Details of the Target

General Information of Target

Target ID LDTP11958
Target Name Rab GTPase-binding effector protein 2 (RABEP2)
Gene Name RABEP2
Gene ID 79874
Synonyms
RABPT5B; Rab GTPase-binding effector protein 2; Rabaptin-5beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHF
RIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFL
HGLQMLKSLQGTHVVTLLGYCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLE
LAMDYVSIINYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGM
LVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDISSFLLGHIEGSD
MVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQAREML
Target Bioclass
Other
Family
Rabaptin family
Subcellular location
Cytoplasm
Function
Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis.
Uniprot ID
Q9H5N1
Ensemble ID
ENST00000357573.10
HGNC ID
HGNC:24817

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.Q330R .
A498 SNV: p.Q515Ter .
AN3CA Deletion: p.Q398RfsTer50
SNV: p.D229Y		 .
CAL33 SNV: p.A9T; p.E13Ter .
CMK SNV: p.A3V .
COLO678 SNV: p.V537G .
HUH7 SNV: p.A220S .
IGROV1 SNV: p.D114E DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.V524G DBIA    Probe Info 
MFE296 SNV: p.S257R .
SW837 SNV: p.R441P .
WM115 SNV: p.P393L .
WM2664 SNV: p.P393L .
WM793 SNV: p.P274S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K169(2.33); K378(3.03)  LDD0277  [2]
Probe 1
 Probe Info  		Y133(7.46)  LDD3495  [3]
DBIA
 Probe Info  		C422(0.84); C423(0.84)  LDD0078  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
IPM
 Probe Info  		C482(0.00); C372(0.00)  LDD0147  [8]
TFBX
 Probe Info  		C372(0.00); C327(0.00)  LDD0148  [8]
W1
 Probe Info  		N.A.  LDD0236  [9]
AOyne
 Probe Info  		14.50  LDD0443  [10]
NAIA_5
 Probe Info  		C372(0.00); C79(0.00); C115(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C372(0.66)  LDD0531  [4]
 LDCM0215  AC10 PaTu 8988t C327(1.25)  LDD1094  [4]
 LDCM0216  AC100 PaTu 8988t C422(1.15); C423(1.15)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C422(0.85); C423(0.85)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C422(0.81); C423(0.81)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C422(1.39); C423(1.39)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C422(0.86); C423(0.86)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C422(0.76); C423(0.76)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C422(1.02); C423(1.02)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C422(0.81); C423(0.81)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C422(1.42); C423(1.42)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C422(1.14); C423(1.14)  LDD1104  [4]
 LDCM0226  AC11 PaTu 8988t C327(1.24)  LDD1105  [4]
 LDCM0227  AC110 PaTu 8988t C422(1.59); C423(1.59)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C422(1.36); C423(1.36)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C422(1.37); C423(1.37)  LDD1108  [4]
 LDCM0230  AC113 PaTu 8988t C422(0.78); C423(0.78)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C422(0.65); C423(0.65)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C422(1.38); C423(1.38)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C422(0.97); C423(0.97)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C422(0.87); C423(0.87)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C422(0.93); C423(0.93)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C422(0.89); C423(0.89)  LDD1115  [4]
 LDCM0237  AC12 PaTu 8988t C327(1.28)  LDD1116  [4]
 LDCM0238  AC120 PaTu 8988t C422(0.64); C423(0.64)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C422(0.79); C423(0.79)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C422(0.78); C423(0.78)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C422(0.76); C423(0.76)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C422(0.97); C423(0.97)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C422(1.63); C423(1.63)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C422(0.92); C423(0.92)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C422(0.84); C423(0.84)  LDD1124  [4]
 LDCM0246  AC128 HCT 116 C372(1.46)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C372(0.91)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C372(1.12)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C372(0.82)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C372(0.95)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C372(1.10)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C372(1.23)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C372(1.23)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C372(1.22)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C372(0.98)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C372(0.96)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C372(1.22)  LDD0575  [4]
 LDCM0259  AC14 PaTu 8988t C327(0.87)  LDD1138  [4]
 LDCM0260  AC140 HCT 116 C372(1.31)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C372(1.19)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C372(0.79)  LDD0579  [4]
 LDCM0263  AC143 PaTu 8988t C422(1.80); C423(1.80); C327(1.32)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C422(2.61); C423(2.61); C327(1.45)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C422(2.43); C423(2.43); C327(2.03)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C422(1.81); C423(1.81); C327(1.69)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C422(2.43); C423(2.43); C327(1.26)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C422(4.69); C423(4.69); C327(1.07)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C422(4.21); C423(4.21); C327(1.79)  LDD1148  [4]
 LDCM0270  AC15 PaTu 8988t C327(0.95)  LDD1149  [4]
