Details of the Target

General Information of Target

Target ID LDTP06299
Target Name Rho guanine nucleotide exchange factor 6 (ARHGEF6)
Gene Name ARHGEF6
Gene ID 9459
Synonyms
COOL2; KIAA0006; PIXA; Rho guanine nucleotide exchange factor 6; Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP
QTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCG
RSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELS
VCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKN
YYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLC
QALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQG
ASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQD
LRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIM
LSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWL
EQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPL
RPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQIL
KVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYA
LKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP
Target Bioclass
Other
Subcellular location
Cell projection, lamellipodium
Function Acts as a RAC1 guanine nucleotide exchange factor (GEF).
Uniprot ID
Q15052
Ensemble ID
ENST00000250617.7
HGNC ID
HGNC:685

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.D350N DBIA    Probe Info 
C4II SNV: p.E742Q .
FTC133 SNV: p.A652V .
HEC1 SNV: p.P497Q .
HT29 SNV: p.E654K .
JURKAT SNV: p.A657V Compound 10    Probe Info 
MEWO SNV: p.E29K .
MOLM13 SNV: p.L616S DBIA    Probe Info 
MOLT4 SNV: p.A361V IA-alkyne    Probe Info 
NCIH1666 SNV: p.P691S .
NCIH2291 SNV: p.V718L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.71  LDD0402  [1]
TH211
 Probe Info  		Y644(18.21)  LDD0260  [2]
STPyne
 Probe Info  		K751(10.00)  LDD0277  [3]
DBIA
 Probe Info  		C182(1.38)  LDD0080  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C119(0.00); C553(0.00); C530(0.00); C42(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C119(0.00); C553(0.00); C530(0.00); C514(0.00)  LDD0036  [5]
IPIAA_L
 Probe Info  		C25(0.00); C738(0.00); C530(0.00)  LDD0031  [6]
Lodoacetamide azide
 Probe Info  		C119(0.00); C77(0.00); C553(0.00); C530(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
Compound 10
 Probe Info  		C119(0.00); C25(0.00); C319(0.00); C42(0.00)  LDD2216  [8]
Compound 11
 Probe Info  		C119(0.00); C319(0.00); C553(0.00); C564(0.00)  LDD2213  [8]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		N.A.  LDD0005  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C763(1.30)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C763(1.34)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C763(1.47)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C763(1.33)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C763(1.19)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C763(1.35)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C763(1.29)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C763(1.39)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C763(1.12)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C763(1.46)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C763(1.06)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C763(1.30)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C763(0.87)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C763(1.45)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C763(1.95)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C763(1.47)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C763(1.02)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C763(1.17)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C763(1.08)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C763(1.37)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C763(1.44)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C763(1.71)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C763(1.60)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C763(1.03)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C763(1.41)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C763(1.56)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C763(2.26)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C763(1.91)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C763(1.56)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C763(1.43)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C763(2.19)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C763(2.66)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C763(1.09)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C763(1.25)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C763(1.61)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C763(1.14)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C763(1.43)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C763(1.35)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C763(1.48)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C763(1.30)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C763(1.46)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C763(1.50)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C763(1.71)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C763(1.80)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C763(1.19)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C763(1.55)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C763(1.75)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C763(1.63)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C763(0.98)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C763(1.04)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C763(1.23)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C763(1.03)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C763(1.00)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C763(1.08)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C763(1.22)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C763(1.09)  LDD0868  [4]
 LDCM0271  AC150 HEK-293T C763(1.06)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C763(1.25)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C763(1.14)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C763(1.45)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C763(1.33)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C763(1.08)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C763(1.33)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C763(1.13)  LDD2165  [4]
 LDCM0276  AC17 HEK-293T C319(1.01); C553(1.01)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C319(1.11); C763(0.96)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C319(1.09); C763(1.04)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C763(1.34)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C319(0.98)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C319(1.04); C763(1.02)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C319(1.05); C553(0.98)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C319(0.89); C763(0.97); C553(1.14)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C319(0.94); C553(1.04)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C763(1.15)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C763(1.20)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C763(1.39)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C763(1.20)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C763(1.33)  LDD0887  [4]
 LDCM0290  AC3 HEK-293T C763(1.23)  LDD0888  [4]
 LDCM0291  AC30 HEK-293T C763(1.25)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C763(1.20)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C763(1.35)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C763(1.36)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C763(1.23)  LDD0893  [4]
