Details of the Target

General Information of Target

Target ID LDTP06183
Target Name Nuclear receptor coactivator 6 (NCOA6)
Gene Name NCOA6
Gene ID 23054
Synonyms
AIB3; KIAA0181; RAP250; TRBP; Nuclear receptor coactivator 6; Activating signal cointegrator 2; ASC-2; Amplified in breast cancer protein 3; Cancer-amplified transcriptional coactivator ASC-2; Nuclear receptor coactivator RAP250; NRC RAP250; Nuclear receptor-activating protein, 250 kDa; Peroxisome proliferator-activated receptor-interacting protein; PPAR-interacting protein; PRIP; Thyroid hormone receptor-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLDDLPNLEDIYTSLCSSTMEDSEMDFDSGLEDDDTKSDSILEDSTIFVAFKGNIDDKD
FKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLR
DLGILSVQIEGEGAINLALAQNRSQDVRMNGPMGAGNSVRMEAGFPMASGPGIIRMNNPA
TVMIPPGGNVSSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLAPPH
HPMQPVSVNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQPQ
GIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTANQGWKKAPLPGPMQQQLQAR
PSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQ
PHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNPMV
QQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPNFMQGQVPSTTATT
PGNSGAPQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGNMNNQQAGTSG
VPQVNLSNMQGQPQQGPPSQLMGMHQQIVPSQGQMVQQQGTLNPQNPMILSRAQLMPQGQ
MMVNPPSQNLGPSPQRMTPPKQMLSQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQ
MQGNKQQFNTQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVNNSPSQV
MGIQGQVLRPPGPSPHMAQQHGDPATTANNDVSLSQMMPDVSIQQTNMVPPHVQAMQGNS
ASGNHFSGHGMSFNAPFSGAPNGNQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHF
GVNNKQNNTNANKPKKKKPPRKKKNSQQDLNTPDTRPAGLEEADQPPLPGEQGINLDNSG
PKLPEFSNRPPGYPSQPVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPPPPSQ
PQSQQQQQQQQQMMMMLMMQQDPKSVRLPVSQNVHPPRGPLNPDSQRMPMQQSGSVPVMV
SLQGPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNPSSSPLAEMASLPEASGSEA
PSVPGGPNNMPSHVVLPQNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNV
AAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQINIPL
PPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTMNPSNFATPQTHKLDSVVVNSGKQSNSGA
TKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTNAALLQNVELPRNVLVSPTP
LANPPVPGSFPNNSGLNPQNSTVSVAAVGGVVEDNKESLNVPQDSDCQNSQSRKEQVNIE
LKAVPAQEVKMVVPEDQSKKDGQPSDPNKLPSVEENKNLVSPAMREAPTSLSQLLDNSGA
PNVTIKPPGLTDLEVTPPVVSGEDLKKASVIPTLQDLSSSKEPSNSLNLPHSNELCSSLV
HPELSEVSSNVAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSANTSAALPTHL
QSALMSTVVTMPNAGSKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPSTIPA
APLTTNSGLMPPSVAVVGPLHIPQNIKFSSAPVPPNALSSSPAPNIQTGRPLVLSSRATP
VQLPSPPCTSSPVVPSHPPVQQVKELNPDEASPQVNTSADQNTLPSSQSTTMVSPLLTNS
PGSSGNRRSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYGADGETEGQGLDTT
APGLMGTEQLSTELDSKTPTPPAPTLLKMTSSPVGPGTASAGPSLPGGALPTSVRSIVTT
LVPSELISAVPTTKSNHGGIASESLAGGLVEEKVGSHPELLPSIAPSQNLVSKETSTTAL
QASVARPELEVNAAIVSGQSSEPKEIVEKSKIPGRRNSRTEEPTVASESVENGHRKRSSR
PASASSSTKDITSAVQSKRRKSK
Target Bioclass
Other
Subcellular location
Nucleus
Function
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
Uniprot ID
Q14686
Ensemble ID
ENST00000359003.7
HGNC ID
HGNC:15936

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.15  LDD0402  [1]
DBIA
 Probe Info  		C1427(1.12)  LDD0080  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
Phosphinate-6
 Probe Info  		C1748(0.00); C1832(0.00)  LDD0018  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1427(1.01)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C1427(1.05)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C1427(0.76)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C1427(0.90)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C1427(0.91)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C1427(0.99)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C1427(0.96)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C1427(0.99)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C1427(1.12)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C1427(0.91)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C1427(0.84)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C1427(0.80)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C1427(1.18)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C1427(0.73)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C1427(0.62)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C1427(0.69)  LDD0546  [2]
 LDCM0230  AC113 HEK-293T C1427(1.21)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C1427(1.04)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C1427(1.14)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C1427(0.99)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C1427(1.15)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C1427(1.16)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C1427(1.20)  LDD0834  [2]
 LDCM0237  AC12 HCT 116 C1427(0.90)  LDD0554  [2]
 LDCM0238  AC120 HEK-293T C1427(1.18)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C1427(1.27)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C1427(1.27)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C1427(1.32)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C1427(1.21)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C1427(1.41)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C1427(1.65)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C1427(1.72)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C1427(1.04)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C1427(1.17)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C1427(1.31)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C1427(1.12)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C1427(1.32)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C1427(1.23)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C1427(1.20)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C1427(1.14)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C1427(1.01)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C1427(1.29)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C1427(1.23)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C1427(1.27)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C1427(0.90)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C1427(1.22)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C1427(1.16)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C1427(1.24)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C1427(0.84)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C1427(1.06)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C1427(1.16)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C1427(1.15)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C1427(0.82)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C1427(0.89)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C1427(1.06)  LDD0867  [2]
 LDCM0270  AC15 HCT 116 C1427(1.12)  LDD0587  [2]