 LDCM0271  AC150 PaTu 8988t C422(4.33); C423(4.33); C327(1.77)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C422(9.56); C423(9.56); C327(3.54)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C422(3.78); C423(3.78); C327(1.54)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C422(9.03); C423(9.03); C327(2.78)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C422(8.64); C423(8.64); C327(2.10)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C422(5.88); C423(5.88); C327(1.59)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C422(5.86); C423(5.86); C327(2.17)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C422(7.22); C423(7.22); C327(1.44)  LDD2169  [4]
 LDCM0276  AC17 HCT 116 C372(0.91)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C372(0.82)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C372(0.94)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C372(1.11)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C372(0.80)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C372(0.91)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C372(0.82)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C372(0.86)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C372(0.68)  LDD0601  [4]
 LDCM0285  AC25 PaTu 8988t C372(1.24); C327(1.37)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C372(1.06); C327(1.16)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C372(1.46); C327(1.11)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C372(1.79); C327(1.42)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C372(1.15); C327(0.87)  LDD1168  [4]
 LDCM0290  AC3 HCT 116 C372(0.86)  LDD0607  [4]
 LDCM0291  AC30 PaTu 8988t C372(1.03); C327(0.99)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C372(1.21); C327(1.30)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C372(1.28); C327(0.95)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C372(1.79); C327(1.58)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C372(1.18); C327(1.04)  LDD1174  [4]
 LDCM0296  AC35 PaTu 8988t C372(1.36); C327(1.34)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C372(1.68); C327(1.56)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C372(1.74); C327(1.20)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C372(1.45); C327(1.52)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C372(1.86); C327(1.51)  LDD1179  [4]
 LDCM0301  AC4 HCT 116 C372(0.72)  LDD0618  [4]
 LDCM0302  AC40 PaTu 8988t C372(1.81); C327(1.53)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C372(1.33); C327(1.11)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C372(1.28); C327(0.98)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C372(1.45); C327(1.27)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C372(1.75); C327(1.37)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C372(1.34); C327(1.26)  LDD1186  [4]
 LDCM0308  AC46 HEK-293T C115(1.32); C482(1.15); C372(1.32)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C115(1.57); C482(1.18); C372(1.21)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C482(1.26); C372(1.73)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C115(1.46); C482(1.41); C372(1.74)  LDD1550  [11]
 LDCM0312  AC5 HCT 116 C372(0.68)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C115(0.84); C482(0.97); C372(0.97)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C115(1.27); C482(1.04); C372(1.08)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C482(1.42)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C115(1.48); C482(1.31); C327(1.26); C372(1.20)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C115(1.80); C482(1.24); C372(1.51)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C115(1.57); C482(1.54); C372(1.43)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C482(1.27); C372(1.49)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C115(1.13); C482(1.22); C372(1.40)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C115(0.98); C482(1.13); C372(1.11)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C115(1.34); C482(0.92); C372(1.17)  LDD1561  [11]
 LDCM0323  AC6 PaTu 8988t C327(1.03)  LDD1202  [4]
 LDCM0324  AC60 HEK-293T C482(1.22)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C115(1.09); C482(1.06); C327(1.04); C372(0.94)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C115(1.46); C482(1.22); C372(1.49)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C115(1.14); C482(1.18); C372(1.14)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C482(0.98); C372(1.08)  LDD1567  [11]
 LDCM0332  AC68 PaTu 8988t C422(0.46); C423(0.46)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C422(0.95); C423(0.95)  LDD1212  [4]
 LDCM0334  AC7 PaTu 8988t C327(1.06)  LDD1213  [4]
 LDCM0335  AC70 PaTu 8988t C422(0.65); C423(0.65)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C422(0.48); C423(0.48)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C422(0.42); C423(0.42)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C422(0.39); C423(0.39)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C422(0.60); C423(0.60)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C422(1.04); C423(1.04)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C422(0.59); C423(0.59)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C422(0.41); C423(0.41)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C422(0.56); C423(0.56)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C422(0.40); C423(0.40)  LDD1223  [4]
 LDCM0345  AC8 PaTu 8988t C327(1.01)  LDD1224  [4]
 LDCM0346  AC80 PaTu 8988t C422(0.35); C423(0.35)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C422(0.70); C423(0.70)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C422(0.49); C423(0.49)  LDD1227  [4]
