Details of the Target

General Information of Target

Target ID LDTP06503
Target Name Zinc finger homeobox protein 3 (ZFHX3)
Gene Name ZFHX3
Gene ID 463
Synonyms
ATBF1; C16orf47; Zinc finger homeobox protein 3; AT motif-binding factor 1; AT-binding transcription factor 1; Alpha-fetoprotein enhancer-binding protein; Zinc finger homeodomain protein 3; ZFH-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGCDSPVVSGKDNGCGIPQHQQWTELNSTHLPDKPSSMEQSTGESHGPLDSLRAPFNER
LAESTASAGPPSEPASKEVTCNECSASFASLQTYMEHHCPSARPPPPLREESASDTGEEG
DEESDVENLAGEIVYQPDGSAYIVESLSQLTQGGGACGSGSGSGPLPSLFLNSLPGAGGK
QGDPSCAAPVYPQIINTFHIASSFGKWFEGPDQAFPNTSALAGLSPVLHSFRVFDVRHKS
NKDYLNSDGSAKSSCVSKDVPNNVDLSKFDGFVLYGKRKPILMCFLCKLSFGYVRSFVTH
AVHDHRMTLSEDERKILSNKNISAIIQGIGKDKEPLVSFLEPKNKNFQHPLVSTANLIGP
GHSFYGKFSGIRMEGEEALPAGSAAGPEQPQAGLLTPSTLLNLGGLTSSVLKTPITSVPL
GPLASSPTKSSEGKDSGAAEGEKQEVGDGDCFSEKVEPAEEEAEEEEEEEEAEEEEEEEE
EEEEEEEDEGCKGLFPSELDEELEDRPHEEPGAAAGSSSKKDLALSNQSISNSPLMPNVL
QTLSRGTASTSSNSASSFVVFDGANRRNRLSFNSEGVRANVAEGGRRLDFADESANKDNA
TAPEPNESTEGDDGGFVPHHQHAGSLCELGVGECPSGSGVECPKCDTVLGSSRSLGGHMT
MMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKSGQPHPRLARGESYT
CGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNMQNLQNGGGEQVFSHTAGAAAAAVAAA
AAAANISSSCGAPSPTKPKTKPTWRCEVCDYETNVARNLRIHMTSEKHMHNMMLLQQNMT
QIQHNRHLGLGSLPSPAEAELYQYYLAQNMNLPNLKMDSAASDAQFMMSGFQLDPAGPMA
AMTPALVGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDM
LGLHMNVERSLSEDEWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKE
GGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESG
VEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFT
IRRCPSTDPEEAIEDVEGPSETAADPEELAKDQEGGASSSQAEKELTDSPATSKRISFPG
SSESPLSSKRPKTAEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPLCQDM
LNNKIHLQLHLTHLHSVAPDCVEKLIMTVTTPEMVMPSSMFLPAAVPDRDGNSNLEEAGK
QPETSEDLGKNILPSASTEQSGDLKPSPADPGSVREDSGFICWKKGCNQVFKTSAALQTH
FNEVHAKRPQLPVSDRHVYKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLCQRSFRT
FQALKKHLETSHLELSEADIQQLYGGLLANGDLLAMGDPTLAEDHTIIVEEDKEEESDLE
DKQSPTGSDSGSVQEDSGSEPKRALPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNIL
LVHYNSVSHLHKLKRALQESATGQPEPTSSPDNKPFKCNTCNVAYSQSSTLEIHMRSVLH
QTKARAAKLEAASGSSNGTGNSSSISLSSSTPSPVSTSGSNTFTTSNPSSAGIAPSSNLL
SQVPTESVGMPPLGNPIGANIASPSEPKEANRKKLADMIASRQQQQQQQQQQQQQQQQQQ
QAQTLAQAQAQVQAHLQQELQQQAALIQSQLFNPTLLPHFPMTTETLLQLQQQQHLLFPF
YIPSAEFQLNPEVSLPVTSGALTLTGTGPGLLEDLKAQVQVPQQSHQQILPQQQQNQLSI
AQSHSALLQPSQHPEKKNKLVIKEKEKESQRERDSAEGGEGNTGPKETLPDALKAKEKKE
LAPGGGSEPSMLPPRIASDARGNATKALLENFGFELVIQYNENKQKVQKKNGKTDQGENL
