Details of the Target

General Information of Target

Target ID LDTP06907
Target Name tRNA wybutosine-synthesizing protein 2 homolog (TRMT12)
Gene Name TRMT12
Gene ID 55039
Synonyms
TRM12; TYW2; tRNA wybutosine-synthesizing protein 2 homolog; tRNA-yW-synthesizing protein 2; EC 2.5.1.114; tRNA(Phe; 4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRENVVVSNMERESGKPVAVVAVVTEPWFTQRYREYLQRQKLFDTQHRVEKMPDGSVALP
VLGETLPEQHLQELRNRVAPGSPCMLTQLPDPVPSKRAQGCSPAQKLCLEVSRWVEGRGV
KWSAELEADLPRSWQRHGNLLLLSEDCFQAKQWKNLGPELWETVALALGVQRLAKRGRVS
PDGTRTPAVTLLLGDHGWVEHVDNGIRYKFDVTQCMFSFGNITEKLRVASLSCAGEVLVD
LYAGIGYFTLPFLVHAGAAFVHACEWNPHAVVALRNNLEINGVADRCQIHFGDNRKLKLS
NIADRVILGLIPSSEEGWPIACQVLRQDAGGILHIHQNVESFPGKNLQALGVSKVEKEHW
LYPQQITTNQWKNGATRDSRGKMLSPATKPEWQRWAESAETRIATLLQQVHGKPWKTQIL
HIQPVKSYAPHVDHIVLDLECCPCPSVG
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, TRM5/TYW2 family
Function
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.
Uniprot ID
Q53H54
Ensemble ID
ENST00000328599.4
HGNC ID
HGNC:26091

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C287(1.20)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [2]
NAIA_5
 Probe Info  		C84(0.00); C101(0.00)  LDD2225  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C287(1.20)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C287(1.12)  LDD0532  [1]
 LDCM0216  AC100 HEK-293T C101(0.79)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C101(1.15)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C101(0.91)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C101(0.75)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C101(0.70)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C101(0.77)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C101(0.95)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C101(0.89)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C101(0.99)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C101(1.09)  LDD0823  [1]
 LDCM0226  AC11 HCT 116 C287(1.26)  LDD0543  [1]
 LDCM0227  AC110 HEK-293T C101(0.92)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C101(1.11)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C101(1.27)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C101(0.88)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C101(1.07)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C101(0.96)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C101(0.98)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C101(0.63)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C101(0.58)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C101(0.40)  LDD0834  [1]
 LDCM0237  AC12 HCT 116 C287(1.14)  LDD0554  [1]
 LDCM0238  AC120 HEK-293T C101(0.67)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C101(0.42)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C101(0.13)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C101(0.11)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C101(0.40)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C101(0.14)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C101(0.08)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C101(0.09)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C101(1.12)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C101(0.74)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C101(0.78)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C101(1.07)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C101(0.98)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C101(0.37)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C101(0.62)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C101(0.57)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C101(0.60)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C101(0.14)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C101(0.10)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C101(0.15)  LDD0856  [1]
 LDCM0259  AC14 HCT 116 C287(1.06)  LDD0576  [1]
 LDCM0260  AC140 HEK-293T C101(0.38)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C101(0.15)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C101(0.40)  LDD0860  [1]
 LDCM0263  AC143 HEK-293T C101(0.61)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C101(0.26)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C101(0.23)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C101(0.25)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C101(0.19)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C101(0.26)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C101(0.85)  LDD0867  [1]
 LDCM0270  AC15 HCT 116 C287(0.93)  LDD0587  [1]
 LDCM0271  AC150 HEK-293T C101(0.50)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C101(0.42)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C101(0.93)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C101(0.50)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C101(1.03)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C101(0.91)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C101(0.19)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C101(0.22)  LDD2165  [1]
 LDCM0276  AC17 HEK-293T C101(1.52)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C101(1.58)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C101(1.75)  LDD0876  [1]
 LDCM0279  AC2 HCT 116 C287(1.12)  LDD0596  [1]
 LDCM0280  AC20 HEK-293T C101(1.21)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C101(2.51)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C101(1.28)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C101(1.72)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C101(1.40)  LDD0882  [1]
