Details of the Target

General Information of Target

Target ID LDTP11767
Target Name Regulator of nonsense transcripts 3A (UPF3A)
Gene Name UPF3A
Gene ID 65110
Synonyms
RENT3A; UPF3; Regulator of nonsense transcripts 3A; Nonsense mRNA reducing factor 3A; Up-frameshift suppressor 3 homolog A; hUpf3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT
FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH
RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI
GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL
ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE
DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE
KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI
EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP
DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF
QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ
PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED
DDDEEDDADEEAPKPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQS
RETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS
Target Bioclass
Other
Family
RENT3 family
Subcellular location
Nucleus
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.
Uniprot ID
Q9H1J1
Ensemble ID
ENST00000351487.5
HGNC ID
HGNC:20332

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.Q229R .
FADU SNV: p.D123N .
JHH1 SNV: p.P108H .
JHH7 Deletion: p.D103EfsTer13 .
MCC13 SNV: p.R262K
Substitution: p.C263K		 .
PC9 SNV: p.E234Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C315(1.44)  LDD3325  [1]
BTD
 Probe Info  		C420(0.88)  LDD2090  [2]
IA-alkyne
 Probe Info  		C420(0.86)  LDD2182  [3]
NAIA_4
 Probe Info  		C52(0.00); C315(0.00)  LDD2226  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C420(0.87)  LDD2112  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C420(0.81)  LDD2103  [2]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C420(0.87)  LDD2132  [2]
 LDCM0214  AC1 HEK-293T C315(1.02)  LDD1507  [6]
 LDCM0215  AC10 PaTu 8988t C52(2.04)  LDD1094  [7]
 LDCM0216  AC100 PaTu 8988t C52(1.22)  LDD1095  [7]
 LDCM0217  AC101 PaTu 8988t C52(0.86)  LDD1096  [7]
 LDCM0218  AC102 PaTu 8988t C52(0.71)  LDD1097  [7]
 LDCM0219  AC103 PaTu 8988t C52(0.84)  LDD1098  [7]
 LDCM0220  AC104 PaTu 8988t C52(0.68)  LDD1099  [7]
 LDCM0221  AC105 PaTu 8988t C52(1.10)  LDD1100  [7]
 LDCM0222  AC106 PaTu 8988t C52(0.70)  LDD1101  [7]
 LDCM0223  AC107 PaTu 8988t C52(1.17)  LDD1102  [7]
 LDCM0224  AC108 PaTu 8988t C52(1.10)  LDD1103  [7]
 LDCM0225  AC109 PaTu 8988t C52(0.82)  LDD1104  [7]
 LDCM0226  AC11 PaTu 8988t C52(1.29)  LDD1105  [7]
 LDCM0227  AC110 PaTu 8988t C52(1.11)  LDD1106  [7]
 LDCM0228  AC111 PaTu 8988t C52(0.97)  LDD1107  [7]
 LDCM0229  AC112 PaTu 8988t C52(1.71)  LDD1108  [7]
 LDCM0230  AC113 PaTu 8988t C52(0.98)  LDD1109  [7]
 LDCM0231  AC114 PaTu 8988t C52(0.77)  LDD1110  [7]
 LDCM0232  AC115 PaTu 8988t C52(0.98)  LDD1111  [7]
 LDCM0233  AC116 PaTu 8988t C52(1.21)  LDD1112  [7]
 LDCM0234  AC117 PaTu 8988t C52(0.74)  LDD1113  [7]
 LDCM0235  AC118 PaTu 8988t C52(0.95)  LDD1114  [7]
 LDCM0236  AC119 PaTu 8988t C52(1.03)  LDD1115  [7]
 LDCM0237  AC12 PaTu 8988t C52(1.31)  LDD1116  [7]
 LDCM0238  AC120 PaTu 8988t C52(0.96)  LDD1117  [7]
 LDCM0239  AC121 PaTu 8988t C52(0.77)  LDD1118  [7]
 LDCM0240  AC122 PaTu 8988t C52(0.98)  LDD1119  [7]
 LDCM0241  AC123 PaTu 8988t C52(1.10)  LDD1120  [7]
 LDCM0242  AC124 PaTu 8988t C52(1.17)  LDD1121  [7]
 LDCM0243  AC125 PaTu 8988t C52(1.16)  LDD1122  [7]
 LDCM0244  AC126 PaTu 8988t C52(0.99)  LDD1123  [7]
 LDCM0245  AC127 PaTu 8988t C52(0.92)  LDD1124  [7]