 LDCM0296  AC35 HEK-293T C763(1.10)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C763(1.00)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C763(1.11)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C763(1.49)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C763(0.97)  LDD0898  [4]
 LDCM0301  AC4 HEK-293T C763(1.43)  LDD0899  [4]
 LDCM0302  AC40 HEK-293T C763(1.21)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C763(1.62)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C763(1.18)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C763(1.26)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C763(1.40)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C763(1.17)  LDD0905  [4]
 LDCM0308  AC46 HEK-293T C763(1.25)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C763(1.43)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C763(1.47)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C763(1.28)  LDD0909  [4]
 LDCM0312  AC5 HEK-293T C763(1.60)  LDD0910  [4]
 LDCM0313  AC50 HEK-293T C763(1.79)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C763(2.01)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C763(1.85)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C763(1.51)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C763(1.81)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C763(1.47)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C763(1.28)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C763(0.84)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C763(0.91)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C763(0.96)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C763(1.34)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C763(0.93)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C763(1.30)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C763(1.07)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C763(1.31)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C763(1.03)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C763(1.33)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C763(1.04)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C763(1.24)  LDD0929  [4]
 LDCM0332  AC68 HEK-293T C763(0.99)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C763(0.99)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C763(0.96)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C763(1.14)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C763(1.19)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C763(1.30)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C763(1.38)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C763(1.01)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C763(1.12)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C763(1.13)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C763(1.11)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C763(1.19)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C763(1.18)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C763(1.15)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C763(1.23)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C763(1.11)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C763(1.28)  LDD0946  [4]
 LDCM0349  AC83 HEK-293T C763(0.89)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C763(1.00)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C763(1.00)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C763(0.91)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C763(1.53)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C763(1.34)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C763(1.26)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C763(1.05)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C763(1.33)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C763(1.26)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C763(1.21)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C763(1.13)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C763(1.77)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C763(1.38)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C763(2.31)  LDD0962  [4]
 LDCM0365  AC98 HEK-293T C763(0.98)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C763(1.18)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C763(0.82)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C763(1.25)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C763(1.29)  LDD0873  [4]
 LDCM0156  Aniline NCI-H1299 13.07  LDD0403  [1]
 LDCM0102  BDHI 8 Jurkat C564(7.13)  LDD0204  [13]
 LDCM0367  CL1 HEK-293T C763(1.27)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C763(1.66)  LDD0966  [4]
 LDCM0369  CL100 HEK-293T C763(2.03)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C763(1.33)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C763(1.31)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C763(1.00)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C763(1.39)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C319(1.01)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C319(1.05)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C319(0.84); C763(0.98); C553(0.75)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C319(1.03)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C319(1.19)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C763(1.69)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C319(1.27)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C319(1.00); C763(0.98); C553(0.93)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C763(1.35)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C763(1.27)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C763(1.86)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C763(1.61)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C763(1.64)  LDD0984  [4]
 LDCM0387  CL117 HEK-293T C763(1.37)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C763(1.02)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C763(1.10)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C763(1.27)  LDD0988  [4]
 LDCM0391  CL120 HEK-293T C763(1.30)  LDD0989  [4]
 LDCM0392  CL121 HEK-293T C763(1.48)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C763(1.50)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C763(1.49)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C763(1.19)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C763(0.94)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C763(1.09)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C763(0.91)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C763(0.77)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C763(1.22)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C763(1.58)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C763(1.43)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C763(1.01)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C763(0.84)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C763(0.84)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C763(0.75)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C763(1.02)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C763(1.05)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C763(0.87)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C763(1.12)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C763(0.70)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C763(0.67)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C763(1.21)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C763(1.19)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C763(1.30)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C763(0.77)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C763(1.01)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C763(1.10)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C763(1.10)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C763(1.18)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C763(1.04)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C763(1.28)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C763(1.27)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C763(1.09)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C763(1.11)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C763(1.14)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C763(2.14)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C763(1.53)  LDD1027  [4]
