Details of the Target

General Information of Target

Target ID LDTP08670
Target Name Katanin p60 ATPase-containing subunit A-like 2 (KATNAL2)
Gene Name KATNAL2
Gene ID 83473
Synonyms
Katanin p60 ATPase-containing subunit A-like 2; Katanin p60 subunit A-like 2; EC 5.6.1.1; p60 katanin-like 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELSYQTLKFTHQAREACEMRTEARRKNLLILISHYLTQEGYIDTANALEQETKLGLRRF
EVCDNIDLETILMEYESYYFVKFQKYPKIVKKSSDTAENNLPQRSRGKTRRMMNDSCQNL
PKINQQRPRSKTTAGKTGDTKSLNKEHPNQEVVDNTRLESANFGLHISRIRKDSGEENAH
PRRGQIIDFQGLLTDAIKGATSELALNTFDHNPDPSERLLKPLSAFIGMNSEMRELAAVV
SRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGK
TLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMS
QRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILV
DLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPV
RKIFDALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPSAKNLAQRYSDWQREFESV
Target Bioclass
Enzyme
Family
AAA ATPase family, Katanin p60 subunit A1 subfamily, A-like 2 sub-subfamily
Subcellular location
Cytoplasm, cytoskeleton
Function Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. {|HAMAP-Rule:MF_03025}.
Uniprot ID
Q8IYT4
Ensemble ID
ENST00000245121.10
HGNC ID
HGNC:25387