EKLECDSCGKLFSNILILKSHQEHVHQNYFPFKQLERFAKQYRDHYDKLYPLRPQTPEPP
PPPPPPPPPPLPAAPPQPASTPAIPASAPPITSPTIAPAQPSVPLTQLSMPMELPIFSPL
MMQTMPLQTLPAQLPPQLGPVEPLPADLAQLYQHQLNPTLLQQQNKRPRTRITDDQLRVL
RQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITSLE
ELKIDSRPPSPEPPKQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLN
LPTRVIVVWFQNARQKARKNYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLVFQRI
FDLIKHQKKLCYKDEDEEGQDDSQNEDSMDAMEILTPTSSSCSTPMPSQAYSAPAPSANN
TASSAFLQLTAEAEELATFNSKTEAGDEKPKLAEAPSAQPNQTQEKQGQPKPELQQQEQP
EQKTNTPQQKLPQLVSLPSLPQPPPQAPPPQCPLPQSSPSPSQLSHLPLKPLHTSTPQQL
ANLPPQLIPYQCDQCKLAFPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPS
NPLLASQLLSGAIPQIPASSATSPSTPTSTMNTLKRKLEEKASASPGENDSGTGGEEPQR
DKRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQ
FRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQM
KGDIFDGTSFSHLPPSSSDGQGVPLSPVSKTMELSPRTLLSPSSIKVEGIEDFESPSMSS
VNLNFDQTKLDNDDCSSVNTAITDTTTGDEGNADNDSATGIATETKSSSAPNEGLTKAAM
MAMSEYEDRLSSGLVSPAPSFYSKEYDNEGTVDYSETSSLADPCSPSPGASGSAGKSGDS
GDRPGQKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAK
EKKSKLSMAKHFGINQTSYEGPKTECTLCGIKYSARLSVRDHIFSQQHISKVKDTIGSQL
DKEKEYFDPATVRQLMAQQELDRIKKANEVLGLAAQQQGMFDNTPLQALNLPTAYPALQG
IPPVLLPGLNSPSLPGFTPSNTALTSPKPNLMGLPSTTVPSPGLPTSGLPNKPSSASLSS
PTPAQATMAMGPQQPPQQQQQQQQPQVQQPPPPPAAQPPPTPQLPLQQQQQRKDKDSEKV
KEKEKAHKGKGEPLPVPKKEKGEAPTATAATISAPLPTMEYAVDPAQLQALQAALTSDPT
ALLTSQFLPYFVPGFSPYYAPQIPGALQSGYLQPMYGMEGLFPYSPALSQALMGLSPGSL
LQQYQQYQQSLQEAIQQQQQRQLQQQQQQKVQQQQPKASQTPVPPGAPSPDKDPAKESPK
PEEQKNTPREVSPLLPKLPEEPEAESKSADSLYDPFIVPKVQYKLVCRKCQAGFSDEEAA
RSHLKSLCFFGQSVVNLQEMVLHVPTGGGGGGSGGGGGGGGGGGGGGSYHCLACESALCG
EEALSQHLESALHKHRTITRAARNAKEHPSLLPHSACFPDPSTASTSQSAAHSNDSPPPP
SAAAPSSASPHASRKSWPQVVSRASAAKPPSFPPLSSSSTVTSSSCSTSGVQPSMPTDDY
SEESDTDLSQKSDGPASPVEGPKDPSCPKDSGLTSVGTDTFRL
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3. Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer. In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation. Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells.
Uniprot ID
Q15911
Ensemble ID
ENST00000268489.10
HGNC ID
HGNC:777

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.G1925VfsTer72 .
A549 SNV: p.L1473F .
AGS SNV: p.F3474L .
AN3CA Deletion: p.R1893GfsTer35 .
CAL51 Deletion: p.G699AfsTer125 .
CCK81 Deletion: p.P105RfsTer4 .
DU145 SNV: p.P643H .
DU4475 SNV: p.A2398D .
FADU SNV: p.L494I .
G415 SNV: p.T2791A .
HCT15 Deletion: p.E763SfsTer61
SNV: p.S1180N;p.P1707H;p.P3069T		 .
HEC1 Deletion: p.S2505PfsTer28
SNV: p.R1114Ter		 .
