Details of the Target

General Information of Target

Target ID LDTP10006
Target Name BLOC-1-related complex subunit 5 (BORCS5)
Gene Name BORCS5
Gene ID 118426
Synonyms
LOH12CR1; BLOC-1-related complex subunit 5; Loss of heterozygosity 12 chromosomal region 1; Myristoylated lysosomal protein; Myrlysin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAREPRKNAALDAQSAEDQTGLLTVKVEKEEASALTAEVRAPCSPARGPERSRQRFRGFR
YPEAAGPREALSRLRELCGQWLQPEMHSKEQILELLVLEQFLTILPGNLQSWVREQHPES
GEEVVVLLEYLERQLDEPAPQVPVGDQGQELLCCKMALLTQTQGSQSSQCQPMKALFKHE
SLGSQPLHDRVLQVPGLAQGGCCREDAMVASRLTPGSQGLLKMEDVALTLTPGWTQLDSS
QVNLYRDEKQENHSSLVSLGGEIQTKSRDLPPVKKLPEKEHGKICHLREDIAQIPTHAEA
GEQEGRLQRKQKNAIGSRRHYCHECGKSFAQSSGLTKHRRIHTGEKPYECEDCGKTFIGS
SALVIHQRVHTGEKPYECEECGKVFSHSSNLIKHQRTHTGEKPYECDDCGKTFSQSCSLL
EHHKIHTGEKPYQCNMCGKAFRRNSHLLRHQRIHGDKNVQNPEHGESWESQGRTESQWEN
TEAPVSYKCNECERSFTRNRSLIEHQKIHTGEKPYQCDTCGKGFTRTSYLVQHQRSHVGK
KTLSQ
Target Bioclass
Other
Family
BORCS5 family
Subcellular location
Lysosome membrane
Function
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility.
Uniprot ID
Q969J3
Ensemble ID
ENST00000298571.6
HGNC ID
HGNC:17950

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.L16V .
HG3 SNV: p.R95Q .
LN18 SNV: p.Q63R .
MCC13 SNV: p.L173F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C93(1.43)  LDD2182  [1]
DBIA
 Probe Info  		C93(0.98)  LDD0532  [2]
m-APA
 Probe Info  		N.A.  LDD2232  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
AOyne
 Probe Info  		14.90  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C93(0.95)  LDD0812  [2]
 LDCM0215  AC10 HCT 116 C93(0.98)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C93(1.04)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C93(1.27)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C93(0.69)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C93(1.55)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C93(1.12)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C93(1.08)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C93(0.86)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C93(1.07)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C93(0.82)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C93(1.27)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C93(0.94)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C93(1.25)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C93(1.59)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C93(1.32)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C93(0.95)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C93(1.10)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C93(1.34)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C93(1.13)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C93(0.92)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C93(1.18)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C93(1.40)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C93(0.94)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C93(1.14)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C93(0.93)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C93(1.41)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C93(1.09)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C93(1.06)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C93(0.95)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C93(1.09)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C93(0.91)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C93(0.99)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C93(1.07)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C93(1.21)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C93(0.74)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C93(0.99)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C93(0.97)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C93(0.94)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C93(1.11)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C93(1.17)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C93(1.20)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C93(1.32)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C93(1.32)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C93(0.98)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C93(1.02)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C93(1.29)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C93(1.15)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C93(0.91)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C93(0.80)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C93(0.80)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C93(1.00)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C93(0.98)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C93(1.25)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C93(0.89)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C93(0.98)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C93(0.83)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C93(1.02)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C93(1.13)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C93(0.99)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C93(0.86)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C93(1.00)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C93(0.84)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C93(0.94)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C93(0.99)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C93(0.86)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C93(0.89)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C93(1.01)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C93(0.89)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C93(0.89)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C93(0.91)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C93(0.91)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C93(0.95)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C93(0.80)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C93(0.78)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C93(1.00)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C93(0.85)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C93(0.80)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C93(1.09)  LDD0888  [2]
 LDCM0291  AC30 HCT 116 C93(0.85)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C93(0.80)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C93(0.84)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C93(0.92)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C93(0.81)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C93(0.96)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C93(1.63)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C93(1.78)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C93(1.10)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C93(1.22)  LDD0898  [2]
 LDCM0301  AC4 HEK-293T C93(0.86)  LDD0899  [2]