 LDCM0246  AC128 PaTu 8988t C52(1.05)  LDD1125  [7]
 LDCM0247  AC129 PaTu 8988t C52(1.04)  LDD1126  [7]
 LDCM0249  AC130 PaTu 8988t C52(0.93)  LDD1128  [7]
 LDCM0250  AC131 PaTu 8988t C52(1.12)  LDD1129  [7]
 LDCM0251  AC132 PaTu 8988t C52(1.15)  LDD1130  [7]
 LDCM0252  AC133 PaTu 8988t C52(1.48)  LDD1131  [7]
 LDCM0253  AC134 PaTu 8988t C52(1.56)  LDD1132  [7]
 LDCM0254  AC135 PaTu 8988t C52(1.84)  LDD1133  [7]
 LDCM0255  AC136 PaTu 8988t C52(1.12)  LDD1134  [7]
 LDCM0256  AC137 PaTu 8988t C52(1.25)  LDD1135  [7]
 LDCM0257  AC138 PaTu 8988t C52(0.97)  LDD1136  [7]
 LDCM0258  AC139 PaTu 8988t C52(1.18)  LDD1137  [7]
 LDCM0259  AC14 PaTu 8988t C52(1.49)  LDD1138  [7]
 LDCM0260  AC140 PaTu 8988t C52(1.33)  LDD1139  [7]
 LDCM0261  AC141 PaTu 8988t C52(1.06)  LDD1140  [7]
 LDCM0262  AC142 PaTu 8988t C52(1.33)  LDD1141  [7]
 LDCM0263  AC143 PaTu 8988t C52(1.13)  LDD1142  [7]
 LDCM0264  AC144 PaTu 8988t C52(1.53)  LDD1143  [7]
 LDCM0265  AC145 PaTu 8988t C52(0.92)  LDD1144  [7]
 LDCM0266  AC146 PaTu 8988t C52(1.00)  LDD1145  [7]
 LDCM0267  AC147 PaTu 8988t C52(1.12)  LDD1146  [7]
 LDCM0268  AC148 PaTu 8988t C52(1.49)  LDD1147  [7]
 LDCM0269  AC149 PaTu 8988t C52(2.05)  LDD1148  [7]
 LDCM0270  AC15 PaTu 8988t C52(1.59)  LDD1149  [7]
 LDCM0271  AC150 PaTu 8988t C52(1.61)  LDD1150  [7]
 LDCM0272  AC151 PaTu 8988t C52(2.38)  LDD1151  [7]
 LDCM0273  AC152 PaTu 8988t C52(1.46)  LDD1152  [7]
 LDCM0274  AC153 PaTu 8988t C52(1.83)  LDD1153  [7]
 LDCM0621  AC154 PaTu 8988t C52(2.22)  LDD2166  [7]
 LDCM0622  AC155 PaTu 8988t C52(1.82)  LDD2167  [7]
 LDCM0623  AC156 PaTu 8988t C52(1.54)  LDD2168  [7]
 LDCM0624  AC157 PaTu 8988t C52(1.60)  LDD2169  [7]
 LDCM0276  AC17 PaTu 8988t C52(1.38)  LDD1155  [7]
 LDCM0277  AC18 PaTu 8988t C52(1.50)  LDD1156  [7]
 LDCM0278  AC19 PaTu 8988t C52(1.26)  LDD1157  [7]
 LDCM0279  AC2 HEK-293T C315(0.90)  LDD1518  [6]
 LDCM0280  AC20 PaTu 8988t C52(1.24)  LDD1159  [7]
 LDCM0281  AC21 PaTu 8988t C52(1.56)  LDD1160  [7]
 LDCM0282  AC22 PaTu 8988t C52(1.89)  LDD1161  [7]
 LDCM0283  AC23 PaTu 8988t C52(1.64)  LDD1162  [7]
 LDCM0284  AC24 PaTu 8988t C52(1.22)  LDD1163  [7]
 LDCM0285  AC25 HEK-293T C315(1.00)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C315(0.89)  LDD1525  [6]
 LDCM0288  AC28 HEK-293T C315(1.13)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C315(1.10)  LDD1528  [6]
 LDCM0292  AC31 HEK-293T C315(1.01)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C315(1.00)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C315(1.06)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C315(1.05)  LDD1534  [6]
 LDCM0296  AC35 PaTu 8988t C52(1.17)  LDD1175  [7]
 LDCM0297  AC36 PaTu 8988t C52(1.35)  LDD1176  [7]
 LDCM0298  AC37 PaTu 8988t C52(1.51)  LDD1177  [7]
 LDCM0299  AC38 PaTu 8988t C52(1.47)  LDD1178  [7]
 LDCM0300  AC39 PaTu 8988t C52(1.55)  LDD1179  [7]
 LDCM0301  AC4 HEK-293T C315(1.17)  LDD1540  [6]
 LDCM0302  AC40 PaTu 8988t C52(2.05)  LDD1181  [7]
 LDCM0303  AC41 PaTu 8988t C52(1.51)  LDD1182  [7]
 LDCM0304  AC42 PaTu 8988t C52(2.47)  LDD1183  [7]
 LDCM0305  AC43 PaTu 8988t C52(1.28)  LDD1184  [7]
 LDCM0306  AC44 PaTu 8988t C52(2.71)  LDD1185  [7]
 LDCM0307  AC45 PaTu 8988t C52(2.66)  LDD1186  [7]
 LDCM0309  AC47 HEK-293T C315(1.14)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C315(1.00)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C315(0.99)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C315(1.06)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C315(0.89)  LDD1552  [6]
