Details of the Target

General Information of Target

Target ID LDTP07944
Target Name Isoaspartyl peptidase/L-asparaginase (ASRGL1)
Gene Name ASRGL1
Gene ID 80150
Synonyms
ALP; CRASH; Isoaspartyl peptidase/L-asparaginase; EC 3.4.19.5; EC 3.5.1.1; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEGAVVALEDDPE
FNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQ
GAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHEKGAQKTDCQKNLGTVGAVALDCKGNV
AYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILKVNLARLTLFHIEQ
GKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPD
DTTITDLP
Target Type
Successful
Target Bioclass
Enzyme
Family
Ntn-hydrolase family
Subcellular location
Cytoplasm
Function
Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
TTD ID
T78277
Uniprot ID
Q7L266
DrugMap ID
TT4WT91
Ensemble ID
ENST00000301776.9
HGNC ID
HGNC:16448

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCSW1 SNV: p.M193I .
NALM6 SNV: p.E154Ter .
NCIH716 SNV: p.V180L .
P31FUJ SNV: p.T234A .
SNU869 SNV: p.D18Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C176(0.92)  LDD0531  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C202(0.00); C97(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C97(0.00); C176(0.00); C202(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C97(0.00); C115(0.00)  LDD0037  [3]
Compound 10
 Probe Info  		N.A.  LDD2216  [4]
Compound 11
 Probe Info  		N.A.  LDD2213  [4]
IPM
 Probe Info  		C176(0.00); C97(0.00); C202(0.00); C115(0.00)  LDD2156  [5]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		12.10  LDD0443  [8]
NAIA_5
 Probe Info  		C97(0.00); C162(0.00); C202(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C176(0.92)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C176(1.14)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C176(0.92)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C176(0.93)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C176(1.02)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C176(1.01)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C176(0.97)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C176(1.10)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C176(1.02)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C176(0.97)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C176(0.93)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C176(0.94)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C176(1.14)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C176(0.95)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C176(0.91)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C176(1.05)  LDD0546  [2]
 LDCM0237  AC12 HCT 116 C176(1.07)  LDD0554  [2]
 LDCM0246  AC128 HCT 116 C176(1.09)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C176(0.74)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C176(0.87)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C176(0.74)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C176(0.81)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C176(0.77)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C176(0.83)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C176(1.02)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C176(0.92)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C176(0.93)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C176(1.04)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C176(0.83)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C176(1.14)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C176(0.94)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C176(0.98)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C176(0.77)  LDD0579  [2]
 LDCM0270  AC15 HCT 116 C176(1.19)  LDD0587  [2]
 LDCM0276  AC17 HCT 116 C176(0.95)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C176(1.15)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C176(1.15)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C176(1.03)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C176(0.96)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C176(1.02)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C176(0.84)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C176(0.89)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C176(1.02)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C176(1.00)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C176(1.36)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C176(1.65)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C176(1.11)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C176(1.04)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C176(1.00)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C176(1.48)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C176(1.24)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C176(1.63)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C176(1.14)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C176(1.20)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C176(0.96)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C176(0.96)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C176(0.83)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C176(0.93)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C176(1.11)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C176(1.12)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C176(1.19)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C176(0.90)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C176(1.04)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C176(1.02)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C176(1.09)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C176(1.22)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C176(1.45)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C176(1.16)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C176(1.22)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C176(1.44)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C176(1.13)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C176(1.28)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C176(1.31)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C176(1.24)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C176(1.14)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C176(1.27)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C176(1.03)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C176(1.27)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C176(0.70)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C176(0.75)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C176(0.85)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C176(1.32)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C176(0.67)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C176(0.65)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C176(0.66)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C176(0.75)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C176(0.66)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C176(0.64)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C176(0.93)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C176(0.75)  LDD0929  [2]
 LDCM0332  AC68 PaTu 8988t C176(1.11)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C176(1.13)  LDD1212  [2]
 LDCM0334  AC7 HCT 116 C176(1.05)  LDD0651  [2]
 LDCM0335  AC70 PaTu 8988t C176(1.18)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C176(1.00)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C176(0.90)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C176(1.00)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C176(1.02)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C176(1.14)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C176(1.10)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C176(1.08)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C176(1.09)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C176(1.10)  LDD1223  [2]
 LDCM0345  AC8 HCT 116 C176(1.10)  LDD0662  [2]
 LDCM0346  AC80 PaTu 8988t C176(0.98)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C176(1.01)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C176(1.07)  LDD1227  [2]
 LDCM0365  AC98 HCT 116 C176(1.09)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C176(0.85)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C176(1.15)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C176(1.13)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C176(1.55)  LDD0592  [2]
 LDCM0632  CL-Sc Hep-G2 C162(0.90); C97(0.79); C176(0.78)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C176(0.69)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C176(0.89)  LDD0966  [2]
