Details of the Target

General Information of Target

Target ID LDTP09822
Target Name Zinc finger protein 516 (ZNF516)
Gene Name ZNF516
Gene ID 9658
Synonyms
KIAA0222; Zinc finger protein 516
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAADTQVSETLKRFAGKVTTASVKERREILSELGKCVAGKDLPEGAVKGLCKLFCLTLHR
YRDAASRRALQAAIQQLAEAQPEATAKNLLHSLQSSGIGSKAGVPSKSSGSAALLALTWT
CLLVRIVFPSRAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDGAVKKLTKLWKENPGLV
EQYLSAILSLEPNQNYAGMLGLLVQFCTSHKEMDVVSQHKSALLDFYMKNILMSKVKPPK
YLLDSCAPLLRYLSHSEFKDLILPTIQKSLLRSPENVIETISSLLASVTLDLSQYAMDIV
KGLAGHLKSNSPRLMDEAVLALRNLARQCSDSSAMESLTKHLFAILGGSEGKLTVVAQKM
SVLSGIGSVSHHVVSGPSSQVLNGIVAELFIPFLQQEVHEGTLVHAVSVLALWCNRFTME
VPKKLTEWFKKAFSLKTSTSAVRHAYLQCMLASYRGDTLLQALDLLPLLIQTVEKAASQS
TQVPTITEGVAAALLLLKLSVADSQAEAKLSSFWQLIVDEKKQVFTSEKFLVMASEDALC
TVLHLTERLFLDHPHRLTGNKVQQYHRALVAVLLSRTWHVRRQAQQTVRKLLSSLGGFKL
AHGLLEELKTVLSSHKVLPLEALVTDAGEVTEAGKAYVPPRVLQEALCVISGVPGLKGDV
TDTEQLAQEMLIISHHPSLVAVQSGLWPALLARMKIDPEAFITRHLDQIIPRMTTQSPLN
QSSMNAMGSLSVLSPDRVLPQLISTITASVQNPALRLVTREEFAIMQTPAGELYDKSIIQ
SAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDR
EAQVRRRLQELDGELEAALGLLDIILAKNPSGLTQYIPVLVDSFLPLLKSPLAAPRIKNP
FLSLAACVMPSRLKALGTLVSHVTLRLLKPECVLDKSWCQEELSVAVKRAVMLLHTHTIT
SRVGKGEPGAAPLSAPAFSLVFPFLKMVLTEMPHHSEEEEEWMAQILQILTVQAQLRASP
NTPPGRVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASDTLTTLCASSSGDDGCAFAE
QEEVDVLLCALQSPCASVRETVLRGLMELHMVLPAPDTDEKNGLNLLRRLWVVKFDKEEE
IRKLAERLWSMMGLDLQPDLCSLLIDDVIYHEAAVRQAGAEALSQAVARYQRQAAEVMGR
LMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNKLSQYLDSSQVKPLFQFF
VPDALNDRHPDVRKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAVRQSVV
VLMGSLAKHLDKSDPKVKPIVAKLIAALSTPSQQVQESVASCLPPLVPAIKEDAGGMIQR
LMQQLLESDKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALF
AFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLP
SLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQ
ALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIV
QRAFQDRSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKA
LGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIV
ATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRA
GQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASE
DDNFGTAQSNKAIITALGVERRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLR
EILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEIIPILEEGLRSQKSDER
QGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQA
LEDILPFLLKQLDDEEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSV
AGDALTRHLGVILPAVMLALKEKLGTPDEQLEMANCQAVILSVEDDTGHRIIIEDLLEAT
RSPEVGMRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAIT
KKLDAGNQLALIEELHKEIRLIGNESKGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQK
EEAAKALGLVIRLTSADALRPSVVSITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIA
LKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLISIHIKVDPLFTELLNGIRAMEDPGV
RDTMLQALRFVIQGAGAKVDAVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAFLTEE
ELSAVLQQCLLADVSGIDWMVRHGRSLALSVAVNVAPGRLCAGRYSSDVQEMILSSATAD
RIPIAVSGVRGMGFLMRHHIETGGGQLPAKLSSLFVKCLQNPSSDIRLVAEKMIWWANKD
PLPPLDPQAIKPILKALLDNTKDKNTVVRAYSDQAIVNLLKMRQGEEVFQSLSKILDVAS
LEVLNEVNRRSLKKLASQADSTEQVDDTILT
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis. May also play a role in the cellular response to replication stress.