 LDCM0315  AC52 HEK-293T C315(1.15)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C315(0.96)  LDD1555  [6]
 LDCM0318  AC55 HEK-293T C315(1.02)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C315(0.90)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C315(1.07)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C315(1.03)  LDD1560  [6]
 LDCM0323  AC6 PaTu 8988t C52(1.52)  LDD1202  [7]
 LDCM0324  AC60 HEK-293T C315(1.11)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C315(1.19)  LDD1564  [6]
 LDCM0327  AC63 HEK-293T C315(1.13)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C315(0.91)  LDD1567  [6]
 LDCM0334  AC7 PaTu 8988t C52(0.91)  LDD1213  [7]
 LDCM0345  AC8 PaTu 8988t C52(1.02)  LDD1224  [7]
 LDCM0365  AC98 PaTu 8988t C52(1.16)  LDD1244  [7]
 LDCM0366  AC99 PaTu 8988t C52(0.73)  LDD1245  [7]
 LDCM0545  Acetamide MDA-MB-231 C420(0.35)  LDD2138  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C52(1.81)  LDD1127  [7]
 LDCM0356  AKOS034007680 PaTu 8988t C52(1.17)  LDD1235  [7]
 LDCM0275  AKOS034007705 PaTu 8988t C52(1.14)  LDD1154  [7]
 LDCM0020  ARS-1620 HCC44 C420(1.18)  LDD2171  [7]
 LDCM0498  BS-3668 MDA-MB-231 C420(0.41)  LDD2091  [2]
 LDCM0632  CL-Sc Hep-G2 C420(0.79)  LDD2227  [4]
 LDCM0367  CL1 PaTu 8988t C52(1.59)  LDD1246  [7]
 LDCM0368  CL10 PaTu 8988t C52(1.82)  LDD1247  [7]
 LDCM0370  CL101 PaTu 8988t C52(1.08)  LDD1249  [7]
 LDCM0371  CL102 PaTu 8988t C52(1.12)  LDD1250  [7]
 LDCM0372  CL103 PaTu 8988t C52(1.96)  LDD1251  [7]
 LDCM0373  CL104 PaTu 8988t C52(1.18)  LDD1252  [7]
 LDCM0374  CL105 PaTu 8988t C52(1.36)  LDD1253  [7]
 LDCM0375  CL106 PaTu 8988t C52(1.13)  LDD1254  [7]
 LDCM0376  CL107 PaTu 8988t C52(1.14)  LDD1255  [7]
 LDCM0377  CL108 PaTu 8988t C52(0.98)  LDD1256  [7]
 LDCM0378  CL109 PaTu 8988t C52(1.27)  LDD1257  [7]
 LDCM0379  CL11 PaTu 8988t C52(1.80)  LDD1258  [7]
 LDCM0380  CL110 PaTu 8988t C52(1.47)  LDD1259  [7]
 LDCM0381  CL111 PaTu 8988t C52(1.87)  LDD1260  [7]
 LDCM0383  CL113 HEK-293T C315(1.00)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C315(1.08)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C315(1.05)  LDD1589  [6]
 LDCM0387  CL117 PaTu 8988t C52(1.43)  LDD1266  [7]
 LDCM0388  CL118 PaTu 8988t C52(1.32)  LDD1267  [7]
 LDCM0389  CL119 PaTu 8988t C52(1.53)  LDD1268  [7]
 LDCM0390  CL12 PaTu 8988t C52(1.36)  LDD1269  [7]
 LDCM0391  CL120 PaTu 8988t C52(1.42)  LDD1270  [7]
 LDCM0392  CL121 HEK-293T C315(1.02)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C315(1.10)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C315(0.92)  LDD1598  [6]
 LDCM0396  CL125 HEK-293T C315(1.07)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C315(1.05)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C315(0.98)  LDD1602  [6]
 LDCM0400  CL13 PaTu 8988t C52(1.52)  LDD1279  [7]
 LDCM0401  CL14 PaTu 8988t C52(1.98)  LDD1280  [7]
 LDCM0402  CL15 PaTu 8988t C52(1.33)  LDD1281  [7]
 LDCM0404  CL17 HEK-293T C315(1.00)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C315(0.81)  LDD1609  [6]
 LDCM0407  CL2 PaTu 8988t C52(1.05)  LDD1286  [7]
 LDCM0408  CL20 HEK-293T C315(1.16)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C315(1.02)  LDD1613  [6]
 LDCM0411  CL23 HEK-293T C315(1.03)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C315(0.95)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C315(1.00)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C315(1.10)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C315(1.24)  LDD1619  [6]
 LDCM0417  CL29 HEK-293T C315(1.05)  LDD1621  [6]
