Details of the Target

General Information of Target

Target ID LDTP08505
Target Name Prolyl 3-hydroxylase 3 (P3H3)
Gene Name P3H3
Gene ID 10536
Synonyms
LEPREL2; Prolyl 3-hydroxylase 3; EC 1.14.11.7; Leprecan-like protein 2; Protein B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRLLRPLLLLLLLPPPGSPEPPGLTQLSPGAPPQAPDLLYADGLRAYAAGAWAPAVALL
REALRSQAALGRVRLDCGASCAADPGAALPAVLLGAPEPDSGPGPTQGSWERQLLRAALR
RADCLTQCAARRLGPGGAARLRVGSALRDAFRRREPYNYLQRAYYQLKKLDLAAAAAHTF
FVANPMHLQMREDMAKYRRMSGVRPQSFRDLETPPHWAAYDTGLELLGRQEAGLALPRLE
EALQGSLAQMESCRADCEGPEEQQGAEEEEDGAASQGGLYEAIAGHWIQVLQCRQRCVGE
TATRPGRSFPVPDFLPNQLRRLHEAHAQVGNLSQAIENVLSVLLFYPEDEAAKRALNQYQ
AQLGEPRPGLGPREDIQRFILRSLGEKRQLYYAMEHLGTSFKDPDPWTPAALIPEALREK
LREDQEKRPWDHEPVKPKPLTYWKDVLLLEGVTLTQDSRQLNGSERAVLDGLLTPAECGV
LLQLAKDAAGAGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGTVGSQGAKLLLEVSE
RVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQEQRMDLSHPVHADNCVLDPDTGECWRE
PPAYTYRDYSGLLYLNDDFQGGDLFFTEPNALTVTARVRPRCGRLVAFSSGVENPHGVWA
VTRGRRCALALWHTWAPEHREQEWIEAKELLQESQEEEEEEEEEMPSKDPSPEPPSRRHQ
RVQDKTGRAPRVREEL
Target Bioclass
Enzyme
Family
Leprecan family
Subcellular location
Endoplasmic reticulum
Function
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases.
Uniprot ID
Q8IVL6
Ensemble ID
ENST00000290510.10
HGNC ID
HGNC:19318

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.N462S .
HCC15 SNV: p.G18W .
JURKAT SNV: p.T26A; p.C588Y .
MEWO SNV: p.P429L DBIA    Probe Info 
NCIH1793 SNV: p.H656Y .
SNGM SNV: p.G51R .
TOV21G SNV: p.D617Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0221  [1]
DBIA
 Probe Info  		C128(1.01)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
Crotonaldehyde
 Probe Info  		C253(0.00); H504(0.00); H507(0.00)  LDD0219  [1]
Methacrolein
 Probe Info  		C124(0.00); C253(0.00)  LDD0218  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C124(1.24); C128(1.24)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C124(0.81); C128(0.93)  LDD0813  [2]
 LDCM0226  AC11 HEK-293T C124(0.99); C128(1.35)  LDD0824  [2]
 LDCM0230  AC113 HEK-293T C124(0.88)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C124(0.63)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C124(0.76)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C124(0.65)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C124(0.64)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C124(0.48)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C124(0.49)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C124(0.94); C128(1.09)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C124(0.46)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C124(0.54)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C124(0.38)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C124(0.39)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C124(0.40)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C124(0.40)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C124(0.34)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C124(0.32)  LDD0843  [2]
 LDCM0259  AC14 HEK-293T C124(0.91); C128(1.08)  LDD0857  [2]
 LDCM0263  AC143 HEK-293T C124(1.33)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C124(0.55)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C124(0.55)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C124(0.58)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C124(0.63)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C124(0.74)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C124(1.11)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C124(0.64); C128(0.77)  LDD0868  [2]
 LDCM0271  AC150 HEK-293T C124(0.73)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C124(0.67)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C124(0.85)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C124(0.81)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C124(0.89)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C124(1.17)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C124(0.51)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C124(0.58)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C667(1.00); C124(1.32); C128(1.32)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C667(0.75); C124(1.14); C128(1.14)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C124(1.03); C128(1.03); C667(1.14)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C124(1.16); C128(1.16)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C124(0.91); C128(0.91); C667(1.15)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C667(1.20); C124(1.20); C128(1.20)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C124(0.84); C128(0.84); C667(1.11)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C667(1.05); C124(1.27); C128(1.27)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C124(0.83); C128(0.83); C667(1.10)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C128(1.07)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C128(0.80)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C128(0.88)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C128(1.16)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C128(0.72)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C124(1.17); C128(1.17)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C128(0.77)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C128(1.09)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C128(1.06)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C128(0.87)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C128(0.88)  LDD0893  [2]
 LDCM0296  AC35 HCT 116 C667(0.82)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C667(1.08)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C667(1.24)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C667(1.04)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C667(0.99)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C124(0.96); C128(0.96)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C667(1.04)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C667(1.05)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C667(0.94)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C667(1.02)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C667(1.06)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C667(1.00)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C478(0.97)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C478(0.96)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C478(0.99)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C478(1.14)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C124(0.77); C128(0.77)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C478(1.07)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C478(0.90)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C478(1.07)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C478(1.03)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C478(0.99)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C478(0.98)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C478(1.01)  LDD1558  [4]