Uniprot ID
Q92618
Ensemble ID
ENST00000443185.7
HGNC ID
HGNC:28990

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C124(0.00); C1016(0.00)  LDD0241  [2]
AHL-Pu-1
 Probe Info  		C875(2.61); C165(3.06)  LDD0171  [3]
DBIA
 Probe Info  		C875(1.08); C386(0.92); C398(0.92)  LDD0078  [4]
IA-alkyne
 Probe Info  		C165(0.00); C1016(0.00); C827(0.00)  LDD0165  [5]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Phosphinate-6
 Probe Info  		C891(0.00); C39(0.00); C33(0.00)  LDD0018  [7]
W1
 Probe Info  		N.A.  LDD0236  [2]
AOyne
 Probe Info  		15.00  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C875(2.61); C165(3.06)  LDD0171  [3]
 LDCM0214  AC1 HCT 116 C875(0.91)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C875(1.01)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C875(0.94)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C875(1.31)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C875(1.10)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C875(1.16)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C875(0.86)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C875(1.28)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C875(1.38)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C875(1.53)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C875(1.07)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C875(1.09)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C875(0.99)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C875(1.12)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C875(1.12)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C875(1.15)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C875(0.91)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C875(1.12)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C875(1.22)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C875(1.22)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C875(0.90)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C875(1.14)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C875(0.93)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C875(0.80)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C875(1.01)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C875(0.86)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C875(1.22)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C875(0.88)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C875(1.03)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C875(1.11)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C875(1.25)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C875(1.20)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C875(0.90); C610(1.05); C611(1.05)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C875(0.81); C610(0.98); C611(0.98)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C875(0.99); C610(0.98); C611(0.98)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C875(1.03); C610(1.44); C611(1.44)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C875(1.04); C610(0.91); C611(0.91)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C875(1.14); C610(0.99); C611(0.99)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C875(1.17); C610(1.02); C611(1.02)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C875(1.25); C610(1.07); C611(1.07)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C875(0.71); C610(1.01); C611(1.01)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C875(0.82); C610(1.28); C611(1.28)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C875(0.75); C610(1.50); C611(1.50)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C875(1.01); C610(1.22); C611(1.22)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C875(0.81)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C875(1.08); C610(1.02); C611(1.02)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C875(0.83); C610(1.27); C611(1.27)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C875(1.35); C610(1.02); C611(1.02)  LDD0860  [4]
 LDCM0263  AC143 HCT 116 C875(0.81); C386(0.98); C398(0.98)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C386(1.02); C398(1.02); C875(1.19)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C875(0.85); C386(1.02); C398(1.02)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C386(1.09); C398(1.09); C875(1.10)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C386(1.05); C398(1.05); C875(1.06)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C386(1.05); C398(1.05); C875(1.61)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C386(1.07); C398(1.07); C875(1.11)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C875(0.67)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C875(0.88); C386(0.97); C398(0.97)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C875(0.82); C386(1.01); C398(1.01)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C386(1.10); C398(1.10); C875(1.36)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C386(0.95); C398(0.95); C875(1.69)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C386(1.06); C398(1.06); C875(1.05)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C386(0.90); C398(0.90); C875(1.21)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C386(1.20); C398(1.20); C875(0.90)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C386(1.15); C398(1.15); C875(0.84)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C386(0.47); C398(0.47)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C386(0.59); C398(0.59)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C386(0.45); C398(0.45)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C875(0.77)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C386(0.61); C398(0.61)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C386(0.64); C398(0.64)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C386(0.50); C398(0.50)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C386(0.48); C398(0.48)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C386(0.63); C398(0.63)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C1016(1.81); C33(0.63); C37(0.63)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C1016(1.63); C33(0.99); C37(0.99)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C1016(1.62); C33(0.82); C37(0.82)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C1016(1.26); C33(0.67); C37(0.67)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C1016(2.09); C33(1.05); C37(1.05)  LDD0887  [4]
 LDCM0290  AC3 HCT 116 C875(0.67)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C1016(2.10); C33(1.08); C37(1.08)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C1016(2.73); C33(0.82); C37(0.82)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C1016(1.95); C33(0.73); C37(0.73)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C1016(2.42); C33(0.90); C37(0.90)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C1016(3.33); C33(1.05); C37(1.05)  LDD0893  [4]
 LDCM0296  AC35 HCT 116 C875(1.15)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C875(1.18)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C875(1.05)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C875(1.24)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C875(1.44)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C875(0.61)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C875(0.88)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C875(1.19)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C875(1.23)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C875(1.56)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C875(1.05)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C875(1.17)  LDD0624  [4]