 LDCM0418  CL3 PaTu 8988t C52(1.30)  LDD1297  [7]
 LDCM0419  CL30 HEK-293T C315(0.97)  LDD1623  [6]
 LDCM0420  CL31 PaTu 8988t C52(0.77)  LDD1299  [7]
 LDCM0421  CL32 PaTu 8988t C52(1.01)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C52(0.97)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C52(1.31)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C52(1.08)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C52(1.71)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C52(1.40)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C52(1.02)  LDD1307  [7]
 LDCM0429  CL4 PaTu 8988t C52(1.30)  LDD1308  [7]
 LDCM0430  CL40 PaTu 8988t C52(0.76)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C52(1.26)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C52(1.64)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C52(1.79)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C52(1.52)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C52(1.01)  LDD1314  [7]
 LDCM0437  CL47 HEK-293T C315(1.00)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C315(0.96)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C315(1.03)  LDD1643  [6]
 LDCM0440  CL5 PaTu 8988t C52(1.60)  LDD1319  [7]
 LDCM0441  CL50 HEK-293T C315(1.28)  LDD1645  [6]
 LDCM0444  CL53 HEK-293T C315(1.01)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C315(0.92)  LDD1648  [6]
 LDCM0447  CL56 HEK-293T C315(1.10)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C315(1.20)  LDD1651  [6]
 LDCM0450  CL59 HEK-293T C315(1.21)  LDD1653  [6]
 LDCM0451  CL6 PaTu 8988t C52(1.18)  LDD1330  [7]
 LDCM0452  CL60 HEK-293T C315(0.98)  LDD1655  [6]
 LDCM0453  CL61 PaTu 8988t C52(1.22)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C52(1.87)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C52(1.27)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C52(1.10)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C52(1.29)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C52(0.99)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C52(1.03)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C52(1.03)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C52(1.67)  LDD1340  [7]
 LDCM0462  CL7 PaTu 8988t C52(1.41)  LDD1341  [7]
 LDCM0463  CL70 PaTu 8988t C52(1.11)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C52(1.75)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C52(1.14)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C52(2.23)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C52(1.43)  LDD1346  [7]
 LDCM0469  CL76 PaTu 8988t C52(1.11)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C52(1.27)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C52(1.51)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C52(1.16)  LDD1351  [7]
 LDCM0473  CL8 PaTu 8988t C52(1.40)  LDD1352  [7]
 LDCM0474  CL80 PaTu 8988t C52(1.54)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C52(1.66)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C52(1.39)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C52(1.22)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C52(2.04)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C52(1.20)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C52(1.47)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C52(2.11)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C52(1.79)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C52(1.95)  LDD1362  [7]
 LDCM0484  CL9 PaTu 8988t C52(1.47)  LDD1363  [7]
 LDCM0485  CL90 PaTu 8988t C52(1.91)  LDD1364  [7]
