Details of the Target

General Information of Target

Target ID LDTP08112
Target Name Sprouty-related, EVH1 domain-containing protein 1 (SPRED1)
Gene Name SPRED1
Gene ID 161742
Synonyms
Sprouty-related, EVH1 domain-containing protein 1; Spred-1; hSpred1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFI
RGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAI
EDISQGCPESKNEAEGADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFED
LNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPLKSIRHVSFQ
DEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDADSSIQFSKPDSKKSDYLYSCGDET
KLSSPKDSVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEENVRGKCQDAPDPIK
RCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLALVALSFIVPCMCCY
VPLRMCHRCGEACGCCGGKHKAAG
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
Uniprot ID
Q7Z699
Ensemble ID
ENST00000299084.9
HGNC ID
HGNC:20249

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C55(1.26)  LDD0531  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C55(1.26)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C296(0.96); C55(0.97)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C55(0.77)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C55(0.98)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C55(0.84)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C55(0.93)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C55(0.79)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C55(0.91)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C55(0.75)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C55(0.83)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C55(0.94)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C55(0.82)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C296(0.91); C55(1.06)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C55(0.79)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C55(1.13)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C55(0.95)  LDD0546  [1]
 LDCM0237  AC12 HCT 116 C296(1.10); C55(1.05)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C296(0.94); C55(1.28)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C296(1.01); C55(1.10)  LDD0587  [1]
 LDCM0277  AC18 HEK-293T C74(0.96)  LDD1516  [2]
 LDCM0279  AC2 HCT 116 C55(1.22)  LDD0596  [1]
 LDCM0286  AC26 HEK-293T C74(1.15)  LDD1525  [2]
 LDCM0290  AC3 HCT 116 C55(1.26)  LDD0607  [1]
 LDCM0295  AC34 HEK-293T C74(0.98)  LDD1534  [2]
 LDCM0296  AC35 HCT 116 C296(1.18)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C296(0.83)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C296(0.79)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C296(1.03)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C296(0.82)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C55(1.34)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C296(1.04)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C296(0.78)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C296(0.79)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C296(0.90)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C296(0.92)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C296(0.95)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C55(0.84)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C55(1.00)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C55(1.15)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C55(1.12)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C55(1.34)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C55(1.12)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C55(1.01)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C55(0.99)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C55(1.01)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C55(1.00)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C55(1.14)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C55(1.33)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C296(0.76)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C296(1.05)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C296(0.99)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C296(1.08); C55(1.13)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C296(0.97)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C296(0.63)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C296(0.73)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C296(0.97)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C296(1.05)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C296(0.90)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C296(0.73)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C296(0.85)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