HEC1B Deletion: p.S2505PfsTer28
SNV: p.R1114Ter		 .
HELA SNV: p.S87F .
HT SNV: p.S2098A .
HT115 SNV: p.R2161W .
Ishikawa (Heraklio) 02 ER Deletion: p.A3407LfsTer78
SNV: p.R2158Ter		 .
K562 SNV: p.P2517S .
KYM1 Insertion: p.P3195LfsTer44; p.Q3197SfsTer45 .
LS180 Deletion: p.A3407LfsTer78
SNV: p.D3699G		 .
MCC13 SNV: p.Q2496Ter .
MFE319 Deletion: p.E763SfsTer61
SNV: p.Q152H		 .
MKN45 SNV: p.K681E .
NCIH1048 SNV: p.C3577G .
NCIH1299 SNV: p.F3044V .
NCIH1975 Substitution: p.T3506G .
NCIH2170 SNV: p.G3168E .
NCIH2172 SNV: p.G1021C; p.C3534W .
NCIH661 SNV: p.H2506P .
OVK18 SNV: p.V233M .
RKO Deletion: p.F1596LfsTer20
SNV: p.S112N		 .
RL952 Deletion: p.S3636LfsTer29
SNV: p.S3446N		 .
SKMEL2 Deletion: p.H3611TfsTer83 .
SKOV3 SNV: p.I935M .
SW1783 SNV: p.R805W .
SW756 SNV: p.K1007Q .
TOV21G Deletion: p.A3407LfsTer78
SNV: p.P2787L		 .
VMRCRCW SNV: p.M3338R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		3.09  LDD0066  [1]
IA-alkyne
 Probe Info  		C287(4.41)  LDD0315  [2]
DBIA
 Probe Info  		C1045(1.33)  LDD0532  [3]
TFBX
 Probe Info  		C1031(0.00); C645(0.00)  LDD0148  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C947(0.92); C950(0.92)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C1045(1.33)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C947(1.15); C950(1.15)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C947(1.16); C950(1.16)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C947(1.10); C950(1.10)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C947(1.12); C950(1.12)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C947(1.13); C950(1.13)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C947(1.22); C950(1.22)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C947(1.57); C950(1.57)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C947(1.23); C950(1.23)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C947(1.13); C950(1.13)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C947(1.16); C950(1.16)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C1045(1.48)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C947(0.58); C950(0.58)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C947(0.27); C950(0.27)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C947(0.47); C950(0.47)  LDD0827  [3]
 LDCM0237  AC12 HCT 116 C1045(1.09)  LDD0554  [3]
 LDCM0246  AC128 HCT 116 C1045(1.12)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C1045(0.89)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C1045(1.07)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C1045(1.08)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C1045(0.92)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C1045(1.13)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C1045(1.04)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C1045(0.90)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C1045(1.06)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C1045(0.81)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C1045(0.92)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C1045(0.83)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C1045(1.25)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C1045(0.98)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C1045(0.99)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C1045(0.71)  LDD0579  [3]
 LDCM0263  AC143 HEK-293T C947(1.59); C950(1.59)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C947(0.76); C950(0.76)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C947(0.81); C950(0.81)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C947(0.80); C950(0.80)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C947(0.65); C950(0.65)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C947(0.87); C950(0.87)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C947(1.18); C950(1.18)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C1045(1.44)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C947(1.06); C950(1.06)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C947(0.89); C950(0.89)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C947(1.07); C950(1.07)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C947(1.06); C950(1.06)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C947(1.27); C950(1.27)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C947(1.01); C950(1.01)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C947(0.60); C950(0.60)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C947(0.39); C950(0.39)  LDD2165  [3]
 LDCM0276  AC17 PaTu 8988t C2964(0.78)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C2964(0.67)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C2964(0.73)  LDD1157  [3]
 LDCM0279  AC2 HEK-293T C947(0.77); C950(0.77)  LDD0877  [3]
 LDCM0280  AC20 PaTu 8988t C2964(0.67)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C2964(0.61)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C2964(0.60)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C2964(0.59)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C2964(0.96)  LDD1163  [3]
 LDCM0285  AC25 PaTu 8988t C1042(0.76); C1045(0.76)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C1042(0.80); C1045(0.80)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C1042(0.74); C1045(0.74)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C1042(0.72); C1045(0.72)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C1042(0.66); C1045(0.66)  LDD1168  [3]
 LDCM0290  AC3 HEK-293T C947(0.76); C950(0.76)  LDD0888  [3]
 LDCM0291  AC30 PaTu 8988t C1042(0.73); C1045(0.73)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C1042(0.69); C1045(0.69)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C1042(0.85); C1045(0.85)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C1042(0.80); C1045(0.80)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C1042(0.76); C1045(0.76)  LDD1174  [3]
 LDCM0296  AC35 PaTu 8988t C1045(2.21)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C1045(1.60)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C1045(1.53)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C1045(1.41)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C1045(1.77)  LDD1179  [3]
 LDCM0301  AC4 HEK-293T C947(1.03); C950(1.03)  LDD0899  [3]