 LDCM0320  AC57 HCT 116 C124(0.70); C128(0.70)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C124(0.50); C128(0.50)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C124(0.77); C128(0.77)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C124(0.66); C128(1.00)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C124(0.68); C128(0.68)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C124(0.89); C128(0.89)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C124(0.59); C128(0.59)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C124(0.57); C128(0.57)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C124(0.75); C128(0.75)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C124(0.51); C128(0.51)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C124(0.68); C128(0.68)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C124(0.34); C128(0.34)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C667(1.02); C124(1.04); C128(1.04)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C124(0.53); C128(0.53); C667(1.01)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C124(0.76); C128(1.39)  LDD0932  [2]
 LDCM0335  AC70 HCT 116 C124(0.44); C128(0.44); C667(0.67)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C667(0.82); C124(0.94); C128(0.94)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C667(0.92); C124(1.14); C128(1.14)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C124(0.53); C128(0.53); C667(1.15)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C124(0.48); C128(0.48); C667(1.01)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C124(0.57); C128(0.57); C667(1.07)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C124(0.49); C128(0.49); C667(0.99)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C124(0.57); C128(0.57); C667(1.19)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C124(0.90); C128(0.90); C667(0.96)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C124(0.89); C128(0.89); C667(1.03)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C124(0.58); C128(1.14)  LDD0943  [2]
 LDCM0346  AC80 HCT 116 C124(0.56); C128(0.56); C667(0.97)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C667(0.78); C124(1.72); C128(1.72)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C124(0.48); C128(0.48); C667(0.76)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C124(0.56); C128(0.56)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C124(0.50); C128(0.50)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C124(0.55); C128(0.55)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C124(0.89); C128(0.89)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C124(1.19); C128(1.19)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C124(0.86); C128(0.86)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C124(0.68); C128(0.68)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C124(0.81); C128(0.81)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C124(0.47); C128(0.47)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C124(0.56); C128(0.56)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C124(0.82); C128(0.82)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C124(0.92); C128(0.92)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C124(0.77); C128(0.77)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C124(0.80); C128(0.80)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C124(0.77); C128(0.77)  LDD0681  [2]
 LDCM0248  AKOS034007472 HEK-293T C124(0.97); C128(1.31)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C124(0.52); C128(0.92)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C124(0.61); C128(0.82)  LDD0873  [2]
 LDCM0020  ARS-1620 HCC44 C128(1.01)  LDD0078  [2]
 LDCM0108  Chloroacetamide HeLa C253(0.00); H507(0.00)  LDD0222  [1]
 LDCM0367  CL1 HEK-293T C478(1.13)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C478(1.00)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C124(1.03); C128(1.03)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C124(0.55); C128(0.79)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C124(0.45); C128(0.86)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C124(0.55); C128(0.89)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C124(0.79); C128(1.41)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C667(1.01); C124(1.22); C128(1.22)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C667(1.03); C124(1.20); C128(1.20)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C667(1.00); C124(1.08); C128(1.08)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C667(0.93); C124(1.33); C128(1.33)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C667(1.03); C124(1.13); C128(1.13)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C478(1.18)  LDD1583  [4]
 LDCM0380  CL110 HCT 116 C667(1.15); C124(1.45); C128(1.45)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C124(1.02); C128(1.02); C667(1.02)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C128(0.64)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C128(0.87)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C128(0.59)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C128(0.83)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C128(0.62)  LDD0984  [2]
 LDCM0387  CL117 HCT 116 C667(1.00)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C667(0.92)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C667(0.95)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C478(1.03)  LDD1594  [4]
 LDCM0391  CL120 HCT 116 C667(1.01)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C478(1.16)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C478(0.94)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C478(0.98)  LDD1598  [4]
