Details of the Target

General Information of Target

Target ID LDTP06996
Target Name BOS complex subunit NOMO2 (NOMO2)
Gene Name NOMO2
Gene ID 283820
Synonyms
BOS complex subunit NOMO2; Nodal modulator 2; pM5 protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLVGQGAGLLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYT
KHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELHVDGVSDICTKGG
DINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKIQSTVTQPGGKFAFFKVLPGD
YEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSS
LVTKEDVLGCNVSPVPGFQPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERI
TFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEAVVTLNNQIKVKTK
ADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIVATGFSVCGRISIIRFP
DTVKQMNKYKVVLSSQDKDKSLVTVETDAHGSFCFKAKPGTYKVQVMVPEAETRAGLTLK
PQTFPLTVTDRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLQLSGKV
NAMTFTFDNVLPGKYKISIMHEDWCWKNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAI
TLEFYQDGNGRENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILT
LTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIEARRQE
REKNGNEEGEERMTKPPVQEMVDELQGPFSYDFSYWARSGEKITVTPSSKELLFYPPSME
AVVSGESCPGKLIEIHGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSV
GPLHSDLEYTVTSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGG
LFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTA
YSCYGTVSSLNGEPEQGVAMEAVGQNDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKA
EGNDHIERALPHHRVIEVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKS
ENLDNPIQTVSLGQSLFFHFPPLLRDGENYVVLLDSTLPRSQYDYILPQVSFTAVGYHKH
ITLIFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVGALGQA
ASDNSGPEDAKRQAKKQKTRRTLRLQEEFQLMWCLVPWRGTLGIHLFSSLPFASEILLET
TATCIHY
Target Bioclass
Transporter and channel
Subcellular location
Endoplasmic reticulum membrane
Function
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions.
Uniprot ID
Q5JPE7
Ensemble ID
ENST00000330537.10
HGNC ID
HGNC:22652

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C565(1.38)  LDD0080  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
IA-alkyne
 Probe Info  		C627(0.00); C411(0.00); C1012(0.00); C788(0.00)  LDD0162  [3]
Lodoacetamide azide
 Probe Info  		C627(0.00); C1012(0.00); C411(0.00); C565(0.00)  LDD0037  [4]
NHS
 Probe Info  		K170(0.00); K356(0.00)  LDD0010  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0471  [8]
FFF probe13
 Probe Info  		20.00  LDD0476  [8]
FFF probe14
 Probe Info  		20.00  LDD0477  [8]
FFF probe2
 Probe Info  		8.56  LDD0463  [8]
FFF probe3
 Probe Info  		20.00  LDD0464  [8]
STS-1
 Probe Info  		N.A.  LDD0136  [9]
STS-2
 Probe Info  		N.A.  LDD0138  [9]
OEA-DA
 Probe Info  		4.68  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C511(1.40); C515(1.40)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C511(0.92); C788(1.25)  LDD0813  [1]
 LDCM0216  AC100 PaTu 8988t C511(1.00); C515(1.00)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C511(1.44); C515(1.44)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C511(1.26); C515(1.26)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C511(1.04); C515(1.04)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C511(0.83); C515(0.83)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C511(0.82); C515(0.82)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C511(0.91); C515(0.91)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C511(0.98); C515(0.98)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C511(0.95); C515(0.95)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C511(0.98); C515(0.98)  LDD1104  [1]
 LDCM0226  AC11 HEK-293T C511(0.95); C788(1.25)  LDD0824  [1]
 LDCM0227  AC110 PaTu 8988t C511(1.10); C515(1.10)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C511(1.04); C515(1.04)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C511(0.90); C515(0.90)  LDD1108  [1]
 LDCM0230  AC113 HCT 116 C511(0.98); C515(0.98)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C511(0.64); C515(0.64)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C511(0.61); C515(0.61)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C511(0.61); C515(0.61)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C511(0.66); C515(0.66)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C511(1.11); C515(1.11)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C511(0.87); C515(0.87)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C511(0.82); C788(1.13)  LDD0835  [1]
 LDCM0238  AC120 HCT 116 C511(0.70); C515(0.70)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C511(0.92); C515(0.92)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C511(0.80); C515(0.80)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C511(0.79); C515(0.79)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C511(0.74); C515(0.74)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C511(0.71); C515(0.71)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C511(0.77); C515(0.77)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C511(0.59); C515(0.59)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C1012(0.83)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C1012(1.09)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C1012(0.99)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C1012(1.07)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C1012(1.06)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C1012(0.98)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C1012(0.97)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C1012(0.93)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C1012(0.99)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C1012(0.94)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C1012(0.92)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C1012(0.89)  LDD0575  [1]
 LDCM0259  AC14 HEK-293T C511(0.84); C788(1.27)  LDD0857  [1]
 LDCM0260  AC140 HCT 116 C1012(0.90)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C1012(1.00)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C1012(1.21)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C1012(0.73)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C1012(0.65)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C1012(0.88)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C1012(0.63)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C1012(0.68)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C1012(0.41)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C1012(0.50)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C511(0.88); C788(1.61)  LDD0868  [1]
 LDCM0271  AC150 HCT 116 C1012(0.99)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C1012(0.61)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C1012(0.60)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C1012(0.39)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C1012(0.57)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C1012(0.57)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C1012(0.69)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C1012(0.83)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C511(0.95); C788(1.10)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C511(0.91); C788(1.98)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C511(0.87); C788(1.45)  LDD0876  [1]
 LDCM0279  AC2 HCT 116 C511(1.43); C515(1.43)  LDD0596  [1]
