Details of the Target

General Information of Target

Target ID LDTP07594
Target Name Poly(A) RNA polymerase GLD2 (TENT2)
Gene Name TENT2
Gene ID 167153
Synonyms
GLD2; PAPD4; Poly(A) RNA polymerase GLD2; hGLD-2; EC 2.7.7.19; PAP-associated domain-containing protein 4; Terminal nucleotidyltransferase 2; Terminal uridylyltransferase 2; TUTase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGN
VSPIQTSASPLFRGRKRLSDEKNLPLDGKRQRFHSPHQEPTVVNQIVPLSGERRYSMPPL
FHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELC
RTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILT
LVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCVEFDLNVNNIVGIRNTFLLRTYAYL
ENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPESF
SPAIQLHLVHQAPCNVPPYLSKNESNLGDLLLGFLKYYATEFDWNSQMISVREAKAIPRP
DGIEWRNKYICVEEPFDGTNTARAVHEKQKFDMIKDQFLKSWHRLKNKRDLNSILPVRAA
VLKR
Target Bioclass
Enzyme
Family
DNA polymerase type-B-like family, GLD2 subfamily
Subcellular location
Cytoplasm
Function
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs.
Uniprot ID
Q6PIY7
Ensemble ID
ENST00000296783.7
HGNC ID
HGNC:26776

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KO52 SNV: p.R305C .
NCIH1975 SNV: p.C167Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C132(121.06)  LDD0209  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C225(0.96)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C225(1.11)  LDD0813  [6]
 LDCM0216  AC100 HCT 116 C225(0.89)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C225(1.08)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C225(0.98)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C225(0.99)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C225(0.89)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C225(0.97)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C225(0.90)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C225(0.90)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C225(0.82)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C225(0.95)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C225(1.12)  LDD0824  [6]
 LDCM0227  AC110 HCT 116 C225(0.91)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C225(1.02)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C225(1.07)  LDD0546  [6]
 LDCM0230  AC113 HEK-293T C225(1.17)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C225(1.08)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C225(1.15)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C225(1.04)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C225(1.16)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C225(1.18)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C225(1.30)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C225(1.01)  LDD0835  [6]
 LDCM0238  AC120 HEK-293T C225(1.02)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C225(1.28)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C225(1.34)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C225(1.46)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C225(1.13)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C225(1.19)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C225(1.40)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C225(1.70)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C225(1.15)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C225(0.98)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C225(1.03)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C225(1.19)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C225(1.13)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C225(1.16)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C225(1.04)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C225(1.11)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C225(1.15)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C225(1.15)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C225(1.23)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C225(1.25)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C225(1.21)  LDD0857  [6]
 LDCM0260  AC140 HEK-293T C225(1.20)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C225(1.25)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C225(1.09)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C225(1.34)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C225(1.29)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C225(1.49)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C225(1.15)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C225(1.69)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C225(1.12)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C225(1.39)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C225(1.08)  LDD0868  [6]
 LDCM0271  AC150 HEK-293T C225(1.40)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C225(1.31)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C225(1.33)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C225(1.47)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C225(1.16)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C225(1.52)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C225(1.32)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C225(1.66)  LDD2165  [6]
 LDCM0276  AC17 HEK-293T C374(1.07); C167(1.03); C225(1.10); C275(0.83)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C374(0.98); C167(0.90); C225(1.05); C431(1.11)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C374(1.34); C167(0.97); C225(1.02); C431(1.07)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C225(1.39)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C374(1.01); C167(1.00); C225(1.00); C431(1.09)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C374(1.10); C167(1.00); C225(1.01); C431(1.09)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C374(1.02); C167(0.93); C225(0.95); C275(0.88)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C374(1.14); C167(1.06); C225(0.96); C275(1.12)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C374(1.21); C167(1.12); C225(1.06); C275(0.87)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C225(0.75)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C225(1.00)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C225(0.84)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C225(0.80)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C225(0.99)  LDD0887  [6]
 LDCM0290  AC3 HEK-293T C225(1.37)  LDD0888  [6]
 LDCM0291  AC30 HEK-293T C225(0.82)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C225(1.06)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C225(0.89)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C225(1.04)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C225(0.81)  LDD0893  [6]
 LDCM0296  AC35 HEK-293T C225(0.96)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C225(0.79)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C225(0.78)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C225(0.91)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C225(1.08)  LDD0898  [6]
