Details of the Target

General Information of Target

Target ID LDTP06619
Target Name Diacylglycerol kinase delta (DGKD)
Gene Name DGKD
Gene ID 8527
Synonyms
KIAA0145; Diacylglycerol kinase delta; DAG kinase delta; EC 2.7.1.107; 130 kDa diacylglycerol kinase; Diglyceride kinase delta; DGK-delta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGML
TKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVITP
CRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSHARPTYCNVC
REALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMPHQWLE
GNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCKVSVIPPTA
LNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPH
LGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGS
ACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSEDSEVQQILFY
EDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCS
VLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASACPARP
QIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSESEEKMDHRVC
PPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKIL
YPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIGLDAKISLDF
NNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPLPSLQGIAV
LNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCR
TVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWEDKQKCEL
PRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAHAVNASSKSM
DRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQLGSALAEMD
RQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKNKEAHSSLGA
PVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRILC
GIKELSRSAPAVEA
Target Bioclass
Enzyme
Family
Eukaryotic diacylglycerol kinase family
Subcellular location
Membrane, clathrin-coated pit; Cell membrane
Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development. May also regulate clathrin-dependent endocytosis.
Uniprot ID
Q16760
Ensemble ID
ENST00000264057.7
HGNC ID
HGNC:2851
ChEMBL ID
CHEMBL1075120

