Details of the Target

General Information of Target

Target ID LDTP09762
Target Name Aquaporin-3 (AQP3)
Gene Name AQP3
Gene ID 360
Synonyms
Aquaporin-3; AQP-3; Aquaglyceroporin-3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MHSPPRDQAAIMLWKLVENVKYEDIYEDRHDGVPSHSSRLSQLGSVSQGPYSSAPPLSHT
PSSDFQPPYFPPPYQPLPYHQSQDPYSHVNDPYSLNPLHQPQQHPWGQRQRQEVGSEAGS
LLPQPRAALPQLSGLDPRRDYHSVRRPDVLLHSAHHGLDAGMGDSLSLHGLGHPGMEDVQ
SVEDANNSGMNLLDQSVIKKVPVPPKSVTSLMMNKDGFLGGMSVNTGEVFCSVPGRLSLL
SSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLRERLEKIGLNLPAGRR
KAANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEYLNRQHTDPSDLHSRKNMLLAT
KQLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLITHGFGAPAICAALTALQNY
LTEALKGMDKMFLNNTTTNRHTSGEGPGSKTGDKEEKHRK
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
MIP/aquaporin (TC 1.A.8) family
Subcellular location
Cell membrane
Function
Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.
TTD ID
T86226
Uniprot ID
Q92482
DrugMap ID
TTLDNMQ
Ensemble ID
ENST00000297991.6
HGNC ID
HGNC:636