 LDCM0285  AC25 HCT 116 C287(0.97)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C287(1.05)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C287(1.10)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C287(1.16)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C287(1.05)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C287(1.07)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C287(1.02)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C287(0.97)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C287(1.13)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C287(0.91)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C287(0.74)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C287(0.84)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C287(0.88)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C287(0.85)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C287(1.08)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C287(0.94)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C287(1.22)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C287(0.84)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C287(0.95)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C287(1.09)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C287(1.17)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C287(1.00)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C287(0.96)  LDD0624  [1]
 LDCM0309  AC47 HEK-293T C101(0.97)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C108(0.95); C84(1.22)  LDD1549  [5]
 LDCM0312  AC5 HCT 116 C287(1.47)  LDD0629  [1]
 LDCM0313  AC50 HEK-293T C101(1.26)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C84(0.91)  LDD1553  [5]
 LDCM0316  AC53 HEK-293T C84(1.20)  LDD1555  [5]
 LDCM0318  AC55 HEK-293T C101(0.88)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C108(0.75); C84(1.14)  LDD1558  [5]
 LDCM0321  AC58 HEK-293T C101(0.98)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C84(1.29)  LDD1561  [5]
 LDCM0323  AC6 HCT 116 C287(1.00)  LDD0640  [1]
 LDCM0325  AC61 HEK-293T C84(1.39)  LDD1564  [5]
 LDCM0327  AC63 HEK-293T C101(0.89)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C108(1.48); C84(0.85)  LDD1567  [5]
 LDCM0332  AC68 PaTu 8988t C215(0.94)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C215(1.21)  LDD1212  [1]
 LDCM0334  AC7 HCT 116 C287(0.94)  LDD0651  [1]
 LDCM0335  AC70 PaTu 8988t C215(1.05)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C215(0.87)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C215(0.74)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C215(0.70)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C215(1.23)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C215(1.02)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C215(0.72)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C215(1.01)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C215(0.85)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C215(0.83)  LDD1223  [1]
 LDCM0345  AC8 HCT 116 C287(0.96)  LDD0662  [1]
 LDCM0346  AC80 PaTu 8988t C215(0.79)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C215(0.78)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C215(1.10)  LDD1227  [1]
 LDCM0349  AC83 PaTu 8988t C215(0.89); C101(0.87)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C215(0.76); C101(0.59)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C215(0.69); C101(0.69)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C215(0.78); C101(0.74)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C215(0.77); C101(1.00)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C215(0.90); C101(0.93)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C215(0.92); C101(0.65)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C215(1.11); C101(0.69)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C215(0.84); C101(0.77)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C215(0.85); C101(0.80)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C215(0.75); C101(1.35)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C215(1.09); C101(0.65)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C215(0.81); C101(1.08)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C215(0.98); C101(0.66)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C215(0.95); C101(0.70)  LDD1243  [1]
 LDCM0365  AC98 HEK-293T C101(0.95)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C101(1.09)  LDD0964  [1]
 LDCM0248  AKOS034007472 HCT 116 C287(1.10)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C287(1.09)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C287(1.09)  LDD0592  [1]
 LDCM0367  CL1 HEK-293T C101(0.91)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C101(0.48)  LDD0966  [1]
 LDCM0369  CL100 HCT 116 C287(1.17)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C287(1.09)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C287(1.19)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C287(1.15)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C287(1.14)  LDD0690  [1]
 LDCM0374  CL105 HEK-293T C101(0.73)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C101(1.31)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C101(1.28)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C101(0.97)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C101(1.37)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C101(0.53)  LDD0977  [1]
 LDCM0380  CL110 HEK-293T C101(1.90)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C101(1.87)  LDD0979  [1]
 LDCM0382  CL112 HCT 116 C287(0.87)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C287(0.85)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C287(0.83)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C287(0.89)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C287(1.01)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C287(0.92)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C287(1.06)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C287(1.09)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C101(3.83)  LDD0988  [1]
 LDCM0391  CL120 HCT 116 C287(1.15)  LDD0708  [1]
 LDCM0394  CL123 HEK-293T C84(1.02)  LDD1598  [5]
 LDCM0398  CL127 HEK-293T C84(1.07)  LDD1602  [5]
 LDCM0400  CL13 HEK-293T C101(1.18)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C101(0.86)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C101(0.88)  LDD1000  [1]
