Details of the Target

General Information of Target

Target ID LDTP06691
Target Name Protein CLEC16A (CLEC16A)
Gene Name CLEC16A
Gene ID 23274
Synonyms
KIAA0350; Protein CLEC16A; C-type lectin domain family 16 member A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFGRSRSWVGGGHGKTSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIW
GDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSN
NYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFN
HPESMVRIAVRTITLNVYKVSLDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDDCVQT
DEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENQD
KGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSEMYAKTEQDIQRSSAKP
SIRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEKGPTEDAQEDAEKAKGT
EGGSKGIKTSGESEEIEMVIMERSKLSELAASTSVQEQNTTDEEKSAAATCSESTQWSRP
FLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPNAAEKTTYNHPLA
ERLIRIMNNAAQPDGKIRLATLELSCLLLKQQVLMSAGCIMKDVHLACLEGAREESVHLV
RHFYKGEDIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDV
EKTRRAIRVFFMLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDG
GMVQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASS
PHSKPFPILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGF
GLGSSTSTQHLPFRFYDQGRRGSSDPTVQRSVFASVDKVPGFAVAQCINQHSSPSLSSQS
PPSASGSPSGSGSTSHCDSGGTSSSSTPSTAQSPADAPMSPELPKPHLPDQLVIVNETEA
DSKPSKNVARSAAVETASLSPSLVPARQPTISLLCEDTADTLSVESLTLVPPVDPHSLRS
LTGMPPLSTPAAACTEPVGEEAACAEPVGTAED
Target Bioclass
Other
Family
CLEC16A/gop-1 family
Subcellular location
Endosome membrane
Function
Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteasomal degradation, RNF41/NRDP1 which regulates proteasomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.
Uniprot ID
Q2KHT3
Ensemble ID
ENST00000409552.4
HGNC ID
HGNC:29013

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DAOY Deletion: p.S444TfsTer76 .
HCT15 SNV: p.A931S; p.K963E .
JURKAT SNV: p.Q523Ter .
LOXIMVI SNV: p.M378V DBIA    Probe Info 
RL952 SNV: p.R812C DBIA    Probe Info 
SNGM Deletion: p.L611WfsTer11 DBIA    Probe Info 
SNU1 Deletion: p.N36TfsTer12 DBIA    Probe Info 
SUPT1 SNV: p.G920E .
TOV21G Deletion: p.L611WfsTer11 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C588(5.25)  LDD0169  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C579(0.95)  LDD0625  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
NPM
 Probe Info  		N.A.  LDD0016  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C588(5.25)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C657(0.97); C588(1.03); C364(1.10)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C657(1.01); C588(0.96); C364(1.02)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C657(0.94); C588(1.03); C364(1.15)  LDD1509  [7]
 LDCM0230  AC113 HEK-293T C588(1.16)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C588(1.17)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C588(0.78)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C588(0.84)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C588(0.62)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C588(0.49)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C588(0.51)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C657(0.99); C588(0.93)  LDD1510  [7]
 LDCM0238  AC120 HEK-293T C588(0.51)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C588(0.53)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C588(0.52)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C588(0.51)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C588(0.54)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C588(0.49)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C588(0.59)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C588(0.57)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C588(1.16)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C588(0.76)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C588(0.86)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C588(1.00)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C588(0.88)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C588(0.64)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C588(0.69)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C588(0.75)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C588(0.69)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C588(0.65)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C588(0.69)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C588(0.66)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C657(0.97); C588(0.98); C364(1.08); C995(1.39)  LDD1512  [7]
 LDCM0260  AC140 HEK-293T C588(0.65)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C588(0.62)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C588(0.69)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C588(1.09)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C588(0.65)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C588(0.75)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C588(0.68)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C588(0.76)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C588(0.79)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C588(0.68)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C657(0.94); C588(0.99)  LDD1513  [7]
 LDCM0271  AC150 HEK-293T C588(0.79)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C588(0.77)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C588(0.97)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C588(0.88)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C588(1.01)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C588(0.94)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C588(0.66)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C588(0.93)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C588(0.78)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C588(0.96)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C588(0.77)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C657(0.96); C588(0.97); C364(1.09)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C588(0.70)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C588(0.96)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C588(0.72)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C588(0.55)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C588(0.93)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C657(1.00); C588(0.98); C364(1.05)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C657(1.02); C588(1.04); C364(1.17)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C657(0.94); C588(0.98); C364(1.18)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C657(0.97); C588(1.01)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C657(0.97); C588(0.95); C471(0.74)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C657(0.91); C588(0.98); C364(0.97)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C657(0.95); C588(0.99); C364(1.02); C995(1.40)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C657(1.00); C588(1.00)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C657(1.01); C588(0.99); C995(1.37)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C657(1.00); C588(0.93); C364(1.18)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C657(0.99); C588(0.97); C364(1.10)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C588(0.75)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C588(0.66)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C588(0.52)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C588(0.66)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C588(0.70)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C657(0.94); C588(0.94)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C588(0.66)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C588(0.66)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C588(0.74)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C588(0.54)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C588(0.54)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C588(0.56)  LDD0905  [3]