 LDCM0349  AC83 PaTu 8988t C422(0.77); C423(0.77)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C422(0.65); C423(0.65)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C422(0.75); C423(0.75)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C422(0.70); C423(0.70)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C422(0.65); C423(0.65)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C422(0.83); C423(0.83)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C422(0.70); C423(0.70)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C422(1.07); C423(1.07)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C422(0.95); C423(0.95)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C422(0.66); C423(0.66)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C422(0.67); C423(0.67)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C422(0.76); C423(0.76)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C422(0.80); C423(0.80)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C422(0.72); C423(0.72)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C422(0.71); C423(0.71)  LDD1243  [4]
 LDCM0365  AC98 PaTu 8988t C422(1.13); C423(1.13)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C422(0.80); C423(0.80)  LDD1245  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C327(0.99)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C327(1.81)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C327(2.01)  LDD1154  [4]
 LDCM0156  Aniline NCI-H1299 12.36  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C422(0.84); C423(0.84)  LDD0078  [4]
 LDCM0632  CL-Sc Hep-G2 C115(2.15); C372(1.96); C372(1.46); C482(1.04)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C115(1.12); C482(1.17); C327(0.85)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C115(0.69); C482(0.99); C372(0.93)  LDD1572  [11]
 LDCM0369  CL100 HCT 116 C372(0.74)  LDD0686  [4]
 LDCM0370  CL101 PaTu 8988t C327(1.53)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C327(0.93)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C327(1.30)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C327(1.53)  LDD1252  [4]
 LDCM0374  CL105 HCT 116 C372(1.05)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C372(0.92)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C372(1.15)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C372(0.91)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C372(1.08)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C115(0.82); C482(1.18); C372(1.07)  LDD1583  [11]
 LDCM0380  CL110 HCT 116 C372(0.91)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C372(1.14)  LDD0698  [4]
 LDCM0382  CL112 PaTu 8988t C372(1.20); C327(0.85)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C372(1.14); C327(0.95)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C372(1.26); C327(0.93)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C372(1.15); C327(1.01)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C372(1.33); C327(1.35)  LDD1265  [4]
 LDCM0387  CL117 PaTu 8988t C372(1.26); C327(1.05)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C372(1.01); C327(1.19)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C372(1.49); C327(1.26)  LDD1268  [4]
 LDCM0390  CL12 HEK-293T C482(1.18); C372(1.25)  LDD1594  [11]
 LDCM0391  CL120 PaTu 8988t C372(1.95); C327(1.46)  LDD1270  [4]
 LDCM0392  CL121 HEK-293T C115(1.30); C482(1.15); C327(1.42)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C115(1.06); C482(1.09)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C482(1.12)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C482(0.85)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C115(0.99); C482(1.00); C327(0.96)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C115(0.95); C482(0.95)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C482(1.10)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C482(0.87)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C115(1.79); C482(1.17); C327(1.24)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C115(1.09); C482(1.16)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C482(1.29)  LDD1606  [11]
 LDCM0403  CL16 PaTu 8988t C372(1.04)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C372(1.48)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C372(1.61)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C372(1.36)  LDD1285  [4]
 LDCM0407  CL2 HEK-293T C115(0.85); C482(1.14)  LDD1611  [11]
 LDCM0408  CL20 PaTu 8988t C372(1.26)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C372(1.61)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C372(1.61)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C372(1.70)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C372(1.57)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C372(1.56)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C372(1.66)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C372(2.46)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C372(1.23)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C372(1.51)  LDD1296  [4]
 LDCM0418  CL3 HEK-293T C482(0.98)  LDD1622  [11]
 LDCM0419  CL30 PaTu 8988t C372(2.24)  LDD1298  [4]
 LDCM0420  CL31 PaTu 8988t C422(1.04); C423(1.04)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C422(1.55); C423(1.55)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C422(3.11); C423(3.11)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C422(2.05); C423(2.05)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C422(1.40); C423(1.40)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C422(7.64); C423(7.64)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C422(1.76); C423(1.76)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C422(1.57); C423(1.57)  LDD1307  [4]
 LDCM0429  CL4 HEK-293T C482(0.84)  LDD1633  [11]
 LDCM0430  CL40 PaTu 8988t C422(1.59); C423(1.59)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C422(1.57); C423(1.57)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C422(1.55); C423(1.55)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C422(2.51); C423(2.51)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C422(1.69); C423(1.69)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C422(2.57); C423(2.57)  LDD1314  [4]