C55(0.96)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C55(0.91)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C296(1.01); C55(1.09)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C55(1.06)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C55(1.01)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C55(0.91)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C55(1.02)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C55(1.16)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C55(0.83)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C55(0.87)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C55(0.84)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C55(0.90)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C55(0.95)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C296(0.96); C55(1.14)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C55(1.10)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C55(0.91)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C55(0.88)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C55(1.28)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C55(1.29)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C55(1.02)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C55(0.96)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C55(0.99)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C55(1.00)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C55(1.06)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C55(0.83)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C55(1.30)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C55(1.12)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C55(0.95)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C55(0.90)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C55(0.95)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C55(1.00)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C55(1.17)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C55(0.90)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C55(0.76)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C296(1.17); C55(1.08)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C296(1.00); C55(1.30)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C296(1.37); C55(1.47)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C55(0.76)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C55(1.23)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C55(1.11)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C296(0.97); C55(1.23)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C55(1.07); C296(1.08)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C296(0.99); C55(1.04)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C55(0.97); C296(1.65)  LDD0690  [1]
 LDCM0379  CL11 HCT 116 C55(1.16)  LDD0696  [1]
 LDCM0387  CL117 HCT 116 C296(1.00)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C296(0.77)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C296(1.20)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C55(1.17)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C296(0.74)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C55(1.49)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C55(1.05)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C55(1.77)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C55(1.09)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C296(0.82)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C296(1.04)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C296(0.86)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C296(0.97)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C55(1.09)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C55(1.31)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C55(1.52)  LDD0719  [1]
 LDCM0405  CL18 HEK-293T C74(1.34)  LDD1609  [2]
 LDCM0407  CL2 HCT 116 C55(0.86)  LDD0724  [1]
 LDCM0418  CL3 HCT 116 C55(1.00)  LDD0735  [1]
 LDCM0419  CL30 HEK-293T C74(0.99)  LDD1623  [2]