 LDCM0308  AC46 HCT 116 C579(0.95)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C579(0.94)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C579(0.76)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C579(0.94)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C657(0.94); C588(0.96); C471(1.31)  LDD1551  [7]
 LDCM0313  AC50 HCT 116 C579(0.90)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C579(0.90)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C579(0.91)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C579(1.00)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C579(1.08)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C579(0.98)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C579(0.98)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C579(0.96)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C579(0.94)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C579(1.08)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C657(0.96); C588(0.92); C364(1.06); C995(1.25)  LDD1562  [7]
 LDCM0324  AC60 HCT 116 C579(0.81)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C579(0.85)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C579(1.11)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C579(0.94)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C579(1.00)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C579(1.25)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C579(1.21)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C579(1.11)  LDD0648  [3]
 LDCM0332  AC68 HEK-293T C588(1.04)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C588(1.01)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C657(1.01); C588(1.01)  LDD1568  [7]
 LDCM0335  AC70 HEK-293T C588(0.73)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C588(0.77)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C588(0.88)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C588(1.02)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C588(0.80)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C588(0.91)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C588(0.89)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C588(0.82)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C588(0.65)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C588(0.90)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C657(1.02); C588(1.01); C995(1.49)  LDD1569  [7]
 LDCM0346  AC80 HEK-293T C588(0.73)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C588(0.78)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C588(0.57)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C588(1.30)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C588(0.80)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C588(0.98)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C588(0.93)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C588(1.06)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C588(0.74)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C588(0.72)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C588(0.75)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C588(0.92)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C588(0.87)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C588(0.91)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C588(0.61)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C588(0.85)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C588(0.88)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C588(0.72)  LDD0962  [3]
 LDCM0248  AKOS034007472 HEK-293T C657(0.96); C588(0.98); C471(0.85)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C657(0.95); C588(0.95); C364(1.11)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C657(1.01); C588(1.02); C995(1.20)  LDD1514  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HCT 116 C579(1.22)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C579(1.49)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C657(0.92); C588(0.99); C364(1.06); C995(1.10)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C657(0.94); C588(1.03)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C657(0.92); C588(0.91)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C657(1.04); C588(1.00)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C657(0.91); C588(1.02); C364(1.09); C995(1.01)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C588(1.21)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C588(0.89)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C588(0.99)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C588(0.93)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C588(0.98)  LDD0976  [3]
 LDCM0379  CL11 HCT 116 C579(1.42)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C588(1.09)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C588(1.03)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C657(1.03); C588(0.98); C364(1.14); C995(1.16)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C657(0.91); C588(1.04)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C657(0.94); C588(0.95)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C657(0.92); C588(1.03)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C657(0.93); C588(1.00); C364(1.02); C995(1.32)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C588(0.72)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C588(0.72)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C588(0.71)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C579(1.37)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C588(0.82)  LDD0989  [3]
