8 PaTu 8988t C59(1.14)  LDD1352  [6]
 LDCM0474  CL80 HEK-293T C59(1.27)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C59(1.25)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C59(0.82)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C59(0.78)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C59(1.13)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C59(1.16)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C59(1.43)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C59(0.92)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C59(0.93)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C59(1.01)  LDD1081  [6]
 LDCM0484  CL9 PaTu 8988t C59(1.15)  LDD1363  [6]
 LDCM0485  CL90 HEK-293T C59(0.80)  LDD1083  [6]
 LDCM0486  CL91 HCT 116 C59(1.05)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C59(1.04)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C59(1.10)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C59(1.07)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C59(1.10)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C59(1.04)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C59(1.05)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C59(1.24)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C59(1.12)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C38(0.81); C765(0.77); C711(1.06); C467(0.96)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C837(2.58); C467(0.77)  LDD1702  [4]
 LDCM0468  Fragment33 HEK-293T C38(0.81); C765(0.85); C711(1.04); C467(1.13)  LDD1671  [13]
 LDCM0427  Fragment51 HCT 116 C59(1.24)  LDD0744  [6]
 LDCM0022  KB02 HCT 116 C59(2.48)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C59(2.46)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C59(2.02)  LDD0082  [6]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C837(0.49)  LDD2089  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C837(0.99)  LDD2093  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C837(0.94)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C837(1.18)  LDD2111  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C837(0.87)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C837(0.70)  LDD2125  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C837(0.79)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C837(1.19)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C837(1.06)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C837(0.99)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C837(0.68)  LDD2140  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C837(0.80)  LDD2146  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein HIRA (HIRA) WD repeat HIR1 family P54198

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402