Details of the Target

General Information of Target

Target ID LDTP09909
Target Name Phosphomannomutase 1 (PMM1)
Gene Name PMM1
Gene ID 5372
Synonyms
PMMH22; Phosphomannomutase 1; PMM 1; EC 5.4.2.8; PMMH-22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEVLPADSGVDTLAVFMASSGTTDVTNRNSPATPPNTLNLRSSHNELLNAEIKHTETKN
STPPKCRKKYALTNIQAAMGLSDPAAQPLLGNGSANIKLVKNGENQLRKAAEQGQQDPNK
NLSPTAVINITSEKLEGKEPHPQDSSSCEILPSQPRRTKSFLNYYADLETSARELEQNRG
NHHGTAEEKSQPVQGQASTIIGNGDLLLQKPNRPQSSPEDGQVATVSSSPETKKDHPKTG
AKTDCALHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSFQTDPDLPPGWKRVS
DIAGTYYWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEKQPWSDFAVLNGG
KINSDIWKDLHAATVNPDPSLKEFEGATLRYASLKLRNAPHPDDDDSCSINSDPEAKCFA
VRSLGWVEMAEEDLAPGKSSVAVNNCIRQLSYCKNDIRDTVGIWGEGKDMYLILENDMLS
LVDPMDRSVLHSQPIVSIRVWGVGRDNGRDFAYVARDKDTRILKCHVFRCDTPAKAIATS
LHEICSKIMAERKNAKALACSSLQERANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPV
DKPVGMDILNSAIENLMTSSNKEDWLSVNMNVADATVTVISEKNEEEVLVECRVRFLSFM
GVGKDVHTFAFIMDTGNQRFECHVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQKVR
PPPPPADSVTRRVTTNVKRGVLSLIDTLKQKRPVTEMP
Target Bioclass
Enzyme
Family
Eukaryotic PMM family
Subcellular location
Cytoplasm
Function
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.
Uniprot ID
Q92871
Ensemble ID
ENST00000216259.8
HGNC ID
HGNC:9114

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K41(7.32)  LDD0277  [1]
DBIA
 Probe Info  		C201(11.98)  LDD0209  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C57(1.30)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C145(0.97)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C57(1.06)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C57(1.10)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C57(1.03)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C57(1.18)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C57(0.98)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C57(1.20)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C57(1.18)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C57(1.09)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C57(1.09)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C57(0.93)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C145(1.05)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C57(1.24)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C57(1.17)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C57(1.11)  LDD0546  [7]
 LDCM0237  AC12 HCT 116 C145(0.93)  LDD0554  [7]
 LDCM0246  AC128 PaTu 8988t C57(1.15)  LDD1125  [7]
 LDCM0247  AC129 PaTu 8988t C57(1.14)  LDD1126  [7]
 LDCM0249  AC130 PaTu 8988t C57(1.09)  LDD1128  [7]
 LDCM0250  AC131 PaTu 8988t C57(1.08)  LDD1129  [7]
 LDCM0251  AC132 PaTu 8988t C57(1.06)  LDD1130  [7]
 LDCM0252  AC133 PaTu 8988t C57(1.36)  LDD1131  [7]
 LDCM0253  AC134 PaTu 8988t C57(1.22)  LDD1132  [7]
 LDCM0254  AC135 PaTu 8988t C57(1.44)  LDD1133  [7]
 LDCM0255  AC136 PaTu 8988t C57(1.46)  LDD1134  [7]
 LDCM0256  AC137 PaTu 8988t C57(1.28)  LDD1135  [7]
 LDCM0257  AC138 PaTu 8988t C57(1.26)  LDD1136  [7]
 LDCM0258  AC139 PaTu 8988t C57(1.26)  LDD1137  [7]
 LDCM0259  AC14 HCT 116 C145(0.89)  LDD0576  [7]
 LDCM0260  AC140 PaTu 8988t C57(1.26)  LDD1139  [7]
 LDCM0261  AC141 PaTu 8988t C57(1.10)  LDD1140  [7]
 LDCM0262  AC142 PaTu 8988t C57(1.23)  LDD1141  [7]
 LDCM0263  AC143 HEK-293T C145(0.99)  LDD0861  [7]
 LDCM0264  AC144 HEK-293T C145(0.95)  LDD0862  [7]
 LDCM0265  AC145 HEK-293T C145(0.91)  LDD0863  [7]
 LDCM0266  AC146 HEK-293T C145(1.04)  LDD0864  [7]
 LDCM0267  AC147 HEK-293T C145(1.33)  LDD0865  [7]
 LDCM0268  AC148 HEK-293T C145(0.81)  LDD0866  [7]
 LDCM0269  AC149 HEK-293T C145(0.83)  LDD0867  [7]
 LDCM0270  AC15 HCT 116 C145(0.95)  LDD0587  [7]
 LDCM0271  AC150 HEK-293T C145(0.99)  LDD0869  [7]
 LDCM0272  AC151 HEK-293T C145(1.17)  LDD0870  [7]
 LDCM0273  AC152 HEK-293T C145(0.94)  LDD0871  [7]
 LDCM0274  AC153 HEK-293T C145(1.11)  LDD0872  [7]
 LDCM0621  AC154 HEK-293T C145(0.91)  LDD2162  [7]
 LDCM0622  AC155 HEK-293T C145(1.14)  LDD2163  [7]
 LDCM0623  AC156 HEK-293T C145(1.22)  LDD2164  [7]
 LDCM0624  AC157 HEK-293T C145(1.08)  LDD2165  [7]
 LDCM0276  AC17 HCT 116 C145(1.06)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C145(1.03)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C145(0.93)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C57(1.15)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C145(1.10)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C145(0.99)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C145(1.10)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C145(0.88)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C145(1.14)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C57(0.82); C145(1.04)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C57(0.81); C145(1.18)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C57(0.92); C145(1.33)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C57(0.83); C145(1.26)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C57(0.93); C145(1.38)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C57(1.19)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C57(1.16); C145(1.25)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C145(1.08); C57(1.12)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C57(1.13); C145(1.18)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C57(0.98); C145(1.19)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C57(1.15); C145(1.32)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C57(0.70); C145(0.82)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C57(0.67); C145(0.88)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C57(0.71); C145(0.88)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C57(0.73); C145(0.99)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C57(0.78); C145(0.99)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C57(1.31)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C145(0.77); C57(1.01)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C145(0.75); C