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.L120I .
KYSE30 SNV: p.E354Q .
NCIH2172 SNV: p.K416R .
NCIH2286 SNV: p.G56W .
OE33 SNV: p.N162H .
PEO1 SNV: p.K198N .
SNU1 SNV: p.A238V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
BTD
 Probe Info  		C311(0.53)  LDD2124  [2]
IPM
 Probe Info  		C311(0.77)  LDD1701  [2]
DBIA
 Probe Info  		C311(0.65)  LDD0531  [3]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [4]
STS-2
 Probe Info  		N.A.  LDD0138  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C311(0.65)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C311(1.01)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C311(1.01)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C311(1.16)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C311(0.87)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C311(1.00)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C311(0.73)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C311(0.70)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C311(0.80)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C311(0.68)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C311(0.87)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C311(0.85)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C311(1.05)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C311(0.74)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C311(0.95)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C311(0.91)  LDD0546  [3]
 LDCM0230  AC113 PaTu 8988t C311(1.19)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C311(0.92)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C311(1.63)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C311(1.33)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C311(1.08)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C311(0.85)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C311(1.08)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C311(1.16)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C311(1.16)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C311(1.16)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C311(0.99)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C311(0.97)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C311(1.22)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C311(1.10)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C311(0.98)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C311(1.29)  LDD1124  [3]
 LDCM0246  AC128 HEK-293T C311(0.79)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C311(0.91)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C311(0.71)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C311(0.91)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C311(0.93)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C311(0.78)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C311(0.91)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C311(0.84)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C311(1.03)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C311(1.02)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C311(0.94)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C311(0.80)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C311(0.95)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C311(0.90)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C311(0.94)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C311(1.05)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C311(0.98)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C311(1.05)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C311(1.02)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C311(1.14)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C311(1.01)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C311(0.86)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C311(1.27)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C311(0.92)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C311(0.88)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C311(1.01)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C311(1.05)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C311(0.92)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C311(1.13)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C311(1.06)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C311(1.11)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C311(1.32)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C311(0.91)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C311(0.87)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C311(1.03)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C311(0.76)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C311(0.96)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C311(0.92)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C311(0.96)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C311(0.95)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C311(1.05)  LDD0601  [3]
 LDCM0290  AC3 HCT 116 C311(0.84)  LDD0607  [3]
 LDCM0296  AC35 HCT 116 C311(1.22)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C311(1.01)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C311(0.95)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C311(1.02)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C311(1.18)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C311(0.81)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C311(1.01)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C311(1.14)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C311(1.01)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C311(1.04)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C311(1.10)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C311(1.10)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C311(1.07)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C311(0.94)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C311(0.74)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C311(0.87)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C311(0.76)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C311(0.68)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C311(0.61)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C311(0.81)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C311(0.64)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C311(0.69)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C311(0.86)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C311(0.67)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C311(0.95)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C311(0.77)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C311(0.81)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C311(1.13)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C311(0.89)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C311(1.15)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C311(0.94)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C311(0.85)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C311(0.96)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C311(0.92)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C311(0.77)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C311(0.85)  LDD0648  [3]
 LDCM0332  AC68 PaTu 8988t C311(1.08)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C311(1.38)  LDD1212  [3]
 LDCM0334  AC7 HCT 116 C311(0.90)  LDD0651  [3]
 LDCM0335  AC70 PaTu 8988t C311(0.95)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C311(0.77)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C311(0.79)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C311(1.04)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C311(0.93)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C311(0.87)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C311(0.94)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C311(0.83)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C311(1.45)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C311(1.15)  LDD1223  [3]
 LDCM0345  AC8 HCT 116 C311(1.02)  LDD0662  [3]
 LDCM0346  AC80 PaTu 8988t C311(0.81)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C311(1.47)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C311(0.68)  LDD1227  [3]
 LDCM0349  AC83 PaTu 8988t C311(1.07)  LDD1228  [3]
 LDCM0350  AC84 PaTu 8988t C311(1.01)  LDD1229  [3]
 LDCM0351  AC85 PaTu 8988t C311(1.04)  LDD1230  [3]
 LDCM0352  AC86 PaTu 8988t C311(1.16)  LDD1231  [3]
 LDCM0353  AC87 PaTu 8988t C311(1.22)  LDD1232  [3]
 LDCM0354  AC88 PaTu 8988t C311(1.25)  LDD1233  [3]
 LDCM0355  AC89 PaTu 8988t C311(1.10)  LDD1234  [3]
 LDCM0357  AC90 PaTu 8988t C311(1.04)  LDD1236  [3]
 LDCM0358  AC91 PaTu 8988t C311(1.07)  LDD1237  [3]
 LDCM0359  AC92 PaTu 8988t C311(1.13)  LDD1238  [3]
 LDCM0360  AC93 PaTu 8988t C311(1.11)  LDD1239  [3]
 LDCM0361  AC94 PaTu 8988t C311(1.12)  LDD1240  [3]
 LDCM0362  AC95 PaTu 8988t C311(1.08)  LDD1241  [3]
 LDCM0363  AC96 PaTu 8988t C311(1.08)  LDD1242  [3]
 LDCM0364  AC97 PaTu 8988t C311(1.04)  LDD1243  [3]
 LDCM0365  AC98 HCT 116 C311(1.03)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C311(0.86)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C311(1.04)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C311(0.96)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C311(1.16)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C311(0.98)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C311(1.11)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C311(0.71)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C311(1.12)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C311(0.99)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C311(0.88)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C311(1.01)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C311(0.95)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C311(0.90)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C311(0.95)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C311(0.95)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C311(1.11)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C311(1.19)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C311(1.05)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C311(1.04)  LDD0698  [3]
 LDCM0387  CL117 HCT 116 C311(0.94)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C311(0.99)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C311(1.07)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C311(1.22)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C311(1.09)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C311(0.79)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C311(0.68)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C311(0.95)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C311(0.95)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C311(0.97)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C311(0.63)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C311(0.79)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C311(1.13)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C311(1.15)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C311(1.12)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C311(1.11)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C311(1.12)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C311(1.07)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C311(1.02)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C311(0.88)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C311(0.98)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C311(0.89)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C311(0.92)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C311(0.85)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C311(1.00)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C311(1.22)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C311(1.11)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C311(1.05)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C311(1.12)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C311(1.29)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C311(1.43)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C311(1.03)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C311(1.11)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C311(0.70)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C311(0.96)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C311(0.85)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C311(0.99)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C311(0.97)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C311(0.93)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C311(0.78)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C311(0.87)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C311(1.03)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C311(0.66)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C311(0.60)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C311(0.66)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C311(0.72)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C311(0.73)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C311(0.72)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C311(0.89)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C311(1.06)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C311(0.94)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C311(1.23)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C311(0.99)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C311(0.97)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C311(0.89)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C311(0.67)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C311(0.81)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C311(0.86)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C311(1.04)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C311(0.70)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C311(0.86)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C311(0.87)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C311(0.87)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C311(1.02)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C311(0.81)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C311(1.17)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C311(1.01)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C311(0.91)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C311(1.16)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C311(1.14)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C311(1.10)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C311(0.99)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C311(0.85)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C311(0.88)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C311(0.99)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C311(0.99)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C311(0.85)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C311(0.99)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C311(1.38)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C311(0.99)  LDD0784  [3]
 LDCM0473  CL8 HCT 116 C311(1.10)  LDD0790  [3]
 LDCM0484  CL9 HCT 116 C311(1.06)  LDD0801  [3]
 LDCM0486  CL91 HCT 116 C311(1.02)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C311(0.77)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C311(0.88)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C311(0.78)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C311(0.76)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C311(0.74)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C311(0.74)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C311(0.80)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C311(0.74)  LDD0811  [3]
 LDCM0468  Fragment33 HCT 116 C311(1.01)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C311(0.67)  LDD0744  [3]
 LDCM0022  KB02 A3-KAW C311(2.26)  LDD2257  [5]
 LDCM0023  KB03 MDA-MB-231 C311(0.77)  LDD1701  [2]
 LDCM0024  KB05 MV4-11 C311(2.47)  LDD3338  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C311(0.53)  LDD2124  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-2 (ACTN2) Alpha-actinin family P35609

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840