 LDCM0403  CL16 HEK-293T C101(1.00)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C101(1.18)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C101(1.10)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C101(0.81)  LDD1004  [1]
 LDCM0407  CL2 HEK-293T C101(0.70)  LDD1005  [1]
 LDCM0408  CL20 HEK-293T C101(1.14)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C101(1.02)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C101(1.22)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C101(1.41)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C101(1.32)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C101(0.85)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C101(1.19)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C101(1.23)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C101(1.13)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C101(1.23)  LDD1015  [1]
 LDCM0418  CL3 HEK-293T C101(1.56)  LDD1016  [1]
 LDCM0419  CL30 HEK-293T C101(0.88)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C101(1.14)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C101(0.97)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C101(0.75)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C101(0.95)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C101(0.97)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C101(0.96)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C101(1.01)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C101(0.58)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C101(1.66)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C101(0.79)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C101(0.61)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C101(0.57)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C101(0.56)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C101(0.87)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C101(0.70)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C101(1.11)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C101(1.37)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C101(0.98)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C101(1.28)  LDD1037  [1]
 LDCM0440  CL5 HEK-293T C101(1.03)  LDD1038  [1]
 LDCM0441  CL50 HEK-293T C101(0.81)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C101(0.62)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C101(1.28)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C101(0.88)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C101(0.86)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C101(0.78)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C101(0.92)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C101(0.88)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C101(0.82)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C101(0.80)  LDD1048  [1]
 LDCM0451  CL6 HEK-293T C101(0.79)  LDD1049  [1]
 LDCM0452  CL60 HEK-293T C101(0.68)  LDD1050  [1]
 LDCM0453  CL61 PaTu 8988t C287(1.04); C215(0.95); C101(1.12)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C287(0.99); C215(1.53); C101(1.30)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C287(1.40); C215(1.30); C101(1.21)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C287(1.17); C215(1.49); C101(1.30)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C287(0.85); C215(1.25); C101(1.22)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C287(0.89); C215(1.47); C101(1.53)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C287(0.94); C215(1.27); C101(1.49)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C287(1.36); C215(1.42); C101(1.39)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C287(0.94); C215(1.59); C101(1.50)  LDD1340  [1]
 LDCM0462  CL7 HEK-293T C101(1.12)  LDD1060  [1]
 LDCM0463  CL70 PaTu 8988t C287(1.09); C215(1.03); C101(1.27)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C287(1.26); C215(1.23); C101(1.17)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C287(1.18); C215(1.29); C101(1.26)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C287(0.97); C215(2.01); C101(1.52)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C287(0.98); C215(1.37); C101(1.32)  LDD1346  [1]
 LDCM0469  CL76 HCT 116 C287(0.70)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C287(0.72)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C287(0.84)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C287(0.78)  LDD0789  [1]
 LDCM0473  CL8 PaTu 8988t C215(1.86); C101(1.49)  LDD1352  [1]
 LDCM0474  CL80 HCT 116 C287(0.85)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C287(0.91)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C287(0.85)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C287(0.70)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C287(0.81)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C287(0.78)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C287(0.75)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C287(0.69)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C287(0.64)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C287(0.77)  LDD0800  [1]
 LDCM0484  CL9 PaTu 8988t C215(2.20); C101(1.97)  LDD1363  [1]
 LDCM0485  CL90 HCT 116 C287(0.63)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C287(0.97)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C287(0.87)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C287(1.06)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C287(0.90)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C287(0.86)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C287(1.05)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C287(1.05)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C287(1.08)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C287(1.19)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C84(1.54)  LDD1698  [5]
 LDCM0468  Fragment33 PaTu 8988t C287(1.04); C215(1.68); C101(1.42)  LDD1347  [1]
 LDCM0427  Fragment51 HEK-293T C101(0.89)  LDD1025  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402