 LDCM0396  CL125 HCT 116 C124(1.28); C128(1.28)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C124(1.26); C128(1.26)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C124(1.08); C128(1.08)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C124(0.68); C128(0.68)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C478(1.08)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C478(0.93)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C478(1.06)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C124(1.14)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C124(1.27)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C124(0.83)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C124(0.89)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C478(0.91)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C124(0.99)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C124(0.81)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C124(0.79)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C124(1.10)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C124(1.04)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C124(0.97)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C124(1.07)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C124(1.07)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C124(0.99)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C124(1.08)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C478(0.98)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C124(0.66)  LDD1017  [2]
 LDCM0420  CL31 HCT 116 C667(1.37)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C667(1.27)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C667(2.11)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C667(1.52)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C667(1.42)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C667(1.32)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C667(1.84)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C667(1.13)  LDD0745  [2]
 LDCM0430  CL40 HCT 116 C667(1.24)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C667(1.40)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C667(2.00)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C667(1.07)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C667(1.68)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C667(1.29)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C128(0.82)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C128(0.91)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C128(1.23)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C128(0.89)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C478(1.25)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C128(0.70)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C128(0.75)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C128(1.27)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C128(1.12)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C128(0.94)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C128(0.93)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C128(0.95)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C128(1.15)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C128(0.84)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C128(0.86)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C478(1.19)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C128(0.68)  LDD1050  [2]
 LDCM0453  CL61 HCT 116 C667(1.34)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C667(1.24)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C667(1.20)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C667(1.35)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C667(1.24)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C667(1.20)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C667(1.10)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C667(1.17)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C667(1.28)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C478(0.84)  LDD1665  [4]
 LDCM0463  CL70 HCT 116 C667(1.12)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C667(1.38)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C667(1.20)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C667(1.27)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C667(1.25)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C124(1.04); C128(1.04)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C124(1.18); C128(1.18)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C124(1.17); C128(1.17)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C124(1.11); C128(1.11)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C478(1.97)  LDD1676  [4]
 LDCM0474  CL80 HCT 116 C124(1.06); C128(1.06)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C124(1.51); C128(1.51)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C124(1.50); C128(1.50)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C124(0.84); C128(0.84)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C124(0.79); C128(0.79)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C124(0.84); C128(0.84)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C124(0.94); C128(0.94)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C124(1.04); C128(1.04)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C124(1.14); C128(1.14)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C124(1.20); C128(1.20)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C478(1.10)  LDD1687  [4]
 LDCM0485  CL90 HCT 116 C124(0.95); C128(0.95)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C124(1.14); C128(1.14)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C124(0.87); C128(0.87)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C124(1.06); C128(1.06)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C124(1.34); C128(1.34)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C124(0.98); C128(0.98)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C124(1.10); C128(1.10)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C124(0.91); C128(0.91)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C124(0.99); C128(0.99)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C124(1.20); C128(1.20)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C478(0.93)  LDD1698  [4]
 LDCM0468  Fragment33 HCT 116 C667(1.32)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C667(1.59)  LDD0744  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [1]
 LDCM0022  KB02 A101D C478(3.28)  LDD2250  [5]
 LDCM0023  KB03 A101D C478(10.43)  LDD2667  [5]
 LDCM0024  KB05 G361 C297(3.62)  LDD3311  [5]
 LDCM0109  NEM HeLa H216(0.00); H504(0.00)  LDD0227  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Optineurin (OPTN) . Q96CV9
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Ubiquilin-1 (UBQLN1) . Q9UMX0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ascorbic Acid Small molecular drug DB00126
Succinic Acid Small molecular drug DB00139
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Proline Small molecular drug DB00172

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840