Details of the Target

General Information of Target

Target ID LDTP12092
Target Name Zinc finger protein 408 (ZNF408)
Gene Name ZNF408
Gene ID 79797
Synonyms
PFM14; PRDM17; Zinc finger protein 408; PR domain zinc finger protein 17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNRTKGDEEEYWNSSKFKAFTFDDEDDELSQLKESKRAVNSLRDFVDDDDDDDLERVSWS
GEPVGSISWSIRETAGNSGSTHEGREQLKSRNSFSSYAQLPKPTSTYSLSSFFRGRTRPG
SFQSLSDALSDTPAKSYAPELGRPKGEYRDYSNDWSPSDTVRRLRKGKVCSLERFRSLQD
KLQLLEEAVSMHDGNVITAVLIFLKRTLSKEILFRELEVRQVALRHLIHFLKEIGDQKLL
LDLFRFLDRTEELALSHYREHLNIQDPDKRKEFLKTCVGLPFSAEDSAHIQDHYTLLERQ
IIIEANDRHLESAGQTEIFRKHPRKASILNMPLVTTLFYSCFYHYTEAEGTFSSPVNLKK
TFKIPDKQYVLTALAARAKLRAWNDVDALFTTKNWLGYTKKRAPIGFHRVVEILHKNNAP
VQILQEYVNLVEDVDTKLNLATKFKCHDVVIDTYRDLKDRQQLLAYRSKVDKGSAEEEKI
DALLSSSQIRWKN
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9H9D4
Ensemble ID
ENST00000311764.3
HGNC ID
HGNC:20041

