Details of the Target

General Information of Target

Target ID LDTP10577
Target Name FYVE, RhoGEF and PH domain-containing protein 4 (FGD4)
Gene Name FGD4
Gene ID 121512
Synonyms
FRABP; ZFYVE6; FYVE, RhoGEF and PH domain-containing protein 4; Actin filament-binding protein frabin; FGD1-related F-actin-binding protein; Zinc finger FYVE domain-containing protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMF
TADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFC
CSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKL
MSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSE
FYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILL
LKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWL
QMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHE
GTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCF
HKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVL
DKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEV
RRCN
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton
Function Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8.
Uniprot ID
Q96M96
Ensemble ID
ENST00000427716.7
HGNC ID
HGNC:19125

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C102(0.99); C234(1.06); C614(1.12); C88(0.99)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C102(0.99); C234(1.06); C614(1.12); C88(0.99)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C102(1.27); C234(1.15); C614(1.07); C88(1.27)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C102(0.80); C88(0.80)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C102(0.80); C88(0.80)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C102(0.80); C88(0.80)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C102(1.05); C88(1.05)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C102(0.81); C88(0.81)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C102(1.03); C88(1.03)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C102(1.06); C88(1.06)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C102(0.95); C88(0.64)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C102(0.97); C88(2.14)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C102(0.89); C88(2.11)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C102(1.21); C234(1.11); C614(1.02); C88(1.21)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C102(0.81); C88(2.02)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C102(0.97); C88(2.47)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C102(0.95); C88(1.19)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C102(1.06); C234(0.98); C614(1.14); C88(1.06)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C102(1.03); C234(1.02); C614(1.19); C88(1.03)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C102(1.19); C234(1.14); C614(1.31); C88(1.19)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C102(1.12); C234(1.16); C614(1.36); C88(1.12)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C102(1.03); C234(1.00); C614(1.57); C88(1.03)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C102(0.99); C234(0.91); C614(1.41); C88(0.99)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C102(1.10); C234(0.94); C614(1.49); C88(1.10)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C102(0.99); C234(1.01); C614(0.99); C88(0.99)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C102(1.11); C234(1.13); C614(1.23); C88(1.11)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C102(0.95); C234(0.80); C614(1.44); C88(0.95)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C102(0.96); C234(0.92); C614(1.30); C88(0.96)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C102(0.86); C234(0.96); C614(1.14); C88(0.86)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C102(1.03); C234(0.91); C614(1.51); C88(1.03)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C102(0.87); C234(1.11); C614(1.37); C88(0.87)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C102(1.04); C234(0.98); C614(1.22); C88(1.04)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C102(0.91); C234(1.02); C614(1.27); C88(0.91)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C102(1.28); C234(1.20); C614(1.00); C88(1.28)  LDD0576  [1]
 LDCM0263  AC143 PaTu 8988t C234(1.11)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C234(1.00)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C234(0.98)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C234(1.54)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C234(1.07)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C234(1.16)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C234(1.24)  LDD1148  [1]
 LDCM0270  AC15 HCT 116 C614(0.98); C102(1.14); C88(1.14); C234(1.22)  LDD0587  [1]
 LDCM0271  AC150 PaTu 8988t C234(1.01)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C234(1.07)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C234(1.04)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C234(1.29)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C234(1.09)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C234(1.04)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C234(1.15)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C234(1.03)  LDD2169  [1]
 LDCM0276  AC17 HCT 116 C234(1.17); C102(1.17); C88(1.17)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C234(1.13); C102(1.16); C88(1.16)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C234(1.25); C102(1.54); C88(1.54)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C102(0.95); C88(0.95); C614(0.98); C234(1.08)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C234(1.05); C102(1.29); C88(1.29)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C234(1.08); C102(1.12); C88(1.12)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C234(0.90); C102(1.01); C88(1.01)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C234(0.96); C102(1.23); C88(1.23)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C234(1.08); C102(1.16); C88(1.16)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C102(0.82); C88(0.82); C234(1.04)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C102(0.96); C88(0.96); C234(1.24)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