57(0.81)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C145(0.82); C57(0.90)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C57(0.98); C145(1.27)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C145(0.86); C57(0.99)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C145(0.86); C57(1.13)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C145(0.87); C57(1.10)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C145(0.82); C57(1.01)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C145(0.97); C57(1.17)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C145(0.82); C57(1.07)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C57(1.47)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C145(1.11); C57(1.38)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C145(0.73); C57(1.13)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C145(0.85); C57(0.91)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C145(0.84); C57(0.99)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C145(0.93); C57(0.95)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C57(0.85); C145(1.01)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C145(0.77); C57(1.42)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C145(1.03)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C145(0.93)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C145(1.12)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C145(1.00)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C145(0.89)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C145(0.86)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C145(1.16)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C145(0.78)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C145(1.08)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C145(0.98)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C145(1.32)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C145(1.08)  LDD0648  [7]
 LDCM0332  AC68 HEK-293T C145(0.92)  LDD0930  [7]
 LDCM0333  AC69 HEK-293T C145(0.98)  LDD0931  [7]
 LDCM0334  AC7 HCT 116 C145(1.00)  LDD0651  [7]
 LDCM0335  AC70 HEK-293T C145(1.02)  LDD0933  [7]
 LDCM0336  AC71 HEK-293T C145(0.94)  LDD0934  [7]
 LDCM0337  AC72 HEK-293T C145(0.97)  LDD0935  [7]
 LDCM0338  AC73 HEK-293T C145(0.90)  LDD0936  [7]
 LDCM0339  AC74 HEK-293T C145(0.89)  LDD0937  [7]
 LDCM0340  AC75 HEK-293T C145(0.74)  LDD0938  [7]
 LDCM0341  AC76 HEK-293T C145(0.98)  LDD0939  [7]
 LDCM0342  AC77 HEK-293T C145(1.03)  LDD0940  [7]
 LDCM0343  AC78 HEK-293T C145(1.20)  LDD0941  [7]
 LDCM0344  AC79 HEK-293T C145(0.90)  LDD0942  [7]
 LDCM0345  AC8 HCT 116 C145(1.05)  LDD0662  [7]
 LDCM0346  AC80 HEK-293T C145(0.92)  LDD0944  [7]
 LDCM0347  AC81 HEK-293T C145(0.86)  LDD0945  [7]
 LDCM0348  AC82 HEK-293T C145(0.84)  LDD0946  [7]
 LDCM0349  AC83 HCT 116 C57(1.01)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C57(0.99)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C57(0.94)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C57(1.25)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C57(1.21)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C57(1.06)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C57(1.10)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C57(1.16)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C57(0.92)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C57(1.07)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C57(0.98)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C57(0.97)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C57(1.17)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C57(0.98)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C57(1.20)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C57(1.18)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C57(1.10)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C145(1.02)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C145(1.06)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C145(1.19)  LDD0592  [7]
 LDCM0367  CL1 PaTu 8988t C57(1.06)  LDD1246  [7]
 LDCM0368  CL10 PaTu 8988t C57(1.23)  LDD1247  [7]
 LDCM0369  CL100 HCT 116 C57(1.31)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C145(1.04)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C145(1.10)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C145(0.90)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C145(0.92)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C145(0.92)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C145(0.92)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C145(0.88)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C145(0.82)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C145(1.09)  LDD0695  [7]
 LDCM0379  CL11 PaTu 8988t C57(1.03)  LDD1258  [7]
 LDCM0380  CL110 HCT 116 C145(0.90)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C145(0.73)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C57(0.98); C145(1.08)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C57(1.04); C145(1.23)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C57(0.96); C145(1.10)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C57(0.89); C145(1.22)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C57(1.07); C145(1.25)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C145(0.87); C57(1.05)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C57(0.69); C145(1.41)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C57(1.07); C145(1.23)  LDD0706  [7]
 LDCM0390  CL12 PaTu 8988t C57(1.03)  LDD1269  [7]
 LDCM0391  CL120 HCT 116 C57(0.76); C145(1.11)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C57(0.85); C145(0.91)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C145(0.86); C57(1.04)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C145(0.71); C57(1.25)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C145(0.74); C57(0.96)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C145(1.61)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C145(0.82)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C145(0.97)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C145(0.95)  LDD0716  [7]
