Details of the Target

General Information of Target

Target ID LDTP06398
Target Name Homeobox protein SIX1 (SIX1)
Gene Name SIX1
Gene ID 6495
Synonyms
Homeobox protein SIX1; Sine oculis homeobox homolog 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHR
GNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRT
IWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDR
AAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVLLLQGNMGH
ARSSNYSLPGLTASQPSHGLQTHQHQLQDSLLGPLTSSLVDLGS
Target Bioclass
Transcription factor
Family
SIX/Sine oculis homeobox family
Subcellular location
Nucleus
Function
Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as a transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as an activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2. Regulates the expression of CCNA1. Promotes brown adipocyte differentiation.
Uniprot ID
Q15475
Ensemble ID
ENST00000645694.3
HGNC ID
HGNC:10887
ChEMBL ID
CHEMBL4630826

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y92(20.00)  LDD0257  [1]
AHL-Pu-1
 Probe Info  		C40(4.26)  LDD0171  [2]
DBIA
 Probe Info  		C130(2.71)  LDD0080  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C40(4.26)  LDD0171  [2]
 LDCM0214  AC1 HEK-293T C40(0.90)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C40(1.33); C130(1.18)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C40(1.00); C130(0.95)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C40(0.83); C130(0.84)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C40(0.93); C130(0.91)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C40(1.16); C130(0.97)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C40(1.06); C130(0.99)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C40(0.88); C130(0.95)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C40(0.75); C130(0.81)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C40(0.86); C130(0.81)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C40(0.96); C130(0.95)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C40(0.85); C130(0.94)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C40(1.23); C130(1.06)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C40(1.13); C130(0.92)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C40(1.22); C130(1.05)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C40(1.27); C130(0.91)  LDD0827  [3]
 LDCM0230  AC113 HCT 116 C130(1.11)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C130(0.85)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C130(0.87)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C130(0.95)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C130(0.93)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C130(0.93)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C130(0.97)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C40(1.33); C130(1.03)  LDD0835  [3]
 LDCM0238  AC120 HCT 116 C130(1.17)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C130(0.82)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C130(0.92)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C130(1.06)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C130(0.84)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C130(0.89)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C130(0.81)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C130(0.88)  LDD0562  [3]
 LDCM0246  AC128 HEK-293T C40(1.14); C130(1.20)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C40(1.31); C130(1.38)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C40(1.21); C130(1.21)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C40(1.31); C130(1.26)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C40(1.45); C130(1.50)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C40(1.29); C130(1.25)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C40(1.25); C130(1.18)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C40(1.42); C130(1.24)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C40(0.98); C130(0.93)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C40(1.23); C130(1.27)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C40(1.22); C130(1.24)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C40(1.32); C130(1.24)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C40(1.14); C130(1.31)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C40(1.30); C130(1.34)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C40(1.29); C130(1.19)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C40(1.48); C130(1.36)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C40(1.24); C130(1.10)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C40(1.33); C130(1.06)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C40(1.50); C130(1.07)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C40(1.38); C130(1.07)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C40(1.56); C130(0.86)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C40(1.49); C130(1.02)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C40(1.06); C130(0.92)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C40(1.63); C130(1.03)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C40(1.15); C130(1.05)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C40(1.30); C130(1.12)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C40(1.07); C130(0.96)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C40(1.15); C130(0.96)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C40(1.09); C130(0.93)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C40(1.25); C130(1.16)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C40(1.39); C130(1.11)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C40(1.48); C130(0.88)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C130(0.91)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C130(0.91)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C130(0.96)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C40(0.99)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C130(0.95)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C130(0.86)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C130(0.92)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C130(0.99)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C130(1.07)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C130(1.06)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C130(1.11)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C130(1.25)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C130(1.56)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C130(1.31)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C40(0.91)  LDD0888  [3]
 LDCM0291  AC30 HCT 116 C130(1.35)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C130(1.13)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C130(1.30)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C130(1.53)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C130(1.51)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C130(1.01)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C130(0.92)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C130(0.97)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C130(1.05)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C130(1.08)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C40(0.96)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C130(1.15)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C130(1.04)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C130(1.09)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C130(1.06)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C130(1.11)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C130(1.15)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C40(1.00); C130(1.27)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C40(1.19); C130(1.08)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C40(0.58); C130(1.12)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C40(0.87); C130(1.06)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C40(0.89)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C40(0.84); C130(1.18)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C40(1.18); C130(1.21)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C40(0.93); C130(1.10)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C40(1.21); C130(1.13)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C40(0.87); C130(1.28)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C40(0.83); C130(1.48)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C40(0.86); C130(1.04)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C130(1.24)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C130(0.97)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C130(1.16)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C40(0.94); C130(1.23)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C130(1.06)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C130(1.13)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C130(0.99)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C130(1.03)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C130(1.09)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C130(1.30)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C130(1.16)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C130(1.21)  LDD0648  [3]