 LDCM0280  AC20 HEK-293T C511(0.99); C788(1.68)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C511(1.02); C788(1.81)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C511(0.91); C788(2.45)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C511(0.96); C788(1.26)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C511(0.89); C788(1.65)  LDD0882  [1]
 LDCM0285  AC25 HEK-293T C788(0.99)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C788(1.27)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C788(0.99)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C788(0.78)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C788(1.22)  LDD0887  [1]
 LDCM0290  AC3 HCT 116 C511(1.46); C515(1.46)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C788(0.99)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C788(1.02)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C788(0.85)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C788(1.07)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C788(0.80)  LDD0893  [1]
 LDCM0296  AC35 HCT 116 C1012(1.37)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C1012(1.35)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C1012(1.24)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C1012(1.13)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C1012(1.08)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C511(0.97); C515(0.97)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C1012(0.85)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C1012(1.26)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C1012(1.07)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C1012(1.35)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C1012(1.03)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C1012(0.97)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C511(1.36); C515(1.36)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C511(0.92); C515(0.92)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C511(1.74); C515(1.74)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C511(0.83); C515(0.83)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C511(1.15); C515(1.15)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C511(0.87); C515(0.87)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C511(1.43); C515(1.43)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C511(0.90); C515(0.90)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C511(0.78); C515(0.78)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C511(0.86); C515(0.86)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C511(0.82); C515(0.82)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C511(0.63); C515(0.63)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C788(1.53)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C788(1.33)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C788(1.58)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C511(1.17); C788(1.23)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C788(1.36)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C788(1.62)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C788(1.59)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C788(1.89)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C788(1.40)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C788(2.26)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C788(2.46)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C788(1.14)  LDD0929  [1]
 LDCM0332  AC68 HCT 116 C1012(0.91)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C1012(0.94)  LDD0650  [1]
 LDCM0334  AC7 HEK-293T C511(0.95); C788(1.16)  LDD0932  [1]
 LDCM0335  AC70 HCT 116 C1012(0.63)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C1012(0.89)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C1012(0.76)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C1012(0.57)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C1012(0.64)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C1012(0.51)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C1012(0.75)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C1012(0.60)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C1012(1.14)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C1012(0.90)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C511(0.90); C788(1.42)  LDD0943  [1]
 LDCM0346  AC80 HCT 116 C1012(0.81)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C1012(1.08)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C1012(0.44)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C1012(0.42)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C1012(0.50)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C1012(0.76)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C1012(0.59)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C1012(0.81)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C1012(0.63)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C1012(0.65)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C1012(0.78)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C1012(0.39)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C1012(0.43)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C1012(0.60)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C1012(0.76)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C1012(1.58)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C1012(0.59)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C1012(0.47)  LDD0681  [1]
 LDCM0365  AC98 PaTu 8988t C511(1.31); C515(1.31)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C511(0.95); C515(0.95)  LDD1245  [1]
 LDCM0248  AKOS034007472 HEK-293T C511(1.00); C788(1.21)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C511(0.91); C788(1.49)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C511(1.05); C788(1.19)  LDD0873  [1]
 LDCM0367  CL1 HCT 116 C511(1.78); C515(1.78)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C511(1.79); C515(1.79)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C511(1.05); C515(1.05)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C511(1.01); C788(1.14)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C511(1.02); C788(1.21)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C511(0.86); C788(1.21)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C511(0.92); C788(1.36)  LDD0971  [1]
 LDCM0374  CL105 HEK-293T C511(1.03); C788(1.30)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C511(1.07); C788(1.77)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C511(0.88); C788(1.49)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C511(0.99); C788(1.27)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C511(0.94); C788(1.10)  LDD0976  [1]
 LDCM0379  CL11 HCT 116 C511(1.52); C515(1.52)  LDD0696  [1]
 LDCM0380  CL110 HEK-293T C511(1.01); C788(1.85)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C511(0.93); C788(1.20)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C788(0.68)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C788(0.94)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C788(1.04)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C788(1.08)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C788(0.91)  LDD0984  [1]
 LDCM0387  CL117 HCT 116 C1012(1.07)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C1012(1.09)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C1012(0.90)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C511(0.88); C515(0.88)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C1012(1.13)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C511(1.35); C515(1.35)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C511(0.92); C515(0.92)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C511(1.01); C515(1.01)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C511(0.67); C515(0.67)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C788(1.50)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C788(1.55)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C788(2.15)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C788(1.95)  LDD0997  [1]
