Details of the Target

General Information of Target

Target ID LDTP06896
Target Name Pleckstrin homology-like domain family A member 2 (PHLDA2)
Gene Name PHLDA2
Gene ID 7262
Synonyms
BWR1C; HLDA2; IPL; TSSC3; Pleckstrin homology-like domain family A member 2; Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein; Imprinted in placenta and liver protein; Tumor-suppressing STF cDNA 3 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; p17-Beckwith-Wiedemann region 1 C; p17-BWR1C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKSPDEVLREGELEKRSDSLFQLWKKKRGVLTSDRLSLFPASPRARPKELRFHSILKVDC
VERTGKYVYFTIVTTDHKEIDFRCAGESCWNAAIALALIDFQNRRALQDFRSRQERTAPA
APAEDAVAAAAAAPSEPSEPSRPSPQPKPRTP
Target Bioclass
Other
Family
PHLDA2 family
Subcellular location
Cytoplasm
Function Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.
Uniprot ID
Q53GA4
Ensemble ID
ENST00000314222.5
HGNC ID
HGNC:12385

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K25(3.66)  LDD0277  [1]
DBIA
 Probe Info  		C84(0.95); C89(0.95)  LDD0531  [2]
TFBX
 Probe Info  		N.A.  LDD0148  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C84(0.95); C89(0.95)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C84(0.55); C89(0.62)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C84(0.61); C89(0.63)  LDD0543  [2]
 LDCM0230  AC113 HCT 116 C84(0.78); C89(0.78)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C84(0.52); C89(0.52)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C84(0.64); C89(0.64)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C84(1.06); C89(1.06)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C84(0.88); C89(0.88)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C84(0.69); C89(0.69)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C84(0.72); C89(0.72)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C84(0.53); C89(0.58)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C84(0.58); C89(0.58)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C84(0.71); C89(0.71)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C84(0.88); C89(0.88)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C84(0.80); C89(0.80)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C84(0.85); C89(0.85)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C84(0.62); C89(0.62)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C84(0.64); C89(0.64)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C84(0.68); C89(0.68)  LDD0562  [2]
 LDCM0246  AC128 PaTu 8988t C84(1.40); C89(1.40)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C84(1.18); C89(1.18)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C84(1.20); C89(1.20)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C84(1.37); C89(1.37)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C84(1.18); C89(1.18)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C84(0.95); C89(0.95)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C84(1.08); C89(1.08)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C84(1.41); C89(1.41)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C84(0.92); C89(0.92)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C84(1.02); C89(1.02)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C84(1.68); C89(1.68)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C84(1.16); C89(1.16)  LDD1137  [2]
 LDCM0259  AC14 HCT 116 C84(0.52); C89(0.43)  LDD0576  [2]
 LDCM0260  AC140 PaTu 8988t C84(1.13); C89(1.13)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C84(1.50); C89(1.50)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C84(1.34); C89(1.34)  LDD1141  [2]
 LDCM0270  AC15 HCT 116 C84(0.66); C89(0.68)  LDD0587  [2]
 LDCM0279  AC2 HCT 116 C84(0.83); C89(0.83)  LDD0596  [2]
 LDCM0290  AC3 HCT 116 C84(0.76); C89(0.76)  LDD0607  [2]
 LDCM0296  AC35 HCT 116 C84(0.61); C89(0.61)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C84(0.50); C89(0.50)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C84(0.56); C89(0.56)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C84(1.69); C89(1.69)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C84(0.36); C89(0.36)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C84(0.70); C89(0.70)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C84(0.70); C89(0.70)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C84(0.43); C89(0.43)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C84(0.46); C89(0.46)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C84(0.47); C89(0.47)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C84(0.40); C89(0.40)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C84(0.76); C89(0.76)  LDD0624  [2]
 LDCM0312  AC5 HCT 116 C84(0.42); C89(0.42)  LDD0629  [2]
 LDCM0323  AC6 HCT 116 C89(0.87); C84(0.88)  LDD0640  [2]
 LDCM0332  AC68 HCT 116 C84(0.94); C89(0.94)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C84(1.75); C89(1.75)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C89(0.54); C84(0.56)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C84(1.11); C89(1.11)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C84(0.85); C89(0.85)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C84(1.75); C89(1.75)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C84(1.49); C89(1.49)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C84(1.27); C89(1.27)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C84(1.73); C89(1.73)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C84(1.38); C89(1.38)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C84(1.56); C89(1.56)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C84(1.18); C89(1.18)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C84(0.94); C89(0.94)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C84(0.41); C89(0.45)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C84(1.25); C89(1.25)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C84(0.55); C89(0.55)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C84(1.14); C89(1.14)  LDD0665  [2]
 LDCM0248  AKOS034007472 HCT 116 C84(0.47); C89(0.46)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C84(0.53); C89(0.59)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C84(0.84); C89(1.02)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C84(1.96); C89(1.96)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C84(1.49); C89(1.49)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C84(1.03); C89(1.03)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C84(0.52); C89(0.56)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C89(0.69); C84(0.85)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C89(1.10); C84(1.16)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C84(1.31); C89(1.43)  LDD0690  [2]
 LDCM0379  CL11 HCT 116 C84(1.22); C89(1.22)  LDD0696  [2]
 LDCM0387  CL117 HCT 116 C84(0.50); C89(0.50)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C84(0.40); C89(0.40)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C84(0.61); C89(0.61)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C84(1.69); C89(1.69)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C84(0.42); C89(0.42)  LDD0708  [2]