 LDCM0308  AC46 HEK-293T C33(0.80); C37(0.80); C610(1.17); C611(1.17)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C33(1.23); C37(1.23); C610(0.73); C611(0.73)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C33(0.72); C37(0.72); C610(0.65); C611(0.65)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C33(0.61); C37(0.61); C610(0.69); C611(0.69)  LDD0909  [4]
 LDCM0312  AC5 HCT 116 C875(0.59)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C33(0.93); C37(0.93); C610(0.89); C611(0.89)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C33(0.75); C37(0.75); C610(0.69); C611(0.69)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C33(0.82); C37(0.82); C610(0.53); C611(0.53)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C33(0.97); C37(0.97); C610(0.52); C611(0.52)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C33(0.73); C37(0.73); C610(0.64); C611(0.64)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C33(0.69); C37(0.69); C610(0.97); C611(0.97)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C33(0.45); C37(0.45); C610(0.90); C611(0.90)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C875(1.58); C1016(0.88)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C875(1.11); C1016(0.98)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C875(1.31); C1016(1.17)  LDD0920  [4]
 LDCM0323  AC6 HCT 116 C875(0.97)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C875(0.93); C1016(1.03)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C875(0.72); C1016(0.88)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C875(0.63); C1016(0.83)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C875(0.66); C1016(1.01)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C875(0.80); C1016(1.13)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C875(0.73); C1016(0.85)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C875(0.70); C1016(0.87)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C875(0.75); C1016(1.23)  LDD0929  [4]
 LDCM0332  AC68 HEK-293T C875(0.68)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C875(0.61)  LDD0931  [4]
 LDCM0334  AC7 HCT 116 C875(0.93)  LDD0651  [4]
 LDCM0335  AC70 HEK-293T C875(0.58)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C875(1.01)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C875(0.81)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C875(0.91)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C875(0.80)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C875(1.16)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C875(0.95)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C875(1.13)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C875(1.02)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C875(0.89)  LDD0942  [4]
 LDCM0345  AC8 HCT 116 C875(0.84)  LDD0662  [4]
 LDCM0346  AC80 HEK-293T C875(0.95)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C875(1.08)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C875(0.96)  LDD0946  [4]
 LDCM0349  AC83 HCT 116 C386(0.66); C398(0.66); C875(1.15)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C386(0.75); C398(0.75); C875(1.03)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C386(0.57); C398(0.57); C875(0.78)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C386(0.58); C398(0.58); C875(0.79)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C386(0.64); C398(0.64); C875(0.96)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C386(0.64); C398(0.64); C875(1.05)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C386(0.72); C398(0.72); C875(0.95)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C386(0.74); C398(0.74); C875(1.16)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C386(0.78); C398(0.78); C875(0.86)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C386(0.56); C398(0.56); C875(0.85)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C386(0.62); C398(0.62); C875(0.96)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C875(0.55); C386(0.63); C398(0.63)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C386(0.62); C398(0.62); C875(0.87)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C875(0.67); C386(0.74); C398(0.74)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C386(0.63); C398(0.63); C875(1.08)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C875(1.20)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C875(1.05)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C875(0.98)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C875(1.18)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C875(0.77)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C875(1.08); C386(0.92); C398(0.92)  LDD0078  [4]
 LDCM0367  CL1 HCT 116 C875(0.85)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C875(1.27)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C875(0.90)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C875(0.85)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C875(1.10)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C875(0.76)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C875(0.72)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C386(0.43); C398(0.43)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C386(0.42); C398(0.42)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C386(0.43); C398(0.43)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C386(0.41); C398(0.41)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C386(0.42); C398(0.42)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C875(1.11)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C386(0.40); C398(0.40)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C386(0.53); C398(0.53)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C1016(2.04); C33(1.08); C37(1.08)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C1016(1.92); C33(1.06); C37(1.06)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C1016(2.03); C33(0.90); C37(0.90)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C1016(1.64); C33(0.96); C37(0.96)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C1016(2.02); C33(0.97); C37(0.97)  LDD0984  [4]
 LDCM0387  CL117 HCT 116 C875(1.16)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C875(1.32)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C875(1.28)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C875(0.90)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C875(1.31)  LDD0708  [4]
 LDCM0392  CL121 HEK-293T C33(0.86); C37(0.86); C610(0.64); C611(0.64)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C33(0.89); C37(0.89); C610(0.50); C611(0.50)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C33(0.83); C37(0.83); C610(0.78); C611(0.78)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C33(0.63); C37(0.63); C610(1.08); C611(1.08)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C875(1.23); C1016(0.91)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C875(1.77); C1016(0.70)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C875(1.25); C1016(0.75)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C875(1.66); C1016(0.86)  LDD0997  [4]