 LDCM0420  CL31 HCT 116 C296(1.78)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C296(0.96)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C296(1.50)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C296(1.53)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C296(1.25)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C296(3.98)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C296(1.20)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C296(1.03)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C55(1.00)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C296(6.76)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C296(1.13)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C296(1.32)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C296(0.92)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C296(1.03)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C296(7.25)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C55(1.07)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C55(1.13)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C55(1.00)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C55(1.03)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C55(1.23)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C55(1.07)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C55(1.16)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C55(0.97)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C55(1.00)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C55(1.19)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C55(1.04)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C55(1.09)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C55(1.16)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C55(0.98)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C55(1.18)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C55(0.94)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C55(1.02)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C55(0.91)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C55(0.86)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C55(0.99)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C55(1.06)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C55(0.91)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C55(1.20)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C55(1.07)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C55(1.13)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C55(0.92)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C55(0.97)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C55(0.90)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C55(0.99)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C55(0.92)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C55(0.95)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C55(0.91)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C55(0.96)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C55(0.81)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C55(0.83)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C55(0.86)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C55(1.00)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C55(0.85)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C55(0.93)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C55(0.97)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C55(0.91)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C55(0.94)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C55(0.91)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C55(0.84)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C55(0.82)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C55(0.74)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C55(0.65)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C55(1.34)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C55(0.81)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C55(1.05)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C55(1.35)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C55(1.01)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C55(1.10)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C55(1.45)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C55(1.16)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C55(1.57)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C55(1.34)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C55(1.41)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C55(1.00)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C296(7.33)  LDD0744  [1]
 LDCM0022  KB02 Hs 839.T C55(1.51)  LDD2361  [3]
 LDCM0023  KB03 Hs 839.T C55(2.00)  LDD2778  [3]
 LDCM0024  KB05 SK-MEL-28 C55(1.27)  LDD3427  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 87 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) 3-beta-HSD family P26439
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Histone acetyltransferase KAT2B (KAT2B) Acetyltransferase family Q92831
Aldo-keto reductase family 1 member C1 (AKR1C1) Aldo/keto reductase family Q04828
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Protein argonaute-2 (AGO2) Argonaute family Q9UKV8
Phosphatidate cytidylyltransferase 2 (CDS2) CDS family O95674
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
