Details of the Target

General Information of Target

Target ID LDTP12320
Target Name Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)
Gene Name TNFRSF12A
Gene ID 51330
Synonyms
FN14; Tumor necrosis factor receptor superfamily member 12A; Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD antigen CD266
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASMARRLWPLLTRRGFRPRGGCISNDSPRRSFTTEKRNRNLLYEYAREGYSALPQLDI
ERFCACPEEAAHALELRKGELRSADLPAIISTWQELRQLQEQIRSLEEEKAAVTEAVRAL
LANQDSGEVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPV
GDESQARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQH
GLVNFTFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNIDPARFKDLNLAGTA
EVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNTGQEPRGLYRVHHFTKVEMFGVTGPG
LEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFGEVT
SASNCTDFQSRRLHIMFQTEAGELQFAHTVNATACAVPRLLIALLESNQQKDGSVLVPPA
LQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS
Target Type
Clinical trial
Target Bioclass
Cytokine and receptor
Subcellular location
Membrane
Function Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
TTD ID
T28717
Uniprot ID
Q9NP84
DrugMap ID
TTKPS7V
Ensemble ID
ENST00000326577.9
HGNC ID
HGNC:18152
ChEMBL ID
CHEMBL3712850

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH2172 SNV: p.I114T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K48(4.20)  LDD3494  [1]
IPM
 Probe Info  		C36(4.08)  LDD1701  [2]
DBIA
 Probe Info  		C122(1.14); C49(1.40); C64(1.27); C67(1.27)  LDD0533  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C122(1.14); C49(1.40); C64(1.27); C67(1.27)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C122(1.08); C49(1.26); C64(1.13); C67(1.13)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C122(1.16); C49(0.70); C64(1.11); C67(1.11)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C122(1.18); C49(1.11); C64(1.24); C67(1.24)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C122(1.10); C49(0.85); C64(1.08); C67(1.08)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C122(1.17); C49(1.24); C64(1.12); C67(1.12)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C122(1.22); C49(1.52); C64(1.78); C67(1.78)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C122(1.08); C49(0.93); C64(1.32); C67(1.32)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C122(1.17); C49(1.19); C64(1.39); C67(1.39)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C122(1.05); C49(0.92); C64(0.99); C67(0.99)  LDD0542  [3]
 LDCM0227  AC110 HCT 116 C122(1.27); C49(0.91); C64(1.29); C67(1.29)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C122(1.38); C49(1.14); C64(1.18); C67(1.18)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C122(1.28); C49(0.92); C64(1.24); C67(1.24)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C122(0.80); C64(0.96); C67(0.96)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C122(0.91); C64(1.31); C67(1.18)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C122(0.93); C64(1.10); C67(1.13)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C122(0.86); C64(1.00); C67(1.28)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C122(0.89); C64(0.77); C67(1.24)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C122(0.86); C64(1.27); C67(1.24)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C122(0.82); C64(0.95); C67(1.25)  LDD0553  [3]
 LDCM0238  AC120 HCT 116 C122(1.20); C64(1.08); C67(1.10)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C122(0.90); C64(1.26); C67(0.82)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C122(0.95); C64(0.85); C67(1.01)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C122(1.14); C64(0.77); C67(0.90)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C122(0.85); C64(1.51); C67(1.15)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C122(1.21); C64(1.47); C67(1.37)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C122(0.91); C64(1.26); C67(0.94)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C122(0.94); C64(1.36); C67(1.06)  LDD0562  [3]
 LDCM0263  AC143 HCT 116 C49(1.36)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C49(2.75)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C49(1.58)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C49(1.87)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C49(1.68)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C49(1.71)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C49(2.17)  LDD0586  [3]
 LDCM0271  AC150 HCT 116 C49(1.59)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C49(1.66)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C49(1.16)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C49(1.81)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C49(2.78)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C49(2.10)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C49(1.33)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C49(1.49)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C67(0.84); C52(1.11)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C67(0.54); C52(1.13)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C67(0.69); C52(1.67)  LDD0595  [3]
 LDCM0280  AC20 HCT 116 C67(1.13); C52(1.14)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C67(0.47); C52(0.82)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C67(0.47); C52(0.73)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C67(0.60); C52(0.91)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C67(1.25); C52(1.59)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C49(0.98); C64(0.99); C67(0.99)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C64(1.18); C67(1.18); C49(1.22)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C64(1.19); C67(1.19); C49(1.36)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C49(1.19); C64(1.29); C67(1.29)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C64(1.38); C67(1.38); C49(1.48)  LDD0606  [3]
