Details of the Target

General Information of Target

Target ID LDTP10337
Target Name E3 ubiquitin-protein transferase RMND5B (RMND5B)
Gene Name RMND5B
Gene ID 64777
Synonyms
E3 ubiquitin-protein transferase RMND5B; EC 2.3.2.27; Protein RMD5 homolog B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTILPKKKPPPPDADPANEPPPPGPMPPAPRRGGGVGVGGGGTGVGGGDRDRDSGVVGAR
PRASPPPQGPLPGPPGALHRWALAVPPGAVAGPRPQQASPPPCGGPGGPGGGPGDALGAA
AAGVGAAGVVVGVGGAVGVGGCCSGPGHSKRRRQAPGVGAVGGGSPEREEVGAGYNSEDE
YEAAAARIEAMDPATVEQQEHWFEKALRDKKGFIIKQMKEDGACLFRAVADQVYGDQDMH
EVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGNHIEMQAMAEMYNRPVEVYQ
YSTGTSAVEPINTFHGIHQNEDEPIRVSYHRNIHYNSVVNPNKATIGVGLGLPSFKPGFA
EQSLMKNAIKTSEESWIEQQMLEDKKRATDWEATNEAIEEQVARESYLQWLRDQEKQARQ
VRGPSQPRKASATCSSATAAASSGLEEWTSRSPRQRSSASSPEHPELHAELGMKPPSPGT
VLALAKPPSPCAPGTSSQFSAGADRATSPLVSLYPALECRALIQQMSPSAFGLNDWDDDE
ILASVLAVSQQEYLDSMKKNKVHRDPPPDKS
Target Bioclass
Enzyme
Subcellular location
Cytoplasm, cytosol
Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1.
Uniprot ID
Q96G75
Ensemble ID
ENST00000313386.9
HGNC ID
HGNC:26181

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.L57I .
HCT15 SNV: p.S217R .
MEC1 Substitution: p.F152Ter .
MELJUSO SNV: p.H167Q DBIA    Probe Info 
MOLT4 SNV: p.R362Ter .
PEO1 Deletion: p.L216_A219del .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C310(0.93)  LDD0532  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C310(0.93)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C310(0.97); C376(0.49); C379(0.49)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C310(0.96); C376(0.59); C379(0.59)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C310(0.93); C376(0.56); C379(0.56)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C310(1.22); C376(0.58); C379(0.58)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C310(1.17); C376(0.53); C379(0.53)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C310(1.20); C376(0.69); C379(0.69)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C310(1.18); C376(0.61); C379(0.61)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C310(1.34); C376(0.44); C379(0.55)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C310(1.02); C376(0.68); C379(0.54)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C310(0.79); C376(0.71); C379(0.56)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C310(0.83)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C310(0.72); C376(0.54); C379(0.59)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C310(0.86); C376(0.61); C379(0.56)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C310(0.96); C376(0.52); C379(0.56)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C310(0.91); C376(0.65); C379(0.65)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C310(0.89); C376(0.70); C379(1.01)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C310(1.02); C376(0.69); C379(1.05)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C310(1.06); C376(0.87); C379(0.95)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C310(0.96); C376(0.77); C379(0.89)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C310(1.04); C376(0.74); C379(0.84)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C310(1.17); C376(0.80); C379(0.96)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C310(0.76)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C310(0.82); C376(0.76); C379(0.90)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C310(0.83); C376(0.88); C379(0.80)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C310(1.13); C376(0.68); C379(0.87)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C310(0.73); C376(0.80); C379(0.89)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C310(0.81); C376(0.75); C379(0.73)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C310(0.88); C376(0.75); C379(0.99)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C310(0.82); C376(0.72); C379(0.97)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C310(1.11); C376(0.74); C379(0.74)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C310(0.93)  LDD0576  [1]
 LDCM0263  AC143 HCT 116 C310(1.16)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C310(1.14)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C310(1.18)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C310(1.29)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C310(0.96)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C310(1.39)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C310(1.51)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C310(0.97)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C310(1.13)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C310(1.18)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C310(1.23)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C310(1.91)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C310(1.19)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C310(1.32)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C310(1.29)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C310(1.27)  LDD2161  [1]
 LDCM0276  AC17 PaTu 8988t C376(0.96); C379(0.96)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C376(1.03); C379(1.03)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C376(1.16); C379(1.16)  LDD1157  [1]
 LDCM0280  AC20 PaTu 8988t C376(1.44); C379(1.44)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C376(1.09); C379(1.09)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C376(1.09); C379(1.09)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C376(1.56); C379(1.56)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C376(1.66); C379(1.66)  LDD1163  [1]
 LDCM0285  AC25 HCT 116 C376(0.40); C379(0.40); C310(1.07)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C376(0.31); C379(0.31); C310(1.20)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C376(0.64); C379(0.64); C310(1.30)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C376(0.34); C379(0.34); C310(1.19)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C376(0.39); C379(0.39); C310(1.21)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C376(0.37); C379(0.37); C310(1.26)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C376(0.53); C379(0.53); C310(1.24)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C376(0.38); C379(0.38); C310(1.39)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C376(0.47); C379(0.47); C310(1.22)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C376(0.53); C379(0.53); C310(1.25)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C310(0.88)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C310(0.91)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C310(0.86)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C310(0.92)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