NADH dehydrogenase 1 alpha subcomplex subunit 8 (NDUFA8) Complex I NDUFA8 subunit family P51970
NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7) Complex I NDUFB7 subunit family P17568
tRNA-specific adenosine deaminase 2 (ADAT2) Cytidine and deoxycytidylate deaminase family Q7Z6V5
Probable E3 ubiquitin-protein ligase DTX3 (DTX3) Deltex family Q8N9I9
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
5' exonuclease Apollo (DCLRE1B) DNA repair metallo-beta-lactamase (DRMBL) family Q9H816
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
DNA primase large subunit (PRIM2) Eukaryotic-type primase large subunit family P49643
Amine oxidase [flavin-containing] B (MAOB) Flavin monoamine oxidase family P27338
Glucose-fructose oxidoreductase domain-containing protein 1 (GFOD1) Gfo/Idh/MocA family Q9NXC2
Glutathione peroxidase 7 (GPX7) Glutathione peroxidase family Q96SL4
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
Putative inactive beta-glucuronidase-like protein SMA3 (GUSBP1) Glycosyl hydrolase 2 family Q15486
Exostosin-like 2 (EXTL2) Glycosyltransferase 47 family Q9UBQ6
Cytochrome c oxidase assembly factor 7 (COA7) Hcp beta-lactamase family Q96BR5
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) Lipoxygenase family P09917
Lysyl oxidase homolog 4 (LOXL4) Lysyl oxidase family Q96JB6
Protein mab-21-like 3 (MAB21L3) Mab-21 family Q8N8X9
Dihydropyrimidinase-related protein 4 (DPYSL4) Hydantoinase/dihydropyrimidinase family O14531
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 (PCMTD2) L-isoaspartyl/D-aspartyl protein methyltransferase family Q9NV79
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Transcriptional repressor NF-X1 (NFX1) NFX1 family Q12986
Transcriptional adapter 3 (TADA3) NGG1 family O75528
Nitric oxide synthase 3 (NOS3) NOS family P29474
E3 SUMO-protein ligase NSE2 (NSMCE2) NSE2 family Q96MF7
Dipeptidyl peptidase 1 (CTSC) Peptidase C1 family P53634
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3) Peptidase C12 family P15374
Sentrin-specific protease 3 (SENP3) Peptidase C48 family Q9H4L4
Ubiquitin thioesterase OTUB1 (OTUB1) Peptidase C65 family Q96FW1
MPN domain-containing protein (MPND) Peptidase M67 family Q8N594
Proteasome subunit beta type-10 (PSMB10) Peptidase T1B family P40306
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PPP2R5A) Phosphatase 2A regulatory subunit B56 family Q15172
Group 10 secretory phospholipase A2 (PLA2G10) Phospholipase A2 family O15496
Phosphorylase b kinase regulatory subunit alpha, liver isoform (PHKA2) Phosphorylase b kinase regulatory chain family P46019
E3 SUMO-protein ligase PIAS1 (PIAS1) PIAS family O75925
Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) PP2C family Q9H0C8
Protein phosphatase PTC7 homolog (PPTC7) PP2C family Q8NI37
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) PPP phosphatase family P62140
Tribbles homolog 2 (TRIB2) CAMK Ser/Thr protein kinase family Q92519
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Serine/threonine-protein kinase 36 (STK36) Ser/Thr protein kinase family Q9NRP7
Tyrosine-protein kinase Lyn (LYN) Tyr protein kinase family P07948
Protein farnesyltransferase subunit beta (FNTB) Protein prenyltransferase subunit beta family P49356
RNA pseudouridylate synthase domain-containing protein 1 (RPUSD1) Pseudouridine synthase RluA family Q9UJJ7
Adenine phosphoribosyltransferase (APRT) Purine/pyrimidine phosphoribosyltransferase family P07741
Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) Purine/pyrimidine phosphoribosyltransferase family P00492
Pyruvate kinase PKM (PKM) Pyruvate kinase family P14618
E3 ubiquitin-protein ligase RNF10 (RNF10) RNF10 family Q8N5U6
Ribonuclease SLFN12 (SLFN12) Schlafen family Q8IYM2
Ras-related protein Rab-11B (RAB11B) Rab family Q15907
GTP-binding nuclear protein Ran (RAN) Ran family P62826
GTPase RhebL1 (RHEBL1) Rheb family Q8TAI7
Rho-related GTP-binding protein RhoJ (RHOJ) Rho family Q9H4E5
Acyl-coenzyme A thioesterase THEM4 (THEM4) THEM4/THEM5 thioesterase family Q5T1C6
Thioredoxin (TXN) Thioredoxin family P10599
Atlastin-1 (ATL1) GB1/RHD3 GTPase family Q8WXF7
Kinesin-like protein KIF1A (KIF1A) Kinesin family Q12756
Developmentally-regulated GTP-binding protein 2 (DRG2) OBG GTPase family P55039
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
E3 ubiquitin-protein ligase UBR1 (UBR1) UBR1 family Q8IWV7
E3 ubiquitin-protein ligase UBR4 (UBR4) UBR4 family Q5T4S7
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase MYLIP (MYLIP) . Q8WY64
E3 ubiquitin-protein ligase RING1 (RING1) . Q06587
E3 ubiquitin-protein ligase RNF138 (RNF138) . Q8WVD3
E3 ubiquitin-protein ligase RNF183 (RNF183) . Q96D59
E3 ubiquitin-protein ligase RNF34 (RNF34) . Q969K3
E3 ubiquitin-protein transferase RMND5B (RMND5B) . Q96G75