 LDCM0400  CL13 HCT 116 C511(1.17); C515(1.17)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C511(1.61); C515(1.61)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C511(1.26); C515(1.26)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C511(0.55); C515(0.55)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C511(1.16); C515(1.16)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C511(0.79); C515(0.79)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C511(1.39); C515(1.39)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C511(1.81); C515(1.81)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C511(0.73); C515(0.73)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C511(0.85); C515(0.85)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C511(0.78); C515(0.78)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C511(1.23); C515(1.23)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C511(0.90); C515(0.90)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C511(1.26); C515(1.26)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C511(4.75); C515(4.75)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C511(1.94); C515(1.94)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C511(1.00); C515(1.00)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C511(1.26); C515(1.26)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C511(0.80); C515(0.80)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C511(1.04); C515(1.04)  LDD0736  [1]
 LDCM0420  CL31 HEK-293T C511(1.09); C788(0.96)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C511(1.05); C788(0.89)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C511(0.90); C788(1.05)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C511(1.06); C788(0.95)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C511(0.97); C788(1.15)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C511(1.01); C788(1.21)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C511(0.92); C788(1.10)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C511(1.05); C788(1.38)  LDD1026  [1]
 LDCM0429  CL4 HCT 116 C511(0.85); C515(0.85)  LDD0746  [1]
 LDCM0430  CL40 HEK-293T C511(0.97); C788(1.34)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C511(1.12); C788(1.57)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C511(1.03); C788(1.45)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C511(1.11); C788(1.19)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C511(0.90); C788(1.36)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C511(0.98); C788(1.37)  LDD1033  [1]
 LDCM0436  CL46 HCT 116 C515(0.62)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C515(0.66)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C515(0.57)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C515(0.94)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C511(1.12); C515(1.12)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C515(0.86)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C515(0.81)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C515(0.75)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C515(0.67)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C515(0.68)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C515(0.75)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C515(0.75)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C515(1.07)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C515(1.00)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C515(0.67)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C511(1.84); C515(1.84)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C515(0.58)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C511(0.69); C515(0.69)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C511(1.32); C515(1.32)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C511(1.02); C515(1.02)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C511(0.74); C515(0.74)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C511(0.85); C515(0.85)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C511(0.70); C515(0.70)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C511(0.60); C515(0.60)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C511(0.59); C515(0.59)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C511(10.00); C515(10.00)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C511(0.99); C515(0.99)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C511(1.07); C515(1.07)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C511(0.82); C515(0.82)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C511(1.65); C515(1.65)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C511(0.65); C515(0.65)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C511(0.86); C515(0.86)  LDD0784  [1]
 LDCM0469  CL76 PaTu 8988t C565(0.93); C788(1.05)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C565(0.88); C788(0.82)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C565(0.98); C788(1.01)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C565(1.29); C788(1.02)  LDD1351  [1]
 LDCM0473  CL8 HCT 116 C511(0.88); C515(0.88)  LDD0790  [1]
 LDCM0474  CL80 PaTu 8988t C565(0.99); C788(1.05)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C565(0.99); C788(1.15)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C565(1.15); C788(1.10)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C565(1.19); C788(1.25)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C565(0.95); C788(1.00)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C565(0.84); C788(0.97)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C565(0.99); C788(1.09)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C565(1.29); C788(1.24)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C565(1.17); C788(1.10)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C565(1.08); C788(0.90)  LDD1362  [1]
 LDCM0484  CL9 HCT 116 C511(1.22); C515(1.22)  LDD0801  [1]
 LDCM0485  CL90 PaTu 8988t C565(0.84); C788(1.02)  LDD1364  [1]
 LDCM0486  CL91 HCT 116 C511(1.11); C515(1.11)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C511(2.94); C515(2.94)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C511(1.04); C515(1.04)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C511(1.11); C515(1.11)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C511(1.37); C515(1.37)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C511(1.75); C515(1.75)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C511(1.31); C515(1.31)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C511(1.07); C515(1.07)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C511(1.50); C515(1.50)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C788(1.01); C116(0.88)  LDD1698  [11]
 LDCM0468  Fragment33 HCT 116 C511(0.62); C515(0.62)  LDD0785  [1]
 LDCM0427  Fragment51 HEK-293T C511(1.03); C788(1.02)  LDD1025  [1]
 LDCM0022  KB02 HCT 116 C565(1.38)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C565(1.20)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C565(1.28)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402