 LDCM0271  AC150 HEK-293T C1427(0.86)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C1427(1.07)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C1427(0.97)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C1427(0.96)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C1427(0.93)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C1427(1.25)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C1427(1.06)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C1427(0.84)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C1427(1.14)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C1427(1.36)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C1427(0.98)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C1427(1.02)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C1427(1.15)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C1427(1.31)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C1427(1.01)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C1427(1.05)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C1427(1.02)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C1427(1.02)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C1427(1.25)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C1427(1.23)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C1427(1.30)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C1427(1.48)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C1427(1.00)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C1427(1.22)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C1427(1.33)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C1427(1.71)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C1427(1.37)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C1427(1.30)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C1427(0.90)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C1427(0.88)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C1427(0.95)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C1427(0.99)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C1427(1.06)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C1427(1.16)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C1427(1.25)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C1427(0.99)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C1427(1.14)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C1427(1.11)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C1427(1.19)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C1427(1.45)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C1427(0.76)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C1427(1.23)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C1427(0.95)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C1427(1.28)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C1427(1.29)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C1427(1.15)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C1427(0.72)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C1427(0.89)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C1427(1.06)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C1427(1.00)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C1427(1.33)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C1427(1.67)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C1427(1.05)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C1427(0.97)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C1427(1.04)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C1427(1.17)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C1427(1.12)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C1427(1.12)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C1427(1.02)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C1427(1.10)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C1427(1.11)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C1427(1.09)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C1427(0.99)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C1427(1.01)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C1427(0.85)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C1427(1.02)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C1427(1.07)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C1427(1.12)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C1427(1.19)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C1427(0.96)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C1427(1.31)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C1427(1.79)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C1427(1.44)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C1427(0.88)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C1427(1.25)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C1427(0.84)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C1427(0.87)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C1427(1.23)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C1427(1.16)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C1427(1.04)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C1427(1.28)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C1427(0.94)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C1427(0.99)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C1427(0.93)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C1427(1.29)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C1427(1.19)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C1427(1.25)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C1427(1.29)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C1427(1.13)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C1427(0.91)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C1427(0.91)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C1427(0.85)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C1427(0.90)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C1427(0.93)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C1427(0.93)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C1427(0.80)  LDD0962  [2]
 LDCM0365  AC98 HCT 116 C1427(1.95)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C1427(0.76)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C1427(1.05)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C1427(0.99)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C1427(1.57)  LDD0592  [2]
 LDCM0367  CL1 HEK-293T C1427(1.40)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C1427(1.29)  LDD0966  [2]
 LDCM0369  CL100 HCT 116 C1427(1.12)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C1427(1.04)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C1427(0.98)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C1427(0.98)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C1427(1.00)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C1427(1.18)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C1427(1.41)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C1427(1.49)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C1427(1.44)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C1427(1.21)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C1427(1.10)  LDD0977  [2]
 LDCM0380  CL110 HCT 116 C1427(1.33)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C1427(1.20)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C1427(0.97)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C1427(1.31)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C1427(1.69)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C1427(1.29)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C1427(1.19)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C1427(1.65)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C1427(1.05)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C1427(1.06)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C1427(1.26)  LDD0988  [2]