 LDCM0332  AC68 HEK-293T C40(1.38); C130(0.97)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C40(1.26); C130(0.97)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C40(1.41); C130(1.22)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C40(1.10); C130(0.91)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C40(1.14); C130(0.96)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C40(1.30); C130(1.14)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C40(1.44); C130(1.21)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C40(1.00); C130(0.88)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C40(1.23); C130(1.09)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C40(1.25); C130(0.93)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C40(1.56); C130(0.92)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C40(0.98); C130(0.97)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C40(1.01); C130(0.92)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C40(1.71); C130(1.09)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C40(1.46); C130(0.99)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C40(1.28); C130(0.99)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C40(1.21); C130(1.00)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C130(1.15)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C130(1.05)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C130(0.97)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C130(0.89)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C130(0.92)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C130(0.97)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C130(1.08)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C130(0.98)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C130(1.01)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C130(0.90)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C130(0.93)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C130(1.11)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C130(0.93)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C130(1.12)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C130(1.13)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C40(0.86); C130(0.96)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C40(0.88); C130(0.87)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C40(1.34); C130(1.12)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C40(1.66); C130(1.01)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C40(1.49); C130(1.29)  LDD0873  [3]
 LDCM0367  CL1 HCT 116 C130(1.02)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C130(0.96)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C40(1.82)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C40(2.50); C130(1.31)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C40(2.66); C130(1.56)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C40(1.54); C130(1.24)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C40(1.71); C130(1.21)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C130(0.89)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C130(0.92)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C130(0.93)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C130(0.97)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C130(0.97)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C130(1.22)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C130(0.96)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C130(0.94)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C130(0.95)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C130(1.38)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C130(1.28)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C130(1.22)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C130(1.27)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C130(1.26)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C130(1.05)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C130(1.13)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C130(1.10)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C130(1.00)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C40(1.02); C130(1.30)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C40(1.67); C130(1.33)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C40(1.53); C130(1.50)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C40(1.05); C130(1.22)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C130(1.08)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C130(0.92)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C130(0.88)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C130(1.15)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C130(1.18)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C130(1.00)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C130(1.28)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C40(1.07); C130(0.99)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C40(3.74); C130(1.16)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C40(1.17); C130(1.08)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C40(1.07); C130(0.93)  LDD1004  [3]
 LDCM0407  CL2 HCT 116 C130(0.86)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C40(1.10); C130(1.10)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C40(4.19); C130(1.55)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C40(1.62); C130(1.19)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C40(1.09); C130(0.90)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C40(0.95); C130(0.91)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C40(2.38); C130(1.13)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C40(1.19); C130(1.09)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C40(1.28); C130(0.93)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C40(2.60); C130(1.03)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C40(1.07); C130(1.04)  LDD1015  [3]
 LDCM0418  CL3 HCT 116 C130(1.00)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C40(1.27); C130(1.07)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C40(1.33); C130(0.94)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C40(1.18); C130(0.95)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C40(3.29); C130(2.07)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C40(1.70); C130(1.01)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C40(1.09); C130(1.12)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C40(1.50); C130(0.95)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C40(1.52); C130(1.12)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C40(2.41); C130(1.21)  LDD1026  [3]
 LDCM0429  CL4 HCT 116 C130(1.92)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C40(1.13); C130(1.04)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C40(4.78); C130(1.13)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C40(1.31); C130(0.95)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C40(1.35); C130(1.11)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C40(1.17); C130(1.03)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C40(2.44); C130(1.04)  LDD1033  [3]
 LDCM0436  CL46 HCT 116 C130(0.96)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C130(0.96)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C130(0.86)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C130(0.97)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C130(0.93)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C130(0.90)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C130(1.02)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C130(1.22)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C130(1.05)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C130(0.91)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C130(0.91)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C130(1.04)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C130(1.01)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C130(0.93)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C130(0.86)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C130(0.92)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C130(0.90)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C40(1.17); C130(0.99)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C40(1.56); C130(1.06)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C40(1.73); C130(1.05)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C40(5.75); C130(1.71)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C40(1.17); C130(1.15)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C40(2.55); C130(1.15)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C40(1.32); C130(1.26)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C40(1.67); C130(0.97)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C40(1.65); C130(1.00)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C130(0.94)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C40(1.11); C130(1.06)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C40(2.21); C130(1.40)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C40(1.30); C130(1.15)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C40(2.51); C130(1.34)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C40(2.58); C130(1.13)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C40(1.19); C130(1.14)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C40(4.58); C130(1.19)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C40(0.91); C130(0.91)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C40(1.09); C130(1.08)  LDD1070  [3]
 LDCM0473  CL8 HCT 116 C130(1.01)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C40(0.93); C130(1.03)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C40(1.05); C130(0.90)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C40(1.09); C130(0.89)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C40(1.73); C130(0.90)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C40(2.17); C130(1.20)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C40(1.14); C130(1.10)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C40(1.20); C130(1.14)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C40(1.80); C130(1.20)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C40(1.34); C130(1.26)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C40(1.02); C130(0.98)  LDD1081  [3]
 LDCM0484  CL9 HCT 116 C130(1.21)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C40(7.89); C130(1.90)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C40(1.05)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C40(2.22)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C40(1.60)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C40(1.79)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C40(5.46)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C40(1.80)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C40(1.96)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C40(1.40)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C40(1.34)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C130(1.07); C40(1.19)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C40(2.94); C130(1.02)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C40(1.25); C130(1.00)  LDD1025  [3]
 LDCM0022  KB02 HCT 116 C130(2.71)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C130(1.98)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C130(2.40)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eyes absent homolog 1 (EYA1) EYA family Q99502
Eyes absent homolog 2 (EYA2) EYA family O00167
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Huntingtin-interacting protein M (H2AP) . O75409
Puratrophin-1 (PLEKHG4) . Q58EX7

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402