 LDCM0302  AC40 PaTu 8988t C1045(1.76)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C1045(1.51)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C1045(2.07)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C1045(1.73)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C1045(2.19)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C1045(2.07)  LDD1186  [3]
 LDCM0308  AC46 HEK-293T C947(0.86); C950(0.86)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C947(0.90); C950(0.90)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C947(0.75); C950(0.75)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C947(0.88); C950(0.88)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C947(0.89); C950(0.89)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C947(0.93); C950(0.93)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C947(0.93); C950(0.93)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C947(0.99); C950(0.99)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C947(1.06); C950(1.06)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C947(0.78); C950(0.78)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C947(0.85); C950(0.85)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C947(0.87); C950(0.87)  LDD0917  [3]
 LDCM0323  AC6 HCT 116 C1045(1.47)  LDD0640  [3]
 LDCM0332  AC68 HEK-293T C947(0.70); C950(0.70)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C947(0.72); C950(0.72)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C1045(1.05)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C947(0.73); C950(0.73)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C947(0.66); C950(0.66)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C947(0.68); C950(0.68)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C947(0.75); C950(0.75)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C947(0.82); C950(0.82)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C947(0.76); C950(0.76)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C947(0.86); C950(0.86)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C947(0.72); C950(0.72)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C947(0.84); C950(0.84)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C947(0.69); C950(0.69)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C1045(1.21)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C947(0.89); C950(0.89)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C947(0.88); C950(0.88)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C947(0.68); C950(0.68)  LDD0946  [3]
 LDCM0365  AC98 HEK-293T C947(1.13); C950(1.13)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C947(1.00); C950(1.00)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C1045(1.22)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C1045(1.13)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C1045(1.70)  LDD0592  [3]
 LDCM0367  CL1 HEK-293T C947(1.00); C950(1.00)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C947(0.45); C950(0.45)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C947(0.80); C950(0.80)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C1045(1.61)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C1045(1.17)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C1045(1.16)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C1045(1.39)  LDD0690  [3]
 LDCM0374  CL105 PaTu 8988t C2964(0.89)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C2964(0.82)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C2964(0.87)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C2964(0.81)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C2964(0.76)  LDD1257  [3]
 LDCM0379  CL11 HEK-293T C947(0.58); C950(0.58)  LDD0977  [3]
 LDCM0380  CL110 PaTu 8988t C2964(0.73)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C2964(0.58)  LDD1260  [3]
 LDCM0382  CL112 PaTu 8988t C1042(0.80); C1045(0.80)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C1042(0.73); C1045(0.73)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C1042(0.83); C1045(0.83)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C1042(0.68); C1045(0.68)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C1042(1.53); C1045(1.53)  LDD1265  [3]
 LDCM0387  CL117 PaTu 8988t C1045(1.73)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C1045(1.93)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C1045(1.44)  LDD1268  [3]
 LDCM0390  CL12 HEK-293T C947(0.88); C950(0.88)  LDD0988  [3]
 LDCM0391  CL120 PaTu 8988t C1045(1.28)  LDD1270  [3]
 LDCM0392  CL121 HEK-293T C947(0.82); C950(0.82)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C947(0.93); C950(0.93)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C947(0.93); C950(0.93)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C947(0.87); C950(0.87)  LDD0993  [3]
 LDCM0400  CL13 HEK-293T C947(0.86); C950(0.86)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C947(0.87); C950(0.87)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C947(0.79); C950(0.79)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C947(1.32); C950(1.32)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C947(1.60); C950(1.60)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C947(0.92); C950(0.92)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C947(0.99); C950(0.99)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C947(0.91); C950(0.91)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C947(0.93); C950(0.93)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C947(1.20); C950(1.20)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C947(0.97); C950(0.97)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C947(0.97); C950(0.97)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C947(0.96); C950(0.96)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C947(1.04); C950(1.04)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C947(1.12); C950(1.12)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C947(1.07); C950(1.07)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C947(0.99); C950(0.99)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C947(1.07); C950(1.07)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C947(0.93); C950(0.93)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C947(0.94); C950(0.94)  LDD1017  [3]
