Details of the Target

General Information of Target

Target ID LDTP06179
Target Name Tubulin monoglutamylase TTLL4 (TTLL4)
Gene Name TTLL4
Gene ID 9654
Synonyms
KIAA0173; Tubulin monoglutamylase TTLL4; EC 6.3.2.-; Protein monoglutamylase TTLL4; Tubulin--tyrosine ligase-like protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASAGTQHYSIGLRQKNSFKQSGPSGTVPATPPEKPSEGRVWPQAHQQVKPIWKLEKKQV
ETLSAGLGPGLLGVPPQPAYFFCPSTLCSSGTTAVIAGHSSSCYLHSLPDLFNSTLLYRR
SSYRQKPYQQLESFCLRSSPSEKSPFSLPQKSLPVSLTANKATSSMVFSMAQPMASSSTE
PYLCLAAAGENPSGKSLASAISGKIPSPLSSSYKPMLNNNSFMWPNSTPVPLLQTTQGLK
PVSPPKIQPVSWHHSGGTGDCAPQPVDHKVPKSIGTVPADASAHIALSTASSHDTSTTSV
ASSWYNRNNLAMRAEPLSCALDDSSDSQDPTKEIRFTEAVRKLTARGFEKMPRQGCQLEQ
SSFLNPSFQWNVLNRSRRWKPPAVNQQFPQEDAGSVRRVLPGASDTLGLDNTVFCTKRIS
IHLLASHASGLNHNPACESVIDSSAFGEGKAPGPPFPQTLGIANVATRLSSIQLGQSEKE
RPEEARELDSSDRDISSATDLQPDQAETEDTEEELVDGLEDCCSRDENEEEEGDSECSSL
SAVSPSESVAMISRSCMEILTKPLSNHEKVVRPALIYSLFPNVPPTIYFGTRDERVEKLP
WEQRKLLRWKMSTVTPNIVKQTIGRSHFKISKRNDDWLGCWGHHMKSPSFRSIREHQKLN
HFPGSFQIGRKDRLWRNLSRMQSRFGKKEFSFFPQSFILPQDAKLLRKAWESSSRQKWIV
KPPASARGIGIQVIHKWSQLPKRRPLLVQRYLHKPYLISGSKFDLRIYVYVTSYDPLRIY
LFSDGLVRFASCKYSPSMKSLGNKFMHLTNYSVNKKNAEYQANADEMACQGHKWALKALW
NYLSQKGVNSDAIWEKIKDVVVKTIISSEPYVTSLLKMYVRRPYSCHELFGFDIMLDENL
KPWVLEVNISPSLHSSSPLDISIKGQMIRDLLNLAGFVLPNAEDIISSPSSCSSSTTSLP
TSPGDKCRMAPEHVTAQKMKKAYYLTQKIPDQDFYASVLDVLTPDDVRILVEMEDEFSRR
GQFERIFPSHISSRYLRFFEQPRYFNILTTQWEQKYHGNKLKGVDLLRSWCYKGFHMGVV
SDSAPVWSLPTSLLTISKDDVILNAFSKSETSKLGKQSSCEVSLLLSEDGTTPKSKKTQA
GLSPYPQKPSSSKDSEDTSKEPSLSTQTLPVIKCSGQTSRLSASSTFQSISDSLLAVSP
Target Bioclass
Enzyme
Family
Tubulin--tyrosine ligase family
Subcellular location
Cytoplasm
Function
Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis.
Uniprot ID
Q14679
Ensemble ID
ENST00000258398.8
HGNC ID
HGNC:28976