 LDCM0436  CL46 PaTu 8988t C422(1.44); C423(1.44); C372(1.29)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C422(1.05); C423(1.05); C372(1.22)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C422(1.71); C423(1.71); C372(1.32)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C422(1.51); C423(1.51); C372(1.59)  LDD1318  [4]
 LDCM0440  CL5 HEK-293T C115(1.09); C482(1.16); C372(1.02)  LDD1644  [11]
 LDCM0441  CL50 PaTu 8988t C422(1.94); C423(1.94); C372(1.62)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C422(1.67); C423(1.67); C372(1.40)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C422(2.43); C423(2.43); C372(1.86)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C422(1.28); C423(1.28); C372(1.76)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C422(1.10); C423(1.10); C372(1.27)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C422(2.44); C423(2.44); C372(1.91)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C422(1.60); C423(1.60); C372(1.56)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C422(2.32); C423(2.32); C372(1.61)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C422(1.97); C423(1.97); C372(1.65)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C422(1.32); C423(1.32); C372(1.37)  LDD1329  [4]
 LDCM0451  CL6 HEK-293T C115(0.70); C482(0.91); C372(0.76)  LDD1654  [11]
 LDCM0452  CL60 PaTu 8988t C422(1.40); C423(1.40); C372(1.35)  LDD1331  [4]
 LDCM0453  CL61 HEK-293T C115(1.37); C482(1.30); C327(1.27)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C115(1.24); C482(1.27)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C482(1.28)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C482(1.11)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C115(1.72); C482(1.51); C372(3.10)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C115(1.46); C482(1.23); C372(1.49)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C115(1.14); C482(0.91); C372(1.08)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C482(1.42)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C115(1.61); C482(1.51); C327(1.34); C372(1.23)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C115(0.92); C482(0.97); C372(0.99)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C115(1.57); C482(1.47); C372(1.71)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C115(1.18); C482(1.32); C372(1.18)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C482(1.86); C372(2.76)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C115(0.77); C482(0.92); C327(0.89)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C115(1.02); C482(0.93)  LDD1670  [11]
 LDCM0469  CL76 HCT 116 C372(1.12)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C372(1.09)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C372(1.03)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C372(1.20)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C482(1.02)  LDD1676  [11]
 LDCM0474  CL80 HCT 116 C372(1.00)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C372(1.10)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C372(0.82)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C372(1.15)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C372(1.00)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C372(1.24)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C372(1.13)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C372(1.14)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C372(1.07)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C372(0.91)  LDD0800  [4]
 LDCM0484  CL9 HEK-293T C115(0.74); C482(1.24); C327(0.92); C372(0.93)  LDD1687  [11]
 LDCM0485  CL90 HCT 116 C372(0.88)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C372(1.35)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C372(1.05)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C372(0.78)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C372(0.65)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C372(0.92)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C372(1.12)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C372(1.20)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C372(1.15)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C372(1.05)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C482(1.33)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C372(1.01)  LDD1702  [12]
 LDCM0625  F8 Ramos C327(0.71)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C327(0.99)  LDD2189  [13]
 LDCM0574  Fragment12 Ramos C327(0.69)  LDD2191  [13]
 LDCM0576  Fragment14 Ramos C327(0.22); C372(0.63)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C327(0.65)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C327(1.01)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C327(2.35)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C327(0.92)  LDD2197  [13]
 LDCM0588  Fragment30 Ramos C327(0.76)  LDD2199  [13]
 LDCM0590  Fragment32 Ramos C327(0.85)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C482(0.93)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C327(0.69)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C327(0.70); C372(1.09)  LDD2184  [13]
 LDCM0427  Fragment51 PaTu 8988t C422(2.35); C423(2.35)  LDD1306  [4]
 LDCM0610  Fragment52 Ramos C327(1.47)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C327(1.68)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C327(0.60); C372(0.77)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C327(0.84)  LDD2188  [13]
 LDCM0022  KB02 HCT 116 C422(3.64); C423(3.64); C372(2.09)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C422(1.49); C423(1.49); C372(1.23)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C422(20.00); C423(20.00); C372(2.47)  LDD0082  [4]
 LDCM0021  THZ1 HCT 116 C422(1.04); C423(1.04)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serologically defined colon cancer antigen 8 (SDCCAG8) . Q86SQ7

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578