C310(1.00)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C310(1.02)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C310(0.97)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C310(1.03)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C310(0.99)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C310(0.95)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C310(1.00)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C310(1.10)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C310(0.80)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C310(0.81)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C310(0.97)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C310(0.92)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C310(0.82)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C310(0.90)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C310(0.89)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C310(0.80)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C310(0.91)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C310(0.73)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C310(0.85); C376(0.89); C379(0.89)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C376(0.90); C379(0.90); C310(1.15)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C376(0.87); C379(0.87); C310(0.95)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C310(1.07)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C310(0.79); C376(0.81); C379(0.81)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C310(0.95); C376(0.99); C379(0.99)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C310(0.80); C376(0.89); C379(0.89)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C310(0.77); C376(0.85); C379(0.85)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C310(0.73); C376(1.02); C379(1.02)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C310(0.92); C376(1.05); C379(1.05)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C376(0.90); C379(0.90); C310(0.95)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C310(0.84); C376(1.06); C379(1.06)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C310(1.02)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C310(1.02)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C310(0.89)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C310(1.27)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C310(1.14)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C310(1.29)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C310(1.41)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C310(1.11)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C310(1.16)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C310(0.97)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C310(0.80)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C310(0.97)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C310(0.98)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C310(0.99)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C310(1.04)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C310(1.16)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C310(0.97)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C376(1.29); C379(1.29)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C376(1.08); C379(1.08)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C376(0.96); C379(0.96)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C376(1.27); C379(1.27)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C376(1.39); C379(1.39)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C376(1.15); C379(1.15)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C376(1.28); C379(1.28)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C376(1.25); C379(1.25)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C376(1.14); C379(1.14)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C376(1.17); C379(1.17)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C376(0.99); C379(0.99)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C376(1.07); C379(1.07)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C376(1.02); C379(1.02)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C376(1.05); C379(1.05)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C376(0.92); C379(0.92)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C376(0.61); C379(0.61); C310(1.40)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C376(0.46); C379(0.46); C310(0.91)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C310(0.86)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C310(0.81)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C310(1.11)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C310(1.03)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C310(1.10)  LDD0685  [1]
 LDCM0370  CL101 HCT 116 C310(0.98)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C310(0.91)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C310(0.79)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C310(1.02)  LDD0690  [1]
 LDCM0374  CL105 PaTu 8988t C376(1.20); C379(1.20)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C376(1.13); C379(1.13)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C376(0.97); C379(0.97)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C376(0.98); C379(0.98)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C376(1.45); C379(1.45)  LDD1257  [1]
 LDCM0379  CL11 HCT 116 C310(1.05)  LDD0696  [1]
 LDCM0380  CL110 PaTu 8988t C376(1.16); C379(1.16)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C376(1.53); C379(1.53)  LDD1260  [1]
 LDCM0382  CL112 HCT 116 C376(0.69); C379(0.69); C310(1.37)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C376(0.38); C379(0.38); C310(1.36)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C376(0.37); C379(0.37); C310(1.82)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C376(0.36); C379(0.36); C310(1.64)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C376(0.47); C379(0.47); C310(1.27)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C310(1.36)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C310(1.29)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C310(1.22)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C310(1.16)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C310(1.10)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C310(1.00)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C310(0.73)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C310(0.67)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C310(0.82)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C376(0.96); C379(0.96); C310(1.17)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C376(0.81); C379(0.81); C310(1.35)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