 LDCM0420  CL31 HCT 116 C1045(1.32)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C1045(1.20)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C1045(1.13)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C1045(1.43)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C1045(1.70)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C1045(1.45)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C1045(1.46)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C1045(1.32)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C947(0.80); C950(0.80)  LDD1027  [3]
 LDCM0430  CL40 HCT 116 C1045(1.41)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C1045(1.68)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C1045(2.08)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C1045(1.86)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C1045(1.62)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C1045(2.12)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C947(1.19); C950(1.19)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C947(1.00); C950(1.00)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C947(1.09); C950(1.09)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C947(0.98); C950(0.98)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C947(0.80); C950(0.80)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C947(0.88); C950(0.88)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C947(0.97); C950(0.97)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C947(1.03); C950(1.03)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C947(0.93); C950(0.93)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C947(0.91); C950(0.91)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C947(1.00); C950(1.00)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C947(0.94); C950(0.94)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C947(0.95); C950(0.95)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C947(1.00); C950(1.00)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C947(0.92); C950(0.92)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C947(0.84); C950(0.84)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C947(0.96); C950(0.96)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C1045(1.10)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C1045(1.11)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C1045(1.21)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C1045(1.57)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C1045(1.20)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C1045(1.40)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C1045(1.81)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C1045(1.47)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C1045(0.88)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C947(0.81); C950(0.81)  LDD1060  [3]
 LDCM0463  CL70 HCT 116 C1045(1.47)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C1045(1.28)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C1045(0.87)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C1045(1.02)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C1045(1.23)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C947(0.71); C950(0.71)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C947(0.83); C950(0.83)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C947(0.55); C950(0.55)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C947(0.61); C950(0.61)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C947(1.14); C950(0.81)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C947(0.70); C950(0.70)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C947(0.75); C950(0.75)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C947(0.69); C950(0.69)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C947(0.78); C950(0.78)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C947(0.57); C950(0.57)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C947(0.65); C950(0.65)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C947(0.44); C950(0.44)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C947(0.67); C950(0.67)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C947(0.63); C950(0.63)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C947(0.50); C950(0.50)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C947(1.05); C950(0.66)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C947(0.66); C950(0.66)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C947(0.79); C950(0.79)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C947(0.72); C950(0.72)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C947(0.98); C950(0.98)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C947(0.86); C950(0.86)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C947(0.59); C950(0.59)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C947(0.68); C950(0.68)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C947(0.97); C950(0.97)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C947(0.85); C950(0.85)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C947(1.06); C950(1.06)  LDD1092  [3]
 LDCM0468  Fragment33 HCT 116 C1045(1.30)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C1045(2.01)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C721(1.00); C1031(0.82)  LDD1492  [6]
 LDCM0023  KB03 Jurkat C287(4.41)  LDD0315  [2]
 LDCM0024  KB05 OV-90 C2330(1.44)  LDD3380  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 6 (COPS6) Peptidase M67A family Q7L5N1
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2) . Q8N7C3
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Homeobox protein MSX-2 (MSX2) Msh homeobox family P35548
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Deuterosome assembly protein 1 (DEUP1) CEP63 family Q05D60
CCR4-NOT transcription complex subunit 2 (CNOT2) CNOT2/3/5 family Q9NZN8
Cytospin-A (SPECC1L) Cytospin-A family Q69YQ0
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Lamin-B2 (LMNB2) Intermediate filament family Q03252
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
PRKCA-binding protein (PICK1) . Q9NRD5
Splicing regulator RBM11 (RBM11) . P57052

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840