 LDCM0400  CL13 HCT 116 C84(1.24); C89(1.24)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C84(2.11); C89(2.11)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C84(1.20); C89(1.20)  LDD0719  [2]
 LDCM0403  CL16 PaTu 8988t C84(0.87); C89(0.87)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C84(1.29); C89(1.29)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C84(0.80); C89(0.80)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C84(1.40); C89(1.40)  LDD1285  [2]
 LDCM0407  CL2 HCT 116 C84(1.22); C89(1.22)  LDD0724  [2]
 LDCM0408  CL20 PaTu 8988t C84(1.23); C89(1.23)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C84(1.07); C89(1.07)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C84(1.10); C89(1.10)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C84(1.34); C89(1.34)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C84(0.97); C89(0.97)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C84(1.10); C89(1.10)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C84(0.85); C89(0.85)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C84(1.01); C89(1.01)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C84(0.97); C89(0.97)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C84(1.48); C89(1.48)  LDD1296  [2]
 LDCM0418  CL3 HCT 116 C84(1.33); C89(1.33)  LDD0735  [2]
 LDCM0419  CL30 PaTu 8988t C84(1.15); C89(1.15)  LDD1298  [2]
 LDCM0420  CL31 HCT 116 C84(1.80); C89(1.80)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C84(1.44); C89(1.44)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C84(3.61); C89(3.61)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C84(2.50); C89(2.50)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C84(4.15); C89(4.15)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C84(2.78); C89(2.78)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C84(4.14); C89(4.14)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C84(2.48); C89(2.48)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C84(1.21); C89(1.21)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C84(2.14); C89(2.14)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C84(2.27); C89(2.27)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C84(2.62); C89(2.62)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C84(3.31); C89(3.31)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C84(2.29); C89(2.29)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C84(2.50); C89(2.50)  LDD0752  [2]
 LDCM0436  CL46 PaTu 8988t C84(1.25); C89(1.25)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C84(1.23); C89(1.23)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C84(1.57); C89(1.57)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C84(1.40); C89(1.40)  LDD1318  [2]
 LDCM0440  CL5 HCT 116 C84(0.88); C89(0.88)  LDD0757  [2]
 LDCM0441  CL50 PaTu 8988t C84(1.57); C89(1.57)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C84(1.22); C89(1.22)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C84(1.13); C89(1.13)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C84(1.88); C89(1.88)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C84(1.46); C89(1.46)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C84(1.15); C89(1.15)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C84(0.27); C89(0.27)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C84(1.65); C89(1.65)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C84(1.39); C89(1.39)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C84(1.89); C89(1.89)  LDD1329  [2]
 LDCM0451  CL6 HCT 116 C84(1.21); C89(1.21)  LDD0768  [2]
 LDCM0452  CL60 PaTu 8988t C84(1.62); C89(1.62)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C84(0.89); C89(0.89)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C84(0.71); C89(0.71)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C84(1.11); C89(1.11)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C84(1.10); C89(1.10)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C84(1.19); C89(1.19)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C84(1.01); C89(1.01)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C84(1.36); C89(1.36)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C84(1.47); C89(1.47)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C84(1.91); C89(1.91)  LDD1340  [2]
 LDCM0462  CL7 HCT 116 C84(0.90); C89(0.90)  LDD0779  [2]
 LDCM0463  CL70 PaTu 8988t C84(1.00); C89(1.00)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C84(1.12); C89(1.12)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C84(0.73); C89(0.73)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C84(1.17); C89(1.17)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C84(0.95); C89(0.95)  LDD1346  [2]
 LDCM0469  CL76 HCT 116 C84(1.09); C89(1.09)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C84(1.30); C89(1.30)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C84(0.98); C89(0.98)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C84(1.65); C89(1.65)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C84(2.67); C89(2.67)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C84(1.64); C89(1.64)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C84(1.32); C89(1.32)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C84(1.50); C89(1.50)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C84(1.41); C89(1.41)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C84(1.76); C89(1.76)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C84(1.40); C89(1.40)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C84(1.01); C89(1.01)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C84(1.23); C89(1.23)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C84(1.45); C89(1.45)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C84(1.43); C89(1.43)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C84(1.46); C89(1.46)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C84(1.58); C89(1.58)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C84(0.75); C89(0.75)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C84(0.78); C89(0.78)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C84(0.98); C89(0.98)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C84(1.05); C89(1.05)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C84(0.88); C89(0.88)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C84(0.68); C89(0.68)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C84(1.31); C89(1.31)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C84(0.90); C89(0.90)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C84(0.84); C89(0.84)  LDD0811  [2]
 LDCM0468  Fragment33 PaTu 8988t C84(1.01); C89(1.01)  LDD1347  [2]
 LDCM0427  Fragment51 HCT 116 C84(2.44); C89(2.44)  LDD0744  [2]
 LDCM0022  KB02 A-549 C60(1.74)  LDD2260  [4]
 LDCM0023  KB03 A-549 C60(2.32)  LDD2677  [4]
 LDCM0024  KB05 HMCB C60(3.73)  LDD3312  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase OTUB2 (OTUB2) Peptidase C65 family Q96DC9

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840