 LDCM0391  CL120 HCT 116 C1427(1.05)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C1427(1.15)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C1427(1.08)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C1427(1.34)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C1427(1.29)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C1427(1.10)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C1427(1.13)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C1427(1.07)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C1427(1.04)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C1427(1.03)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C1427(1.15)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C1427(1.29)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C1427(0.86)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C1427(1.09)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C1427(1.13)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C1427(1.19)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C1427(1.30)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C1427(1.28)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C1427(1.21)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C1427(1.52)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C1427(1.10)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C1427(1.35)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C1427(1.23)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C1427(1.37)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C1427(1.11)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C1427(1.12)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C1427(1.26)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C1427(1.27)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C1427(1.35)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C1427(0.88)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C1427(0.80)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C1427(1.05)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C1427(0.96)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C1427(1.14)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C1427(1.08)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C1427(1.08)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C1427(1.28)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C1427(1.28)  LDD1027  [2]
 LDCM0430  CL40 HEK-293T C1427(1.05)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C1427(1.27)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C1427(1.20)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C1427(1.14)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C1427(1.04)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C1427(1.07)  LDD1033  [2]
 LDCM0436  CL46 HCT 116 C1427(1.13)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C1427(1.10)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C1427(1.33)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C1427(1.11)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C1427(1.41)  LDD1038  [2]
 LDCM0441  CL50 HCT 116 C1427(1.34)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C1427(1.13)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C1427(1.13)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C1427(1.50)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C1427(1.27)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C1427(1.16)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C1427(1.02)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C1427(1.37)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C1427(1.19)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C1427(1.04)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C1427(1.98)  LDD1049  [2]
 LDCM0452  CL60 HCT 116 C1427(1.22)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C1427(0.88)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C1427(1.13)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C1427(0.94)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C1427(1.00)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C1427(0.86)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C1427(0.90)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C1427(0.91)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C1427(1.04)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C1427(1.08)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C1427(1.34)  LDD1060  [2]
 LDCM0463  CL70 HCT 116 C1427(1.06)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C1427(1.07)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C1427(0.98)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C1427(1.00)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C1427(1.02)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C1427(1.71)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C1427(1.09)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C1427(1.50)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C1427(1.47)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C1427(0.79)  LDD1071  [2]
 LDCM0474  CL80 HCT 116 C1427(1.07)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C1427(1.41)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C1427(2.16)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C1427(2.46)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C1427(4.28)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C1427(1.62)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C1427(1.32)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C1427(1.64)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C1427(1.83)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C1427(3.48)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C1427(0.88)  LDD1082  [2]
 LDCM0485  CL90 HCT 116 C1427(1.36)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C1427(1.04)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C1427(1.05)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C1427(1.06)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C1427(1.07)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C1427(1.23)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C1427(1.09)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C1427(0.99)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C1427(1.25)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C1427(1.16)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C1748(1.09)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C1427(0.95)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C1427(1.05)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C1427(1.12)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C1427(0.76)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C1427(0.63)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase 2B (KMT2B) Histone-lysine methyltransferase family Q9UMN6
Histone-lysine N-methyltransferase 2C (KMT2C) Histone-lysine methyltransferase family Q8NEZ4
CREB-binding protein (CREBBP) . Q92793
E3 ubiquitin-protein ligase NEDD4 (NEDD4) . P46934
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L) . Q9UBL3
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Retinoblastoma-associated protein (RB1) Retinoblastoma protein (RB) family P06400
WD repeat-containing protein 5 (WDR5) WD repeat WDR5/wds family P61964
TP53-binding protein 1 (TP53BP1) . Q12888

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402