 LDCM0400  CL13 HCT 116 C875(1.25)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C875(1.08)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C875(1.01)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C1016(1.40)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C1016(0.91)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C1016(1.14)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C1016(0.94)  LDD1004  [4]
 LDCM0407  CL2 HCT 116 C875(0.78)  LDD0724  [4]
 LDCM0408  CL20 HEK-293T C1016(0.99)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C1016(0.73)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C1016(0.92)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C1016(0.69)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C1016(0.97)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C1016(0.83)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C1016(0.84)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C1016(0.83)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C1016(0.66)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C1016(0.65)  LDD1015  [4]
 LDCM0418  CL3 HCT 116 C875(0.83)  LDD0735  [4]
 LDCM0419  CL30 HEK-293T C1016(0.88)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C33(0.97); C37(0.97)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C33(1.14); C37(1.14)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C33(1.03); C37(1.03)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C33(0.96); C37(0.96)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C33(0.94); C37(0.94)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C33(0.93); C37(0.93)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C33(0.88); C37(0.88)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C33(0.67); C37(0.67)  LDD1026  [4]
 LDCM0429  CL4 HCT 116 C875(0.81)  LDD0746  [4]
 LDCM0430  CL40 HEK-293T C33(0.93); C37(0.93)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C33(1.17); C37(1.17)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C33(0.78); C37(0.78)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C33(0.92); C37(0.92)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C33(0.84); C37(0.84)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C33(0.81); C37(0.81)  LDD1033  [4]
 LDCM0436  CL46 HCT 116 C386(1.04); C398(1.04)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C386(0.80); C398(0.80)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C386(1.05); C398(1.05)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C386(0.96); C398(0.96)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C875(0.94)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C386(1.09); C398(1.09)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C386(1.08); C398(1.08)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C386(1.43); C398(1.43)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C386(1.31); C398(1.31)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C386(1.16); C398(1.16)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C386(1.04); C398(1.04)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C386(1.19); C398(1.19)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C386(1.33); C398(1.33)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C386(1.31); C398(1.31)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C386(1.14); C398(1.14)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C875(0.90)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C386(1.18); C398(1.18)  LDD0769  [4]
 LDCM0453  CL61 HEK-293T C1016(0.96); C33(0.86); C37(0.86)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C1016(0.89); C33(0.95); C37(0.95)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C1016(1.80); C33(0.61); C37(0.61)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C1016(0.80); C33(0.64); C37(0.64)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C1016(0.87); C33(0.86); C37(0.86)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C1016(0.85); C33(0.60); C37(0.60)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C1016(0.91); C33(0.42); C37(0.42)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C1016(0.82); C33(0.32); C37(0.32)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C1016(0.76); C33(0.52); C37(0.52)  LDD1059  [4]
 LDCM0462  CL7 HCT 116 C875(1.16)  LDD0779  [4]
 LDCM0463  CL70 HEK-293T C1016(0.64); C33(0.49); C37(0.49)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C1016(0.94); C33(0.43); C37(0.43)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C1016(1.05); C33(0.64); C37(0.64)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C1016(0.68); C33(0.73); C37(0.73)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C1016(0.96); C33(0.63); C37(0.63)  LDD1065  [4]
 LDCM0469  CL76 HEK-293T C1016(1.05)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C1016(0.95)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C1016(1.26)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C1016(1.23)  LDD1070  [4]
 LDCM0473  CL8 HCT 116 C875(1.20)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C1016(0.95)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C1016(1.03)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C1016(0.68)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C1016(0.70)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C1016(1.21)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C1016(1.04)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C1016(1.05)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C1016(1.12)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C1016(0.88)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C1016(1.05)  LDD1081  [4]
 LDCM0484  CL9 HCT 116 C875(1.12)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C1016(0.99)  LDD1083  [4]
 LDCM0486  CL91 HCT 116 C875(0.85)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C875(1.00)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C875(0.68)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C875(0.91)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C875(1.05)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C875(0.79)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C875(0.78)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C875(1.14)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C875(1.06)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C1016(1.11)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C1016(0.96); C33(0.86); C37(0.86)  LDD1066  [4]
 LDCM0427  Fragment51 HEK-293T C33(0.48); C37(0.48)  LDD1025  [4]
 LDCM0022  KB02 HCT 116 C610(4.24); C611(4.24); C33(3.76); C37(3.76)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C610(1.66); C611(1.66); C33(1.92); C37(1.92)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C610(2.59); C611(2.59); C33(1.63); C37(1.63)  LDD0082  [4]
 LDCM0112  W16 Hep-G2 C1016(0.71)  LDD0239  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-terminal-binding protein 1 (CTBP1) D-isomer specific 2-hydroxyacid dehydrogenase family Q13363
C-terminal-binding protein 2 (CTBP2) D-isomer specific 2-hydroxyacid dehydrogenase family P56545
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Histone deacetylase 2 (HDAC2) Histone deacetylase family Q92769
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
REST corepressor 1 (RCOR1) CoREST family Q9UKL0

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402