G2/M phase-specific E3 ubiquitin-protein ligase (G2E3) . Q7L622
Germ cell-less protein-like 2 (GMCL2) . Q8NEA9
LON peptidase N-terminal domain and RING finger protein 2 (LONRF2) . Q1L5Z9
ORC ubiquitin ligase 1 (OBI1) . Q5W0B1
Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) . Q96AY3
Probable E3 ubiquitin-protein ligase MARCHF10 (MARCHF10) . Q8NA82
RING finger and CHY zinc finger domain-containing protein 1 (RCHY1) . Q96PM5
RING finger protein 208 (RNF208) . Q9H0X6
Transporter and channel
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 4E transporter (EIF4ENIF1) 4E-T/EIF4E-T family Q9NRA8
ATPase inhibitor, mitochondrial (ATP5IF1) ATPase inhibitor family Q9UII2
Bcl-2 homologous antagonist/killer (BAK1) Bcl-2 family Q16611
Growth hormone-inducible transmembrane protein (GHITM) BI1 family Q9H3K2
H(+)/Cl(-) exchange transporter 7 (CLCN7) Chloride channel (TC 2.A.49) family P51798
Gastrokine-1 (GKN1) Gastrokine family Q9NS71
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Lysosomal-associated transmembrane protein 4A (LAPTM4A) LAPTM4/LAPTM5 transporter family Q15012
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Peroxisome proliferator-activated receptor alpha (PPARA) Nuclear hormone receptor family Q07869
Exocyst complex component 5 (EXOC5) SEC10 family O00471
Exocyst complex component 6 (EXOC6) SEC15 family Q8TAG9
Syntaxin-19 (STX19) Syntaxin family Q8N4C7
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) WD repeat G protein beta family P62879
Calcium and integrin-binding protein 1 (CIB1) . Q99828
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Syntenin-1 (SDCBP) . O00560
Tumor necrosis factor receptor superfamily member 16 (NGFR) . P08138
Uncharacterized protein CXorf38 (CXorf38) . Q8TB03
Transcription factor
Click To Hide/Show 66 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B7 (HOXB7) Antp homeobox family P09629
Homeobox protein Hox-C4 (HOXC4) Antp homeobox family P09017
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Basic leucine zipper transcriptional factor ATF-like (BATF) BZIP family Q16520
Transcription factor NF-E2 45 kDa subunit (NFE2) BZIP family Q16621
Transcription factor COE1 (EBF1) COE family Q9UH73
Zinc finger protein ZFPM2 (ZFPM2) FOG (Friend of GATA) family Q8WW38
Krueppel-like factor 6 (KLF6) Krueppel C2H2-type zinc-finger protein family Q99612
Zinc finger and SCAN domain-containing protein 12 (ZSCAN12) Krueppel C2H2-type zinc-finger protein family O43309
Zinc finger and SCAN domain-containing protein 16 (ZSCAN16) Krueppel C2H2-type zinc-finger protein family Q9H4T2
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Zinc finger and SCAN domain-containing protein 9 (ZSCAN9) Krueppel C2H2-type zinc-finger protein family O15535
Zinc finger protein 124 (ZNF124) Krueppel C2H2-type zinc-finger protein family Q15973
Zinc finger protein 138 (ZNF138) Krueppel C2H2-type zinc-finger protein family P52744
Zinc finger protein 165 (ZNF165) Krueppel C2H2-type zinc-finger protein family P49910
Zinc finger protein 20 (ZNF20) Krueppel C2H2-type zinc-finger protein family P17024
Zinc finger protein 23 (ZNF23) Krueppel C2H2-type zinc-finger protein family P17027
Zinc finger protein 239 (ZNF239) Krueppel C2H2-type zinc-finger protein family Q16600
Zinc finger protein 286A (ZNF286A) Krueppel C2H2-type zinc-finger protein family Q9HBT8
Zinc finger protein 345 (ZNF345) Krueppel C2H2-type zinc-finger protein family Q14585
Zinc finger protein 414 (ZNF414) Krueppel C2H2-type zinc-finger protein family Q96IQ9
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 436 (ZNF436) Krueppel C2H2-type zinc-finger protein family Q9C0F3
Zinc finger protein 460 (ZNF460) Krueppel C2H2-type zinc-finger protein family Q14592
Zinc finger protein 496 (ZNF496) Krueppel C2H2-type zinc-finger protein family Q96IT1
Zinc finger protein 497 (ZNF497) Krueppel C2H2-type zinc-finger protein family Q6ZNH5
Zinc finger protein 500 (ZNF500) Krueppel C2H2-type zinc-finger protein family O60304
Zinc finger protein 524 (ZNF524) Krueppel C2H2-type zinc-finger protein family Q96C55
Zinc finger protein 566 (ZNF566) Krueppel C2H2-type zinc-finger protein family Q969W8
Zinc finger protein 57 (ZNF57) Krueppel C2H2-type zinc-finger protein family Q68EA5
Zinc finger protein 572 (ZNF572) Krueppel C2H2-type zinc-finger protein family Q7Z3I7
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 597 (ZNF597) Krueppel C2H2-type zinc-finger protein family Q96LX8
Zinc finger protein 649 (ZNF649) Krueppel C2H2-type zinc-finger protein family Q9BS31
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Zinc finger protein 670 (ZNF670) Krueppel C2H2-type zinc-finger protein family Q9BS34