C102(1.20); C88(1.20); C234(1.23)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C234(1.13); C102(1.14); C88(1.14)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C234(1.12); C102(1.15); C88(1.15)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C614(0.97); C234(1.01); C102(1.02); C88(1.02)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C234(1.24); C102(1.34); C88(1.34)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C102(1.17); C88(1.17); C234(1.24)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C102(1.23); C88(1.23); C234(1.34)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C102(1.19); C88(1.19); C234(1.26)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C102(1.11); C88(1.11); C234(1.42)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C234(0.83); C102(0.93); C88(0.93)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C234(0.80); C102(0.95); C88(0.95)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C102(0.90); C88(0.90); C234(0.91)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C234(0.86); C102(0.99); C88(0.99)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C234(0.91); C102(0.91); C88(0.91)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C102(1.04); C88(1.04); C234(1.12); C614(1.18)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C102(0.99); C88(0.99); C234(1.01)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C234(0.79); C102(1.04); C88(1.04)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C234(0.85); C102(1.17); C88(1.17)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C234(0.87); C102(1.16); C88(1.16)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C234(0.88); C102(0.96); C88(0.96)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C234(1.01); C102(1.08); C88(1.08)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C234(0.90); C614(1.01); C102(1.10); C88(1.10)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C102(0.87); C88(0.87); C234(0.89); C614(0.99)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C234(0.81); C102(0.87); C88(0.87); C614(1.06)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C614(0.97); C102(1.11); C88(1.11); C234(1.32)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C102(0.99); C88(0.99); C614(1.09); C234(1.16)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C102(0.92); C88(0.92); C614(1.03); C234(1.11)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C234(0.73); C102(1.01); C88(1.01); C614(1.02)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C102(0.94); C88(0.94); C234(0.95); C614(1.02)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C102(1.02); C88(1.02); C614(1.09); C234(1.09)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C102(0.84); C88(0.84); C234(1.04); C614(1.09)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C614(0.98); C102(1.09); C88(1.09); C234(1.29)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C102(0.88); C88(0.88); C614(1.03); C234(1.43)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C614(1.21); C102(1.24); C88(1.24)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C614(0.86); C102(1.09); C88(1.09)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C614(1.27); C102(1.55); C88(1.55)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C614(0.96); C234(1.09); C102(1.21); C88(1.21)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C614(1.22); C102(1.38); C88(1.38)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C614(1.02); C102(1.03); C88(1.03)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C614(1.30); C102(1.34); C88(1.34)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C102(1.31); C88(1.31); C614(1.32)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C102(1.38); C88(1.38); C614(1.43)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C614(1.18); C102(1.26); C88(1.26)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C614(1.01); C102(1.22); C88(1.22)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C102(1.40); C88(1.40); C614(1.49)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C234(0.96); C102(1.20); C88(1.20)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C234(1.05); C102(1.21); C88(1.21)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C102(0.88); C88(0.88); C614(0.90); C234(1.04)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C234(0.85); C102(0.97); C88(0.97)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C234(0.90); C102(1.08); C88(1.08)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C234(1.01); C102(1.15); C88(1.15)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C234(1.25); C102(1.63); C88(1.63)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C102(1.40); C88(1.40); C234(1.43)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C234(1.29); C102(1.93); C88(1.93)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C234(1.07); C102(1.38); C88(1.38)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C234(1.11); C102(1.63); C88(1.63)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C234(0.84); C102(1.30); C88(1.30)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C234(0.91); C102(1.01); C88(1.01)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C102(0.84); C88(0.84); C614(0.96); C234(1.19)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C234(1.27); C102(1.40); C88(1.40)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C234(0.28); C102(0.89); C88(0.89)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C234(1.00); C102(1.49); C88(1.49)  LDD0665  [1]
 LDCM0349  AC83 PaTu 8988t C102(1.15); C88(1.15); C234(1.00)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C102(0.93); C88(0.93); C234(0.85)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C102(1.26); C88(1.26); C234(0.88)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C102(1.22); C88(1.22); C234(0.99)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C102(1.36); C88(1.36); C234(0.96)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C102(1.16); C88(1.16); C234(1.04)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C102(0.98); C88(0.98); C234(0.99)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C102(0.99); C88(0.99); C234(0.92)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C102(1.10); C88(1.10); C234(0.90)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C102(1.08); C88(1.08); C234(1.04)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C102(1.07); C88(1.07); C234(0.94)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C102(1.19); C88(1.19); C234(1.11)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C102(1.06); C88(1.06); C234(0.97)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C102(0.87); C88(0.87); C234(0.94)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C102(0.81); C88(0.81); C234(0.93)  LDD1243  [1]