C376(0.82); C379(0.82); C310(1.18)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C310(0.97); C376(1.06); C379(1.06)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C310(0.95)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C310(0.89)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C310(1.10)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C310(1.04); C376(1.06); C379(1.06)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C376(1.01); C379(1.01); C310(1.28)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C376(0.89); C379(0.89); C310(1.28)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C376(0.99); C379(0.99); C310(1.08)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C310(1.03)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C376(1.10); C379(1.10); C310(1.24)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C376(1.26); C379(1.26); C310(1.42)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C310(1.49); C376(1.89); C379(1.89)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C376(1.06); C379(1.06); C310(1.15)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C310(1.37); C376(1.23); C379(1.23)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C310(1.45); C376(1.23); C379(1.23)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C310(0.98); C376(0.91); C379(0.91)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C310(1.07); C376(1.07); C379(1.07)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C310(1.14); C376(1.05); C379(1.05)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C310(1.13); C376(1.03); C379(1.03)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C310(0.92)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C310(1.12); C376(0.94); C379(0.94)  LDD0736  [1]
 LDCM0420  CL31 PaTu 8988t C376(0.94); C379(0.94)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C376(0.95); C379(0.95)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C376(0.93); C379(0.93)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C376(0.92); C379(0.92)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C376(0.89); C379(0.89)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C376(0.24); C379(0.24)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C376(0.96); C379(0.96)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C376(0.99); C379(0.99)  LDD1307  [1]
 LDCM0429  CL4 HCT 116 C310(0.92)  LDD0746  [1]
 LDCM0430  CL40 PaTu 8988t C376(0.95); C379(0.95)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C376(0.84); C379(0.84)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C376(0.94); C379(0.94)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C376(0.96); C379(0.96)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C376(0.95); C379(0.95)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C376(1.04); C379(1.04)  LDD1314  [1]
 LDCM0436  CL46 HCT 116 C376(0.95); C379(0.95)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C376(0.91); C379(0.91)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C376(0.72); C379(0.72)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C376(0.95); C379(0.95)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C310(1.00)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C376(0.71); C379(0.71)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C376(1.02); C379(1.02)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C376(0.82); C379(0.82)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C376(0.62); C379(0.62)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C376(0.80); C379(0.80)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C376(0.89); C379(0.89)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C376(0.76); C379(0.76)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C376(0.87); C379(0.87)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C376(0.85); C379(0.85)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C376(1.04); C379(1.04)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C310(1.24)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C376(0.91); C379(0.91)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C310(1.26)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C310(1.32)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C310(1.10)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C310(1.51)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C310(1.32)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C310(1.40)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C310(1.18)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C310(1.32)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C310(1.15)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C310(1.15)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C310(1.16)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C310(1.11)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C310(1.05)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C310(1.11)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C310(1.14)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C310(1.06); C376(0.80); C379(0.80)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C310(0.99); C376(1.03); C379(1.03)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C310(0.91); C376(0.93); C379(0.93)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C310(1.19); C376(1.05); C379(1.05)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C310(1.36)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C310(1.06); C376(1.15); C379(1.15)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C310(1.20); C376(1.33); C379(1.33)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C310(1.26); C376(1.15); C379(1.15)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C310(1.23); C376(0.67); C379(0.67)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C310(1.18); C376(1.36); C379(1.36)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C310(0.89); C376(1.01); C379(1.01)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C310(0.89); C376(1.06); C379(1.06)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C310(1.00); C376(1.21); C379(1.21)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C310(1.11); C376(1.29); C379(1.29)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C310(1.27); C376(1.09); C379(1.09)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C310(1.05)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C310(1.01); C376(1.24); C379(1.24)  LDD0802  [1]
 LDCM0468  Fragment33 HCT 116 C310(1.29)  LDD0785  [1]
 LDCM0427  Fragment51 PaTu 8988t C376(0.98); C379(0.98)  LDD1306  [1]
 LDCM0022  KB02 A-172 C310(1.36)  LDD2251  [2]
 LDCM0023  KB03 A-172 C310(2.36)  LDD2668  [2]
 LDCM0024  KB05 MKN45 C310(3.34)  LDD3332  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840