 LDCM0392  CL121 HCT 116 C579(0.80)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C579(0.95)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C579(0.99)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C579(1.06)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C579(0.91)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C579(0.91)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C579(0.96)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C579(1.13)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C579(1.39)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C579(1.57)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C579(1.43)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C579(1.02)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C579(0.78)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C579(0.65)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C579(0.86)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C579(1.24)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C579(0.83)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C579(0.86)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C579(0.76)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C579(0.85)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C579(0.84)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C579(0.81)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C579(0.77)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C579(0.95)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C579(0.84)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C579(0.89)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C579(1.42)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C579(0.87)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C579(0.90)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C579(0.80)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C579(0.82)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C579(1.15)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C579(1.15)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C579(1.05)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C579(1.24)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C579(1.00)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C579(1.40)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C579(0.99)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C579(1.11)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C579(1.17)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C579(1.05)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C579(0.94)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C579(1.10)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C588(0.82)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C588(0.97)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C588(1.09)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C588(0.94)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C579(1.15)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C588(0.71)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C588(0.91)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C588(1.12)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C588(1.61)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C588(0.86)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C588(0.70)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C588(1.04)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C588(1.30)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C588(1.01)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C588(0.67)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C579(1.31)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C588(0.63)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C657(0.95); C588(0.99)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C657(0.96); C588(0.98)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C657(1.05); C588(1.03)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C657(0.90); C588(1.02); C364(1.13); C995(0.99)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C657(0.99); C588(1.02); C364(1.01)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C657(1.06); C588(1.00); C364(0.92)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C657(1.00); C588(1.09); C364(1.01)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C657(0.98); C588(1.10)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C657(1.02); C588(1.09); C471(0.85)  LDD1664  [7]
 LDCM0462  CL7 HCT 116 C579(1.27)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C657(1.00); C588(1.15); C364(0.95); C995(1.00)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C657(1.04); C588(1.12)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C657(1.06); C588(1.13); C995(0.88)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C657(0.87); C588(0.95)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C657(0.95); C588(1.01)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C657(0.94); C588(1.04); C364(1.11); C995(0.92)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C657(0.96); C588(0.87); C364(1.11)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C657(0.98); C588(1.00); C364(0.93)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C657(0.98); C588(1.09); C364(0.99)  LDD1675  [7]
 LDCM0473  CL8 HCT 116 C579(1.12)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C657(1.01); C588(1.07)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C657(0.97); C588(1.12); C471(0.80)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C657(0.98); C588(1.21); C364(1.01); C995(0.99)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C657(0.99); C588(1.11)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C657(0.98); C588(1.12); C995(1.10)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C657(0.88); C588(0.96)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C657(0.90); C588(0.88)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C657(0.96); C588(1.01)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C657(0.93); C588(1.06); C364(1.18); C995(1.39)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C657(0.91); C588(0.99); C364(1.07)  LDD1686  [7]
 LDCM0484  CL9 HCT 116 C579(1.16)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C657(0.83); C588(0.87); C364(1.13)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C657(0.91); C588(1.06); C364(0.99)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C657(0.91); C588(1.01)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C657(0.93); C588(1.04); C471(1.43)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C657(0.99); C588(1.01); C364(0.99); C995(1.11)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C657(0.97); C588(0.99)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C657(1.02); C588(1.02); C995(1.48)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C657(0.91); C588(0.97)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C657(0.96); C588(0.99)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C657(0.97); C588(1.00)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C657(0.92); C588(1.00)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C657(0.94); C588(1.01)  LDD1671  [7]
 LDCM0427  Fragment51 HCT 116 C579(1.13)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C588(1.06); C657(0.94)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C588(1.01); C657(1.00)  LDD1497  [7]
 LDCM0024  KB05 HMCB C657(1.84)  LDD3312  [8]
 LDCM0109  NEM HeLa N.A.  LDD0232  [2]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840