 LDCM0302  AC40 HEK-293T C93(1.11)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C93(0.88)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C93(1.10)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C93(1.21)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C93(1.31)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C93(1.52)  LDD0905  [2]
 LDCM0308  AC46 HEK-293T C103(1.05); C93(1.09)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C103(1.22); C93(1.09)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C103(1.54); C93(1.18)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C103(1.16); C93(0.79)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C93(1.07)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C93(0.98)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C103(1.21); C93(0.90)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C103(1.29); C93(1.24)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C103(1.28); C93(1.22)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C103(1.07); C93(1.09)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C103(1.20); C93(1.25)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C103(1.26); C93(1.17)  LDD1558  [9]
 LDCM0320  AC57 HCT 116 C93(1.16)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C93(1.20)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C93(1.23)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C93(0.94)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C93(1.12)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C93(0.93)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C93(1.00)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C93(1.01)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C93(1.09)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C93(0.98)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C93(1.05)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C93(1.19)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C93(1.13)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C93(0.97)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C93(0.81)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C93(0.97)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C93(1.08)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C93(0.98)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C93(1.24)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C93(1.22)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C93(1.52)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C93(1.14)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C93(0.97)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C93(0.85)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C93(1.12)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C93(0.75)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C93(1.19)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C93(0.86)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C93(1.48)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C93(0.93)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C93(1.39)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C93(1.07)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C93(1.10)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C93(1.04)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C93(1.16)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C93(1.04)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C93(1.12)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C93(1.00)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C93(1.18)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C93(1.21)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C93(1.16)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C93(1.03)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C93(1.33)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C93(1.47)  LDD0962  [2]
 LDCM0365  AC98 HEK-293T C93(0.74)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C93(1.02)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C93(0.99)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C93(0.89)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C93(1.17)  LDD0592  [2]
 LDCM0367  CL1 HEK-293T C103(1.06); C93(1.04)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C103(1.18); C93(1.06)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C93(0.94)  LDD0967  [2]
 LDCM0370  CL101 HCT 116 C93(0.97)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C93(1.03)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C93(0.89)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C93(1.00)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C93(0.97)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C93(1.04)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C93(1.03)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C93(1.08)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C93(0.86)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C103(1.12); C93(0.90)  LDD1583  [9]
 LDCM0380  CL110 HCT 116 C93(1.04)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C93(0.95)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C93(0.87)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C93(0.81)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C93(0.69)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C93(0.72)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C93(0.77)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C93(1.38)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C93(1.69)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C93(1.53)  LDD0987  [2]
 LDCM0390  CL12 HEK-293T C103(1.62); C93(1.16)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C93(1.10)  LDD0989  [2]
 LDCM0392  CL121 HEK-293T C103(1.23); C93(1.05)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C103(1.08); C93(0.96)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C103(1.13)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C103(1.02); C93(1.19)  LDD1599  [9]
 LDCM0396  CL125 HCT 116 C93(1.09)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C93(1.02)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C93(1.10)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C93(1.16)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C103(1.11); C93(1.22)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C103(1.05); C93(1.11)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C103(1.26)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C103(1.23); C93(1.17)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C103(1.04); C93(1.32)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C93(1.08)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C103(1.29); C93(0.91)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C103(1.10); C93(0.96)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C103(1.26); C93(1.10)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C103(1.29); C93(1.19)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C103(1.19); C93(1.12)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C103(1.24); C93(1.19)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C103(1.42); C93(1.08)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