 LDCM0291  AC30 HCT 116 C49(1.05); C64(1.23); C67(1.23)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C49(0.90); C64(1.29); C67(1.29)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C49(1.07); C64(1.43); C67(1.43)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C64(1.31); C67(1.31); C49(1.50)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C64(1.10); C67(1.10); C49(1.54)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C122(0.39); C49(0.71)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C49(0.57); C122(0.67)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C122(0.52); C49(0.70)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C122(0.68); C49(0.99)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C122(0.49); C49(0.72)  LDD0617  [3]
 LDCM0302  AC40 HCT 116 C122(0.68); C49(0.98)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C122(0.57); C49(0.72)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C122(0.53); C49(0.66)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C122(0.64); C49(0.97)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C122(0.58); C49(0.79)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C122(0.68); C49(1.01)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C64(1.03); C67(1.03); C49(1.20)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C64(1.07); C67(1.07); C49(1.15)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C64(1.07); C67(1.07); C49(1.32)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C49(1.05); C64(1.30); C67(1.30)  LDD0628  [3]
 LDCM0313  AC50 HCT 116 C49(0.99); C64(1.30); C67(1.30)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C49(1.12); C64(1.44); C67(1.44)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C64(1.09); C67(1.09); C49(1.46)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C49(1.12); C64(1.23); C67(1.23)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C64(0.99); C67(0.99); C49(1.84)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C64(1.20); C67(1.20); C49(1.92)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C64(1.44); C67(1.44); C49(1.80)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C64(1.06); C67(1.06); C49(1.43)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C64(1.12); C67(1.12); C49(1.19)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C64(0.99); C67(0.99); C49(1.78)  LDD0639  [3]
 LDCM0324  AC60 HCT 116 C64(1.28); C67(1.28); C49(1.43)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C64(1.37); C67(1.37); C49(1.53)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C49(1.24); C64(1.66); C67(1.66)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C64(1.19); C67(1.19); C49(1.25)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C64(1.34); C67(1.34); C49(2.03)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C49(0.77); C64(2.71); C67(2.71)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C49(0.75); C64(1.80); C67(1.80)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C49(0.50); C64(1.31); C67(1.31)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C52(0.82); C64(0.85); C67(0.85); C49(1.25)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C52(0.74); C49(0.87); C64(0.88); C67(0.88)  LDD0650  [3]
 LDCM0335  AC70 HCT 116 C52(0.69); C64(0.83); C67(0.83); C49(0.89)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C64(0.76); C67(0.76); C52(0.90); C49(1.07)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C64(0.79); C67(0.79); C52(0.91); C49(1.06)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C52(0.51); C64(0.80); C67(0.80); C49(0.98)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C52(0.43); C49(0.69); C64(0.79); C67(0.79)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C52(0.38); C49(0.80); C64(0.92); C67(0.92)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C52(0.68); C49(1.06); C64(1.07); C67(1.07)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C64(0.86); C67(0.86); C52(0.89); C49(1.00)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C64(0.78); C67(0.78); C52(1.04); C49(1.25)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C52(0.83); C49(1.06); C64(1.15); C67(1.15)  LDD0661  [3]
 LDCM0346  AC80 HCT 116 C52(0.78); C64(0.86); C67(0.86); C49(0.98)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C52(0.87); C49(0.94); C64(0.96); C67(0.96)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C52(0.21); C49(0.57); C64(0.87); C67(0.87)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C64(1.08); C67(1.08)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C64(0.86); C67(0.86)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C64(1.23); C67(1.23)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C64(0.88); C67(0.88)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C64(0.85); C67(0.85)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C64(1.13); C67(1.13)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C64(1.02); C67(1.02)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C64(1.24); C67(1.24)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C64(1.03); C67(1.03)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C64(1.25); C67(1.25)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C64(1.10); C67(1.10)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C64(1.47); C67(1.47)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C64(1.20); C67(1.20)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C64(1.60); C67(1.60)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C64(1.62); C67(1.62)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C49(0.61); C122(1.18); C64(1.37); C67(1.37)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C49(0.83); C122(1.01); C64(1.57); C67(1.57)  LDD0683  [3]
 LDCM0632  CL-Sc Hep-G2 C122(20.00); C122(1.00)  LDD2227  [4]
 LDCM0374  CL105 HCT 116 C67(0.70); C52(0.99)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C67(0.65); C52(1.18)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C67(0.87); C52(0.97)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C67(0.59); C52(1.01)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C67(0.58); C52(1.49)  LDD0695  [3]
 LDCM0380  CL110 HCT 116 C67(0.71); C52(1.41)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C52(0.80); C67(1.19)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C49(0.65); C64(0.86); C67(0.86)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C64(1.19); C67(1.19); C49(1.23)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C49(0.96); C64(1.15); C67(1.15)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C64(0.99); C67(0.99); C49(1.10)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C64(1.08); C67(1.08); C49(1.38)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C122(0.59); C49(0.64)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C122(0.51); C49(0.56)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C122(0.57); C49(0.87)  LDD0706  [3]