 LDCM0365  AC98 HCT 116 C102(1.04); C88(1.04)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C102(0.76); C88(0.76)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C102(0.97); C234(0.97); C614(1.03); C88(0.97)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C102(0.91); C88(0.91); C614(1.00); C234(1.17)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C614(0.99); C234(1.55); C102(1.87); C88(1.87)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C102(1.35); C88(1.35)  LDD2171  [1]
 LDCM0367  CL1 HCT 116 C234(0.80); C102(0.89); C88(0.89)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C102(1.08); C88(1.08); C234(1.16)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C614(0.94); C102(1.01); C88(1.01); C234(1.12)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C614(0.98); C234(1.19); C102(1.33); C88(1.33)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C614(0.99); C234(1.02); C102(1.18); C88(1.18)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C614(0.93); C234(0.94); C102(1.09); C88(1.09)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C614(0.98); C102(1.08); C88(1.08); C234(1.11)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C234(1.08); C102(1.27); C88(1.27)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C102(1.39); C88(1.39); C234(1.46)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C102(1.22); C88(1.22); C234(1.38)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C102(1.27); C88(1.27); C234(1.54)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C234(1.21); C102(1.59); C88(1.59)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C102(1.12); C88(1.12); C234(1.31)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C234(1.12); C102(1.72); C88(1.72)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C234(1.05); C102(1.22); C88(1.22)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C234(0.82); C102(1.04); C88(1.04)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C234(1.16); C102(1.22); C88(1.22)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C102(1.05); C88(1.05); C234(1.11)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C234(1.08); C102(1.17); C88(1.17)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C102(0.98); C88(0.98); C234(1.12)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C102(1.19); C88(1.19); C234(1.28)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C234(1.00); C102(1.19); C88(1.19)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C234(0.99); C102(1.30); C88(1.30)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C102(1.46); C88(1.46); C234(1.56)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C234(0.77); C102(1.13); C88(1.13)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C234(0.76); C614(1.01); C102(1.22); C88(1.22)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C102(0.92); C88(0.92); C614(0.94); C234(1.03)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C102(0.90); C88(0.90); C234(1.01); C614(1.06)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C102(0.87); C88(0.87); C614(1.06); C234(1.22)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C614(1.09); C102(1.33); C88(1.33)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C102(1.07); C88(1.07); C614(1.11)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C614(1.03); C102(1.17); C88(1.17)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C102(1.17); C88(1.17); C614(1.20)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C102(0.89); C88(0.89); C234(1.18)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C234(0.99); C102(1.23); C88(1.23)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C234(1.17); C102(1.18); C88(1.18)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C234(1.04); C102(1.24); C88(1.24)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C234(0.88); C102(1.20); C88(1.20)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C234(1.02); C102(1.20); C88(1.20)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C234(1.10); C102(1.42); C88(1.42)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C102(0.86); C88(0.86); C234(0.96)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C234(1.08); C102(1.99); C88(1.99)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C234(1.17); C102(1.81); C88(1.81)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C234(1.53); C102(2.10); C88(2.10)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C234(1.30); C102(1.35); C88(1.35)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C234(1.12); C102(1.68); C88(1.68)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C102(1.77); C234(0.94); C88(1.77)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C102(1.28); C234(1.07); C88(1.28)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C102(1.66); C234(0.98); C88(1.66)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C102(1.51); C234(1.12); C88(1.51)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C102(1.93); C234(1.01); C88(1.93)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C102(0.90); C234(1.00); C88(0.90)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C102(1.15); C234(1.03); C88(1.15)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C102(0.95); C88(0.95)  LDD0737  [1]
 LDCM0421  CL32 PaTu 8988t C234(1.22)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C234(1.12)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C234(1.23)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C234(1.28)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C234(0.89)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C234(1.34)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C234(1.13)  LDD1307  [1]