 LDCM0301  AC4 HEK-293T C225(0.93)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C225(0.84)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C225(1.02)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C225(0.85)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C225(1.22)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C225(0.88)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C225(0.79)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C374(1.07); C167(1.01); C225(1.03); C275(0.90)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C374(1.18); C167(1.04); C225(1.07); C275(1.16)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C374(1.31); C167(0.96); C225(1.14); C275(0.72)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C374(1.10); C167(0.97); C225(1.08); C275(1.43)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C225(0.97)  LDD0910  [6]
 LDCM0313  AC50 HEK-293T C374(1.10); C167(0.93); C225(1.20); C431(1.16)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C374(1.23); C167(1.09); C225(1.03); C431(1.01)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C374(0.98); C167(1.12); C225(1.02); C431(1.07)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C374(1.12); C167(1.01); C225(0.98); C431(0.93)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C374(1.01); C167(1.00); C225(1.05); C275(0.89)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C374(1.06); C167(0.96); C225(0.95); C275(1.09)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C374(1.01); C167(0.92); C225(1.11); C275(0.95)  LDD1558  [7]
 LDCM0320  AC57 HCT 116 C225(0.98)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C225(1.21)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C225(1.32)  LDD0639  [6]
 LDCM0323  AC6 HEK-293T C225(0.80)  LDD0921  [6]
 LDCM0324  AC60 HCT 116 C225(1.23)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C225(0.89)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C225(1.13)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C225(1.47)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C225(1.41)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C225(1.25)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C225(1.55)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C225(1.17)  LDD0648  [6]
 LDCM0332  AC68 HEK-293T C225(1.32)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C225(1.43)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C225(1.00)  LDD0932  [6]
 LDCM0335  AC70 HEK-293T C225(1.35)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C225(1.15)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C225(1.53)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C225(1.33)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C225(1.38)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C225(1.37)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C225(1.47)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C225(1.22)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C225(1.22)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C225(1.31)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C225(1.02)  LDD0943  [6]
 LDCM0346  AC80 HEK-293T C225(1.61)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C225(1.41)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C225(1.67)  LDD0946  [6]
 LDCM0349  AC83 HCT 116 C225(1.17)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C225(1.18)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C225(1.26)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C225(1.09)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C225(0.90)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C225(1.01)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C225(1.10)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C225(0.84)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C225(1.14)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C225(1.03)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C225(1.02)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C225(1.05)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C225(1.04)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C225(1.12)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C225(1.05)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C225(1.15)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C225(0.89)  LDD0683  [6]
 LDCM0248  AKOS034007472 HEK-293T C225(1.07)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C225(1.18)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C225(1.02)  LDD0873  [6]
 LDCM0367  CL1 HCT 116 C225(1.39)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C225(1.12)  LDD0685  [6]
 LDCM0369  CL100 HEK-293T C225(0.90)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C225(0.91)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C225(1.14)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C225(1.01)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C225(1.11)  LDD0971  [6]
 LDCM0374  CL105 HEK-293T C374(1.18); C167(0.89); C225(0.95); C431(1.00)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C374(1.47); C167(0.90); C225(1.07); C431(1.00)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C374(1.04); C167(1.03); C225(1.01); C431(0.96)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C374(1.09); C167(1.06)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C374(1.10); C167(0.87); C225(1.07); C431(1.02)  LDD1582  [7]
 LDCM0379  CL11 HCT 116 C225(1.82)  LDD0696  [6]
 LDCM0380  CL110 HEK-293T C374(0.98); C167(0.92); C225(1.10); C431(1.02)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C374(1.14); C167(0.90); C225(1.12); C431(0.88)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C225(0.93)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C225(0.86)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C225(0.90)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C225(1.10)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C225(1.15)  LDD0984  [6]
 LDCM0387  CL117 HEK-293T C225(0.76)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C225(0.81)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C225(0.99)  LDD0987  [6]
 LDCM0390  CL12 HCT 116 C225(1.75)  LDD0707  [6]
 LDCM0391  CL120 HEK-293T C225(1.00)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C374(1.01); C167(1.00); C225(0.95); C431(1.04)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C374(0.86); C167(0.97); C225(1.06); C431(1.08)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C374(1.12); C167(0.74); C225(1.36); C431(1.04)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C374(1.04); C167(1.06)  LDD1599  [7]
 LDCM0396  CL125 HCT 116 C225(1.02)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C225(1.42)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C225(1.28)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C225(1.01)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C225(1.48)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C225(1.45)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C225(2.02)  LDD0719  [6]