 LDCM0400  CL13 PaTu 8988t C57(1.62)  LDD1279  [7]
 LDCM0401  CL14 PaTu 8988t C57(1.29)  LDD1280  [7]
 LDCM0402  CL15 PaTu 8988t C57(0.98)  LDD1281  [7]
 LDCM0403  CL16 HEK-293T C145(1.12)  LDD1001  [7]
 LDCM0404  CL17 HCT 116 C145(1.09)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C145(1.06)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C145(0.96)  LDD0723  [7]
 LDCM0407  CL2 PaTu 8988t C57(1.00)  LDD1286  [7]
 LDCM0408  CL20 HCT 116 C145(1.03)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C145(1.04)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C145(0.97)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C145(0.94)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C145(1.02)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C145(0.86)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C145(1.05)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C145(0.93)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C145(1.29)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C145(1.00)  LDD0734  [7]
 LDCM0418  CL3 PaTu 8988t C57(1.25)  LDD1297  [7]
 LDCM0419  CL30 HCT 116 C145(0.92)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C145(0.98)  LDD0737  [7]
 LDCM0421  CL32 PaTu 8988t C57(1.26)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C57(1.41)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C57(1.28)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C57(1.26)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C57(1.54)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C57(1.54)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C57(1.25)  LDD1307  [7]
 LDCM0429  CL4 PaTu 8988t C57(1.30)  LDD1308  [7]
 LDCM0430  CL40 PaTu 8988t C57(1.26)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C57(1.46)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C57(1.50)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C57(1.68)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C57(1.49)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C57(1.70)  LDD1314  [7]
 LDCM0436  CL46 PaTu 8988t C57(1.14)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C57(1.16)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C57(0.99)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C57(1.26)  LDD1318  [7]
 LDCM0440  CL5 PaTu 8988t C57(1.54)  LDD1319  [7]
 LDCM0441  CL50 PaTu 8988t C57(1.28)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C57(1.25)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C57(1.27)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C57(1.28)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C57(1.27)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C57(1.22)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C57(0.76)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C57(1.79)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C57(1.27)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C57(1.60)  LDD1329  [7]
 LDCM0451  CL6 PaTu 8988t C57(1.04)  LDD1330  [7]
 LDCM0452  CL60 PaTu 8988t C57(1.41)  LDD1331  [7]
 LDCM0453  CL61 HCT 116 C57(1.06)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C57(1.08)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C57(1.10)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C57(1.15)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C57(0.98)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C57(0.92)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C57(0.98)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C57(0.85)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C57(1.10)  LDD0778  [7]
 LDCM0462  CL7 PaTu 8988t C57(1.31)  LDD1341  [7]
 LDCM0463  CL70 HCT 116 C57(1.18)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C57(1.10)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C57(0.96)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C57(1.05)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C57(1.00)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C57(1.09)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C57(0.99)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C57(1.08)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C57(1.30)  LDD0789  [7]
 LDCM0473  CL8 PaTu 8988t C57(1.34)  LDD1352  [7]
 LDCM0474  CL80 HCT 116 C57(1.00)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C57(1.07)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C57(1.42)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C57(1.39)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C57(1.47)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C57(1.12)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C57(1.06)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C57(1.25)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C57(1.30)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C57(1.55)  LDD0800  [7]
 LDCM0484  CL9 PaTu 8988t C57(1.22)  LDD1363  [7]
 LDCM0485  CL90 HCT 116 C57(1.04)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C57(1.18)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C57(1.18)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C57(1.12)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C57(1.60)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C57(1.70)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C57(1.27)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C57(1.29)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C57(1.22)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C57(1.42)  LDD0811  [7]
 LDCM0468  Fragment33 HCT 116 C57(1.03)  LDD0785  [7]
 LDCM0427  Fragment51 PaTu 8988t C57(1.47)  LDD1306  [7]
 LDCM0022  KB02 22RV1 C16(0.96)  LDD2243  [8]
 LDCM0023  KB03 Jurkat C201(11.98)  LDD0209  [2]
 LDCM0024  KB05 COLO792 C16(1.14); C57(1.42)  LDD3310  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-6A (RAB6A) Rab family P20340
Ras-related protein Rab-6B (RAB6B) Rab family Q9NRW1

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840