 LDCM0429  CL4 HCT 116 C102(1.01); C234(1.15); C88(1.01)  LDD0746  [1]
 LDCM0430  CL40 PaTu 8988t C234(1.15)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C234(1.13)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C234(1.39)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C234(1.64)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C234(1.36)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C234(1.34)  LDD1314  [1]
 LDCM0436  CL46 PaTu 8988t C102(1.04); C88(1.04); C234(1.11)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C102(0.83); C88(0.83); C234(1.33)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C102(1.22); C88(1.22); C234(1.21)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C102(1.17); C88(1.17); C234(1.18)  LDD1318  [1]
 LDCM0440  CL5 HCT 116 C102(1.07); C234(1.12); C88(1.07)  LDD0757  [1]
 LDCM0441  CL50 PaTu 8988t C102(1.30); C88(1.30); C234(1.41)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C102(1.14); C88(1.14); C234(1.16)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C102(1.10); C88(1.10); C234(1.29)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C102(1.19); C88(1.19); C234(1.22)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C102(1.06); C88(1.06); C234(1.09)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C102(1.23); C88(1.23); C234(1.38)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C102(0.99); C88(0.99); C234(1.43)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C102(1.10); C88(1.10); C234(1.36)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C102(1.29); C88(1.29); C234(1.39)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C102(1.12); C88(1.12); C234(1.31)  LDD1329  [1]
 LDCM0451  CL6 HCT 116 C102(1.33); C234(0.99); C88(1.33)  LDD0768  [1]
 LDCM0452  CL60 PaTu 8988t C102(1.05); C88(1.05); C234(1.31)  LDD1331  [1]
 LDCM0453  CL61 HCT 116 C102(0.97); C234(0.91); C88(0.97)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C102(0.90); C234(0.76); C88(0.90)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C102(0.82); C234(0.89); C88(0.82)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C102(0.98); C234(0.89); C88(0.98)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C102(0.80); C234(0.92); C88(0.80)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C102(0.84); C234(0.97); C88(0.84)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C102(0.93); C234(1.14); C88(0.93)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C102(0.91); C234(0.97); C88(0.91)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C102(1.01); C234(0.89); C88(1.01)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C102(0.95); C234(1.27); C88(0.95)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C102(0.91); C234(0.72); C88(0.91)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C102(0.94); C234(0.81); C88(0.94)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C102(1.43); C234(0.94); C88(1.43)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C102(1.08); C234(1.05); C88(1.08)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C102(1.21); C234(0.86); C88(1.21)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C102(1.10); C234(1.05); C88(1.10)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C102(1.07); C234(1.15); C88(1.07)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C102(0.98); C234(1.20); C88(0.98)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C102(0.97); C234(1.54); C88(0.97)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C102(0.91); C234(1.55); C88(0.91)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C102(0.93); C234(1.17); C88(0.93)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C102(1.20); C234(1.21); C88(1.20)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C102(0.94); C234(1.57); C88(0.94)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C102(1.02); C234(1.39); C88(1.02)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C102(0.94); C234(2.00); C88(0.94)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C102(1.04); C234(1.20); C88(1.04)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C102(0.96); C234(0.97); C88(0.96)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C102(0.91); C234(1.20); C88(0.91)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C102(1.02); C234(1.50); C88(1.02)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C102(0.95); C234(1.83); C88(0.95)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C102(0.98); C234(1.28); C88(0.98)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C102(0.95); C234(0.77); C88(0.95)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C102(0.99); C234(0.99); C614(1.02); C88(0.99)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C102(0.89); C234(1.02); C614(1.05); C88(0.89)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C102(0.80); C234(1.06); C614(1.02); C88(0.80)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C102(1.10); C234(1.18); C614(1.19); C88(1.10)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C102(1.14); C234(1.14); C614(1.22); C88(1.14)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C102(1.22); C234(1.10); C614(1.01); C88(1.22)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C102(1.06); C234(1.17); C614(1.04); C88(1.06)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C102(1.02); C234(1.12); C614(1.01); C88(1.02)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C102(0.93); C234(1.26); C614(1.11); C88(0.93)  LDD0811  [1]
 LDCM0625  F8 Ramos C11(1.10)  LDD2187  [6]
 LDCM0576  Fragment14 Ramos C11(3.71)  LDD2193  [6]
 LDCM0468  Fragment33 HCT 116 C102(1.01); C234(0.84); C88(1.01)  LDD0785  [1]
 LDCM0566  Fragment4 Ramos C11(0.84)  LDD2184  [6]
 LDCM0427  Fragment51 PaTu 8988t C234(1.36)  LDD1306  [1]
 LDCM0569  Fragment7 Ramos C11(0.94)  LDD2186  [6]
 LDCM0022  KB02 Ramos C11(2.09)  LDD2182  [6]
 LDCM0023  KB03 Ramos C11(0.98)  LDD2183  [6]
 LDCM0024  KB05 MEWO C234(1.22)  LDD3319  [7]
 LDCM0021  THZ1 HCT 116 C102(1.35); C88(1.35)  LDD2173  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840