 LDCM0403  CL16 HEK-293T C374(1.12); C167(1.27)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C374(1.19); C167(0.85); C225(1.41); C275(1.13)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C374(0.92); C167(1.21); C225(1.11); C431(1.27)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C374(1.08); C167(1.13); C225(0.85); C431(1.07)  LDD1610  [7]
 LDCM0407  CL2 HCT 116 C225(1.13)  LDD0724  [6]
 LDCM0408  CL20 HEK-293T C374(1.18); C167(1.18); C225(0.96); C431(1.27)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C374(1.22); C167(0.89); C225(1.51); C431(0.92)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C374(1.19); C167(1.01); C225(1.02); C275(1.28)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C374(1.16); C167(1.04); C225(0.98); C275(1.11)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C374(0.97); C167(1.07); C225(1.10); C275(0.78)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C374(1.19); C167(0.98); C225(1.19); C431(1.15)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C374(1.04); C167(0.93); C225(1.03); C431(0.96)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C374(1.05); C167(0.86); C225(1.08); C431(1.05)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C374(1.13); C167(1.11)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C374(1.08); C167(0.90); C225(1.01); C275(0.85)  LDD1621  [7]
 LDCM0418  CL3 HCT 116 C225(1.22)  LDD0735  [6]
 LDCM0419  CL30 HEK-293T C374(0.96); C167(1.04); C225(1.01); C431(1.20)  LDD1623  [7]
 LDCM0420  CL31 HCT 116 C225(1.65)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C225(1.13)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C225(1.17)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C225(1.11)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C225(1.07)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C225(1.48)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C225(1.27)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C225(1.15)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C225(4.38)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C225(2.79)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C225(1.39)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C225(1.77)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C225(1.72)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C225(1.46)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C225(2.00)  LDD0752  [6]
 LDCM0436  CL46 HEK-293T C225(0.78)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C225(0.92)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C225(0.86)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C225(1.07)  LDD1037  [6]
 LDCM0440  CL5 HCT 116 C225(0.90)  LDD0757  [6]
 LDCM0441  CL50 HEK-293T C225(1.36)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C225(0.98)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C225(0.96)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C225(0.91)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C225(1.08)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C225(0.92)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C225(0.90)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C225(1.16)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C225(1.07)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C225(0.98)  LDD1048  [6]
 LDCM0451  CL6 HCT 116 C225(1.08)  LDD0768  [6]
 LDCM0452  CL60 HEK-293T C225(1.13)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C374(0.98); C167(1.09); C225(0.98); C431(1.06)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C374(1.01); C167(1.08); C225(1.02); C431(1.25)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C374(1.10); C167(0.76); C225(1.04); C431(1.07)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C374(1.08); C167(1.01)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C374(1.12); C167(1.01); C225(1.08); C275(1.15)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C374(0.94); C167(1.25); C225(1.16); C431(1.29)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C374(1.00); C167(0.99); C225(0.93); C431(1.07)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C374(0.98); C167(1.17); C225(1.10); C431(1.15)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C374(1.22); C167(0.98); C225(1.13); C431(1.11)  LDD1664  [7]
 LDCM0462  CL7 HCT 116 C225(0.92)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C374(1.03); C167(0.99); C225(1.04); C275(1.29)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C374(1.16); C167(1.06); C225(1.09); C275(0.93)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C374(1.12); C167(1.03); C225(1.17); C275(1.21)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C374(1.00); C167(1.05); C225(1.08); C431(1.12)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C374(1.02); C167(0.99); C225(1.02); C431(1.05)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C225(0.99)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C225(0.86)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C225(0.89)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C225(1.14)  LDD1070  [6]
 LDCM0473  CL8 HCT 116 C225(1.06)  LDD0790  [6]
 LDCM0474  CL80 HEK-293T C225(1.01)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C225(1.03)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C225(1.16)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C225(1.38)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C225(1.08)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C225(1.01)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C225(1.09)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C225(0.95)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C225(0.87)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C225(1.12)  LDD1081  [6]
 LDCM0484  CL9 HCT 116 C225(1.69)  LDD0801  [6]
 LDCM0485  CL90 HEK-293T C225(0.81)  LDD1083  [6]
 LDCM0486  CL91 HEK-293T C225(1.27)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C225(1.22)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C225(1.31)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C225(1.05)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C225(1.60)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C225(1.35)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C225(1.31)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C225(1.47)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C225(1.30)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C374(0.97); C167(1.13); C225(1.34); C431(1.01)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C374(1.17); C167(0.93); C225(1.18); C431(0.97)  LDD1671  [7]
 LDCM0427  Fragment51 HCT 116 C225(3.33)  LDD0744  [6]
 LDCM0022  KB02 HEK-293T C374(0.97); C167(0.95)  LDD1492  [7]
 LDCM0023  KB03 Jurkat C132(121.06)  LDD0209  [1]
 LDCM0024  KB05 MKN45 C167(1.62)  LDD3332  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
RNA-binding protein with multiple splicing (RBPMS) . Q93062

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840