Details of the Target

General Information of Target

Target ID LDTP11242
Target Name Ribonuclease P protein subunit p25 (RPP25)
Gene Name RPP25
Gene ID 54913
Synonyms
Ribonuclease P protein subunit p25; RNase P protein subunit p25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRMTMEEMKNEAETTSMVSMPLYAVMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQ
DIIMKILEKKSVEVNFTESLLRMAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDE
INDRVRFLQTIKDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKT
YFKDGKAINVFVSANRLIHQTNLILQTFKTVA
Target Bioclass
Enzyme
Family
Histone-like Alba family
Subcellular location
Nucleus, nucleolus
Function
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
Uniprot ID
Q9BUL9
Ensemble ID
ENST00000322177.6
HGNC ID
HGNC:30361

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C16(2.92)  LDD0171  [2]
DBIA
 Probe Info  		C16(1.16)  LDD0078  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
IA-alkyne
 Probe Info  		C70(0.00); C80(0.00); C16(0.00)  LDD0162  [5]
IPM
 Probe Info  		C70(0.00); C16(0.00)  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
TFBX
 Probe Info  		C16(0.00); C80(0.00)  LDD0027  [6]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		C16(0.00); C70(0.00)  LDD0018  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C16(2.92)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C70(1.61)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C70(1.12)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C70(0.98)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C70(0.95)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C70(0.92)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C70(1.29)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C70(0.98)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C70(1.06)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C70(0.91)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C70(1.01)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C70(1.02)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C70(1.01)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C70(1.04)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C70(1.01)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C70(1.08)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C70(0.97)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C70(0.87)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C70(1.05)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C70(0.86)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C70(1.23)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C70(1.03)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C70(0.95)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C70(0.99)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C70(0.94)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C70(0.89)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C70(1.20)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C70(1.26)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C70(0.81)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C70(0.84)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C70(1.01)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C70(1.09)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C70(1.15)  LDD0843  [3]
 LDCM0259  AC14 HCT 116 C70(1.16)  LDD0576  [3]
 LDCM0263  AC143 HEK-293T C70(0.68)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C70(0.80)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C70(0.81)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C70(0.79)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C70(0.71)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C70(0.79)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C70(0.61)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C70(1.44)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C70(0.81)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C70(0.60)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C70(0.50)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C70(0.81)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C70(0.58)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C70(0.69)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C70(0.53)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C70(0.60)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C70(0.94)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C70(0.99)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C70(0.98)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C70(1.63)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C70(1.02)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C70(1.05)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C70(0.85)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C70(0.82)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C70(0.91)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C70(1.07)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C70(1.24)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C70(1.14)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C70(1.48)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C70(1.15)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C70(1.35)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C70(1.11)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C70(1.25)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C70(1.35)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C70(1.14)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C70(1.45)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C16(1.00); C70(1.07)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C16(0.93); C70(1.03)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C16(1.06); C70(1.09)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C16(0.66); C70(1.18)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C16(0.89); C70(1.41)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C70(1.63)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C16(1.13); C70(1.30)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C16(1.04); C70(1.70)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C16(1.41); C70(1.25)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C16(1.18); C70(1.70)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C16(1.01); C70(1.25)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C16(1.29); C70(1.66)  LDD0905  [3]
 LDCM0308  AC46 HCT 116 C70(1.61)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C70(1.19)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C70(1.95)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C70(1.55)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C70(1.55)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C70(1.26)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C70(1.28)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C70(1.09)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C70(1.48)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C70(1.48)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C70(1.55)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C70(2.17)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C70(1.39)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C70(1.01)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C70(1.15)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C70(0.92)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C70(1.43)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C70(1.18)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C70(1.13)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C70(1.17)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C70(1.03)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C70(1.14)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C70(1.07)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C70(1.09)  LDD0929  [3]
 LDCM0332  AC68 HCT 116 C70(0.65)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C70(0.66)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C70(1.00)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C70(0.75)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C70(0.69)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C70(0.52)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C70(0.78)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C70(1.11)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C70(0.73)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C70(0.76)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C70(0.79)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C70(0.56)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C70(0.60)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C70(1.05)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C70(0.57)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C70(1.07)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C70(0.80)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C70(1.60)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C70(1.49)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C70(1.26)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C70(1.37)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C70(0.90)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C70(1.16)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C70(1.36)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C70(1.13)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C70(1.53)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C70(1.40)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C70(0.92)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C70(1.05)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C70(1.08)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C70(1.19)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C70(1.12)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C70(0.91)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C70(1.00)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C70(1.24)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C70(1.47)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C70(1.31)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C16(1.16)  LDD0078  [3]
 LDCM0630  CCW28-3 231MFP C16(1.50)  LDD2214  [12]