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.T569PfsTer43 .
AU565 SNV: p.D97H DBIA    Probe Info 
CCK81 SNV: p.A1096V .
IGROV1 SNV: p.E959K .
JURKAT SNV: p.W269Ter; p.P405L .
LS180 SNV: p.M157I .
MFE319 SNV: p.G1099D .
NB1 SNV: p.Y927Ter DBIA    Probe Info 
RL SNV: p.Q496K .
RL952 SNV: p.A1211T .
SKMEL24 SNV: p.A876V .
SNU1196 SNV: p.H893Q .
SUPT1 SNV: p.R590H .
TOV21G Deletion: p.G855VfsTer48 .
WM1552C SNV: p.V111I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C121(1.25)  LDD0532  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
IPM
 Probe Info  		C596(0.00); C121(0.00)  LDD0147  [3]
AOyne
 Probe Info  		13.90  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C121(1.25)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C286(0.67); C291(0.67)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C286(0.67); C291(0.67)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C286(0.54); C291(0.54)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C286(0.44); C291(0.44)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C286(0.42); C291(0.42)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C286(0.45); C291(0.45)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C286(0.47); C291(0.47)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C286(0.62); C291(0.62)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C286(0.54); C291(0.54)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C286(0.56); C291(0.56)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C121(1.30)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C286(0.48); C291(0.48)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C286(0.48); C291(0.48)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C286(0.51); C291(0.51)  LDD0546  [1]
 LDCM0237  AC12 HCT 116 C121(0.86)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C121(1.40)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C121(0.99)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C121(0.97)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C121(0.89)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C121(0.78)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C121(0.99)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C121(0.81)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C121(0.93)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C121(0.89)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C121(1.03)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C286(0.94); C291(0.94)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C286(1.00); C291(1.00)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C286(1.03); C291(1.03)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C286(1.35); C291(1.35)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C286(0.68); C291(0.68)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C286(0.64); C291(0.64)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C286(1.01); C291(1.01)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C286(0.87); C291(0.87)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C286(0.91); C291(0.91)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C286(0.83); C291(0.83)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C121(0.77)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C121(0.79)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C121(0.74)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C121(1.03)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C121(1.04)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C121(0.89)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C121(0.84)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C121(1.03)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C121(0.89)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C121(0.87)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C121(0.94)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C121(1.02)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C121(1.04)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C121(1.13)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C121(1.20)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C121(1.29)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C121(1.36)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C121(1.37)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C121(1.07)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C121(1.15)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C121(1.37)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C121(1.17)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C286(0.64); C291(0.64)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C286(0.70); C291(0.70)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C286(0.65); C291(0.65)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C121(1.09)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C286(0.74); C291(0.74)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C286(0.85); C291(0.85)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C286(0.64); C291(0.64)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C286(0.65); C291(0.65)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C286(0.65); C291(0.65)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C286(0.85); C291(0.85)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C286(0.85); C291(0.85)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C286(0.61); C291(0.61)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C286(0.91); C291(0.91); C121(0.93)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C286(0.87); C291(0.87); C121(0.91)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C121(0.96)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C286(0.78); C291(0.78); C121(1.06)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C121(0.84); C286(1.25); C291(1.25)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C121(0.92); C286(0.96); C291(0.96)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C286(0.79); C291(0.79); C121(1.09)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C286(0.78); C291(0.78); C121(1.03)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C286(0.79); C291(0.79); C121(1.01)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C286(0.85); C291(0.85); C121(1.03)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C121(0.87); C286(0.87); C291(0.87)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C121(1.01); C286(1.25); C291(1.25)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C121(1.01); C286(1.06); C291(1.06)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C121(0.75)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C286(0.83); C291(0.83); C121(1.13)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C121(0.89); C286(1.15); C291(1.15)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C286(0.78); C291(0.78); C121(1.04)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C121(1.38)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C121(1.31)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C121(1.33)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C121(1.36)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C121(1.36)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C121(1.25)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C121(1.41)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C121(1.20)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C121(1.23)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C121(1.39)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C121(1.17)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C121(1.07)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C121(1.50)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C121(1.04)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C121(1.35)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C286(0.31); C291(0.31)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C286(0.78); C291(0.78)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C121(0.92)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C121(1.31)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C121(1.48)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C121(0.92)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C121(0.85)  LDD0685  [1]
 LDCM0369  CL100 HEK-293T C660(0.83); C291(1.05)  LDD1573  [5]
 LDCM0370  CL101 HCT 116 C121(1.20)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C121(1.34)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C121(1.04)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C121(1.31)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C121(0.86)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C121(0.75)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C121(0.83)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C121(0.97)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C121(0.91)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C121(0.83)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C121(0.92)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C121(0.84)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C286(0.76); C291(0.76)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C286(0.65); C291(0.65)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C286(0.52); C291(0.52)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C286(0.67); C291(0.67)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C286(0.87); C291(0.87)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C121(1.03)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C121(0.79)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C121(0.82)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C121(0.72)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C121(0.98)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C121(0.64)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C121(0.77)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C121(1.09)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C121(0.96)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C286(0.95); C291(0.95)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C286(0.92); C291(0.92)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C286(0.98); C291(0.98)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C286(0.74); C291(0.74)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C121(0.82)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C121(0.91)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C121(0.76)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C121(1.16)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C121(0.89)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C121(0.96)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C121(1.15)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C121(0.84)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C121(1.29)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C121(1.28)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C121(1.18)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C121(1.46)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C121(1.24)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C121(1.18)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C121(1.33)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C121(1.16)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C121(1.37)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C121(1.10)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C121(0.74)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C121(1.16)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C121(1.11); C291(0.57)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C121(1.03); C291(0.91)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C121(1.05); C291(1.03)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C121(1.14); C291(1.35)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C121(1.20); C291(1.09)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C121(1.19); C291(0.99)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C121(1.08); C291(1.02)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C121(1.21); C291(0.90)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C121(0.88)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C121(1.13); C291(0.78)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C121(0.99); C291(0.91)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C121(0.96); C291(0.77)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C121(1.00); C291(0.98)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C121(1.11); C291(0.95)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C121(1.02); C291(1.01)  LDD0752  [1]
 LDCM0437  CL47 HEK-293T C660(0.76)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C291(1.04)  LDD1642  [5]
 LDCM0440  CL5 HCT 116 C121(0.75)  LDD0757  [1]
 LDCM0443  CL52 HEK-293T C660(0.93); C291(0.99)  LDD1646  [5]
 LDCM0450  CL59 HEK-293T C660(1.40)  LDD1653  [5]
 LDCM0451  CL6 HCT 116 C121(0.75)  LDD0768  [1]
 LDCM0452  CL60 HEK-293T C291(0.91)  LDD1655  [5]
 LDCM0453  CL61 HCT 116 C121(1.03)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C121(1.02)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C121(0.91)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C121(0.97)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C121(0.75)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C121(0.84)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C121(0.84)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C121(0.92)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C121(0.89)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C121(0.85)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C121(0.83)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C121(0.90)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C121(0.73)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C121(0.81)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C121(0.87)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C121(0.92)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C121(0.81)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C121(0.94)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C121(0.98)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C121(0.96)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C121(1.52)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C121(1.34)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C121(1.33)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C121(1.27)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C121(1.22)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C121(1.43)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C121(2.08)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C121(1.02)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C121(0.70)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C121(1.04)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C121(0.86)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C121(0.74)  LDD0802  [1]
 LDCM0490  CL95 HEK-293T C660(1.04)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C291(0.84)  LDD1694  [5]
 LDCM0468  Fragment33 HCT 116 C121(0.92)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C121(1.23); C291(0.68)  LDD0744  [1]
 LDCM0022  KB02 AU565 C596(2.69)  LDD2265  [6]
 LDCM0023  KB03 BRX211 C77(2.15); C508(7.62)  LDD2685  [6]
 LDCM0024  KB05 COLO792 C596(2.28)  LDD3310  [6]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alpha-tocopherol Succinate . DB14001
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phosphatidyl Serine Small molecular drug DB00144

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840