C103(1.18); C93(1.14)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C103(1.14); C93(1.11)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C103(1.12)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C103(0.92); C93(1.09)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C103(1.06); C93(1.17)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C103(0.99)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C93(1.12)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C103(1.00); C93(0.85)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C103(1.17); C93(1.16)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C103(1.09); C93(1.21)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C103(1.26); C93(1.16)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C103(1.23); C93(1.20)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C103(1.42); C93(1.18)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C103(1.34); C93(1.07)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C103(1.15)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C103(1.11); C93(1.14)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C103(1.15); C93(1.09)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C103(1.15); C93(1.17)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C93(0.99)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C103(1.13); C93(0.74)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C103(1.14); C93(1.13)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C103(1.02); C93(1.09)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C103(1.25); C93(1.10)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C103(1.31); C93(1.28)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C103(1.62); C93(1.35)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C103(1.14); C93(1.13)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C103(0.97); C93(0.90)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C103(1.15); C93(1.04)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C103(1.00); C93(1.13)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C103(1.05); C93(1.32)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C93(1.07)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C103(1.07); C93(0.94)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C103(1.23); C93(0.99)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C103(1.02); C93(1.11)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C103(1.19); C93(1.14)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C103(1.30); C93(1.16)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C93(1.08)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C103(1.61); C93(1.35)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C103(1.27); C93(1.17)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C103(1.12); C93(1.06)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C103(1.22)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C103(1.14); C93(1.23)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C103(1.25); C93(1.24)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C93(1.04)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C103(1.24); C93(0.98)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C103(1.32); C93(1.13)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C103(1.10); C93(1.29)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C103(1.19); C93(0.88)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C103(1.40); C93(1.06)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C103(1.23); C93(1.07)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C103(1.50); C93(1.24)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C103(1.11); C93(1.05)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C103(0.98); C93(1.07)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C103(0.99); C93(1.17)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C103(0.90); C93(0.73)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C93(0.85)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C103(0.98); C93(0.77)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C103(1.30); C93(1.26)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C103(0.96); C93(0.94)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C103(1.15); C93(1.15)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C103(0.97); C93(1.04)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C103(1.09); C93(0.92)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C103(1.24); C93(1.04)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C103(1.36); C93(1.25)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C103(0.96); C93(1.01)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C103(1.04)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C103(1.16); C93(1.16)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C103(1.20); C93(1.38)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C103(1.04); C93(1.12)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C93(1.15)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C93(0.90)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C93(0.76)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C93(0.92)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C93(0.97)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C93(0.98)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C93(0.85)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C93(1.03)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C93(1.01)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C93(1.04)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C103(1.08)  LDD1698  [9]
 LDCM0625  F8 Ramos C93(1.03)  LDD2187  [1]
 LDCM0572  Fragment10 Ramos C93(0.77)  LDD2189  [1]
 LDCM0573  Fragment11 Ramos C93(20.00)  LDD2190  [1]
 LDCM0574  Fragment12 Ramos C93(0.94)  LDD2191  [1]
 LDCM0575  Fragment13 Ramos C93(0.95)  LDD2192  [1]
 LDCM0576  Fragment14 Ramos C93(2.25)  LDD2193  [1]
 LDCM0579  Fragment20 Ramos C93(0.78)  LDD2194  [1]
 LDCM0580  Fragment21 Ramos C93(0.88)  LDD2195  [1]
 LDCM0582  Fragment23 Ramos C93(3.91)  LDD2196  [1]
 LDCM0578  Fragment27 Ramos C93(1.05)  LDD2197  [1]
 LDCM0586  Fragment28 Ramos C93(0.51)  LDD2198  [1]
 LDCM0588  Fragment30 Ramos C93(1.09)  LDD2199  [1]
 LDCM0589  Fragment31 Ramos C93(1.24)  LDD2200  [1]
 LDCM0590  Fragment32 Ramos C93(0.65)  LDD2201  [1]
 LDCM0468  Fragment33 HEK-293T C103(0.92)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C93(0.84)  LDD2203  [1]
 LDCM0566  Fragment4 Ramos C93(1.39)  LDD2184  [1]
 LDCM0427  Fragment51 HEK-293T C103(1.18); C93(1.03)  LDD1631  [9]
 LDCM0610  Fragment52 Ramos C93(1.03)  LDD2204  [1]
 LDCM0614  Fragment56 Ramos C93(1.16)  LDD2205  [1]
 LDCM0569  Fragment7 Ramos C93(0.62)  LDD2186  [1]
 LDCM0571  Fragment9 Ramos C93(1.16)  LDD2188  [1]
 LDCM0022  KB02 Ramos C93(1.43)  LDD2182  [1]
 LDCM0023  KB03 Ramos C93(2.01)  LDD2183  [1]
 LDCM0024  KB05 RVH-421 C93(1.90)  LDD3413  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Poly(U)-binding-splicing factor PUF60 (PUF60) RRM half pint family Q9UHX1

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840