 LDCM0369  CL100 HCT 116 C176(0.98)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C176(1.28)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C176(1.04)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C176(1.03)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C176(1.09)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C176(1.09)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C176(1.32)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C176(1.26)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C176(1.33)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C176(1.08)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C176(0.91)  LDD0977  [2]
 LDCM0380  CL110 HCT 116 C176(1.28)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C176(0.97)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C176(1.11)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C176(1.14)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C176(0.92)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C176(1.19)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C176(1.30)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C176(1.31)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C176(1.04)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C176(1.09)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C176(0.59)  LDD0988  [2]
 LDCM0391  CL120 HCT 116 C176(0.96)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C176(1.17)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C176(1.08)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C176(0.98)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C176(1.26)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C176(0.83)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C176(0.70)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C176(0.81)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C176(0.82)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C176(0.67)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C176(0.93)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C176(0.64)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C176(0.99)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C176(0.85)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C176(1.08)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C176(1.02)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C176(0.61)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C176(0.98)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C176(0.82)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C176(0.90)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C176(0.93)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C176(1.07)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C176(0.89)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C176(0.97)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C176(0.92)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C176(0.97)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C176(0.89)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C176(0.63)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C176(0.95)  LDD1017  [2]
 LDCM0420  CL31 HCT 116 C176(0.97)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C176(1.02)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C176(1.19)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C176(1.11)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C176(1.02)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C176(0.92)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C176(0.98)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C176(1.01)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C176(0.68)  LDD1027  [2]
 LDCM0430  CL40 HCT 116 C176(0.90)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C176(0.91)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C176(0.84)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C176(0.92)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C176(0.93)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C176(0.96)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C176(1.13)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C176(1.06)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C176(1.15)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C176(0.99)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C176(0.61)  LDD1038  [2]
 LDCM0441  CL50 HCT 116 C176(0.95)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C176(0.96)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C176(0.99)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C176(0.94)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C176(1.04)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C176(1.01)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C176(1.08)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C176(0.99)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C176(1.05)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C176(0.97)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C176(0.64)  LDD1049  [2]
 LDCM0452  CL60 HCT 116 C176(1.03)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C176(1.19)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C176(1.08)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C176(1.18)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C176(1.32)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C176(1.02)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C176(1.35)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C176(1.17)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C176(1.17)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C176(1.08)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C176(0.59)  LDD1060  [2]
 LDCM0463  CL70 HCT 116 C176(1.02)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C176(1.23)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C176(1.01)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C176(1.24)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C176(1.15)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C176(0.99); C202(0.98); C97(1.04); C115(1.61)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C176(0.88); C97(0.87); C115(0.92)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C176(0.97); C97(1.06)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C176(0.89); C97(1.03); C115(0.98)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C176(0.98)  LDD1071  [2]
 LDCM0474  CL80 HEK-293T C176(1.03); C97(0.98); C115(0.80)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C176(0.98); C202(1.06); C97(1.12); C115(0.97)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C176(0.95); C202(1.33); C97(1.03)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C176(0.93); C97(1.04); C115(0.76)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C176(0.97); C97(1.00); C115(0.99)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C176(0.94); C202(1.22); C97(0.96); C115(0.87)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C176(0.99); C202(0.93); C97(1.03); C115(1.09)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C176(0.90); C202(0.96); C97(0.92); C115(1.04)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C176(0.97); C202(0.98); C97(1.01); C115(1.30)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C176(0.95); C97(1.04); C115(0.88)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C176(1.15)  LDD1082  [2]
 LDCM0485  CL90 HEK-293T C176(0.78); C97(1.00)  LDD1688  [10]
 LDCM0486  CL91 HCT 116 C176(1.13)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C176(0.97)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C176(1.00)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C176(1.01)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C176(1.12)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C176(1.06)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C176(1.09)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C176(1.05)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C176(1.04)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C176(0.91); C202(1.03); C97(0.93); C115(1.37)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C176(1.18)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C176(0.97)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C176(0.99); C97(1.02)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C176(1.05); C97(1.05)  LDD1497  [10]
 LDCM0024  KB05 NB1 C48(2.43)  LDD3340  [11]
 LDCM0628  OTUB2-COV-1 HEK-293T C162(0.44)  LDD2207  [12]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calaspargase Pegol Antibody D0C9DA
Asparagine Small molecular drug DB00174
Aspartic Acid Small molecular drug DB00128
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Graspa Protein D09JKS

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
12 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.