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C829(1.18)  LDD0531  [2]
AOyne
 Probe Info  		15.00  LDD0443  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C829(1.18)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C829(2.23)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C829(0.94)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C829(1.29)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C829(1.35)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C829(1.37)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C829(0.96)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C829(1.10)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C829(1.23)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C829(1.17)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C829(0.75)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C829(1.14)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C829(1.38)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C829(1.00)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C829(0.92)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C829(1.08)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C640(1.09)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C640(1.16)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C640(1.00)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C640(1.18)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C640(1.11)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C640(1.14)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C640(1.17)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C829(1.40)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C640(1.35)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C640(1.05)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C640(1.37)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C640(1.47)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C640(1.31)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C640(1.36)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C640(1.22)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C640(1.51)  LDD0562  [2]
 LDCM0259  AC14 HCT 116 C829(1.27)  LDD0576  [2]
 LDCM0263  AC143 HCT 116 C829(1.53)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C829(1.78)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C829(2.38)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C829(2.24)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C829(2.10)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C829(2.42)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C829(1.83)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C829(1.28)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C829(2.00)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C829(1.49)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C829(1.83)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C829(3.24)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C829(1.90)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C829(1.25)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C829(1.26)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C829(0.97)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C640(1.15); C829(1.77)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C640(1.03); C829(1.65)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C829(1.11); C640(1.26)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C829(1.63)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C640(0.89); C829(1.34)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C640(1.03); C829(1.27)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C640(0.94); C829(1.28)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C640(0.93); C829(1.15)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C640(1.25); C829(1.31)  LDD0601  [2]
 LDCM0290  AC3 HCT 116 C829(1.11)  LDD0607  [2]
 LDCM0296  AC35 HCT 116 C829(0.96)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C829(1.15)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C829(0.83)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C829(0.91)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C829(1.02)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C829(1.21)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C829(1.20)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C829(1.00)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C829(0.98)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C829(1.42)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C829(0.99)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C829(0.82)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C829(0.92); C640(1.05)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C640(0.92); C829(0.96)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C640(0.93); C829(0.94)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C640(1.01); C829(1.35)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C829(1.19)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C640(1.17); C829(1.29)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C829(0.91); C640(1.02)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C829(0.91); C640(0.94)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C829(0.86); C640(0.87)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C640(1.10); C829(1.14)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C640(0.87); C829(1.38)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C640(1.04); C829(1.49)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C640(1.01)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C640(1.11)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C640(1.16)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C829(0.74)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C640(0.88)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C640(1.21)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C640(1.11)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C640(1.18)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C640(1.26)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C640(1.00)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C640(1.24)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C640(1.12)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C640(1.02); C829(1.35)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C829(0.92); C640(1.07)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C829(0.82)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C829(0.79); C640(1.10)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C829(0.88); C640(1.09)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C829(0.90); C640(1.06)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C829(1.05); C640(1.02)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C640(1.02); C829(1.48)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C640(1.03); C829(1.41)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C640(1.02); C829(1.27)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C640(0.89); C829(1.26)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C640(0.92); C829(0.95)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C640(0.93); C829(1.08)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C829(1.64)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C640(0.86); C829(1.01)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C829(0.90); C640(0.94)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C640(0.94); C829(1.43)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C829(2.29)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C829(2.32)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C829(2.63)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C829(1.29)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C829(1.85)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C829(2.29)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C829(2.02)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C829(1.21)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C829(2.78)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C829(5.89)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C829(1.24)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C829(1.68)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C829(1.69)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C829(1.50)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C829(1.66)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C829(1.73)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C829(0.66)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C829(1.03)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C829(1.74)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C829(2.23)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C640(1.30)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C640(1.04)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C829(1.33)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C829(1.38)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C829(1.23)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C829(0.98)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C829(1.14)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C640(0.98); C829(1.52)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C640(0.96); C829(2.39)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C640(1.00); C829(1.76)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C640(1.16); C829(1.73)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C640(1.06); C829(1.55)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C640(1.01)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C640(1.08); C829(1.91)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C640(0.89); C829(1.75)  LDD0698  [2]
 LDCM0387  CL117 HCT 116 C829(1.94)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C829(0.88)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C829(0.99)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C640(1.07)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C829(1.00)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C829(0.63); C640(0.85)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C829(0.79); C640(0.96)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C640(0.93); C829(1.28)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C640(0.93); C829(1.68)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C640(1.02)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C640(0.89)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C640(1.02)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C640(0.90)  LDD0997  [2]
 LDCM0400  CL13 HCT 116 C640(0.98)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C640(0.96)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C640(1.10)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C640(0.88)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C640(0.90)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C640(1.00)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C640(0.91)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C640(1.22)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C640(0.90)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C640(1.07)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C640(0.98)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C640(0.70)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C640(0.81)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C640(0.78)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C640(0.76)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C640(0.74)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C640(0.81)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C640(0.84)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C640(0.89)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C640(0.81)  LDD0736  [2]
 LDCM0420  CL31 PaTu 8988t C829(1.18)  LDD1299  [2]
 LDCM0421  CL32 HCT 116 C640(0.92)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C640(1.06)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C640(1.07)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C640(0.96)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C640(1.17)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C640(1.14)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C640(1.10)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C640(0.90)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C640(0.99)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C640(0.94)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C640(1.05)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C640(0.94)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C640(1.22)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C640(1.03)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C829(1.44)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C829(0.66)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C829(0.72)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C829(1.05)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C640(0.88)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C829(1.01)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C829(1.03)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C829(0.94)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C829(0.65)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C829(0.68)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C829(0.75)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C829(0.88)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C829(0.76)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C829(0.67)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C829(0.75)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C640(1.08)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C829(1.21)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C829(1.79)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C829(1.45)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C829(1.50)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C829(1.76)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C829(1.53)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C829(2.25)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C829(1.52)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C829(1.71)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C829(1.63)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C640(0.91)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C829(1.60)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C829(1.55)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C829(1.43)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C829(1.64)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C829(1.90)  LDD0784  [2]
 LDCM0469  CL76 PaTu 8988t C829(0.90)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C829(0.95)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C829(1.46)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C829(0.89)  LDD1351  [2]
 LDCM0473  CL8 HCT 116 C640(1.31)  LDD0790  [2]
 LDCM0474  CL80 PaTu 8988t C829(1.08)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C829(1.40)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C829(1.11)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C829(1.00)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C829(2.16)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C829(1.06)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C829(1.05)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C829(1.17)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C829(1.12)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C829(1.33)  LDD1362  [2]
 LDCM0484  CL9 HCT 116 C640(0.91)  LDD0801  [2]
 LDCM0485  CL90 PaTu 8988t C829(1.75)  LDD1364  [2]
 LDCM0486  CL91 HCT 116 C829(1.67)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C829(1.16)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C829(1.08)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C829(1.36)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C829(1.69)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C829(1.00)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C829(1.21)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C829(1.19)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C829(1.07)  LDD0811  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1174(2.93)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C829(1.44)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C640(1.06)  LDD0744  [2]
 LDCM0023  KB03 Hs 936.T C1174(1.29)  LDD2780  [5]
 LDCM0024  KB05 Hs 936.T C1174(1.32)  LDD3197  [5]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840