 LDCM0430  CL40 HEK-293T C763(1.31)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C763(1.83)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C763(1.96)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C763(2.04)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C763(1.28)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C763(1.77)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C319(0.81); C553(1.02)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C319(0.86); C763(1.17); C553(0.91)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C319(1.02); C553(0.93)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C319(1.15)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C763(1.04)  LDD1038  [4]
 LDCM0441  CL50 HEK-293T C319(1.17)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C319(1.00)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C319(1.10); C553(1.10)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C319(1.32); C763(0.90)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C319(0.87); C763(1.06)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C319(0.89)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C319(1.34); C763(0.90)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C319(0.89); C553(1.11)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C319(0.86); C763(1.08); C553(0.96)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C763(1.00)  LDD1049  [4]
 LDCM0452  CL60 HEK-293T C319(1.04); C553(0.92)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C763(1.14)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C763(1.22)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C763(1.47)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C763(1.21)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C763(1.35)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C763(1.45)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C763(1.18)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C763(1.40)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C763(1.20)  LDD1059  [4]
 LDCM0462  CL7 HEK-293T C763(1.51)  LDD1060  [4]
 LDCM0463  CL70 HEK-293T C763(1.09)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C763(1.44)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C763(1.05)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C763(1.42)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C763(2.32)  LDD1065  [4]
 LDCM0469  CL76 HEK-293T C763(1.38)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C763(1.27)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C763(1.32)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C763(1.31)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C763(0.83)  LDD1071  [4]
 LDCM0474  CL80 HEK-293T C763(1.28)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C763(1.16)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C763(1.16)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C763(1.16)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C763(1.55)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C763(1.48)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C763(1.62)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C763(1.32)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C763(1.38)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C763(1.56)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C763(1.13)  LDD1082  [4]
 LDCM0485  CL90 HEK-293T C763(1.38)  LDD1083  [4]
 LDCM0486  CL91 HEK-293T C763(1.32)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C763(1.52)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C763(1.47)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C763(2.01)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C763(1.85)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C763(1.42)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C763(1.50)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C763(1.82)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C763(1.38)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C319(1.13); C763(1.05); C553(1.34)  LDD1698  [12]
 LDCM0625  F8 Ramos C25(0.81); C553(1.08); C119(1.07); C564(1.60)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C25(1.10); C553(1.83); C119(1.79); C564(0.97)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C25(0.38); C553(5.07); C119(0.50); C564(6.34)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C25(1.05); C553(1.36); C119(0.98); C564(0.83)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C25(0.95); C553(1.14); C119(1.00); C564(1.06)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C25(0.78); C553(0.70); C119(1.07); C564(0.95)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C25(1.72); C553(1.72); C119(1.45); C564(1.47)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C25(1.06); C553(1.07); C119(0.93); C564(0.85)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C25(1.50); C553(1.36); C119(1.10); C564(1.09)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C25(0.95); C553(1.28); C119(0.88); C564(0.91)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C25(0.50); C553(0.71); C119(0.76); C564(0.82)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C25(1.20); C553(1.47); C119(1.20); C564(1.15)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C25(0.94); C553(1.13); C119(0.84); C564(1.10)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C25(0.73); C553(1.22); C119(2.02); C564(1.12)  LDD2201  [14]
 LDCM0468  Fragment33 HEK-293T C763(2.09)  LDD1066  [4]
 LDCM0596  Fragment38 Ramos C25(1.07); C553(1.18); C119(0.91); C564(0.99)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C25(1.68); C553(1.32); C119(1.02); C564(1.10)  LDD2184  [14]
 LDCM0427  Fragment51 HEK-293T C763(1.29)  LDD1025  [4]
 LDCM0610  Fragment52 Ramos C25(1.07); C553(1.66); C119(1.28); C564(1.41)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C25(1.18); C553(2.26); C119(1.57); C564(1.62)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C25(1.37); C553(1.04); C119(1.28); C564(1.12)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C25(2.18); C553(3.69); C119(2.10); C564(1.55)  LDD2188  [14]
 LDCM0022  KB02 HCT 116 C182(1.38)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C182(1.21)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C182(1.11)  LDD0082  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
Serine/threonine-protein kinase PAK 1 (PAK1) STE Ser/Thr protein kinase family Q13153
Serine/threonine-protein kinase PAK 2 (PAK2) STE Ser/Thr protein kinase family Q13177
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
RWD domain-containing protein 2A (RWDD2A) . Q9UIY3
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578