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C366(8.66)  LDD1705  [1]
DBIA
 Probe Info  		C366(0.90)  LDD0078  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C366(0.80)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C366(0.94)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C366(0.92)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C366(0.91)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C366(1.03)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C366(0.98)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C366(0.95)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C366(1.05)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C366(1.13)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C366(0.92)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C366(0.87)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C366(1.00)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C366(0.84)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C366(0.93)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C366(1.08)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C366(0.87)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C366(0.95)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C366(1.00)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C366(1.10)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C366(1.13)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C366(1.09)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C366(0.97)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C366(1.08)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C366(0.95)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C366(1.07)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C366(1.00)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C366(0.98)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C366(0.95)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C366(0.96)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C366(0.97)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C366(1.07)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C366(1.15)  LDD0562  [2]
 LDCM0259  AC14 HCT 116 C366(0.86)  LDD0576  [2]
 LDCM0263  AC143 HCT 116 C366(1.20)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C366(1.53)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C366(1.22)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C366(1.54)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C366(1.55)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C366(2.14)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C366(1.67)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C366(0.85)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C366(1.23)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C366(1.23)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C366(1.63)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C366(2.05)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C366(1.57)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C366(1.43)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C366(1.09)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C366(1.05)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C366(1.09)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C366(1.25)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C366(1.00)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C366(0.81)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C366(1.02)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C366(1.02)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C366(1.02)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C366(1.04)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C366(0.94)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C366(1.06)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C366(1.29)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C366(1.31)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C366(1.37)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C366(1.23)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C366(0.80)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C366(1.34)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C366(1.27)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C366(1.49)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C366(1.23)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C366(1.53)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C366(0.95)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C366(0.99)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C366(0.96)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C366(0.93)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C366(0.92)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C366(0.76)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C366(0.92)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C366(1.13)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C366(0.91)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C366(1.14)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C366(1.04)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C366(1.19)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C366(1.06)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C366(1.11)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C366(1.00)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C366(1.36)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C366(0.72)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C366(1.26)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C366(0.94)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C366(1.07)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C366(1.23)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C366(1.19)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C366(1.27)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C366(1.39)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C366(1.11)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C366(0.70)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C366(0.96)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C366(0.80)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C366(1.05)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C366(0.93)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C366(1.00)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C366(0.97)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C366(0.96)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C366(0.90)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C366(0.60)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C366(1.07)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C366(0.94)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C366(0.83)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C366(0.84)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C366(0.72)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C366(0.81)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C366(0.87)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C366(0.95)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C366(0.97)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C366(0.91)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C366(0.93)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C366(0.91)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C366(0.83)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C366(0.85)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C366(0.92)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C366(0.89)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C366(0.80)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C366(0.89)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C366(1.11)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C366(1.18)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C366(1.17)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C366(1.22)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C366(1.09)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C366(1.02)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C366(1.21)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C366(1.11)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C366(1.04)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C366(1.00)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C366(0.97)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C366(1.11)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C366(1.11)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C366(1.02)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C366(1.20)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C366(0.88)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C366(0.77)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C366(1.01)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C366(0.91)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C366(0.88)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C366(0.90)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C366(1.00)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C366(1.25)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C366(0.85)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C366(0.80)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C366(0.90)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C366(0.85)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C366(0.90)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C366(1.10)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C366(1.24)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C366(1.24)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C366(1.16)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C366(1.11)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C366(1.32)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C366(1.19)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C366(1.09)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C366(1.04)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C366(1.41)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C366(0.99)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C366(1.42)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C366(1.42)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C366(1.00)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C366(0.89)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C366(0.94)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C366(1.47)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C366(0.93)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C366(0.92)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C366(1.14)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C366(1.28)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C366(1.25)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C366(1.12)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C366(0.73)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C366(0.86)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C366(1.06)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C366(1.21)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C366(1.16)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C366(1.26)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C366(0.94)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C366(1.11)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C366(0.95)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C366(1.04)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C366(0.86)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C366(1.08)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C366(1.11)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C366(1.18)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C366(1.13)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C366(1.01)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C366(1.08)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C366(0.87)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C366(1.01)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C366(1.05)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C366(1.03)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C366(1.00)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C366(0.93)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C366(0.81)  LDD0737  [2]
 LDCM0421  CL32 HEK-293T C366(1.01)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C366(0.76)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C366(0.79)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C366(1.02)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C366(1.05)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C366(0.96)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C366(1.04)  LDD1026  [2]
 LDCM0429  CL4 HCT 116 C366(1.07)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C366(1.02)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C366(0.80)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C366(1.29)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C366(1.21)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C366(1.11)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C366(0.92)  LDD1033  [2]
 LDCM0436  CL46 HCT 116 C366(0.86)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C366(0.87)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C366(0.79)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C366(0.88)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C366(1.02)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C366(0.85)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C366(0.82)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C366(0.90)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C366(0.74)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C366(0.76)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C366(0.78)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C366(0.82)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C366(0.78)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C366(0.80)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C366(0.88)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C366(1.05)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C366(0.88)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C366(1.06)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C366(1.02)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C366(1.22)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C366(1.35)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C366(1.11)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C366(1.49)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C366(1.41)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C366(1.23)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C366(0.99)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C366(1.13)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C366(1.04)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C366(1.29)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C366(1.20)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C366(1.15)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C366(1.20)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C366(0.71)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C366(0.62)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C366(0.88)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C366(0.69)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C366(1.91)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C366(0.84)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C366(0.87)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C366(0.78)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C366(0.97)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C366(0.95)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C366(0.70)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C366(1.05)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C366(0.80)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C366(1.06)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C366(0.74)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C366(1.09)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C366(0.95)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C366(0.84)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C366(0.81)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C366(0.77)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C366(0.92)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C366(0.89)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C366(0.74)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C366(0.84)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C366(0.80)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C366(0.81)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C366(0.95)  LDD1698  [4]
 LDCM0468  Fragment33 HCT 116 C366(1.25)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C366(1.21)  LDD1025  [2]
 LDCM0022  KB02 697 C366(2.04)  LDD2245  [5]
 LDCM0023  KB03 697 C366(2.13)  LDD2662  [5]
 LDCM0024  KB05 HMCB C366(2.55)  LDD3312  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) Cytidine and deoxycytidylate deaminase family Q9NRW3
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomere zinc finger-associated protein (ZBTB48) Krueppel C2H2-type zinc-finger protein family P10074
Zinc finger protein 317 (ZNF317) Krueppel C2H2-type zinc-finger protein family Q96PQ6
Zinc finger protein 473 (ZNF473) Krueppel C2H2-type zinc-finger protein family Q8WTR7
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Zinc finger protein 764 (ZNF764) Krueppel C2H2-type zinc-finger protein family Q96H86
Zinc finger protein 792 (ZNF792) Krueppel C2H2-type zinc-finger protein family Q3KQV3
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Zinc finger protein 408 (ZNF408) . Q9H9D4
Other
Click To Hide/Show 34 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) KHDRBS family O75525
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Protein LDOC1 (LDOC1) LDOC1 family O95751
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Zinc finger protein 330 (ZNF330) NOA36 family Q9Y3S2
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Paraneoplastic antigen Ma2 (PNMA2) PNMA family Q9UL42
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Ribosome-recycling factor, mitochondrial (MRRF) RRF family Q96E11
Exosome complex component RRP4 (EXOSC2) RRP4 family Q13868
U6 snRNA-associated Sm-like protein LSm2 (LSM2) SnRNP Sm proteins family Q9Y333
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Four and a half LIM domains protein 2 (FHL2) . Q14192
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
G patch domain-containing protein 2-like (GPATCH2L) . Q9NWQ4
Myomegalin (PDE4DIP) . Q5VU43
PRKCA-binding protein (PICK1) . Q9NRD5
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) . O43586
RNA-binding motif protein, Y chromosome, family 1 member F/J (RBMY1F; RBMY1J) . Q15415
RNA-binding protein 10 (RBM10) . P98175
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Zinc finger C4H2 domain-containing protein (ZC4H2) . Q9NQZ6

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840