Details of the Target

General Information of Target

Target ID LDTP05817
Target Name Voltage-gated potassium channel subunit beta-2 (KCNAB2)
Gene Name KCNAB2
Gene ID 8514
Synonyms
KCNA2B; KCNK2; Voltage-gated potassium channel subunit beta-2; EC 1.1.1.-; K(+) channel subunit beta-2; Kv-beta-2; hKvbeta2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTF
GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF
WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG
MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA
MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG
CTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY
SKKDYRS
Target Bioclass
Transporter and channel
Family
Shaker potassium channel beta subunit family
Subcellular location
Cytoplasm
Function
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability. Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity. Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes KCNA4 channel closure. Modulates the functional properties of KCNA5. Enhances KCNB2 channel activity. Binds NADPH and has NADPH-dependent aldoketoreductase activity. Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro).
Uniprot ID
Q13303
Ensemble ID
ENST00000164247.5
HGNC ID
HGNC:6229

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y360(20.00); Y270(8.42)  LDD0260  [1]
STPyne
 Probe Info  		K124(20.00)  LDD2219  [2]
NAIA_5
 Probe Info  		C248(20.00)  LDD2227  [3]
DBIA
 Probe Info  		C248(27.72)  LDD0209  [4]
HHS-482
 Probe Info  		Y360(1.02)  LDD0285  [5]
HHS-475
 Probe Info  		Y360(1.51)  LDD0264  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		C248(0.00); C212(0.00); C311(0.00); C301(0.00)  LDD0036  [7]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C248(0.00); C212(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C248(1.14)  LDD1510  [11]
 LDCM0270  AC15 HEK-293T C248(1.05)  LDD1513  [11]
 LDCM0280  AC20 HEK-293T C248(1.09)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C248(1.09)  LDD1520  [11]
 LDCM0283  AC23 HEK-293T C248(1.05)  LDD1522  [11]
 LDCM0288  AC28 HEK-293T C248(1.01)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C248(0.98)  LDD1528  [11]
 LDCM0292  AC31 HEK-293T C248(1.14)  LDD1531  [11]
 LDCM0297  AC36 HEK-293T C248(1.11)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C248(1.11)  LDD1537  [11]
 LDCM0300  AC39 HEK-293T C248(1.15)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C248(1.18)  LDD1540  [11]
 LDCM0306  AC44 HEK-293T C248(1.24)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C248(0.97)  LDD1546  [11]
 LDCM0309  AC47 HEK-293T C248(1.16)  LDD1548  [11]
 LDCM0312  AC5 HEK-293T C248(1.06)  LDD1551  [11]
 LDCM0315  AC52 HEK-293T C248(1.22)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C248(1.06)  LDD1555  [11]
 LDCM0318  AC55 HEK-293T C248(0.99)  LDD1557  [11]
 LDCM0324  AC60 HEK-293T C248(0.99)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C248(1.02)  LDD1564  [11]
 LDCM0327  AC63 HEK-293T C248(1.08)  LDD1566  [11]
 LDCM0334  AC7 HEK-293T C248(1.14)  LDD1568  [11]
 LDCM0248  AKOS034007472 HEK-293T C248(1.03)  LDD1511  [11]
 LDCM0632  CL-Sc Hep-G2 C248(20.00)  LDD2227  [3]
 LDCM0379  CL11 HEK-293T C248(0.96)  LDD1583  [11]
 LDCM0408  CL20 HEK-293T C248(1.04)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C248(0.78)  LDD1613  [11]
 LDCM0411  CL23 HEK-293T C248(0.89)  LDD1615  [11]
 LDCM0421  CL32 HEK-293T C248(0.94)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C248(0.97)  LDD1626  [11]
 LDCM0424  CL35 HEK-293T C248(0.89)  LDD1628  [11]
 LDCM0434  CL44 HEK-293T C248(0.91)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C248(0.87)  LDD1639  [11]
 LDCM0437  CL47 HEK-293T C248(0.88)  LDD1641  [11]
 LDCM0447  CL56 HEK-293T C248(1.12)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C248(0.94)  LDD1651  [11]
 LDCM0450  CL59 HEK-293T C248(0.96)  LDD1653  [11]
 LDCM0460  CL68 HEK-293T C248(1.00)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C248(0.98)  LDD1664  [11]
 LDCM0464  CL71 HEK-293T C248(0.88)  LDD1667  [11]
 LDCM0473  CL8 HEK-293T C248(1.16)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C248(1.00)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C248(0.97)  LDD1678  [11]
 LDCM0477  CL83 HEK-293T C248(0.87)  LDD1680  [11]
 LDCM0484  CL9 HEK-293T C248(1.03)  LDD1687  [11]
 LDCM0487  CL92 HEK-293T C248(1.04)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C248(1.06)  LDD1691  [11]
 LDCM0490  CL95 HEK-293T C248(0.82)  LDD1693  [11]
 LDCM0625  F8 Ramos C248(1.28)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C248(1.84)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C248(0.05)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C248(1.60)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C248(1.24)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C248(0.88)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C248(1.33)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C248(1.03)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C248(1.21)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C248(0.97)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C248(0.93)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C248(1.19)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C248(1.55)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C248(1.64)  LDD2201  [12]
 LDCM0468  Fragment33 Ramos C248(2.93)  LDD2202  [12]
 LDCM0596  Fragment38 Ramos C248(1.00)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C248(2.05)  LDD2184  [12]
 LDCM0610  Fragment52 Ramos C248(1.45)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C248(0.97)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C248(2.21)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C248(1.55)  LDD2188  [12]
 LDCM0116  HHS-0101 DM93 Y360(1.51)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y360(1.32)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y360(0.71)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y360(0.67)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y360(0.86)  LDD0268  [6]
 LDCM0123  JWB131 DM93 Y360(1.02)  LDD0285  [5]
 LDCM0124  JWB142 DM93 Y360(0.66)  LDD0286  [5]
 LDCM0125  JWB146 DM93 Y360(0.79)  LDD0287  [5]
 LDCM0126  JWB150 DM93 Y360(3.43)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y360(2.54)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y360(1.30)  LDD0290  [5]
 LDCM0129  JWB202 DM93 Y360(0.86)  LDD0291  [5]
 LDCM0130  JWB211 DM93 Y360(1.11)  LDD0292  [5]
 LDCM0022  KB02 HEK-293T C248(0.99)  LDD1492  [11]
 LDCM0023  KB03 Jurkat C248(27.72)  LDD0209  [4]
 LDCM0024  KB05 COLO792 C296(1.35)  LDD3310  [13]
 LDCM0131  RA190 MM1.R C248(1.36)  LDD0304  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Huntingtin (HTT) Huntingtin family P42858

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Enflurane Small molecular drug DB00228
Miconazole Small molecular drug DB01110
Promethazine Small molecular drug DB01069

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.