 LDCM0487  CL92 HEK-293T C315(1.14)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C315(1.05)  LDD1691  [6]
 LDCM0490  CL95 HEK-293T C315(1.01)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C315(0.89)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C315(1.00)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C315(1.19)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C315(1.05)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C315(0.95)  LDD1698  [6]
 LDCM0625  F8 Ramos C420(1.74); C52(1.54)  LDD2187  [3]
 LDCM0572  Fragment10 Ramos C420(0.76)  LDD2189  [3]
 LDCM0573  Fragment11 Ramos C420(4.92); C52(7.73)  LDD2190  [3]
 LDCM0574  Fragment12 Ramos C420(0.75); C52(0.86)  LDD2191  [3]
 LDCM0575  Fragment13 Ramos C420(0.98); C52(0.82)  LDD2192  [3]
 LDCM0576  Fragment14 Ramos C420(0.48); C52(0.94)  LDD2193  [3]
 LDCM0579  Fragment20 Ramos C420(0.65); C52(0.63)  LDD2194  [3]
 LDCM0580  Fragment21 Ramos C420(0.98); C52(0.88)  LDD2195  [3]
 LDCM0582  Fragment23 Ramos C420(0.92); C52(1.51)  LDD2196  [3]
 LDCM0578  Fragment27 Ramos C420(1.01); C52(0.90)  LDD2197  [3]
 LDCM0586  Fragment28 Ramos C420(0.85); C52(0.89)  LDD2198  [3]
 LDCM0588  Fragment30 Ramos C420(1.51); C52(1.33)  LDD2199  [3]
 LDCM0589  Fragment31 Ramos C420(1.40); C52(0.95)  LDD2200  [3]
 LDCM0590  Fragment32 Ramos C420(1.19)  LDD2201  [3]
 LDCM0468  Fragment33 PaTu 8988t C52(1.25)  LDD1347  [7]
 LDCM0596  Fragment38 Ramos C420(1.31); C52(0.43)  LDD2203  [3]
 LDCM0566  Fragment4 Ramos C420(0.99); C52(0.98)  LDD2184  [3]
 LDCM0427  Fragment51 PaTu 8988t C52(1.37)  LDD1306  [7]
 LDCM0610  Fragment52 Ramos C420(1.38)  LDD2204  [3]
 LDCM0614  Fragment56 Ramos C420(2.04); C52(2.85)  LDD2205  [3]
 LDCM0569  Fragment7 Ramos C420(0.86); C52(1.09)  LDD2186  [3]
 LDCM0571  Fragment9 Ramos C420(0.45)  LDD2188  [3]
 LDCM0022  KB02 HEK-293T C315(0.90)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C315(0.91)  LDD1497  [6]
 LDCM0024  KB05 UACC257 C315(1.44)  LDD3325  [1]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C420(0.39)  LDD2121  [2]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C420(0.88)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C420(0.70)  LDD2092  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C420(1.03)  LDD2094  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C420(0.96)  LDD2098  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C420(0.71)  LDD2100  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C420(0.98)  LDD2105  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C420(0.59)  LDD2108  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C420(0.95)  LDD2120  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C420(0.88)  LDD2128  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C420(1.10)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C420(0.53)  LDD2141  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C420(0.90)  LDD2143  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C420(0.37)  LDD2150  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C420(1.06)  LDD2153  [2]
 LDCM0021  THZ1 HCT 116 C420(1.18)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Regulator of nonsense transcripts 1 (UPF1) DNA2/NAM7 helicase family Q92900
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding protein 8A (RBM8A) RBM8A family Q9Y5S9
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Regulator of nonsense transcripts 2 (UPF2) . Q9HAU5

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.