 LDCM0391  CL120 HCT 116 C122(0.53); C49(0.69)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C49(0.56); C64(1.12); C67(1.12)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C49(1.03); C64(1.19); C67(1.19)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C64(1.10); C67(1.10); C49(1.50)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C49(1.03); C64(1.41); C67(1.41)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C49(0.85); C64(1.29); C67(1.29)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C49(0.64); C64(1.27); C67(1.27)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C49(0.75); C64(1.12); C67(1.12)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C49(1.43); C64(1.56); C67(1.56)  LDD0716  [3]
 LDCM0403  CL16 HCT 116 C49(0.59)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C49(0.99)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C49(1.06)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C49(0.81)  LDD0723  [3]
 LDCM0408  CL20 HCT 116 C49(1.11)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C49(0.90)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C49(0.92)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C49(1.52)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C49(1.29)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C49(0.96)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C49(0.82)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C49(1.06)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C49(0.81)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C49(1.47)  LDD0734  [3]
 LDCM0419  CL30 HCT 116 C49(0.90)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C122(0.94); C52(1.31)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C122(1.21); C52(1.16)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C122(1.49); C52(0.92)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C122(1.24); C52(1.39)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C122(1.20); C52(1.34)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C122(1.08); C52(1.00)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C122(1.27); C52(1.25)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C122(1.19); C52(1.58)  LDD0745  [3]
 LDCM0430  CL40 HCT 116 C122(1.42); C52(0.98)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C122(0.99); C52(1.07)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C122(1.20); C52(1.39)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C122(1.22); C52(1.56)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C122(1.11); C52(1.37)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C122(1.21); C52(0.95)  LDD0752  [3]
 LDCM0453  CL61 HCT 116 C122(1.05); C52(0.85); C64(1.20); C67(1.20)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C122(0.97); C52(0.79); C64(1.24); C67(1.24)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C122(1.15); C52(0.94); C64(1.29); C67(1.29)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C122(1.19); C52(0.92); C64(1.44); C67(1.44)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C122(1.15); C52(0.91); C64(1.01); C67(1.01)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C122(1.01); C52(1.15); C64(1.09); C67(1.09)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C122(1.14); C52(1.24); C64(0.92); C67(0.92)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C122(1.65); C52(1.13); C64(1.23); C67(1.23)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C122(1.52); C52(1.02); C64(1.34); C67(1.34)  LDD0778  [3]
 LDCM0463  CL70 HCT 116 C122(1.15); C52(1.28); C64(1.21); C67(1.21)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C122(1.30); C52(0.79); C64(1.12); C67(1.12)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C122(1.73); C52(1.26); C64(0.96); C67(0.96)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C122(1.70); C52(1.10); C64(1.09); C67(1.09)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C122(1.47); C52(1.44); C64(1.07); C67(1.07)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C122(0.83)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C122(1.06)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C122(1.08)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C122(0.89)  LDD0789  [3]
 LDCM0474  CL80 HCT 116 C122(0.88)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C122(0.88)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C122(1.17)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C122(0.82)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C122(0.67)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C122(0.59)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C122(0.78)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C122(0.94)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C122(0.78)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C122(0.78)  LDD0800  [3]
 LDCM0485  CL90 HCT 116 C122(0.89)  LDD0802  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C36(1.33)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C122(1.24); C52(1.13); C64(0.99); C67(0.99)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C122(1.30); C52(0.84)  LDD0744  [3]
 LDCM0022  KB02 769-P C87(0.97)  LDD2246  [5]
 LDCM0023  KB03 MDA-MB-231 C36(4.08)  LDD1701  [2]
 LDCM0024  KB05 MKN-1 C87(1.66)  LDD3331  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Baculoviral IAP repeat-containing protein 2 (BIRC2) IAP family Q13490
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proton-coupled zinc antiporter SLC30A2 (SLC30A2) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q9BRI3
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 12 (TNFSF12) Tumor necrosis factor family O43508
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 3-3 (KRTAP3-3) KRTAP type 3 family Q9BYR6

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Enavatuzumab Antibody D07UKJ

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840