Zinc finger protein 696 (ZNF696) Krueppel C2H2-type zinc-finger protein family Q9H7X3
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein GLI4 (GLI4) Krueppel C2H2-type zinc-finger protein family P10075
Zinc finger protein interacting with ribonucleoprotein K (ZIK1) Krueppel C2H2-type zinc-finger protein family Q3SY52
Zinc finger protein with KRAB and SCAN domains 5 (ZKSCAN5) Krueppel C2H2-type zinc-finger protein family Q9Y2L8
Zinc finger protein with KRAB and SCAN domains 8 (ZKSCAN8) Krueppel C2H2-type zinc-finger protein family Q15776
Zinc finger protein ZFP2 (ZFP2) Krueppel C2H2-type zinc-finger protein family Q6ZN57
Homeobox protein MSX-2 (MSX2) Msh homeobox family P35548
NF-kappa-B inhibitor beta (NFKBIB) NF-kappa-B inhibitor family Q15653
Nuclear receptor subfamily 1 group D member 2 (NR1D2) Nuclear hormone receptor family Q14995
Retinoic acid receptor RXR-gamma (RXRG) Nuclear hormone receptor family P48443
PHD finger-like domain-containing protein 5A (PHF5A) PHF5 family Q7RTV0
Transcriptional repressor protein YY1 (YY1) YY transcription factor family P25490
Achaete-scute homolog 4 (ASCL4) . Q6XD76
Deoxynucleotidyltransferase terminal-interacting protein 1 (DNTTIP1) . Q9H147
DNA-binding protein inhibitor ID-1 (ID1) . P41134
DNA-binding protein inhibitor ID-3 (ID3) . Q02535
DNA-binding protein inhibitor ID-4 (ID4) . P47928
Golgin-45 (BLZF1) . Q9H2G9
Heart- and neural crest derivatives-expressed protein 1 (HAND1) . O96004
Homeobox protein MOX-1 (MEOX1) . P50221
LIM/homeobox protein Lhx5 (LHX5) . Q9H2C1
LIM/homeobox protein Lhx8 (LHX8) . Q68G74
Mesoderm posterior protein 1 (MESP1) . Q9BRJ9
Oligodendrocyte transcription factor 3 (OLIG3) . Q7RTU3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) . Q9P0W2
Zinc finger and BTB domain-containing protein 25 (ZBTB25) . P24278
Zinc finger protein 366 (ZNF366) . Q8N895
Zinc finger protein 408 (ZNF408) . Q9H9D4
Zinc finger protein 581 (ZNF581) . Q9P0T4
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 141 (GPR141) G-protein coupled receptor 1 family Q7Z602
Frizzled-4 (FZD4) G-protein coupled receptor Fz/Smo family Q9ULV1
Cytokine and receptor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytokine receptor-like factor 3 (CRLF3) Cytokine receptor-like factor 3 family Q8IUI8
Protein Red (IK) RED family Q13123
CD27 antigen (CD27) . P26842
Other
Click To Hide/Show 134 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat and SOCS box protein 13 (ASB13) Ankyrin SOCS box (ASB) family Q8WXK3
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Protein BEX2 (BEX2) BEX family Q9BXY8
Protein BEX3 (BEX3) BEX family Q00994
Protein BEX5 (BEX5) BEX family Q5H9J7
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Fatty acid-binding protein, brain (FABP7) Fatty-acid binding protein (FABP) family O15540
Protein canopy homolog 3 (CNPY3) Canopy family Q9BT09
Cyclin-dependent kinase inhibitor 1 (CDKN1A) CDI family P38936
Cytochrome c oxidase copper chaperone (COX17) COX17 family Q14061
Reticulocalbin-1 (RCN1) CREC family Q15293
TIMELESS-interacting protein (TIPIN) CSM3 family Q9BVW5
Cyclin-C (CCNC) Cyclin family P24863
Cytoplasmic FMR1-interacting protein 1 (CYFIP1) CYFIP family Q7L576
Cystatin-A (CSTA) Cystatin family P01040
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
EF-hand calcium-binding domain-containing protein 4B (CRACR2A) EFCAB4 family Q9BSW2
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8L2) EPS8 family Q9H6S3
Small ribosomal subunit protein eS4, X isoform (RPS4X) Eukaryotic ribosomal protein eS4 family P62701
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM221A (FAM221A) FAM221 family A4D161
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Protein FAM98C (FAM98C) FAM98 family Q17RN3
Fibulin-5 (FBLN5) Fibulin family Q9UBX5
Centromere protein V (CENPV) Gfa family Q7Z7K6
HAUS augmin-like complex subunit 7 (HAUS7) HAUS7 family Q99871
Iron-sulfur cluster assembly 2 homolog, mitochondrial (ISCA2) HesB/IscA family Q86U28
Protein HEXIM2 (HEXIM2) HEXIM family Q96MH2
Protein HID1 (HID1) Hid-1 family Q8IV36
Inhibitor of growth protein 4 (ING4) ING family Q9UNL4
PAK4-inhibitor INKA1 (INKA1) INKA family Q96EL1
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Prelamin-A/C (LMNA) Intermediate filament family P02545
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Late cornified envelope protein 2A (LCE2A) LCE family Q5TA79
Putative RNA-binding protein Luc7-like 1 (LUC7L) Luc7 family Q9NQ29
Calcium-binding protein 39-like (CAB39L) Mo25 family Q9H9S4
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
Negative elongation factor C/D (NELFCD) NELF-D family Q8IXH7
Protein CIMAP1D (CIMAP1D) ODF3 family Q3SX64
Paralemmin-1 (PALM) Paralemmin family O75781
Gamma-parvin (PARVG) Parvin family Q9HBI0
Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) PI3K p85 subunit family O00459
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46
Testin (TES) Prickle / espinas / testin family Q9UGI8
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
Proline-rich protein 15 (PRR15) PRR15 family Q8IV56
Hippocalcin-like protein 1 (HPCAL1) Recoverin family P37235
Hippocalcin-like protein 4 (HPCAL4) Recoverin family Q9UM19
Neurocalcin-delta (NCALD) Recoverin family P61601
Visinin-like protein 1 (VSNL1) Recoverin family P62760
Rhophilin-1 (RHPN1) RHPN family Q8TCX5
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
Protein ripply2 (RIPPLY2) Ripply family Q5TAB7
Actin-binding protein WASF2 (WASF2) SCAR/WAVE family Q9Y6W5
E-selectin (SELE) Selectin/LECAM family P16581
Ski-like protein (SKIL) SKI family P12757
Mitochondrial import inner membrane translocase subunit Tim8 A (TIMM8A) Small Tim family O60220
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) SNF5 family Q12824
Charged multivesicular body protein 7 (CHMP7) SNF7 family Q8WUX9
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Protein sprouty homolog 4 (SPRY4) Sprouty family Q9C004
Protein SSX2 (SSX2; SSX2B) SSX family Q16385
Syndecan-2 (SDC2) Syndecan proteoglycan family P34741
Syntaxin-11 (STX11) Syntaxin family O75558
Centromere protein S (CENPS) TAF9 family Q8N2Z9
Protein TASOR 2 (TASOR2) TASOR family Q5VWN6
Transcription elongation factor A protein-like 8 (TCEAL8) TFS-II family Q8IYN2
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463
Translin-associated protein X (TSNAX) Translin family Q99598
Centrosomal protein of 57 kDa (CEP57) Translokin family Q86XR8
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Synaptic plasticity regulator PANTS (C22orf39) UPF0545 family Q6P5X5
UPF0561 protein C2orf68 (C2orf68) UPF0561 family Q2NKX9
Macrophage-capping protein (CAPG) Villin/gelsolin family P40121
Vacuolar protein sorting-associated protein 11 homolog (VPS11) VPS11 family Q9H270
Vacuolar protein sorting-associated protein 37A (VPS37A) VPS37 family Q8NEZ2
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
Acrosomal protein SP-10 (ACRV1) . P26436
Ankyrin repeat domain-containing protein 23 (ANKRD23) . Q86SG2
Axin-1 (AXIN1) . O15169
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Coiled-coil domain-containing glutamate-rich protein 1 (CCER1) . Q8TC90
Coiled-coil domain-containing protein 185 (CCDC185) . Q8N715
COMM domain-containing protein 2 (COMMD2) . Q86X83
Cytohesin-interacting protein (CYTIP) . O60759
Fanconi anemia group G protein (FANCG) . O15287
FAS-associated factor 1 (FAF1) . Q9UNN5
FMR1-interacting protein NUFIP2 (NUFIP2) . Q7Z417
Follistatin-related protein 1 (FSTL1) . Q12841
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
HCLS1-binding protein 3 (HS1BP3) . Q53T59
Heat shock factor 2-binding protein (HSF2BP) . O75031
Insulin-like growth factor-binding protein 1 (IGFBP1) . P08833
Insulin-like growth factor-binding protein 4 (IGFBP4) . P22692
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
Kelch-like protein 20 (KLHL20) . Q9Y2M5
Ligand of Numb protein X 2 (LNX2) . Q8N448
Lung adenoma susceptibility protein 2 (LAS2) . Q8IYD9
Lysine-rich coiled-coil protein 1 (KRCC1) . Q9NPI7
Melanoma-associated antigen C2 (MAGEC2) . Q9UBF1
Migration and invasion-inhibitory protein (MIIP) . Q5JXC2
Nebulette (NEBL) . O76041
Neurofibromin (NF1) . P21359
Nucleolar protein 3 (NOL3) . O60936
Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) . Q9Y239
Outer dynein arm-docking complex subunit 3 (ODAD3) . A5D8V7
PHD finger protein 7 (PHF7) . Q9BWX1
Pleckstrin homology domain-containing family G member 7 (PLEKHG7) . Q6ZR37
Polyamine-modulated factor 1 (PMF1) . Q6P1K2
Protein delta homolog 1 (DLK1) . P80370
Rab-interacting lysosomal protein (RILP) . Q96NA2
Ras GTPase-activating-like protein IQGAP3 (IQGAP3) . Q86VI3
Regulator of G-protein signaling 17 (RGS17) . Q9UGC6
Required for excision 1-B domain-containing protein (REX1BD) . Q96EN9
RING1 and YY1-binding protein (RYBP) . Q8N488
RUN and FYVE domain-containing protein 4 (RUFY4) . Q6ZNE9
Shieldin complex subunit 1 (SHLD1) . Q8IYI0
Small integral membrane protein 14 (SMIM14) . Q96QK8
Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) . Q7Z698
Superkiller complex protein 8 (SKIC8) . Q9GZS3
Suppressor of cytokine signaling 4 (SOCS4) . Q8WXH5
TNFAIP3-interacting protein 3 (TNIP3) . Q96KP6
TP53-binding protein 1 (TP53BP1) . Q12888
Transmembrane protein 61 (TMEM61) . Q8N0U2
U11/U12 small nuclear ribonucleoprotein 48 kDa protein (SNRNP48) . Q6IEG0
Uncharacterized protein C3orf62 (C3orf62) . Q6ZUJ4
Uncharacterized protein C8orf48 (C8orf48) . Q96LL4
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840