 LDCM0108  Chloroacetamide HeLa C80(0.00); C70(0.00)  LDD0222  [10]
 LDCM0367  CL1 HCT 116 C70(1.03)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C70(1.70)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C70(1.52)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C70(1.21)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C70(0.98)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C70(0.96)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C70(1.36)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C70(1.01)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C70(1.31)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C70(1.50)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C70(1.40)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C70(1.03)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C70(1.14)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C70(1.29)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C70(0.87)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C70(0.98)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C70(1.25)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C70(1.36)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C70(1.21)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C70(1.26)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C16(0.83); C70(1.48)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C16(1.16); C70(1.31)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C16(0.93); C70(1.37)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C70(1.59)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C16(0.84); C70(1.38)  LDD0989  [3]
 LDCM0392  CL121 HCT 116 C70(2.23)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C70(1.43)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C70(1.44)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C70(1.54)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C70(0.91)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C70(1.32)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C70(1.00)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C70(1.08)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C70(1.21)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C70(0.97)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C70(1.44)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C70(0.97)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C70(0.75)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C70(0.81)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C70(0.85)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C70(1.10)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C70(0.68)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C70(0.77)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C70(0.91)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C70(0.98)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C70(0.86)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C70(0.93)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C70(0.85)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C70(0.75)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C70(0.77)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C70(0.72)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C70(1.17)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C70(1.13)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C70(1.32)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C70(1.19)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C70(0.96)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C70(1.28)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C70(1.28)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C70(1.20)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C70(1.07)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C70(0.98)  LDD1026  [3]
 LDCM0429  CL4 HCT 116 C70(0.94)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C70(1.13)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C70(1.13)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C70(1.11)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C70(1.18)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C70(1.26)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C70(1.51)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C16(1.19); C70(1.06)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C16(1.08); C70(1.25)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C16(1.04); C70(1.16)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C16(1.04); C70(1.22)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C70(0.87)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C16(1.48); C70(1.35)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C16(1.37); C70(1.54)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C16(0.78); C70(1.14)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C16(0.99); C70(1.19)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C16(1.07); C70(1.24)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C16(1.43); C70(1.31)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C16(1.06); C70(1.41)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C16(1.19); C70(1.35)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C16(1.38); C70(1.29)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C16(1.46); C70(1.43)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C70(0.91)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C16(1.78); C70(1.41)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C16(0.99); C70(0.86)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C16(1.01); C70(0.87)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C16(0.90); C70(0.97)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C16(0.97); C70(0.91)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C16(1.04); C70(0.88)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C16(0.78); C70(1.00)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C16(0.89); C70(0.95)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C16(0.88); C70(0.80)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C16(0.78); C70(0.74)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C70(1.05)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C16(1.04); C70(1.03)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C16(1.29); C70(0.83)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C16(0.96); C70(0.78)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C16(0.93); C70(0.98)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C16(1.26); C70(0.83)  LDD1065  [3]
 LDCM0469  CL76 HCT 116 C70(1.10)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C70(1.22)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C70(1.08)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C70(1.20)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C70(1.74)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C70(0.93)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C70(1.01)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C70(1.36)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C70(1.25)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C70(1.33)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C70(1.03)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C70(1.03)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C70(1.21)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C70(1.22)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C70(1.34)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C70(1.09)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C70(1.06)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C70(1.18)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C70(1.20)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C70(1.26)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C70(1.32)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C70(1.34)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C70(1.32)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C70(1.53)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C70(1.63)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C70(1.67)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C70(1.13); C16(1.02)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C70(1.00)  LDD1702  [14]
 LDCM0468  Fragment33 HEK-293T C16(1.43); C70(0.70)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C70(1.61)  LDD1025  [3]
 LDCM0022  KB02 HEK-293T C70(1.04); C16(0.95)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C70(1.00); C16(1.00)  LDD1497  [13]
 LDCM0024  KB05 G361 C70(3.58)  LDD3311  [15]
 LDCM0131  RA190 MM1.R C16(1.42)  LDD0304  [16]
 LDCM0021  THZ1 HCT 116 C70(1.15)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diamine acetyltransferase 1 (SAT1) Acetyltransferase family P21673
Superoxide dismutase [Cu-Zn] (SOD1) Cu-Zn superoxide dismutase family P00441
Protein DDI1 homolog 1 (DDI1) DDI1 family Q8WTU0
Ribonuclease P protein subunit p29 (POP4) Eukaryotic/archaeal RNase P protein component 1 family O95707
Ribonuclease P protein subunit p14 (RPP14) Eukaryotic/archaeal RNase P protein component 2 family O95059
Ribonuclease P/MRP protein subunit POP5 (POP5) Eukaryotic/archaeal RNase P protein component 2 family Q969H6
Ribonuclease P protein subunit p20 (POP7) Histone-like Alba family O75817
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Transcription initiation factor IIB (GTF2B) TFIIB family Q00403
Ribonucleases P/MRP protein subunit POP1 (POP1) . Q99575
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Optineurin (OPTN) . Q96CV9
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription regulator protein BACH2 (BACH2) BZIP family Q9BYV9
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Protein LDOC1 (LDOC1) LDOC1 family O95751
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
RNA-binding protein FUS (FUS) RRM TET family P35637
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
DnaJ homolog subfamily B member 6 (DNAJB6) . O75190
General transcription factor 3C polypeptide 3 (GTF3C3) . Q9Y5Q9
Leucine-rich repeat-containing protein 73 (LRRC73) . Q5JTD7
PDZ and LIM domain protein 7 (PDLIM7) . Q9NR12
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
12 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
16 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.