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURKAT SNV: p.V195M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K287(4.70)  LDD0277  [1]
Acrolein
 Probe Info  		N.A.  LDD0226  [2]
DBIA
 Probe Info  		C11(0.96)  LDD0531  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		N.A.  LDD2156  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C11(0.96)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C11(1.09)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C11(0.86)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C11(1.02)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C11(0.95)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C11(0.91)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C11(0.99)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C11(0.85)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C11(0.92)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C11(0.93)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C11(0.89)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C11(0.93)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C11(1.10)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C11(1.07)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C11(1.05)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C11(0.88)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C11(1.03)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C11(0.87)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C11(0.61)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C11(0.59)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C11(1.04)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C11(0.91)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C11(0.72)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C11(0.91)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C11(0.73)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C11(1.12)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C11(1.42)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C11(1.36)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C11(0.87)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C11(0.97)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C11(0.68)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C11(0.83)  LDD0562  [3]
 LDCM0259  AC14 HCT 116 C11(0.95)  LDD0576  [3]
 LDCM0263  AC143 HCT 116 C11(1.11)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C11(1.28)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C11(1.44)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C11(1.21)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C11(1.20)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C11(1.31)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C11(1.50)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C11(0.96)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C11(1.11)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C11(1.28)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C11(1.42)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C11(1.96)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C11(1.26)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C11(1.32)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C11(1.36)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C11(1.39)  LDD2161  [3]
 LDCM0279  AC2 HCT 116 C11(1.01)  LDD0596  [3]
 LDCM0285  AC25 HCT 116 C11(1.27)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C11(1.31)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C11(1.60)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C11(1.05)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C11(1.28)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C11(0.98)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C11(1.26)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C11(1.38)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C11(1.65)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C11(1.52)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C11(1.23)  LDD0612  [3]
 LDCM0301  AC4 HCT 116 C11(1.20)  LDD0618  [3]
 LDCM0308  AC46 HCT 116 C11(1.38)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C11(1.25)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C11(1.62)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C11(1.01)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C11(1.08)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C11(0.99)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C11(1.09)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C11(1.13)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C11(1.22)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C11(0.86)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C11(1.24)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C11(1.36)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C11(1.21)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C11(1.25)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C11(1.18)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C11(1.07)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C11(1.22)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C11(1.23)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C11(1.43)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C11(1.18)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C11(1.31)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C11(1.81)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C11(1.47)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C11(1.37)  LDD0648  [3]
 LDCM0334  AC7 HCT 116 C11(0.90)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C11(0.84)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C11(1.12)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C11(0.94)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C11(1.00)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C11(1.08)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C11(0.87)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C11(0.93)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C11(1.00)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C11(0.95)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C11(0.96)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C11(0.93)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C11(1.01)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C11(1.11)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C11(1.07)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C11(1.17)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C11(1.06)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C11(1.09)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C11(0.91)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C11(0.96)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C11(0.94)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C11(0.90)  LDD0592  [3]
 LDCM0369  CL100 HCT 116 C11(0.87)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C11(0.98)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C11(1.06)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C11(1.12)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C11(0.86)  LDD0690  [3]
 LDCM0382  CL112 HCT 116 C11(0.96)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C11(1.00)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C11(1.54)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C11(1.21)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C11(1.57)  LDD0703  [3]
 LDCM0392  CL121 HCT 116 C11(0.74)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C11(1.31)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C11(1.03)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C11(1.05)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C11(1.00)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C11(0.92)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C11(1.03)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C11(1.34)  LDD0716  [3]
 LDCM0420  CL31 HCT 116 C11(1.10)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C11(1.02)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C11(1.32)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C11(1.29)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C11(1.11)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C11(1.57)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C11(1.10)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C11(1.00)  LDD0745  [3]
 LDCM0430  CL40 HCT 116 C11(1.14)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C11(1.35)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C11(1.11)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C11(1.17)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C11(1.24)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C11(1.14)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C11(1.08)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C11(0.73)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C11(0.68)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C11(0.89)  LDD0756  [3]
 LDCM0441  CL50 HCT 116 C11(0.81)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C11(0.79)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C11(0.93)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C11(1.25)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C11(0.69)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C11(0.61)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C11(0.93)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C11(0.92)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C11(0.80)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C11(0.89)  LDD0767  [3]
 LDCM0452  CL60 HCT 116 C11(0.68)  LDD0769  [3]
 LDCM0486  CL91 HCT 116 C11(0.83)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C11(0.92)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C11(0.91)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C11(0.75)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C11(0.82)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C11(1.05)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C11(1.13)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C11(1.02)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C11(1.07)  LDD0811  [3]
 LDCM0580  Fragment21 Ramos C11(1.85)  LDD2195  [9]
 LDCM0578  Fragment27 Ramos C11(1.35)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C11(0.79)  LDD2198  [9]
 LDCM0468  Fragment33 Ramos C11(2.25)  LDD2202  [9]
 LDCM0427  Fragment51 HCT 116 C11(1.09)  LDD0744  [3]
 LDCM0022  KB02 22RV1 C11(2.00)  LDD2243  [10]
 LDCM0023  KB03 22RV1 C11(5.47)  LDD2660  [10]
 LDCM0024  KB05 SKMEL24 C11(2.21)  LDD3323  [10]
 LDCM0109  NEM HeLa N.A.  LDD0226  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
rRNA methyltransferase 1, mitochondrial (MRM1) RNA methyltransferase TrmH family Q6IN84
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Sphingosine-1-phosphate lyase 1 (SGPL1) Group II decarboxylase family O95470
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) HIBADH-related family P31937
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Lysoplasmalogenase TMEM86A (TMEM86A) TMEM86 family Q8N2M4
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-3 (AQP3) MIP/aquaporin (TC 1.A.8) family Q92482
Syntaxin-1A (STX1A) Syntaxin family Q16623
Proteolipid protein 2 (PLP2) . Q04941
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paired-like homeodomain transcription factor LEUTX (LEUTX) Paired homeobox family A8MZ59
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor (TNF) Tumor necrosis factor family P01375
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC) . Q8N912
Olfactomedin-4 (OLFM4) . Q6UX06
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Transmembrane protein 107 (TMEM107) . Q6UX40
Transmembrane protein 42 (TMEM42) . Q69YG0
Vasorin (VASN) . Q6EMK4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bisacodyl . DB09020
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sennosides . DB11365

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840